ライフサイエンスコーパス: germ layer

1 e of progeny to differentiate into all three germ layers).

2 of blood lineage formation from the mesoderm germ layer.

3 vivo yielded cell types from each embryonic germ layer.

4 ng the development and specification of this germ layer.

5 and asynchronously committed to a particular germ layer.

6 express late differentiation markers of that germ layer.

7 SCs representing each of the three embryonic germ layers.

8 e levels of specific markers of the distinct germ layers.

9 l step toward differentiation into all three germ layers.

10 ntiate, in vitro and in vivo, into different germ layers.

11 generated teratomas consisting of the three germ layers.

12 encompassed derivatives of the three primary germ layers.

13 as distantly related as cells from different germ layers.

14 as in vivo, and differentiate into all three germ layers.

15 otency, the capacity to specify cells of all germ layers.

16 changes, and formed teratomas with all three germ layers.

17 ent and are able to form all three embryonic germ layers.

18 te-specific structure derived from all three germ layers.

19 contribute to specific portions of different germ layers.

20 entiate into teratomas composed of the three germ layers.

21 including lineages from all three embryonic germ layers.

22 et of gastrulation affect the subdivision of germ layers.

23 milar ontogenies, but originate in different germ layers.

24 delays or enhances differentiation into the germ layers.

25 gastrulation, cells separate into different germ layers.

26 differentiate into derivatives of all three germ layers.

27 rentiation into cells representing all three germ layers.

28 ignaling centers that induce and pattern the germ layers.

29 to advanced derivatives of all three primary germ layers.

30 and the organization of all three embryonic germ layers.

31 at results in the formation of three primary germ layers.

32 nteraction of tissues derived from all three germ layers.

33 ects in morphogenesis of all three embryonic germ layers.

34 gramming, and differentiation into the three germ layers.

35 city for differentiation into cells of all 3 germ layers.

36 ation stage after the formation of the three germ layers.

37 vasculature and of tissues arising from all germ layers.

38 piboly movements expand and thin the nascent germ layers.

39 specifications or for formation of the three germ layers.

40 ication of the dorsoventral axis and primary germ layers.

41 formation of endoderm, mesoderm, or ectoderm germ layers.

42 formation of both the mesoderm and endoderm germ layers.

43 an differentiate into tissues from all three germ layers.

44 oes not restrict cells to or from any of the germ layers.

45 mposed of derivatives of all three embryonic germ layers.

46 atrix all blocked LvTbx2/3 expression in all germ layers.

47 n of human embryonic stem cells to the three germ layers.

48 ifferentiation potential of hPSCs across all germ layers.

49 em cell niches, or signal inductively across germ layers.

50 atomas, and can differentiate into all three germ layers.

51 tiation propensities of hPSCs into all three germ layers.

52 entiation of pluripotent epiblast cells into germ layers.

53 differentiation that gives rise to all three germ layers.

54 c expression in the derivatives of all three germ layers.

55 lerate mouse ESC formation of cells of three germ layers.

56 iation of mouse ESCs into cells of all three germ layers.

57 en broadly attributed to the three embryonic germ layers.

58 necessary for differentiation into all three germ layers.

59 d differentiate into derivatives of multiple germ layers.

60 n different contexts to pattern the emerging germ layers.

61 le in regulating the separation of embryonic germ layers.

62 luripotency, to differentiate into all three germ layers.

63 differentiate into derivatives of all three germ layers.

64 tency and commit to multiple lineages in all germ-layers.

65 erentiated cells representative of all three germ layers, a definitive test of pluripotency.

66 gate the underlying mechanisms of scaling of germ layers across Drosophila species, we quantified the

67 Despite their origins in different germ layers, all of these insulin-producing cells share

68 e and induced stem cell markers generating 3-germ layers, all qualifiers of acquired pluripotency.

69 la species, which result in unequally scaled germ layers along the dorso-ventral axis and the reposit

70 Specification of germ layers along the dorsoventral axis by morphogenetic

71 ble to differentiate into cells of the three germ layers, although after SPRY2 KD there was a tendenc

72 distribution of maternal transcripts for the germ layer and dorsal/ventral determinants VegT and Wnt1

73 can be used to track the development of this germ layer and its specification to a hepatic fate.

74 roenvironmental signals that appear to cross germ layer and species specificities should prove valuab

75 ptome of small groups of cells from a single germ layer and to retain spatial information, dorsal and

76 tive cell types spanning the three embryonic germ layers and assessed their immunogenicity in vitro a

77 o derivatives of all three primary embryonic germ layers and can self-renew indefinitely.

