ライフサイエンスコーパス: germ cell

1 autophagy member proteins to clear apoptotic germ cells.

2 of gamete arise from the same precursor, the germ cells.

3 13 is required for axoneme formation in male germ cells.

4 e-encoding mature mRNA isoform in Drosophila germ cells.

5 anism promoting sexual differentiation of XY germ cells.

6 directly in Sertoli, Leydig and pre-meiotic germ cells.

7 sm that helps oocytes function as long-lived germ cells.

8 oliferation of the rescued, nondysfunctional germ cells.

9 ucial role in transposon silencing in animal germ cells.

10 the mitosis-meiosis transition in mouse male germ cells.

11 ist of two cell lineages - somatic cells and germ cells.

12 matin upon sex differentiation in developing germ cells.

13 ites (BORIS) are simultaneously expressed in germ cells.

14 and in adult post-mitotic and proliferative germ cells.

15 ovaries can result in further rapid loss of germ cells.

16 hway links the environment and proliferative germ cell accumulation.

17 o AURK isoforms (AURKA and AURKB), mammalian germ cells also express a third, AURKC.

18 ly manipulated GSC depletion, E(z) knockdown germ cells also fail to replenish lost GSCs.

19 sms of MRLs and their physiological roles in germ cell and neural development, oncogenic functions in

20 ession pattern that is primary restricted to germ cells and aberrantly reactivated in various cancers

21 T signalling pathway are expressed in female germ cells and embryos.

22 ship between evolution of chromatin state in germ cells and evolution of gene regulatory programs gov

23 (CTCF&BORIS) or BORIS alone (BORIS-only) in germ cells and in BORIS-positive somatic cancer cells.

24 ritable L1 insertions may therefore arise in germ cells and in pluripotent embryonic cells, prior to

25 PLAG1 was sparsely expressed in germ cells and in Sertoli cells.

26 Germ-cell tumours (GCTs) are derived from germ cells and occur most frequently in the testes.

27 d induced pluripotent stem cells, primordial germ cells and oocytes.

28 ed to support cell adhesion and transport of germ cells and organelles (e.g., residual bodies, phagos

29 ion into late primordial germ cells, meiotic germ cells and ovarian follicles.

30 condensate (CSC) causes molecular defects in germ cells and phenotypic effects in their offspring.

31 s receptor results in loss of differentiated germ cells and sexual maturity.

32 ialized region of the oocyte that prefigures germ cells and specifies the germline of descendants in

33 largely unknown how meiosis is initiated in germ cells and why non-germline cells do not undergo mei

34 at SMG-1 mainly acts in mitotically dividing germ cells, and during late embryonic and larval develop

35 on in the dermal papilla, the secondary hair germ cells, and the epidermis.

36 Autoimmune responses to meiotic germ cell antigens (MGCA) that are expressed on sperm an

37 g miR-471-5p in Sertoli cells show increased germ cell apoptosis and compromised male fertility.

38 ishes CEP-1/p53-dependent DNA damage-induced germ cell apoptosis in the nematode Caenorhabditis elega

39 g to attenuated Akt activation and increased germ cell apoptosis, effectively halting spermatozoa pro

40 ombinant human GDF9 and BMP15, these meiotic germ cells are further induced to form ovarian FLCs, inc

41 f two modes: a likely ancestral mode wherein germ cells are induced during embryogenesis by cell-cell

42 oocyte to embryo, genetic programs in mouse germ cells are reshaped by chromatin remodeling to orche

43 ich the fittest, strongest, or least damaged germ cells are selected for transmission to the next gen

44 g (induction) or a derived mechanism whereby germ cells are specified by using germ plasm-that is, ma

45 Male and female germ cells are usually produced during spermatogenesis a

46 are required for normal piRNA biogenesis in germ cells, are dispensable.

47 impaired LAP-mediated clearance of apoptotic germ cells as miR-471-5p transgenic mice show lower leve

48 (c.1297_8ins353, p.K433Rins31*) in the male germ cell-associated kinase (MAK) gene (39% of families

49 a polarity protein expressed by Sertoli and germ cells at the basal compartment in the seminiferous

50 t for initiating the first meiosis in female germ cells at the SD stage.

51 rational inheritance by invading presumptive germ cells before they are formed.

