ライフサイエンスコーパス: germinal centre

1 cription and subsequent B-cell exit from the germinal centre.

2 eptors by follicular helper T (TFH) cells in germinal centres.

3 erated, secreted cytokines and formed normal germinal centres.

4 omas (DLCLs), which are tumours derived from germinal centres.

5 f follicular B cells to proliferate and form germinal centres.

6 tic hypermutation is thought to occur within germinal centres.

7 not absolutely dependent on the presence of germinal centres.

8 pleen and can develop even in the absence of germinal centres.

9 ng help to B lymphocytes in the induction of germinal centres.

10 ing that all B cells scan antigen trapped in germinal centres.

11 l responses underlying the activation of the germinal centre activities leading to the generation of

12 Bm12.Kd.IE heart grafts provoked strong germinal centre alloantibody and autoantibody responses

13 egs at transplant or 3 weeks later abrogated germinal centre alloantibody responses and blocked devel

14 reports, Th17 cells were not detected inside germinal centres, although they were found in close prox

15 c B cells colonize a follicle to establish a germinal centre and become rapidly dividing germinal-cen

16 on is sufficient to recruit B cells into the germinal centre and induce memory and plasma cell respon

17 lar dendritic cells, Tfh cells move into the germinal centre and provide help to B cells both by dire

18 with this there was enhanced persistence of germinal centres and of plasma-cell responses, which per

19 cell help-undergo affinity maturation within germinal centres and persist as long-lived IgG plasma ce

20 It is essential for the formation of germinal centres and the production of high-affinity ant

21 ong-lived IgG plasma cells, which develop in germinal centres and then home to the bone marrow, IgM p

22 During the secondary response in the germinal centres, antibodies are diversified by somatic

23 We tested whether germinal centres are essential for maturation of antibod

24 Germinal centres are specialized structures wherein B ly

25 GANP (germinal- centre associated nuclear protein) promotes th

26 MCM3 acetylase (MCM3AP) and germinal-centre associated nuclear protein (GANP) are tr

27 Mammalian TREX-2 is based on a germinal-centre associated nuclear protein (GANP) scaffo

28 shows that KDM6B transcriptional targets in germinal centre B (GC B) cells are significantly enriche

29 The normal germinal centre B cell is the presumed cell of origin fo

30 eparately from a common precursor, usually a germinal centre B cell.

31 One type expressed genes characteristic of germinal centre B cells ('germinal centre B-like DLBCL')

32 Galpha13-deficient mouse germinal centre B cells and human GCB-DLBCL cells were u

33 me cells move to the follicle centre, become germinal centre B cells and undergo antibody affinity ma

34 point mutations into immunoglobulin genes in germinal centre B cells during an immune response.

35 himaeras, EBI2-deficient B cells phenocopied germinal centre B cells in preferentially localizing to

36 ressing growth and blocking dissemination of germinal centre B cells that is frequently disrupted in

37 ansgene mutation was considerably reduced in germinal centre B cells that poorly expressed the transg

38 he PCR amplified JH flanking region DNA from germinal centre B cells yields mismatched heteroduplexes

39 Germinal centre B cells, unlike most lymphocytes, are ti

40 to perturbed processing of antibody genes in germinal centre B cells.

41 transgenes are targets for hypermutation in germinal centre B cells.

42 s growth regulation and local confinement of germinal centre B cells.

43 olecular features of germinal centre or post-germinal centre B cells.

44 er activation, before being downregulated in germinal centre B cells.

45 ither mechanism and accumulated mutations in germinal centre B cells.

46 ription factor that is normally expressed in germinal centre B cells.

47 differentiation, AKNA is mainly expressed by germinal centre B lymphocytes, a stage in which receptor

48 a distinct distribution of MNK1 and MNK2 in germinal centre B-cell (GCB) and activated B-cell (ABC)

49 CL-6 is a transcription factor essential for germinal centre B-cell development.

50 eficiency in Galpha13, but not S1PR2, led to germinal centre B-cell dissemination into lymph and bloo

51 ARHGEF1, and Arhgef1 deficiency also led to germinal centre B-cell dissemination.

52 requently mutated residue, with up to 22% of germinal centre B-cell DLBCL and follicular lymphoma har

53 lignancy, Burkitt's lymphoma, also represses germinal centre B-cell growth and promotes confinement v

54 wide distributions in related states of post-germinal centre B-cell transformation.