78 UCSFB lines formed derivatives of the three germ layers and CDX2-positive progeny, from which we der

79 25+ MASCs generated derivatives of the three germ layers and contributed to chimaeric embryos, with c

80 ue interactions between derivates of all the germ layers and coordinated morphogenetic movements in t

81 with the animal cap, mix with cells of other germ layers and differentiate according to their new pos

82 This mechanism spatially separates the germ layers and establishes the organizational foundatio

83 Expanded Nanog null cells colonize embryonic germ layers and exhibit multilineage differentiation bot

84 cells to segregate inappropriately to other germ layers and express late differentiation markers of

85 d with the factors initially responsible for germ layers and organizer formation, including Nodal its

86 e the embryonic arrangement of the mammalian germ layers and provide an assay to assess the structura

87 anizer, a signaling center that patterns the germ layers and regulates gastrulation movements.

88 Gastrulation movements form the germ layers and shape them into the vertebrate body.

89 cation, leading to the formation of distinct germ layers and specialized tissues.

90 n the amphipod Parhyale hawaiensis all three germ layers and the germ line are determined by the eigh

91 l lineage analyses have shown that all three germ layers and the germ line are exclusively specified

92 n, the relative mRNA expression in the three germ layers and the trophoblast was abnormal in the EBs

93 tions from epithelial tissues from all three germ layers and therefore may be broadly applicable for

94 ty of GD hiPSC to differentiate to all three germ layers and to form teratomas in vivo.

95 with specific loss of DNA methylation in one germ layer, and in many cases a reciprocal gain in the o

96 genes in segmentation is restricted to this germ layer, and that mesoderm segmentation is either dep

97 me region may express markers of two or more germ layers, and 'rogue' cells that express a marker out

98 s differentiate into cell types of all three germ layers, and a pluripotent gene expression program i

99 expressed widely in derivatives of all three germ layers, and high levels of expression are observed

100 opment, involves contributions from multiple germ layers, and is controlled by many genes.

101 ferentiation of ESCs into cells of all three germ layers, and it is from these differentiating aggreg

102 characteristic of trophoectoderm, markers of germ layers, and of more specialized progenitor cells.

103 e process of gastrulation, the three primary germ layers are created under the guidance of numerous s

104 interact is crucial to understanding how the germ layers are established.

105 he mid-tailbud stage, days after the somatic germ layers are established.

106 Inductive signals across germ layers are important for the development of the end

107 onset of gastrulation but then segregate by germ layer as gastrulation proceeds.

108 on, we initiate rapid emergence of all three germ layers as a complex function of GATA6 expression le

109 eriorly and medially within the plane of the germ layers at the transition from mid- to late gastrula

110 dhesion, which limits cell mixing as primary germ layers become specified.

111 uring vertebrate development, the endodermal germ layer becomes regionalized along its anteroposterio

112 l to form derivatives of all three embryonic germ layers both in vitro and in teratomas.

113 l to form derivatives of all three embryonic germ layers both in vitro and in teratomas.

114 matic fates representing all three embryonic germ layers both in vitro and in vivo, despite a persist

115 n a germ layer (NSM transfating) or across a germ layer boundary (endoderm transfating).

116 Specification of the three germ layers by graded Nodal signaling has long been seen

117 ratomas, tumors consisting cells of multiple germ layers; by contrast, these tumors have never been o

118 itors normally fated to enter the mesodermal germ layer can be redirected towards the neural lineage.

119 ) cells to form cells and tissues from all 3 germ layers can be exploited to generate cells that can

120 y-active somatic cells derived from separate germ layers can be interconverted.

121 ement profile, and differentiated into all 3 germ layer cell types.

122 ficient in HS, to differentiate into primary germ layer cells.

123 ng a tissue that originates from a different germ layer compared with blood, demonstrates that the aD

124 ectoderm producing blastomeres display intra-germ layer compensation.

125 haracteristic of all the three developmental germ layers, confirming their EB identity.

126 The endoderm germ layer contributes to the respiratory and gastrointe

127 e concerted movement of cells from different germ layers contributes to morphogenesis during early em

128 hat dynamic local Wnt signaling cues specify germ layer contribution and mesodermal tissue type speci

129 gastrulation stages, cells of the mesodermal germ layer converge slowly; during segmentation stages,

130 he posterior wall of the tailbud that make a germ layer decision after gastrulation to form spinal co

131 fter gastrulation and continue to make basic germ layer decisions.

