ライフサイエンスコーパス: germline stem cell

1 initiated with the asymmetric division of a germline stem cell.

2 vival, differentiation, and proliferation of germline stem cells.

3 cell overproliferation and dedifferentiated germline stem cells.

4 not required for the maintenance of ovarian germline stem cells.

5 verge on meiotic RNAs to ensure silencing in germline stem cells.

6 ired (Upd), leading to a concomitant loss of germline stem cells.

7 demonstrated that Ago1 regulates the fate of germline stem cells.

8 re translation of the BMP antagonist Brat in germline stem cells.

9 conserved role in promoting self-renewal of germline stem cells.

10 t does not affect the maintenance of ovarian germline stem cells.

11 e stem cell niche in the aging of Drosophila germline stem cells.

12 s is dependent on the continuous activity of germline stem cells.

13 ired for the maintenance of hub cells or the germline stem cells.

14 preventing inappropriate translation in the germline stem cells.

15 rform transcriptome analysis in mouse female germline stem cells.

16 the male germline, increasing the number of germline stem cells.

17 is essential for the normal function of the germline stem cells.

18 uired in somatic signaling cells to maintain germline stem cells.

19 Yb acts in these signaling cells to maintain germline stem cells.

20 that the dpp signal is directly received by germline stem cells.

21 aining the undifferentiated status of female germline stem cells.

22 ing the fundamental features of mouse female germline stem cells.

23 meiosis-like cytological changes in cultured germline stem cells.

24 ry culture system for Caenorhabditis elegans germline stem cells.

25 e of sexual identity when compared with male germline stem cells.

26 pro-apoptotic Smac/DIABLO orthologue, Hid in germline stem cells.

27 dult mammalian ovary is devoid of definitive germline stem cells.

28 il to mature, and remain as undifferentiated germline stem cells.

29 inate from early-stage germ cells, including germline stem cells.

30 ains male fertility and is sustained by rare germline stem cells.

31 ring asymmetric divisions of Drosophila male germline stem cells.

32 In Drosophila male germline stem cells, ACD is prepared by stereotypical ce

33 Transplantation studies show that germline stem cell activity is confined to the Tert(High

34 Adult germline stem cells (AGSCs) self-renew (Thy1(+) enriched

35 ivides asymmetrically to generate a daughter germline stem cell and a cystoblast that will develop in

36 dria partition equally on the spindle during germline stem cell and cystocyte divisions.

37 approach to studying the biology of the male germline stem cell and its microenvironment, the stem ce

38 oss of Miwi2, a mouse Piwi homolog, leads to germline stem cell and meiotic defects correlated with i

39 ing (lola) is required cell autonomously for germline stem cell and somatic cyst stem cell maintenanc

40 atin remodeling factors ISWI and DOM control germline stem cell and somatic stem cell self-renewal in

41 of mouse embryonic stem cells and Drosophila germline stem cells and for repressing stem cell prolife

42 -glp-1 are all required for proliferation of germline stem cells and for specifying blastomere fates

43 detect high levels of Pumilio protein in the germline stem cells and high levels of Nanos in the divi

44 NA and protein are strongly expressed in the germline stem cells and in 16-cell cysts.

45 h as Drosophila melanogaster neuroblasts and germline stem cells and mammalian skin stem cells.

46 orientation in Drosophila melanogaster male germline stem cells and neuroblasts has brought into sha

47 niche and germline cells to regulate ovarian germline stem cells and oogenesis.

48 clear genome contributed to death of ovarian germline stem cells and reduced egg production, which wa

49 egation of X and Y chromosomes in Drosophila germline stem cells and shed light on the complex mechan

50 ale-specific expression in early germ cells, germline stem cells and spermatogonia in insects, and it

51 erentiated cells can develop into functional germline stem cells and support normal fertility.

52 s with self-renewal of Drosophila neural and germline stem cells and that equalizing centrosomes disr

53 s somatic expression modulates the number of germline stem cells and the rate of their division, whil

54 lls causes an increase both in the number of germline stem cells and the rate of their division.

55 e find that nuclear localization of Zfrp8 in germline stem cells and their offspring is regulated by

56 s, SC proteins are expressed precociously in germline stem cells and their precursors.