52 the human fetal testis and alteration of the germ cell biology.

53 platin and carboplatin are used primarily in germ cell, breast and lung malignancies, oxaliplatin is

54 ipt levels in several tumor tissues, such as germ cell, breast, and ovarian tumors, with in the latte

55 ryogenesis and differentiation of primordial germ cells but is reduced substantially during post-pube

56 og FOLR-1 is required for the stimulation of germ cells by 10-formyl-tetrahydrofolate-Glun and dihydr

57 cells interact with and regulate primordial germ cells by actively excising and digesting germ cell

58 P.Although phagocytic clearance of apoptotic germ cells by Sertoli cells is essential for spermatogen

59 Phagocytic clearance of apoptotic germ cells by Sertoli cells is vital for germ cell devel

60 sential for efficient clearance of apoptotic germ cells by Sertoli cells using LAP.Although phagocyti

61 e transition from mitosis to meiosis in male germ cells by targeting DMRT1 for degradation.

62 ents given systemic treatment for testicular germ cell cancer (GCC) are at increased risk for a secon

63 as poor risk according to the International Germ Cell Cancer Collaborative Group (IGCCCG) model.

64 International Germ Cell Cancer Collaborative Group (IGCCCG) prognostic

65 routine follow-up, 98% in the International Germ Cell Cancer Collaborative Group good prognosis grou

66 ow-up, pulmonary impairment in patients with germ cell cancer who were treated with BEP was limited.

67 For patients with germ cell cancer, various pulmonary toxicity risk factor

68 Furthermore their stem cell and germ cell characteristics remain disputed.

69 ansposition in postnatal day 14 Mov10l1(-/-) germ cells compared with the wild-type.

70 hat: (1) inhibition of retinoid signaling in germ cells completely blocked spermatogonial differentia

71 its meaning by visiting multiple examples of germ cell connectivity observed in evolutionarily distan

72 m cells lies at the heart of inheritance, as germ cells contain all of the genetic and epigenetic inf

73 Our data showed that germ cells cultured with 5H-purin-6-amine could maintain

74 gulators that are enriched at the primordial germ cell cytoplasmic bridge to ensure its stability dur

75 A-binding proteins specifically expressed in germ cells, DAZL and BOULE, regulate the exit from pluri

76 Germ cell death occurs in many species [1-3] and has bee

77 ion of either gene during pachytene triggers germ cell death.

78 ous spermatogonial death and reduces overall germ cell death.

79 ration in triggering meiotic checkpoints and germ-cell death.

80 opausal biology on ovarian cancer risk using germ cell-deficient white-spotting variant (Wv) mice, in

81 ghts piRNA deficiency or actually drives the germ-cell demise.

82 ted PM cells were able to colonize testes of germ cell-depleted mice after transplantation.

83 Vasa is a key germ cell determinant in many animal species and is posi

84 Germ cells develop as a cyst of interconnected sibling c

85 tic germ cells by Sertoli cells is vital for germ cell development and differentiation.

86 that cytoplasmic Drosophila Rbfox1 regulates germ cell development and represses the translation of m

87 ion by NRF1 and epigenetic modulation during germ cell development and unequivocally demonstrate a no

88 are critical for BTB function and subsequent germ cell development during spermatogenesis.

89 Germ cell development involves major reprogramming of th

90 ether pseudo-tetraploid cells arise early in germ cell development or just prior to meiosis has remai

91 hese de novo mutations occurred during early germ cell development.

92 e small non-coding RNAs essential for animal germ cell development.

93 g occurs: early mouse embryos and primordial germ cell development.

94 for embryonic development and regulates male germ cell development.

95 s RNA-binding proteins play crucial roles in germ cell development.

96 pecific endosiRNAs present during primordial germ cell development.

97 ryonic cell transcription factor 1) in mouse germ cell development.

98 namic, changing size at precise times during germ cell development.

99 The beta-TrCP-deficient male germ cells did not enter meiosis, but instead underwent

100 cience, Lei and Spradling (2016) uncover how germ cells differentiate into oocytes in mouse embryos.

