ライフサイエンスコーパス: germinal

1 or using small bioactive molecules to direct germinal activity in the SVZ, which has therapeutic pote

2 show that ibrutinib selectively targets pre-germinal B cells and depletes Th2 helper cells.

3 The remaining 2 DLBCL models were germinal B-cell type, with characteristic alterations of

4 ophils infiltrated CXCL-8(+) DLBCL from both germinal center (GC) and non-GC subtypes.

5 s capable of measuring total and Ag-specific germinal center (GC) B cell and follicular Th cell respo

6 rated that E2A together with E2-2 controlled germinal center (GC) B cell and plasma cell development.

7 Despite enhanced germinal center (GC) B cell differentiation, the formati

8 Qa-1 deficiency enhanced CD4 TFH and germinal center (GC) B cell numbers in naive mice and ha

9 own that type I latency is associated with a germinal center (GC) B cell phenotype, and type III late

10 cells profoundly impaired the acquisition of germinal center (GC) B cell phenotype, plasma cell gener

11 on of bivalent chromatin domains at critical germinal center (GC) B cell promoters.

12 ate IL-21 and IL-17A, which drive pathogenic germinal center (GC) B cell reactions and monocyte-macro

13 We identify that germinal center (GC) B cell reactions, isotype-switched

14 lar Th (Tfh) cells orchestrate physiological germinal center (GC) B cell responses, whereas in lupus

15 Follicular helper T (Tfh) cells promote germinal center (GC) B cell survival and proliferation a

16 tly mutated in the activated B cell-like and germinal center (GC) B cell-like subtypes of diffuse lar

17 on of the immunoglobulin (Ig) genes occur in germinal center (GC) B cells and are initiated through d

18 ) TET2 is turned off in normal and malignant germinal center (GC) B cells but expressed in other B ce

19 During antibody affinity maturation, germinal center (GC) B cells cycle between affinity-driv

20 Germinal center (GC) B cells evolve toward increased aff

21 induced higher proportions of TFH cells and germinal center (GC) B cells following immunization than

22 rates of T follicular helper (Tfh) cells and germinal center (GC) B cells from draining lymph nodes (

23 Germinal center (GC) B cells undergo affinity selection,

24 Antigen-stimulated germinal center (GC) B cells undergo somatic hypermutati

25 CL13 recruited follicular helper T (Tfh) and germinal center (GC) B cells, promoted the formation of

26 t arise from the malignant transformation of germinal center (GC) B cells, underscoring the importanc

27 ibited a deficit in latency amplification in germinal center (GC) B cells.

28 t is gained by virus-driven proliferation in germinal center (GC) B cells.

29 ell responses by inhibiting proliferation of germinal center (GC) B cells.

30 -based selection toward antigen in activated germinal center (GC) B cells.

31 In contrast to germinal center (GC) B-cell (GCB) DLBCL, ABC DLBCL cell

32 d that levels of this molecule are higher in germinal center (GC) B-cell DLBCL (GCB-DLBCL) compared w

33 Hodgkin lymphoma (HL) is a malignancy of germinal center (GC) B-cell origin.

34 ics analysis data have implicated YY1 in the germinal center (GC) B-cell transcriptional program.

35 Here, we show that among B cells, germinal center (GC) cells exhibited the highest rate of

36 Here, we examined the role of Id3 in germinal center (GC) cells.

37 B1a cells are characterized by lack of germinal center (GC) development, and the B1a cell popul

38 n wild-type (WT) mice and extended them with germinal center (GC) disruption experiments and variable

39 egulators driving B cell differentiation and germinal center (GC) formation by lowering the threshold

40 We found spontaneous anti-insulin germinal center (GC) formation throughout lymphoid tissu

41 riptional repressor that is required for the germinal center (GC) reaction and is implicated in lymph

42 The germinal center (GC) reaction begins with a diverse and

43 t infection depends on the initiation of the germinal center (GC) reaction in secondary lymphoid orga

44 The germinal center (GC) reaction produces high-affinity Abs

45 been shown to be critically required for the germinal center (GC) reaction where B cells undergo clas

46 ssed the autoimmune response by reducing the germinal center (GC) reaction, which was associated with

47 B cells and on light zone B cells during the germinal center (GC) reaction.

48 Germinal center (GC) responses are required for the gene

49 Furthermore, the germinal center (GC) responses in the spleen were more e

50 he diversity of B cell clones recruited into germinal center (GC) responses is likely to be important

51 T cell-dependent germinal center (GC) responses require coordinated inter

52 Mer-deficient mice (Mer(-/-)) have increased germinal center (GC) responses, T cell activation, and A

53 ented roles in T follicular helper (TFH) and germinal center (GC) responses.