55 o S1P, and Galpha13-deficient mice developed germinal centre B-cell-derived lymphoma.

56 ntre B cells that is frequently disrupted in germinal centre B-cell-derived lymphoma.

57 tor that is mutated in GCB-DLBCL and another germinal centre B-cell-derived malignancy, Burkitt's lym

58 y and clinically distinct subtypes including germinal centre B-cell-like (GCB) and activated B-cell-l

59 88 TIR domain, occurring in both the ABC and germinal centre B-cell-like (GCB) DLBCL subtypes.

60 Germinal centre B-cell-like diffuse large B-cell lymphom

61 n activated B-cell-like DLBCL cells, but not germinal centre B-cell-like DLBCL cells, shRNAs targetin

62 BCL), termed activated B-cell-like DLBCL and germinal centre B-cell-like DLBCL.

63 dose, five (71%) of seven patients with the germinal centre B-cell-like subtype and two (100%) patie

64 subtype and two (100%) patients with the non-germinal centre B-cell-like subtype had a complete respo

65 upon molecular features with similarities to germinal centre B-cells (GCB-like) or activated B-cells

66 onal repressor, which is highly expressed in germinal centre B-cells and is essential for germinal ce

67 Patients with germinal centre B-like DLBCL had a significantly better

68 characteristic of germinal centre B cells ('germinal centre B-like DLBCL'); the second type expresse

69 transcription factor BCL6, which directs the germinal-centre B cell and follicular T-helper cell prog

70 these mutations are not detectable in normal germinal-centre B cells or in other germinal-centre-deri

71 at an important function of BCL6 is to allow germinal-centre B cells to tolerate the physiological DN

72 nd, accordingly, p53 expression is absent in germinal-centre B cells where BCL6 is highly expressed.

73 In germinal-centre B cells, AID is highly expressed, and ha

74 Here we show that B-1 cells, like germinal-centre B cells, can express recombinase-activat

75 es DNA damage-induced apoptotic responses in germinal-centre B cells.

76 enes are subject to somatic hypermutation in germinal-centre B cells.

77 n lymphoma, a malignancy often deriving from germinal-centre B cells.

78 were motile and physically restricted to the germinal centre but migrated bi-directionally between da

79 was found in 13 of 24 (54%) clones from the germinal centre but only in 1 of 24 (4%) clones from the

80 ssed in both B cells and CD4+ T cells within germinal centres, but its precise function is unknown.

81 irect visualization of B cells in lymph node germinal centres by two-photon laser-scanning microscopy

82 finity maturation of antibodies occurring in germinal centres, by multiple cycles of random mutation

83 , another B-cell malignancy of atypical post-germinal-centre cell origin.

84 IgE germinal centre cells are transient, most IgE cells are

85 was required to maintain BCL6 expression in germinal centre cells by avoiding BCL6-negative autoregu

86 entre dynamics or the migratory behaviour of germinal-centre cells in vivo.

87 germinal centre and become rapidly dividing germinal-centre centroblasts that give rise to dark zone

88 se (AID), which is expressed specifically in germinal-centre centroblasts, is required for this proce

89 ents with synovial tissue containing ectopic germinal centres compared with diffuse synovial tissue.

90 icular B cells were frequent visitors to the germinal-centre compartment, suggesting that all B cells

91 These results offer an explanation for the germinal centre defect due to SAP deficiency and provide

92 n normal germinal-centre B cells or in other germinal-centre-derived lymphomas, suggesting a DLCL-ass

93 The precise function of BCL6 in germinal-centre development and lymphomagenesis is uncle

94 However, there have been no studies of germinal-centre dynamics or the migratory behaviour of g

95 We conclude that the open structure of germinal centres enhances competition and ensures that r

96 ns as a transcriptional switch that controls germinal centre formation and may also modulate specific

97 germinal centre B-cells and is essential for germinal centre formation and T-dependent antibody respo

98 ncoded by SH2D1a) cause a profound defect in germinal centre formation by an as yet unknown mechanism

99 ccord with the defective isotype production, germinal centre formation is absent in these mutant mice

100 cells, a reduction in B cell activation and germinal centre formation, and the inhibition of antigen

101 ype class switching, accompanied by impaired germinal centre formation.