101 enesis, a process through which haploid male germ cells differentiate into spermatozoa, represents an

102 has significant consequences for progenitor germ cell differentiation and the ability to transmit DN

103 ptibility, consistent with failed primordial germ cell differentiation as an initiating step in oncog

104 However, germ cell differentiation resumed after ceasing the abla

105 otic arrest complex, to transcripts for male germ cell differentiation.

106 ropeptide required for sexual maturation and germ cell differentiation.

107 events that characterize the development of germ cells during fetal life as they commit to, and prep

108 ze zygotic inductive cell signals to specify germ cells during later embryogenesis.

109 tem cells (ESCs) and gonad-derived embryonic germ cells (EGCs) represent two classic types of pluripo

110 onal TOPBP1 deletion during pachynema causes germ cell elimination associated with defective X chromo

111 YTHDC2-deficient male germ cells enter meiosis but have a mixed identity, main

112 Once germ cells enter meiosis, pachytene spermatocytes produc

113 In females, fetal germ cells enter meiosis, whereas in males they delay me

114 ied INSL6 as a novel CUL4B substrate in male germ cells, evidenced by its direct polyubiquination and

115 ucing apical ES degeneration, which leads to germ cell exfoliation from the seminiferous epithelium.

116 ent, Arf-null mice are blind, and their male germ cells exhibit defects in meiotic maturation and spe

117 piRNA-deficient mice, L1-overexpressing male germ cells exhibit excessive DNA damage and meiotic defe

118 We show that mouse and human germ cells exhibit non-canonical X dosage states that di

119 We hypothesized that germ cells express negative regulators of nucleic acid s

120 resistance to infection through the receptor germ cell expressed (gce).

121 lies like Drosophila, the ancestral receptor germ cell-expressed (gce) gene has duplicated to yield t

122 Somatic gonadal precursor cells and germ cells fail to proliferate fully and complete their

123 ated RHAMM as an intrinsic regulator of male germ cell fate and as a gatekeeper preventing initiation

124 These findings suggest that Nanos promotes germ cell fate by downregulating maternal RNAs and prote

125 st development for competency for primordial germ cell fate.

126 s A1CF and AGO2 in the epigenetic control of germ-cell fate, urogenital development, and gamete funct

127 Mouse primordial germ cells form germline cysts, but the role of cysts in

128 sophila oocyte defines where the abdomen and germ cells form in the embryo.

129 imal species and is posited to control avian germ cell formation.

130 sm for functional studies of induction-based germ cell formation.

131 dent process; mRNAs necessary for primordial germ-cell formation are enriched in the germ plasm at la

132 c stability, which is inextricably linked to germ-cell formation, by forming Piwi ribonucleoproteins

133 Analysis of adult Mov10l1(-/-) germ-cell fractions indicated a stage-specific increase

134 falciparum proteins prepared using the wheat germ cell-free system (WGCFS).

135 /H3K27me3 bivalent) epigenetic state in male germ cells from five mammalian and one avian species.

136 elopment, whereas genes that gain poising in germ cells from individual species act downstream of cor

137 We find that core genes poised in germ cells from multiple amniote species are ancient reg

138 ity provides a genetic barrier that prevents germ cells from reverting back to an earlier development

139 ted loci were shared between the somatic and germ cells from the same individual.

140 e dysgenetic areas, with more ectopic SC and germ cells (GC) than DBP-FW treatment; DBP-LW induces no

141 As germ cells (GC) undergo developmental and epigenetic cha

142 genetic or epigenetic information carried by germ cells (GCs).

143 7 exhibits male-specific expression in early germ cells, germline stem cells and spermatogonia in ins

144 However, siRNA movement into germ cells has remained controversial, and has gained in

145 Human primordial germ cells (hPGCs), the precursors of sperm and eggs, or

146 ly, DPY-21 also associates with autosomes of germ cells in a DCC-independent manner to enrich H4K20me

147 e analyzed the DNA methylomes of somatic and germ cells in a four-generation family.

148 eless,Cul4bglobal knock-out males lost their germ cells in an age-dependent manner, implying failure

149 trans-epithelial migration of the primordial germ cells in early embryos.

150 Two broadly known characteristics of germ cells in many organisms are their development as a

151 ired for sexual differentiation of male (XY) germ cells in mice, the underlying mechanisms and the id

152 play a crucial role in the specification of germ cells in mice.