57 lonal expansion, maintained the phenotype of germline stem cells, and reconstituted spermatogenesis i

58 ale-specific expression in early germ cells, germline stem cells, and spermatogonia.

59 contrast, rab11 is required to maintain the germline stem cells, and to maintain the vesicle content

60 Adult germline stem cells are capable of self-renewal, tissue

61 In Caenorhabditis elegans, germline stem cells are controlled by the somatic distal

62 Germline stem cells are defined by their unique ability

63 Germline stem cells are key to genome transmission to fu

64 The iswi mutant germline stem cells are lost rapidly because of defects

65 We also propose that C. elegans adult germline stem cells are maintained by proximity to the n

66 s critical for production of male and female germline stem cells, as well as sperm versus eggs.

67 We suggest that FBF controls germline stem cells, at least in part, by repressing gld

68 t mitotically dividing germ cells--including germline stem cells--become quiescent in the absence of

69 Germline stem cells begin to differentiate by forming in

70 de that a cell-extrinsic mechanism regulates germline stem cell behaviour.

71 h niche and intrinsic mechanisms to maintain germline stem cells, but its underlying mechanism remain

72 We constructed mutant germline stem cell clones to show that the dpp signal is

73 ural selection also operates at the level of germline stem cell clones.

74 wed the emergence of competitive somatic and germline stem cell clones.

75 We show that in mice germline stem cells compete for gonad niches, and in mic

76 Although no germline stem cells could be identified by SSEA-1 immuno

77 lls, do not adhere to and migrate along with germline stem cell daughters as previously proposed.

78 imilarities and both genes ultimately affect germline stem cell development, the focus of these pheno

79 y and temporally distinct processes by which germline stem cells differentiate into functional oocyte

80 est not only that mago nashi is required for germline stem cell differentiation but that surprisingly

81 miR-184 controls germline stem cell differentiation by tuning the DPP rec

82 d, resulting in germline loss and a block in germline stem cell differentiation.

83 Overexpression of dpp blocks germline stem cell differentiation.

84 Germline stem cells divide asymmetrically, producing a s

85 Drosophila oogenesis starts when a germline stem cell divides asymmetrically to generate a

86 During Drosophila melanogaster oogenesis, a germline stem cell divides forming a cyst of 16 intercon

87 ndings reveal that the genetic regulation of germline stem cell division involves dosage-sensitive me

88 ulin-like peptides (DILPs) directly regulate germline stem cell division rate, demonstrating that sig

89 nge of developmental processes, ranging from germline stem cell division to epithelial tissue homeost

90 second role as a cell-autonomous promoter of germline stem cell division.

91 )Yb gene is essential for the maintenance of germline stem cells during oogenesis.

92 ages, consistent with its role in regulating germline stem cells during oogenesis.

93 i-induced/Tai-dependent genes, including the germline stem cell factors nanos and piwi.

94 receptor on adjacent germ cells to maintain germline stem cell fate.

95 In germline stem cells, FBF prevents premature meiotic entr

96 s the lineage-specific enhancers involved in germline stem cell features.

97 Zebrafish female germline stem cell (FGSC) cultures were generated from a

98 the growth and survival of zebrafish female germline stem cells (FGSCs) in culture.

99 ctive oocyte progenitor cells, termed female germline stem cells (fGSCs) or oogonial stem cells (OSCs

100 Here we show that the Drosophila male germline stem cells form previously unrecognized structu

101 a strategy to optimize culture conditions of germline stem cells from other species.

102 both the niche and the environment modulate germline stem cell function.

103 etrically distributed during Drosophila male germline stem cell (GSC) asymmetric division.

104 is, the JAK-STAT signaling pathway regulates germline stem cell (GSC) attachment to the apical hub an

105 In Drosophila testes, each Germline Stem Cell (GSC) contacts apical hub cells and i

106 owed that insulin signals directly stimulate germline stem cell (GSC) division and indirectly promote

107 croRNA (miRNA) pathway for proper control of germline stem cell (GSC) division in Drosophila melanoga

108 During Drosophila oogenesis, germline stem cell (GSC) identity is maintained largely

109 In the Drosophila male germline stem cell (GSC) lineage, a key differentiation

110 differentiation genes in the Drosophila male germline stem cell (GSC) lineage.