54 Identification of Ag-specific germinal center (GC) T follicular helper (Tfh) cells by

55 on is the elimination of viral reservoirs in germinal center (GC) T follicular helper (Tfh) cells.

56 GNA13 is the most frequently mutated gene in germinal center (GC)-derived B-cell lymphomas, including

57 phoproliferative disorders, including mostly germinal center (GC)-derived B-cell lymphomas.

58 riety of neoplasms, many of which arise from germinal center (GC)-experienced B cells.

59 nificantly affecting clonal expansion in the germinal center (GC).

60 arameters, thus providing new tools to study germinal center and Ab responses.

61 the development of plasmablasts derived from germinal center and extrafollicular sources, we hypothes

62 ulatory (Tfr) cell subset can migrate to the germinal center and inhibit Tfh-mediated B-cell activati

63 site-specific Ab-secreting cells, as well as germinal center and memory B cells.

64 ents Ag-specific B cell differentiation into germinal center and memory precursor B cells as well as

65 d that both combinations enhanced lymph node germinal center and T follicular helper cell responses.

66 (CD69 and CD86) on these cells and stronger germinal center B and T cell responses, relative to DV23

67 Id3 expression depleted displayed a block in germinal center B cell maturation, showed reduced number

68 greater impact on changing plasma cells and germinal center B cell populations in females than males

69 T follicular helper responses and subsequent germinal center B cell responses following birth.

70 stable covalent bond, resulting in enhanced germinal center B cell responses that generated higher a

71 es the function of TFH cells during aberrant germinal center B cell responses.

72 icular helper cells, and blunted PE-specific germinal center B cell responses.

73 ns regarding a possible division of labor in germinal center B cell selection and elimination.

74 rs and function, which resulted in increased germinal center B cells and Ab production.

75 cally enhanced the development of Tfh cells, germinal center B cells and antibody responses against p

76 cacy over soluble glycoprotein in activating germinal center B cells and eliciting tier-2 autologous

77 eased Th1-associated responses, and expanded germinal center B cells and memory T cells.

78 Enpp1 (-/-) mice generated normal levels of germinal center B cells and plasmablasts in periphery, t

79 to stimulate nitrophenyl-specific lambda(+) germinal center B cells and sequenced the unexpressed ka

80 Here, we report that germinal center B cells are formed normally after deplet

81 eased the positive selection of B1 cells and germinal center B cells by self and foreign antigens.

82 l3-/- mice, splenic T and B cells as well as germinal center B cells from Peyer's patches showed mark

83 mer-binding protein 2, encoded by Pou2f2) in germinal center B cells has proved controversial.

84 educed frequency of Peyer's Patches IgG1 and germinal center B cells in addition to small but signifi

85 Nevertheless, neither germinal center B cells nor lymphocytic choriomeningitis

86 nalysis of lymphocytes indicated that GL7(+) germinal center B cells were induced at higher levels in

87 the induction of protective IgG antibodies, germinal center B cells, and plasma cells secreting anti

88 genome reorganization from naive B cells to germinal center B cells, centered on a locus control reg

89 IV Env-specific IL-21(+) TFH cells and total germinal center B cells, the size and number of germinal

90 quired for the generation and maintenance of germinal center B cells, which require high glycolytic a

91 r lymphoma (FL) is an indolent malignancy of germinal center B cells.

92 essed by FOXP1 in activated B-cell (ABC) and germinal center B-cell (GCB) DLBCL cell lines with aberr

93 howed that BCR signaling differs between the germinal center B-cell (GCB) subtype, which is insensiti

94 ma (DLBCL) subtype from the better prognosis germinal center B-cell (GCB)-DLBCL subtype and is highly

95 to COO (activated B-cell [ABC]-like DLBCL v germinal center B-cell [GCB]-like DLBCL) were observed i

96 Pirfenidone dampened splenic germinal center B-cell and T-follicular helper cell freq

97 antially enriched in ABC-DLBCL compared with germinal center B-cell DLBCL.