153 Germ cells in most animals are connected by intercellula

154 developmental accumulation of proliferative germ cells in the C. elegans hermaphrodite is sensitive

155 and irregular head morphology in postmeiotic germ cells in the seminiferous epithelium, which led to

156 verexpression rescues clearance of apoptotic germ cells in the testes of Mertk (-/-) mice it fails to

157 adotropes of the pituitary and in Leydig and germ cells in the testes, but at very low levels in Sert

158 o maintain the epigenomic characteristics of germ cells in vivo.

159 previously reported that BMP signaling-based germ cell induction is conserved in both the mouse Mus m

160 s with transplantation of mutated primordial germ cells into a wild-type host.

161 We find that the decision to die is a germ cell-intrinsic process linked to quantitative diffe

162 rating that NHE8's role in spermiogenesis is germ cell-intrinsic.

163 hila TZ assembly in sensory neurons and male germ cells involves cooperative actions of Cby and Dila.

164 Whether X dosage compensation occurs in germ cells is unclear.

165 Here, we show that Drosophila Germ cell-less (GCL) is a critical component in this pro

166 The Germ Cell-Less (GCL) protein is a key regulator of primo

167 Developmental specification of germ cells lies at the heart of inheritance, as germ cel

168 uripotent stem cell-derived human primordial germ cell-like cells (hPGCLCs) provide important opportu

169 ly reported ChIP-seq datasets for primordial germ cell-like cells and E18.5 small intestine, combined

170 Induced germ cell-like cells showed a marked switch in their tra

171 ls (hFSK (46, XY), and hMSC (46, XY)) into a germ cell-like phenotype in vitro.

172 XY iPSCs can be differentiated into the male germ cell lineage and functional sperm that can be used

173 The germ cell lineage is specified early in embryogenesis an

174 the asymmetric division that segregates the germ cell lineage.

175 ntinue indefinitely, because of its immortal germ-cell lineage.

176 erm cells by actively excising and digesting germ cell lobes.

177 gained an epigenetically privileged state in germ cells, manifested in amniotes by H3K4me3/H3K27me3 p

178 ated by a live-cell sorting method using the germ cell marker DDX4, which has previously been assumed

179 itiate expression of mesoderm and primordial germ cell markers asymmetrically on the embryonic and ex

180 le arrest in premeiotic G2 phase coordinates germ cell maturation and meiotic cell division with horm

181 neral importance in posterior patterning and germ cell maturation.

182 em cell differentiation into late primordial germ cells, meiotic germ cells and ovarian follicles.

183 nables distinct spatiotemporal regulation of germ cell migration.

184 nally inherited germ determinants to specify germ cells, most animals, including mice, appear to util

185 hanges in the vinclozolin-exposed fetal male germ cells (n = 3) to control samples (n = 3), their cou

186 associated with hypoadenylated mRNAs (e.g., germ cells/neurons) and/or limiting cytoplasmic PABP (e.

187 We report an ancient family of GCNA (germ cell nuclear antigen) proteins that arose in the ea

188 nditional inactivation of beta-TrCP2 in male germ cells of beta-TrCP1 knockout mice resulted in steri

189 ine (Aub) maintains genome integrity in late germ cells of the Drosophila ovary through Piwi-associat

190 eceptor alpha (RARalpha) specifically to the germ cells of transgenic mice to subvert the activity of

191 roven testicular tumors (benign or malignant germ cell or stromal tumors).

192 ays a novel and important role in primordial germ cell (PGC) development and that ephrinB1 (efnb1) is

193 Primordial germ cell (PGC) development is characterized by global e

194 CL) protein is a key regulator of primordial germ cell (PGC) formation in Drosophila embryos.

195 a at the posterior at the site of primordial germ cell (PGC) formation through an actin-dependent mec

196 re competent for both somatic and primordial germ cell (PGC) specification.

197 nheritance correlates with higher primordial germ cell (PGC) survival probability.

198 The migration of primordial germ cells (PGCs) from their place of origin to the embr

199 In animals, primordial germ cells (PGCs) give rise to the germ lines, the cell

200 s, is also expressed in unipotent primordial germ cells (PGCs) in mice, where its precise role is yet

201 enin signaling pathway in chicken primordial germ cells (PGCs) in vitro.