132 have the potential to differentiate into all germ layer derivatives and may also be important for any

133 aintaining the ability to generate all three germ-layer derivatives.

134 much broader role for Notch signaling during germ layer determination than previously reported in a v

135 s function in part to restrict inappropriate germ layer development throughout the vertebrate embryo.

136 ies on the requirements for BMP signaling in germ layer development.

137 gulates multiple embryonic events, including germ layer differentiation and morphogenesis; the cellul

138 ssential for morphogenesis of the mesodermal germ layer during gastrulation.

139 st stage embryos, the formation of the three germ layers during gastrulation and the differentiation

140 ecification of the mesodermal and endodermal germ layers during gastrulation.

141 roadly expressed in derivatives of all three germ layers during mammalian development, and its derang

142 tions are crucial in spatial organization of germ layers during mammalian gastrulation.

143 erentiation into cell types derived of all 3 germ layers during teratoma formation.

144 city to differentiate into the three primary germ layers, ectoderm, mesoderm and endoderm, from which

145 The three germ layers--ectoderm, mesoderm, and endoderm--are affec

146 Pa results in self-organization of all three germ layers: ectoderm on the outside layer, mesoderm in

147 ogenesis is the specification of the primary germ layers: ectoderm, mesoderm and endoderm.

148 o the derivatives of all the three embryonic germ layers: ectoderm, mesoderm and endoderm.

149 rentiate into functional derivatives of each germ layer, ectodermal, endodermal, and mesodermal.

150 brafish that local posterior signals specify germ layer fate in two basal tailbud midline progenitor

151 that maintain ESC identity, also orchestrate germ layer fate selection.

152 growth factors and other signals that govern germ layer fate.

153 ave the pluripotent state and choose between germ layer fates.

154 tiate into advanced derivatives of all three germ layers, features very useful for understanding the

155 These germ layers form irregular double or triple layers of ro

156 suggesting roles for Notch signaling during germ layer formation and establish an evolutionarily con

157 investigated cellular rearrangements during germ layer formation at the onset of gastrulation.

158 The molecular basis of vertebrate germ layer formation has been the focus of intense scrut

159 at is involved in the suppression of ectopic germ layer formation in the frog, Xenopus laevis.

160 ssion and to establish the normal pattern of germ layer formation in Xenopus.

161 of cell adhesion and cortical tension during germ layer formation in zebrafish.

162 ted that the regulated inhibition of ectopic germ layer formation is also crucial for patterning the

163 mechanisms responsible for the regulation of germ layer formation.

164 Germ-layer formation during gastrulation is both a funda

165 b-group proteins, which coordinate embryonic germ-layer formation in response to extraembryonic cues.

166 Overall, these results lead to a model of germ-layer formation in which, upon N-cadherin expressio

167 layer, indicating its critical role in early germ-layer formation.

168 avoidance as an unexplored mechanism driving germ-layer formation.

169 tes that the embryo's regulative response to germ layer founder loss, in the form of altered cell beh

170 we present a method of generating organized germ layers from a single mouse embryonic stem cell cult

171 Convergence movements narrow the germ layers from lateral to medial while extension movem

172 rentiation of mature cell types of all three germ layers from pluripotent cells.

173 s and differentiation events, the endodermal germ layer gives rise to the epithelial lining of the di

174 onic blastomeres can contribute to different germ layers has never been fully explained.

175 rived organoids with components of all three germ layers have been generated, resulting in the establ

176 ge-specific stem/progenitor cells of another germ layer in one step, bypassing the intermediate pluri

177 Embryos allocate cells to the three germ layers in a spatially ordered sequence.

178 -1-60, give rise to derivatives of the three germ layers in a teratoma assay, and are karyotypically

179 nderstand the relationship between segmented germ layers in arthropods, we asked whether segmentation

180 atomas, and contributed to cell types of all germ layers in chimeric animals.

181 ic stem cells (hESCs) can generate the three germ layers in culture; however, differentiation is typi

182 to ES cells and formed teratomas with three germ layers in nonobese diabetic/severely compromised im

183 e and female ES cells gave rise to all three germ layers in teratoma assays, though sex-specific diff

184 ed to allow for the development of the three germ layers in the developing embryo.

185 Amphioxus Gbx is expressed in all germ layers in the posterior 75% of the embryo, and in t

186 migration contribute to the establishment of germ layers in vertebrates and other animals, but a comp

187 fferentiated into cells of the three primary germ layers in vitro and also can generate chimeric mice

188 differentiated into derivatives of all three germ layers in vitro and in teratomas, and showed germ l

189 ifferentiating into derivatives of the three germ layers in vitro and into neurons and muscle fibers

190 re capable of differentiation into all three germ layers in vitro.