98 es that have prognostic significance, namely germinal center B-cell like (GCB) and activated B-cell l

99 ate responses were observed in two models of germinal center B-cell like (GCB) DLBCL.

100 on in lymph nodes and increased Tfh cell and germinal center B-cell numbers.

101 ysis to the 10% of DLBCL patients who have a germinal center B-cell phenotype and coexpress MYC and B

102 s with vaccines toward the goal of enhancing germinal center B-cell responses to favor bNAb B-cell li

103 and BCL2 translocation with poor outcome in germinal center B-cell subtypes, respectively.

104 Patients with activated B-cell or non-germinal center B-cell type DLBCL also had an increased

105 tain 2 major molecular subtypes; namely, the germinal center B-cell-like (GCB) and the activated B-ce

106 Here, we show that in the germinal center B-cell-like (GCB) DLBCL subtype, IRE1 ex

107 es in previously untreated patients with non-germinal center B-cell-like (non-GCB) diffuse large B-ce

108 Activated B-cell-like (ABC) and germinal center B-cell-like diffuse large B-cell lymphom

109 lls, but the function of extrafollicular and germinal center CD4(+) T and B interactions in cGVHD pat

110 ivity by direct assessment of GC B cells and germinal center CD4(+) T follicular helper (GC Tfh) cell

111 e mutation frequency was lower than found in germinal center cells after deliberate immunization, sug

112 follicular NKT cells triggers the seeding of germinal center cells and serves as an innate link betwe

113 In germinal center diffuse large B-cell lymphoma, BCL-2 lev

114 B-cell differentiation programs and impeding germinal center exit.

115 s cells at governing T follicular helper and germinal center formation after intradermal immunization

116 We detected superior germinal center formation and enhanced autologous neutra

117 d proteins in B cells that may contribute to germinal center formation and IgE switching in type 2 im

118 Further, germinal center formation and LCMV-specific Ab responses

119 ses: T follicular helper (Tfh) cells support germinal center formation and provide help for affinity

120 or class switch recombination to IgE and for germinal center formation during type 2 immune responses

121 , IL-17 can enhance B cell proliferation and germinal center formation in dry eye disease mice, sugge

122 SRBCs induce robust germinal center formation in mice.

123 vation, hypergammaglobulinemia, and enhanced germinal center formation in the absence of organ-specif

124 ons are sufficient for inducing cGVHD, while germinal center formation is dispensable.

125 eleration in the onset of renal disease, SLO germinal center formation, and autoreactive plasma cell

126 differentiation of follicular B cells during germinal center formation, and normal signaling through

127 -ordered trimers enhances B cell activation, germinal center formation, and the elicitation of tier-2

128 specific BTK overexpression show spontaneous germinal center formation, anti-nuclear autoantibodies,

129 ymus-independent Ags generally do not induce germinal center formation.

130 elopment of long-lasting humoral immunity by germinal center formation.

131 y, early IgE class switching did not require germinal center formation.

132 typed the NLPHL cell line (DEV) confirming a germinal center immunophenotype, lack of expression of C

133 iency reduces B cell clonal expansion in the germinal center in mice and blocks the proliferation of

134 vel therapeutic targets, and discovered that germinal center kinase (GCK) was extensively activated.

135 s among the most frequently mutated genes in germinal center lymphomas.

136 henotype (73%), which included expression of germinal center markers (CD75/Bcl-6-positive, CD32-weak/

137 l-defined zonal areas that expressed classic germinal center markers, peanut lectin (agglutinin) and

138 t was required for their survival within the germinal center niche.

139 pression signatures reminiscent of dark zone germinal center or activated B cells.

140 N-gamma production was accompanied by a poor germinal center output, an accumulation of T-box transcr

141 is that disrupt pathways associated with the germinal center reaction (TNFRSF14, IRF8), immune escape

142 Under normal circumstances, the germinal center reaction results in antibodies that prec

143 ollicular regulatory (Tfr) cells inhibit the germinal center reaction to limit autoantibody productio

144 e rise to B cells capable of entering into a germinal center reaction, and they developed into memory

145 produced by B cells themselves controls the germinal center reaction, plasma cell differentiation, a

146 alized roles of Tfr cells in controlling the germinal center reaction.