111 nuclear ribonucleoproteins (hnRNPs) regulate germline stem cell (GSC) maintenance and egg chamber pol

112 n essential role in embryonic patterning and germline stem cell (GSC) maintenance during oogenesis in

113 demonstrated that DBHD is required for male germline stem cell (GSC) maintenance in the fly testis.

114 In Drosophila, germline stem cell (GSC) maintenance requires regulation

115 ng integrates the effects of diet and age on germline stem cell (GSC) maintenance through the dual re

116 in that is intrinsically required for female germline stem cell (GSC) maintenance.

117 methylase 1 (Lsd1) regulates the size of the germline stem cell (GSC) niche in Drosophila ovaries.

118 In the Drosophila melanogaster female germline stem cell (GSC) niche, Decapentaplegic (Dpp), a

119 cans (HSPGs) are essential regulators of the germline stem cell (GSC) niches in the Drosophila melano

120 fic reproductive capacity, suggesting that a germline stem cell (GSC) population drives oocyte produc

121 distinct developmental paths with respect to germline stem cell (GSC) production and the types of dif

122 n of udd or TAF1B results in reduced ovarian germline stem cell (GSC) proliferation.

123 this study, we show that DNA damage retards germline stem cell (GSC) self-renewal and progeny differ

124 P) signaling activated by the niche promotes germline stem cell (GSC) self-renewal and proliferation,

125 In the Drosophila ovary, germline stem cell (GSC) self-renewal is controlled by b

126 gaster ovary, some intrinsic factors promote germline stem cell (GSC) self-renewal, whereas others st

127 The transition from a Drosophila ovarian germline stem cell (GSC) to its differentiated daughter

128 he, comprising ten hub cells, maintains both germline stem cells (GSC) and somatic stem cells (CySC).

129 ural stem cells (neuroblasts [NBs]) and male germline stem cells (GSCs) [1-3].

130 We found that germline stem cells (GSCs) actively modulate lipid hydro

131 molog String (Stg) is a crucial regulator of germline stem cells (GSCs) and cyst stem cells (CySCs) i

132 ate the self-renewal and maintenance of male germline stem cells (GSCs) and discuss how these factors

133 Although it is highly expressed in germline stem cells (GSCs) and early progeny, it remains

134 We previously showed that germline stem cells (GSCs) and follicle stem cells (FSCs

135 ystems for studying stem cell behavior, with germline stem cells (GSCs) and somatic cyst stem cells (

136 pathway in two adjacent types of stem cells: germline stem cells (GSCs) and somatic cyst stem cells (

137 rosophila testes, two stem cell populations, germline stem cells (GSCs) and somatic cyst stem cells (

138 , is required to coordinate proliferation of germline stem cells (GSCs) and somatic cyst stem cells (

139 essor that regulates the competition between germline stem cells (GSCs) and somatic cyst stem cells (

140 ide the behavior and differentiation of both germline stem cells (GSCs) and somatic follicle stem cel

141 ehog (hh) that regulate the division of both germline stem cells (GSCs) and somatic stem cells (SSCs)

142 Drosophila ovarian germline stem cells (GSCs) are maintained by Dpp signali

143 For example, Drosophila ovarian germline stem cells (GSCs) are maintained by exquisitely

144 Throughout the cell cycle, centrosomes in germline stem cells (GSCs) are oriented within their nic

145 Drosophila male and female germline stem cells (GSCs) are sustained by niches and r

146 ntified delayed completion of cytokinesis in germline stem cells (GSCs) as a mechanism that regulates

147 Drosophila male germline stem cells (GSCs) attach to somatic hub cells,

148 enty-hydroxyecdysone (20E) regulates ovarian germline stem cells (GSCs) but was considered dispensabl

149 It was proposed that somatic Piwi maintains germline stem cells (GSCs) by promoting Dpp signaling, p

150 large-scale RNAi screen in Drosophila female germline stem cells (GSCs) covering approximately 25% of