202 The migration of primordial germ cells (PGCs) is a useful model for studying this pr

203 ave profiled the transcriptome of primordial germ cells (PGCs) lacking the nanos homologs nos-1 and n

204 During development, primordial germ cells (PGCs) navigate a complex journey to generate

205 omatin modifications occur in the primordial germ cells (PGCs) of emergent starved L1 larvae that cor

206 the translational activity in the primordial germ cells (PGCs) of the sea urchin embryo (Strongylocen

207 In the developing embryo, primordial germ cells (PGCs) represent the exclusive progenitors of

208 er requires directed migration of primordial germ cells (PGCs) towards somatic gonadal precursor cell

209 1 is required for the survival of primordial germ cells (PGCs), as well as the suppression of germ ce

210 en in preimplantation embryos and primordial germ cells (PGCs), or locus specific, which can regulate

211 ineages is the differentiation of primordial germ cells (PGCs), precursors of sex-specific gametes th

212 the DDX4 (vasa) locus in chicken primordial germ cells (PGCs).

213 constructed by transplantation of primordial germ cells (PGCs).

214 important opportunities to study primordial germ cells (PGCs).

215 late the directional migration of primordial germ cells (PGCs).

216 ylated cytosines is a hallmark of primordial germ cells (PGCs).

217 c cells and, strikingly, to early primordial germ cells (PGCs).

218 ptor, Trapped in endoderm 1 (Tre1), mediates germ cell polarization at the onset of active migration

219 against the hypothesis that acquisition of a germ-cell program in somatic cells increases lifespan an

220 late precursor dihydropteroate also promotes germ cell proliferation in vitro and in vivo, despite it

221 We show that germ cell proliferation is stimulated by the folate 10-f

222 down-regulated these germline genes, blocked germ cell proliferation, and subsequently led to male in

223 bacterial folate as a positive regulator of germ cell proliferation.

224 ed compound as exogenous signals to modulate germ cell proliferation.

225 xcessive planar division of undifferentiated germ cells promotes their self-renewal and TGCT developm

226 In mammalian females, germ cells remain arrested as primordial follicles.

227 unctions, and speculates as to why mammalian germ cells require expression of three AURKs instead of

228 Inactivation of PRC1 in male germ cells results in the gradual loss of a stem cell po

229 lean switch from mitosis to meiosis in mouse germ cells, revealing a conserved role for YTHDC2 in thi

230 is necessary for meiotic progression of male germ cells, similar to the known function of boule in in

231 s required for the maintenance of early male germ cells, similar to vertebrate Dazl To examine if Bou

232 In Caenorhabditis elegans, removing germ cells slows aging and extends life.

233 oocytes, we developed a mouse model with the germ cell-specific constitutive activation of betacateni

234 Germ cell-specific deletion of Cul4bled to male infertil

235 timulated by retinoic acid gene 8 (Stra8), a germ cell-specific gene activated during meiotic commitm

236 transgenic system, here we identify Dazl, a germ cell-specific gene encoding an RNA-binding protein

237 (TSTRs) and associated with highly expressed germ cell-specific genes and histone retention in mature

238 directly regulate the expression of multiple germ cell-specific genes, including Asz1 In addition, co

239 ith distinct developmental states, including germ cell-specific genes.

240 We show that the germ cell-specific RNA-binding protein deleted in azoosp

241 Germ cell-specific, but not Sertoli cell-specific Nhe8 d

242 Abe et al. (2017) identify NLRP14 as a germ-cell-specific negative regulator of DNA sensing tha

243 tween BMP signaling and Blimp-1 in inductive germ cell specification between mouse and cricket suppor

244 his molecular mechanism regulated primordial germ cell specification in a last common bilaterian ance

245 her insight into the functional evolution of germ cell specification, here we examined the Gryllus or

246 a melanogaster and other animals, primordial germ-cell specification in the developing embryo is driv

247 tamins to rescue folate deficiency lack this germ cell stimulatory activity.

248 on the heterochromatic Y chromosome in male germ cells, strongly suggesting that it controls the seg

249 ser-capture microdissected cells of specific germ cell subtypes from fixed human testis samples.

250 Transcriptomic analyses of these successive germ cell subtypes reveals dynamic transcription of over

251 compartment, which surrounds the nucleus of germ cells, suggesting that sequestration of RNA to this

252 s known about how the choice is made between germ cell survival and death.