147 ed by T follicular helper (Tfh) cells in the germinal center reaction.

148 g B cells transiting different stages of the germinal center reaction.

149 lper T cell-mediated B cell responses in the germinal center reaction.

150 f tonsils as lymphoid sites for the study of germinal center reactions after vaccination in children.

151 ions demonstrate a role for the Breg cell in germinal center reactions and suggest that deficient act

152 he mechanism by which B cells initially seed germinal center reactions remains elusive.

153 CD4(+) Th (Tfh) cells provide B cell help in germinal center reactions that support class switching,

154 nd NFAT2 in CD4(+) T cells leads to impaired germinal center reactions upon viral infection because o

155 ZIKV-specific Ab-secreting cells, germinal center reactions, and monocyte, dendritic cell,

156 nAb responses were strongly associated with germinal center reactions, as assessed by lymph node fin

157 on and antibody responses without disturbing germinal center reactions.

158 mpared with controls, mirroring an increased germinal center reactivity in the tonsils.

159 Computational modeling of the germinal center response suggested that antigen availabi

160 ed role for MZB cells in controlling the TFH-germinal center response to a cholesterol-rich diet and

161 However, germinal center responses appeared unaffected.

162 vels were reduced and, upon viral infection, germinal center responses were defective in TC10-deficie

163 early during development, as well as during germinal center responses, suggesting that T cell-indepe

164 Therefore, this Ag is commonly used to study germinal center responses.

165 Germinal center T follicular helper cells (GCTfh) in lym

166 However, CGS did abrogate germinal center T follicular helper cells, and blunted P

167 ction in induced germinal centers and CD4(+) germinal center T follicular helper cells.

168 restores their ability to expand and become germinal center T follicular helpers and enhances B cell

169 nd for positively regulating Id3 to restrain germinal center TFH cell differentiation.

170 ected hepatoma cells lead to an expansion of germinal center Tfr.

171 nerated by aberrant somatic mutations in the germinal center, are rapidly eliminated.

172 In the germinal center, B cells undergo somatic hypermutation,

173 Mice lacking CD37 developed germinal center-derived B cell lymphoma in lymph nodes a

174 inding led us to examine the role of OCT2 in germinal center-derived lymphomas.

175 and is characterized by the accumulation of germinal center-derived malignant B cells engaged in a b

176 jority of the Ag-specific CD4(+) T cells are germinal center-homing CXCR5(+)Bcl6(+) Tfh cells.

177 non-Hodgkin lymphoma able to transform into germinal center-type diffuse large B-cell lymphoma.

178 ated B-cell help is regulated locally in the germinal center.

179 on and affinity maturation of B cells in the germinal center.

180 , and plasma cell differentiation within the germinal center.

181 for deletion of autoreactive B cells in the germinal center.

182 e fraction of the Tfh cell repertoire in the germinal center.

183 urine xenograft models of mantle cell (MCL), germinal-center diffuse large B-cell (GCB-DLBCL), and ac

184 mprints of germinal-center-inexperienced and germinal-center-experienced B cells, and we found that D

185 respectively carrying epigenetic imprints of germinal-center-inexperienced and germinal-center-experi

186 We define the half-lives of antigen-specific germinal centers (23.3 days), IgE(+) and IgG1(+) PCs (60

187 mune response, including in the formation of germinal centers (GC) and the development and maturation

188 et of T follicular helper cells (TFH) within germinal centers (GC) is highly permissive to HIV-1.

189 sis that T follicular helper (Tfh) cells and germinal centers (GC) play a critical role in the abilit

190 VRC01-class B cells successfully competed in germinal centers (GC), underwent extensive somatic hyper

191 ltransferase is required for B cells to form germinal centers (GC).

192 tion in LSCC culminating in the formation of germinal centers (GC).