151 In Drosophila, germline stem cells (GSCs) descend from a subset of prim

152 In Drosophila ovaries, germline stem cells (GSCs) divide asymmetrically to prod

153 Drosophila male germline stem cells (GSCs) divide asymmetrically, balanc

154 In Caenorhabditis elegans, ablation of germline stem cells (GSCs) extends lifespan, but also in

155 We developed a method to highly purify germline stem cells (GSCs) from the Drosophila ovary, on

156 Fmr1 is required for controlling the fate of germline stem cells (GSCs) has gone unanswered.

157 Drosophila ovarian germline stem cells (GSCs) have been one of the most pro

158 ing to be identified, but Drosophila oogenic germline stem cells (GSCs) have emerged as an important

159 In the Drosophila ovary, two or three germline stem cells (GSCs) have recently been shown to r

160 Studies of Drosophila male germline stem cells (GSCs) have served as a paradigm in

161 Drosophila female germline stem cells (GSCs) have short G1 and long G2 pha

162 morphogenetic protein (BMP) ligands maintain germline stem cells (GSCs) in an undifferentiated state.

163 Germline stem cells (GSCs) in Drosophila are descendants

164 Male germline stem cells (GSCs) in Drosophila melanogaster di

165 Here we address the division frequency of Germline Stem Cells (GSCs) in testes of Drosophila melan

166 Germline stem cells (GSCs) in the Drosophila ovary provi

167 and functions in the niche cells to maintain germline stem cells (GSCs) in the Drosophila ovary.

168 intrinsically required in the regulation of germline stem cells (GSCs) in the Drosophila ovary.

169 Germline stem cells (GSCs) in the Drosophila testis are

170 Germline stem cells (GSCs) in the Drosophila testis have

171 ulates the number and asymmetric division of germline stem cells (GSCs) in the Drosophila testis.

172 In the Drosophila ovary, germline stem cells (GSCs) in the niche continuously sel

173 ated cell adhesion is required for anchoring germline stem cells (GSCs) in their niches in the Drosop

174 Germline stem cells (GSCs) must express components of th

175 tly the piwi gene was found in the embryonic germline stem cells (GSCs) of Drosophila melanogaster an

176 The germline stem cells (GSCs) of the Drosophila ovary maint

177 he germarium form an environmental niche for germline stem cells (GSCs) of the Drosophila ovary.

178 Drosophila melanogaster male germline stem cells (GSCs) possess a checkpoint, termed

179 The niche for germline stem cells (GSCs) provides a Dpp/Bmp signal, wh

180 In Drosophila females, germline stem cells (GSCs) require Sex lethal (Sxl) to e

181 Drosophila female germline stem cells (GSCs) reside adjacent to a cellular

182 The Drosophila germline stem cells (GSCs) reside in a somatic cell nich

183 Our previous work showed that germline stem cells (GSCs) respond to diet via neural in

184 lized the ability of Drosophila melanogaster germline stem cells (GSCs) to survive exposure to low do

185 dult males do indeed possess a population of germline stem cells (GSCs) with properties similar to th

186 adult testis and ovary in Drosophila contain germline stem cells (GSCs) with well-defined niches, and

187 2), is required to maintain a stable pool of germline stem cells (GSCs) within the niche microenviron

188 ds to an increase in the mitotic activity of germline stem cells (GSCs), as well as a decrease in pro

189 Many stem cells, including Drosophila germline stem cells (GSCs), divide asymmetrically, produ

190 ld" versus "new" histones in Drosophila male germline stem cells (GSCs), we show that preexisting can

191 In the Drosophila ovary, germline stem cells (GSCs), which are adjacent to cap ce

192 Germline stem cells (GSCs), which can self-renew and gen

193 he apical hub form the niche for neighboring germline stem cells (GSCs), with CySCs as the proposed s

194 organization of the niche that supports the germline stem cells (GSCs).

195 , except for a small population of protected germline stem cells (GSCs).

196 te the cell cycle in Drosophila melanogaster germline stem cells (GSCs).

197 ing on regulators of adult Drosophila testis germline stem cells (GSCs).

198 ide in vivo RNAi screen in female Drosophila germline stem cells (GSCs).