253 re, we focus on the mechanisms that regulate germ cell survival during embryonic development in Droso

254 s who were 17 years or older, diagnosed with germ cell testicular cancer, and previously treated with

255 adverse drug reaction in adult patients with germ cell testicular cancer.

256 M was more strongly expressed in human fetal germ cells than in somatic cells.

257 liferation of germline cells, producing more germ cells than strictly needed, explaining the random c

258 Bombyx mori BmN4 cells are culturable germ cells that equip the piRNA pathway.

259 id cells normally arise only as post-meiotic germ cells that serve to ensure a diploid genome upon fe

260 nents, suggesting that proper progression of germ cells through meiosis is licensed by YTHDC2 through

261 could increase true SSC concentration within germ cells to 1.96-fold.

262 data suggest that E(z) acts intrinsically in germ cells to activate dedifferentiation and thus replen

263 , and it functions cell autonomously in male germ cells to ensure spermatozoa motility, whereas it fu

264 tivates the GLP-1/Notch receptor on adjacent germ cells to maintain germline stem cell fate.

265 roalgal life cycles - from the production of germ cells to the growth and fertility of the adult orga

266 Germ cells toggle between uni- and pluripotent states as

267 Germ cell transcripts POU5F1, TFAP2C, LIN28A, ALPP and K

268 Purpose Patients with relapsed metastatic germ cell tumor (GCT) can be cured with second-line and

269 es were conducted on 488 North American male germ cell tumor (GCT) survivors in relation to cumulativ

270 Unconventional inheritance for testicular germ cell tumor (TGCT) risk both in humans and mice impl

271 enome-wide association studies of testicular germ cell tumor (TGCT; 3,558 cases and 13,970 controls)

272 ion of the resected tissue showed metastatic germ cell tumor predominantly consisting of a yolk sac e

273 y sensitivity, most patients with metastatic germ cell tumors (GCTs) are cured with cisplatin-based c

274 CRs) in two thirds of patients with advanced germ cell tumors (GCTs) who relapsed after first-line ch

275 scents with intermediate-risk (IR) malignant germ cell tumors (MGCT) if the administration of cisplat

276 Testicular germ cell tumors (TGCT) are the most frequently diagnose

277 isk factor for the development of testicular germ cell tumors (TGCT), but the initiating event linkin

278 Testicular germ cell tumors (TGCTs) share germline ancestry but div

279 nderstanding of susceptibility to testicular germ cell tumors (TGCTs), but much of the heritability r

280 icancer drug for the treatment of testicular germ cell tumors (TGCTs).

281 Germ cell tumors of the ovary constitute less than one p

282 Malignant germ cell tumors were identified in 2.8% (31 of 1097) of

283 wide spectrum of human neoplasms, including germ cell tumors, high-grade and low-grade carcinomas an

284 approach from the Brazilian GCT-99 study on germ cell tumors.

285 5% CI 20.9-27.5]) and lowest in survivors of germ cell tumours (14.0 [11.5-16.6]).

286 cells (PGCs), as well as the suppression of germ cell tumours in mice.

287 miology, genetics, and biology of testicular germ cell tumours.

288 Germ-cell tumours (GCTs) are derived from germ cells and

289 Germ-cell tumours are a heterogeneous group of neoplasms

290 Management of paediatric extracranial germ-cell tumours carries a unique set of challenges.

291 Paediatric germ-cell tumours differ from the adolescent and adult d

292 stratification, and treatment approaches for germ-cell tumours have evolved disparately along several

293 rgeted and reversible ablation of premeiotic germ cells undergoing differentiation into oocytes in tr

294 er proteins regulates clearance of apoptotic germ cells via LC3-associated phagocytosis (LAP).

295 p of functional links and DNA methylation in germ cells, we are able to predict the recombination rat

296 To find the components, germ cells were cultured with comprehensive natural plan

297 d its expression promotes spermatogenesis in germ cells when they are present in a male soma.

298 Surprisingly, germ cells, which do not arise from the CE, were also af

299 genetic features of closed chromatin in male germ cells, which suggests that CNVs may repress recombi

300 During aging, germ cells with reduced E(z) activity cannot meet that r