193 f the secondary lymphoid structures known as germinal centers (GCs) and the environmental and signali

194 ypermutation, and affinity maturation within germinal centers (GCs) are required for high-affinity me

195 Germinal centers (GCs) are the primary sites of clonal B

196 Germinal centers (GCs) are the site of antibody diversif

197 evalent in women and associates with ectopic germinal centers (GCs) development and inflammation in t

198 n murine models of lupus is the formation of germinal centers (GCs) in lymphoid tissues where self-re

199 Germinal centers (GCs) perform the remarkable task of op

200 Plasma cells (PCs) derived from germinal centers (GCs) secrete the high-affinity antibod

201 The follicular pathway gives rise to germinal centers (GCs) that can take weeks to fully deve

202 s that have passed this step generate normal germinal centers (GCs) upon a T-dependent immune challen

203 d with blood, although it is well known that germinal centers (GCs) within lymph nodes (LNs) serve as

204 at support B cell affinity maturation within germinal centers (GCs), resulting in the production of h

205 ls promote affinity maturation of B cells in germinal centers (GCs), whereas T follicular regulatory

206 response to T-dependent (TD) antigens within germinal centers (GCs).

207 mature their antigen receptor repertoire in germinal centers (GCs).

208 pe to enable antibody affinity maturation in germinal centers (GCs).

209 increased through the affinity maturation in germinal centers (GCs).

210 lly distinct sites in lymphoid organs called germinal centers (GCs).

211 ed the lymphoid follicle size (p < 0.01) and germinal centers (p < 0.01) with in the Peyer's patch we

212 ated with a significant reduction in induced germinal centers and CD4(+) germinal center T follicular

213 1 and SpiB in mature B cells do not generate germinal centers and high-affinity antibody after protei

214 chestrates B cell differentiation within the germinal centers and humoral response.

215 T-bet from B cells impaired the formation of germinal centers and mitigated the development of kidney

216 in RasGRP1 and CD275 formed Tfh17 cells and germinal centers and produced similar titers of autoanti

217 xpression patterns typically associated with germinal centers and T follicular helper cells were exam

218 , and disruption of the formation of ectopic germinal centers are considered the main therapeutic tar

219 In CLCa-null mice, the germinal centers have fewer B cells, and they are enrich

220 evelopment and affinity maturation occurs in germinal centers in lymphoid follicles through a critica

221 e the rapid appearance of autoantibodies and germinal centers in spontaneous murine models of systemi

222 tation and affinity maturation take place in germinal centers leading to the generation of memory B c

223 orly understood as selection taking place in germinal centers occurs on the basis of antibody affinit

224 lar helper T cells (Tfh ) are located within germinal centers of lymph nodes.

225 suggest that FMDV persistence occurs in the germinal centers of lymphoid tissue but that the duratio

226 red humoral immunity as indicated by reduced germinal centers reactions, follicular CD4 T cells, and

227 cking IL-17R had fewer germinal centers, and germinal centers that formed contained fewer autoreactiv

228 develop mathematical models of Tfh cells in germinal centers to explicitly define the mechanisms of

229 of CD278 coordinate with their appearance in germinal centers, all attributes of T follicular helper

230 grp1-deficient mice lacking IL-17R had fewer germinal centers, and germinal centers that formed conta

231 new insights into the dynamic regulation of germinal centers, and suggesting more efficacious vaccin

232 minal center B cells, the size and number of germinal centers, and the frequency of SIV-specific Ab-s

233 ls; this caused the spontaneous formation of germinal centers, increased titers of serum autoantibodi

234 lymphoid aggregates give rise to functional germinal centers, which produce Abs.

235 endritic cells, hindering B-cell division in germinal centers, which results in a delayed production

236 activated B cells seek T cell help and form germinal centers.

237 r helper T (Tfh) cells occurring in lymphoid germinal centers.

238 different follicular helper T (Tfh) cells in germinal centers.

239 n lymphoid tissues, mainly within lymph node germinal centers.

240 grate throughout follicular areas, including germinal centers.

241 e marrow while also obliterating preexisting germinal centers.

242 required for a break in B cell tolerance in germinal centers.

243 ains, even in mice that lacked TFH cells and germinal centers.

244 ease and the level of destruction of splenic germinal centers.

245 icular T helper (TFH)-B cell interactions in germinal centers.

246 -switched antibody-secreting cells (ASCs) in germinal centers.

247 ed protein 2 (EBI2), but significantly fewer germinal centre (GC) B cells compared with tonsil.

248 use a 3D GC organoid and show EZH2 mediates germinal centre (GC) formation through epigenetic silenc

249 igh-affinity antibody production through the germinal centre (GC) response is a pivotal process in ad

250 le Pfs25, as well as to significantly higher germinal centre (GC) responses.