199 the stem cell centrosome in Drosophila male germline stem cells (GSCs).

200 ber, ophis, that controls differentiation of germline stem cells (GSCs).

201 ing a reduced pool of actively proliferating germline stem cells (GSCs).

202 vary control the number and proliferation of germline stem cells (GSCs).

203 would affect the maintenance of stem cells (germline stem cells, GSCs; somatic stem cells, SSCs) in

204 assay system to unequivocally identify male germline stem cells has allowed their in vitro culture,

205 ell systems, including embryonic stem cells, germline stem cells, hematopoietic stem cells, and intes

206 ions between embryonic stem cells and female germline stem cells identifies the lineage-specific enha

207 preventing them from displacing neighboring germline stem cells in a manner that depends on the adhe

208 effector protein TomO, which maintains host germline stem cells in an undifferentiated state.

209 s distal tip cell (DTC) provides a niche for germline stem cells in both hermaphrodites and males.

210 piwi mutants fail to maintain germline stem cells in both male and female gonads.

211 Our studies of circulating competing germline stem cells in colonial protochordates led us to

212 Pumilio controls germline stem cells in Drosophila females, and, in lower

213 A motor protein called Klp10A ensures that germline stem cells in male fruit flies divide to produc

214 The loss of germline stem cells in nos mutant mothers appears to be

215 n of cystoblasts, the committed daughters of germline stem cells in the Drosophila ovary.

216 As we discuss here, after emerging from germline stem cells in the fetus, they grow in a follicu

217 Here we report that FBF also controls germline stem cells: in an fbf-1 fbf-2 double mutant, ge

218 A pool of proliferating germline stem cells is essential for gamete production i

219 n invertebrates, the proliferation of female germline stem cells is regulated by nutritional status.

220 However, in mammals, the number of female germline stem cells is set early in development, with oo

221 ion (Jak-STAT) pathway maintains stem cells; germline stem cells lacking Jak-STAT signaling different

222 However, germline stem cells lacking tsunagi/Y14 function are ind

223 promises activation of Dpp signalling within germline stem cells, leading to germline stem cell loss.

224 on to differentiation in the Drosophila male germline stem cell lineage is mediated by translational

225 Here, we show in the Drosophila male germline stem cell lineage that a spermatocyte-specific

226 vent marking onset of differentiation in the germline stem cell lineage.

227 fate decisions within the Drosophila ovarian germline stem cell lineage.

228 lling within germline stem cells, leading to germline stem cell loss.

229 It has been suggested that germline stem cells maintain oogenesis in postnatal mous

230 ntermingled cells, which contributes to both germline stem cell maintenance and differentiation niche

231 It is important for germline stem cell maintenance and gametogenesis in male

232 involved in germline-specific events such as germline stem cell maintenance and meiosis.

233 ntrol machinery regulate the balance between germline stem cell maintenance and the differentiation o

234 Despite the early expression of Mov10l1, germline stem cell maintenance appears unaffected in Mov

235 TAT pathway maintains the niche required for germline stem cell maintenance in the testis, providing

236 in a number of defects, including a loss of germline stem cell maintenance, mispositioning of the oo

237 ne loss, revealing a function for Yb in male germline stem cell maintenance.

238 kine signaling 36E (SOCS36E) is required for germline stem cell maintenance.

239 es not reduce follicle cell proliferation or germline stem cell maintenance.

240 key component of the signaling machinery for germline stem cell maintenance.

241 at least 3R-TAS1 piRNA and is essential for germline stem-cell maintenance.

242 as well as partly rescuing their defects in germline stem-cell maintenance.

243 eq, by characterizing Caenorhabditis elegans germline stem cell mutation accrual and asking how matin

244 A new study on the Drosophila testicular germline stem cell niche has revealed that BMP signaling

245 The male germline stem cell niche in Drosophila houses two stem c

246 de in the gonadal distal tip cell (DTC), the germline stem cell niche, where it negatively regulates

247 nd the TGF-beta receptor pathway acts in the germline stem cell niche.

248 ts negatively on Notch to restrict the ovary germline stem cell niche.