191 lling pathway patterns the embryo into three germ layers, in part by inducing the expression of no ta

192 cted differentiation into cells of all three germ layers including peripheral neurons.

193 into cell types representing each embryonic germ layer, including cells of adipogenic, osteogenic, m

194 of the entire eve-expressing lineage in this germ layer, including those progeny that do not continue

195 tiate into cells representative of all three germ layers, including cells of the central nervous syst

196 the ability to differentiate into all three germ layers, including tissues of endodermal origin (i.e

197 polarized, perpendicular to the plane of the germ layers, independently of Wnt/PCP signaling.

198 neages representative of the three embryonic germ layers indicating the pluripotency of these cells.

199 been implicated as an important component in germ layer induction and patterning in vertebrate embryo

200 Our results indicate that germ layer induction in the zebrafish tailbud is not a s

201 sence of Wnt signaling, indicating a lack of germ layer induction that normally occurs during gastrul

202 x regulatory interactions underlying primary germ layer induction.

203 t the early developmental events involved in germ-layer induction in the embryo are recapitulated in

204 ciated with high levels of E-cadherin at the germ layer interface.

205 ormation and ingression, known mechanisms of germ layer internalisation.

206 unction as morphogens to subdivide the three germ layers into distinct territories and act to organiz

207 Induction and patterning of the mesodermal germ layer is a key early step of vertebrate embryogenes

208 Formation of the three embryonic germ layers is a fundamental developmental process that

209 The establishment of the germ layers is amongst the earliest events of developmen

210 of the vertebrate embryo into three primary germ layers is one of the earliest developmental decisio

211 Spatial organization of germ layers is regulated by cortical tension of the colo

212 ells in kidney are derived from an embryonic germ layer known as intermediate mesoderm.

213 emain plastic to transdifferentiation across germ layer lineage boundaries and can be remodeled to ad

214 erm and the endoderm is a location where two germ layers meet and establish an enduring relationship

215 t of the primitive streak and its derivative germ layers, mesoderm and endoderm, are prerequisite ste

216 We traced this phenotype to disrupted germ-layer morphogenesis at the primitive streak.

217 eposited as pillars between widely separated germ layers, namely the somitic mesoderm and the endoder

218 eprogramming in this system, either within a germ layer (NSM transfating) or across a germ layer boun

219 In mammals, specification of the three major germ layers occurs during gastrulation, when cells ingre

220 nts to (or exclude them from) the endodermal germ layer of the zebrafish.

221 ndergo lineage-specific differentiation into germ layers of endoderm, mesoderm and ectoderm during ga

222 cells that can differentiate into all three germ layers of the developing human has fundamentally ch

223 movements during gastrulation establish the germ layers of the vertebrate embryo and coordinate thei

224 s, possibly through indirect effects of this germ layer on neighboring tissues.

225 in treated embryos, but has little effect on germ layer or anterior-posterior markers.

226 nce that they have a single rather than dual germ layer origin during embryogenesis.

227 Despite the disparate germ layer origins and morphology of the vasculature, th

228 eratomas comprised of tissues from all three germ layer origins suggested that defects in Pofut2 muta

229 es representing differentiation to all three germ layers over the first 3-5 days of LIF withdrawal.

230 Despite their origins in different germ layers, pancreatic islet cells share many common de

231 he Spemann organizer, which is essential for germ layer patterning and axis formation.

232 is an essential signaling center in Xenopus germ layer patterning and axis formation.

233 l events, ranging from the earliest steps in germ layer patterning of the pre-gastrula embryo to tiss

234 oogenesis have been reported to function in germ layer patterning, axis determination, and developme

235 f Gtpbp2 causes defects in ventral-posterior germ layer patterning, gastrulation and tadpole morpholo

236 port of RNAs to the vegetal cortex underlies germ layer patterning.

237 nstructions for key aspects of body axis and germ layer patterning; however, the complex genetics of

238 pmental biology to replicate these organized germ layer patterns in culture.

239 Despite exhibiting germ layer plasticity, these cells never give rise to mi

240 es undergo major rearrangements that lead to germ layer positioning, patterning, and organ morphogene

241 rm a genome-wide transcriptome comparison of germ layer precursor cells.