102 normally leading to B cell proliferation and germinal centre formation.

103 nscriptional repressor that is necessary for germinal-centre formation and is implicated in the patho

104 ed protein 2 (EBI2), but significantly fewer germinal centre (GC) B cells compared with tonsil.

105 in controlling T follicular helper (Tfh) and germinal centre (GC) B-cell responses to influenza.

106 use a 3D GC organoid and show EZH2 mediates germinal centre (GC) formation through epigenetic silenc

107 el which reproduces experimental data on the germinal centre (GC) kinetics of the primed primary immu

108 few days of infection, resulting in a weaker germinal centre (GC) response and diminished immune memo

109 igh-affinity antibody production through the germinal centre (GC) response is a pivotal process in ad

110 ls is required for optimal maturation of the germinal centre (GC) response.

111 le Pfs25, as well as to significantly higher germinal centre (GC) responses.

112 relative contribution of extrafollicular and germinal centre (GC) T-B interaction is unclear.

113 +) PC development pathway, namely (i) IgE(+) germinal centre (GC)-like B cells, (ii) IgE(+) PC-like '

114 Germinal centres (GCs) promote humoral immunity and vacc

115 rsification of their immunoglobulin genes in germinal centres (GCs).

116 h nodes or Peyer's patches, and fail to form germinal centres in the spleen.

117 pment of the germinal centre response and/or germinal centre-independent events, consistent with thei

118 hway for peripheral T cells and suggest that germinal centres induce a lymphocyte phenotype necessary

119 Germinal-centre-like reactions are well-documented in th

120 f NP-OVA, even though they failed to produce germinal centres, manifested a high-affinity anti-NP IgG

121 c mutation typical of antigen-selected (post-germinal-centre) memory cells.

122 rimary and secondary immune responses in the germinal centres of lymphoid organs have been studied in

123 emble human DLBCL with molecular features of germinal centre or post-germinal centre B cells.

124 induced T-B-cell interactions increase total germinal centre output and accelerate it by days.

125 r helper (Tfh) cells is vital in driving the germinal centre reaction and high affinity antibody form

126 rmutation several days before the end of the germinal centre reaction is beneficial for affinity matu

127 cells was antagonized, participation in the germinal centre reaction was impaired.

128 control the magnitude and specificity of the germinal centre reaction, but how regulation is containe

129 rm antibody-mediated immunity depends on the germinal centre reaction, which requires cooperation bet

130 in a nascent germinal centre to sustain the germinal centre reaction.

131 antigen-specific B cells participating in a germinal-centre reaction were motile and physically rest

132 cific B cells can be recruited to an ongoing germinal-centre reaction.

133 earlier in the initiation/development of the germinal centre response and/or germinal centre-independ

134 zed subset of lymphocytes that influence the germinal centre response through interactions with folli

135 results in impaired TFH-cell development and germinal centre response.

136 Thus, TFR contribute to inefficient germinal centre responses and inhibit HIV and SIV cleara

137 t defective T-cell-dependent plasma cell and germinal centre responses.

138 are important in supporting plasma cell and germinal centre responses.

139 hat have failed the physiological process of germinal centre selection into memory.

140 Here we show that in splenic germinal centres, T cells regain thymocyte-like sensitiv

141 he spontaneous formation of T-cell-dependent germinal centres that are enriched with B cells expressi

142 In germinal centres the feedback loop is overridden, with B

143 ently recruited to and retained in a nascent germinal centre to sustain the germinal centre reaction.

144 ubiquitination and degradation of YY1, a key germinal centre transcription factor.

145 nization or infection, which localize to the germinal centre where they control the magnitude of the

146 thought to migrate to the light zone of the germinal centre, which is rich in antigen-trapping folli

147 Although germinal centres within follicles were described in 1885