249 -1(0);fbf(RNAi) animals failed to maintain a germline stem cell niche.

250 In neural and germline stem cells, Nin localizes asymmetrically to the

251 highest expression in hub cells, a niche for germline stem cells of testis.

252 istent with separate lineages of somatic and germline stem cells or pluripotent stem cells that diffe

253 ister chromatid segregation is randomized in germline stem cell overproliferation and dedifferentiate

254 Germline stem cells play an essential role in establishi

255 e to modulate developmental expansion of the germline stem cell pool.

256 In Drosophila, a small germline stem cell population is influenced by a complex

257 In addition, the germline stem cell population remains active for a longe

258 st germline proliferation that builds up the germline stem cell population; and (2) distinct insulin-

259 d nanotubes are observed specifically within germline stem cell populations, and require intraflagell

260 This limits germline stem cell predation to kin, as the locus has hu

261 The removal of germline stem cells preserves jmjd-3.1 expression, suppr

262 The mago nashi null germline stem cells produce clones over a period of at l

263 re required for the late larval expansion of germline stem cell progenitors in the C. elegans gonad.

264 best known for maintaining undifferentiated germline stem cells/progenitors.

265 allel to Notch signaling, a key regulator of germline stem cell proliferation and differentiation.

266 nstrate here that differential regulation of germline stem cell proliferation rates in Caenorhabditis

267 different contexts [5], but its function in germline stem cell proliferation remains poorly understo

268 Fertility depends on germline stem cell proliferation, meiosis and gametogene

269 ere, we describe a function for autophagy in germline stem cell proliferation.

270 signaling helps define a niche that controls germline stem cell proliferation.

271 receptor (IIR) signaling pathway to promote germline stem cell proliferation.

272 egardless of their systemic levels, to block germline stem cell proliferation.

273 e fundamental properties of mammalian female germline stem cells remain poorly understood.

274 Notably, when oocytes are depleted, but germline stem cells remain, adult females sex-revert to

275 but not the inappropriate differentiation of germline stem cells, requires the function of the cell d

276 spermatogonia, the mitotic population where germline stem cells reside.

277 exists an exchange of somatic stem cells and germline stem cells, resulting in somatic chimeras and s

278 ntiating progeny, whereas the neuroblast and germline stem cells retain HNE during division.

279 classical mouse mutant luxoid affects adult germline stem cell self-renewal.

280 ntinued production of oocytes by maintaining germline stem cells self-renewal.

281 n, in differentiating daughter cells renders germline stem cells sensitive to IR, suggesting that the

282 found to be necessary for the maintenance of germline stem cells, shows that Stwl is present in a pun

283 Removing PIWI protein from single germline stem cells significantly decreases the rate of

284 ial primordial follicle pool supplemented by germline stem cells (stem cell model).

285 ent deprivation leads to G2 arrest of animal germline stem cells, suggest that carbohydrate availabil

286 legans FBF are essential for self-renewal of germline stem cells, suggesting that a common function o

287 ordial germ cells arise from piwi-expressing germline stem cells that are distinct from somatic stem

288 Spermatogonia are adult germline stem cells that can both self-renew and differe

289 Germline stem cells that produce oocytes in vitro and fe

290 n contains at least one apparently bona fide germline stem cell, the majority of cells exhibit an int

291 While both contain germline stem cells, the testis niche also contains "cys

292 xpression is a fundamental characteristic of germline stem cells, thus explaining the broad dependenc

293 es, suggest that Sxl enables the switch from germline stem cell to committed daughter cell by posttra

294 dUTX also acts in germline stem cells to maintain hub structure through re

295 hat help explain its dual role in regulating germline stem cell totipotency and embryonic cell fate s

296 methylation primarily contributes to female germline stem cell unipotency by suppressing the somatic

297 Here, we show that dividing Drosophila male germline stem cells use intracellular mechanisms involvi

298 tigate the Notch transcriptional response in germline stem cells using single-molecule fluorescence i

299 Highly successful germline stem cells usually outcompete less successful c

300 eport cellular analyses designed to identify germline stem cells within the germline mitotic region o

301 elegans Notch signaling maintains a pool of germline stem cells within their single-celled mesenchym