242 iotemporal pattern of gene expression across germ layers provides evidence that the endoderm was the

243 locus was similar in tissues from the three germ layers, providing evidence that epigenetic patterni

244 movements during gastrulation, cells in both germ layers read their positional information coordinate

245 ecific markers associated with the embryonic germ layers, reminiscent of gastrulating embryos.

246 ate that is responsive to inductive cues for germ layer segregation.

247 e specification of cell fate prior to actual germ layer segregation.

248 agonism during gastrulation may have been in germ-layer segregation and/or epithelial patterning rath

249 However, the cellular and molecular basis of germ-layer segregation is poorly understood, mostly beca

250 all cells, while the zygotic component has a germ layer-specific effect on the ectoderm.

251 tive PCR for the presence of pluripotent and germ layer-specific markers in differentiated ciPSCs; (i

252 Loss-of-function and germ layer-specific rescue experiments suggest that pann

253 In addition, we identified germ-layer-specific H3K27me3 enrichment at sites exhibit

254 ation of gene regulatory networks underlying germ layer specification and axis formation during embry

255 uding symmetry breaking, axial organisation, germ layer specification and cell behaviour, as well as

256 to the post-implantation epiblast, prior to germ layer specification and down-regulation of key plur

257 e positive effects extend beyond the initial germ layer specification and enable efficient differenti

258 hermore, existing models of Dorsal-dependent germ layer specification and patterning consider steady-

259 al role for the let-7 and miR-18 families in germ layer specification and reveal a remarkable conserv

260 activate the expression of genes involved in germ layer specification during mESC differentiation in

261 factors are required for axis formation and germ layer specification from sea urchins to mammals.

262 e critical molecular signaling inputs during germ layer specification in bilaterian metazoans, but th

263 contribution of FGF and BMP pathways during germ layer specification in vertebrate embryos.

264 dings present a unique approach to study how germ layer specification is regulated and offer a promis

265 Germ layer specification is tightly coupled with zygotic

266 We discovered that germ layer specification progresses normally in rest mut

267 sensory placode specification, ciliogenesis, germ layer specification).

268 he early embryo to the signals that regulate germ layer specification, and that this early function i

269 t roles in a variety of processes, including germ layer specification, patterning, cell differentiati

270 l survival, but failed to correct defects in germ layer specification.

271 factors and signaling molecules involved in germ layer specification.

272 netic commitment to differentiation prior to germ layer specification.

273 y in vertebrate embryogenesis by controlling germ layer specification.

274 The Nodal pathway plays a crucial role in germ layer specification.

275 they act as suppressors of commitment during germ layer specification.

276 genes suggests that they may play a role in germ layer specification.

277 timate connection between Tfeb/lysosomes and germ layer specification.

278 qt) and Cyclops (Cyc) - are expressed during germ-layer specification in zebrafish.

279 y structures, and tissues derived from other germ layers such as the pronephros.

280 the early gastrula are less committed to one germ layer than are cells of the late gastrula embryo.

281 often, these lineages derive from different germ layers that are specified during gastrulation, well

282 red epithelium is transformed into the three germ layers that are the basis of the embryonic body pla

283 epithelial compartments derive from a single germ layer, the endoderm, thus refuting the 'dual-origin

284 After induction of the germ layers, the blastula is transformed by gastrulation

285 criptomics on the topics of the evolution of germ layers, the phylotypic stage, and developmental con

286 l-ventral axes, the development of the three germ layers, the specification of organ progenitors, and

287 onic development is the specification of the germ layers, the subdivision of the blastula embryo into

288 or beta (TGFbeta) family influence all three germ layers; the ligands are required to induce endoderm

289 hiPSCs and hESCs to differentiate into all 3 germ layers, their functional equivalence at the single

290 oper body architecture and establishes three germ layers through coordinated cellular actions of prol

291 ct is established and maintained between the germ layers through mesoderm cell protrusions.

292 des evidence that the endoderm was the first germ layer to evolve.

293 hes a novel signaling mechanism that crosses germ layers to diversify bilaterally symmetric neuronal

294 and differentiation into the three embryonic germ layers under appropriate conditions.

295 as with derivatives from all three embryonic germ layers were obtained.

296 iate into derivatives of the three embryonic germ layers when cultured in the appropriate conditions.

297 bodies, expressing genes representing all 3 germ layers when cultured under differentiating conditio

298 morphogenetic defects in derivatives of each germ layer with no apparent loss in specification events

299 neously differentiate into cell types of all germ layers within embryoid bodies (EBs) in a highly var

300 ive rise to derivatives of all three primary germ layers, yet little is known about the signaling cas