251 relative contribution of extrafollicular and germinal centre (GC) T-B interaction is unclear.

252 +) PC development pathway, namely (i) IgE(+) germinal centre (GC)-like B cells, (ii) IgE(+) PC-like '

253 l responses underlying the activation of the germinal centre activities leading to the generation of

254 on is sufficient to recruit B cells into the germinal centre and induce memory and plasma cell respon

255 lar dendritic cells, Tfh cells move into the germinal centre and provide help to B cells both by dire

256 IgE germinal centre cells are transient, most IgE cells are

257 cells, a reduction in B cell activation and germinal centre formation, and the inhibition of antigen

258 induced T-B-cell interactions increase total germinal centre output and accelerate it by days.

259 r helper (Tfh) cells is vital in driving the germinal centre reaction and high affinity antibody form

260 control the magnitude and specificity of the germinal centre reaction, but how regulation is containe

261 t defective T-cell-dependent plasma cell and germinal centre responses.

262 are important in supporting plasma cell and germinal centre responses.

263 nization or infection, which localize to the germinal centre where they control the magnitude of the

264 Germinal centres (GCs) promote humoral immunity and vacc

265 cell help-undergo affinity maturation within germinal centres and persist as long-lived IgG plasma ce

266 ong-lived IgG plasma cells, which develop in germinal centres and then home to the bone marrow, IgM p

267 ents with synovial tissue containing ectopic germinal centres compared with diffuse synovial tissue.

268 eptors by follicular helper T (TFH) cells in germinal centres.

269 pleen and can develop even in the absence of germinal centres.

270 and in several animals, in sloughing of the germinal epithelium.

271 Germinal matrix (GM), a key primordium for the brain rew

272 ntly lower in the embryonic white matter and germinal matrix relative to the neocortex in both infant

273 Low-grade germinal matrix-intraventricular hemorrhage (GM-IVH) is

274 ARGC1A expression in a patient with an HNF1B germinal mutation.

275 lt rodent brain, new neurons are born in two germinal regions that are associated with blood vessels,

276 They can be derived from foetal or adult germinal tissues and continuously propagated in vitro as

277 ogenous betaine was present at low levels in germinal vesicle (GV) stage mouse oocytes before ovulati

278 ing proteolysis of cyclins and Cdc25B at the germinal vesicle (GV) stage, APC/C associated with the C

279 By exchanging the germinal vesicle between mouse and pig oocytes, we obtai

280 reases during cell cycle reentry, well after germinal vesicle breakdown (GVBD).

281 ys the increase in Cdk1 activity, leading to germinal vesicle breakdown (GVBD).

282 Resumption of meiosis is heralded by germinal vesicle breakdown, condensation of chromosomes,

283 ion and meiotic cell cycle progression after germinal vesicle breakdown.

284 anic osmolyte, during vitrification of mouse germinal vesicle stage oocyte and/or subsequent maturati

285 Mouse oocytes at germinal vesicle stage were prevented from meiosis resum

286 ed by a TRP ion channel in immature oocytes (germinal vesicle stage), matured oocytes (metaphase II e

287 an oocyte involves a series of steps whereby germinal-vesicle oocytes (in which the nuclei are intact

288 olarization and retains progenitors in their germinal zone (GZ).

289 e neurons derived from the zebrafish pallial germinal zone arrange in outside-in, age-related layers

290 velopment, Pax6 is robustly expressed in the germinal zone of all glutamatergic neurons [cerebellar n

291 The subventricular zone (SVZ) is the largest germinal zone of the forebrain and is responsible for th

292 lar plexus (SVP) extends through a hindbrain germinal zone populated by NPCs whose peak mitotic activ

293 Neuronal migration from a germinal zone to a final laminar position is essential f

294 Therefore, germinal zone vascularization sustains NPC proliferation

295 ignificantly decreased cell proliferation in germinal zones and profound deficits in radial migration

296 iption factors Pax6 and Tbr2, in the various germinal zones of developing ferret neocortex.

297 s maintaining progenitor pools in cerebellar germinal zones, including cerebellar granule neuron prec

298 Well-characterized germinal zones, mitogenic signals and cell types make th

299 loss of the proliferating cell population of germinal zones.

300 regulating neurogenesis from both cerebellar germinal zones.