ライフサイエンスコーパス: ghrelin receptor

1 the GH secretagogue receptor 1a (GHSR1a, ie, ghrelin receptor).

2 growth hormone secretagogue receptor (GHSR; ghrelin receptor).

3 p with the high constitutive activity of the ghrelin receptor.

4 one (GH), a major downstream effector of the ghrelin receptor.

5 he functional and structural behavior of the ghrelin receptor.

6 nverse agonist K-(d-1-Nal)-FwLL-NH(2) at the ghrelin receptor.

7 ing that the GHSR is a biologically relevant ghrelin receptor.

8 that the GHSR is a physiologically relevant ghrelin receptor.

9 sepsis by vagus nerve activation via central ghrelin receptors.

10 uced gut barrier dysfunction through central ghrelin receptors.

11 the growth hormone secretagogue receptor 1a (ghrelin receptor), a peptidic G-protein-coupled receptor

12 the amygdala and behavioral insensitivity to ghrelin receptor agonism.

13 Repeated systemic administration of a ghrelin receptor agonist enhanced fear memory but did no

14 Repeated intraamygdala infusion of a ghrelin receptor agonist produced a similar enhancement

15 Anamorelin is an oral ghrelin-receptor agonist with appetite-enhancing and ana

16 We assessed anamorelin, a novel ghrelin-receptor agonist, on cachexia in patients with a

17 The ghrelin receptor, also known as the growth hormone secre

18 hormone secretagogues act as agonists at the ghrelin receptor and have been described as "ago-alloste

19 dual peptides simultaneously inhibiting the ghrelin receptor and stimulating the Y2 receptor.

20 s prepared from cells coexpressing the human ghrelin receptor and the G protein Galpha(o1), N-[1(R)-1

21 ents of the ghrelin system, including native ghrelin, receptors and the recently discovered splicing

22 Ghrelin receptor antagonism during repeated stress aboli

23 ventricular (LV) ghrelin increased, while LV ghrelin receptor antagonism suppressed the magnitude of

24 and improved glucose tolerance, whereas the ghrelin receptor antagonist D-Lys GHRP-6 reduced plasma

25 Notably, administration of a ghrelin receptor antagonist further reduced blood glucos

26 programs aimed at delivering small molecule ghrelin receptor antagonists and inverse agonists to the

27 t cells containing both leptin receptors and ghrelin receptors are mainly located in the medial part

28 with a model system composed of the purified ghrelin receptor assembled into lipid discs.

29 ce for the high constitutive activity of the ghrelin receptor being an intrinsic property of the prot

30 st- and signaling protein-induced changes in ghrelin receptor conformation, thus preventing it from a

31 ly on distinct neuronal populations and that ghrelin receptor deficiency does not affect sensitivity

32 red fasting blood glucose levels observed in ghrelin receptor-deficient mice were returned to wild-ty

33 ptor distribution, we explored the effect of ghrelin receptor deletion on leptin sensitivity.

34 et-derived growth factor by inhibiting, in a ghrelin-receptor-dependent manner, Rac1 activation and c

35 Surprisingly, we found that deletion of the ghrelin receptor did not affect the sensitivity to exoge

36 The ghrelin receptor displays a high constitutive activity s

37 memories, and pharmacological agonism of the ghrelin receptor during the memory consolidation period

38 ly occurring truncated splice variant of the ghrelin receptor exerts a dominant negative effect on gh

39 ould allow localization and visualization of ghrelin receptor expressing carcinomas using PET imaging

40 stingly, both leptin receptor expression and ghrelin receptor expression have been observed within ma

41 Notably, selective hindbrain ghrelin receptor expression was not sufficient to restor

42 Here we report that ghrelin and ghrelin receptor expression within the thymus diminished

43 Plasma GH levels, ghrelin receptor expression, and neuronal activity in th

44 histological mapping of leptin receptor and ghrelin receptor expression, we found that cells contain

45 In mice lacking ghrelin receptors, FAA is significantly reduced.

46 phila and Anopheles) and to neuromedin U and ghrelin receptors from vertebrates.

47 lin secretion, and both are mediated through ghrelin receptor GHS-R.

48 In this context, ghrelin receptor GHS-R1a is a peculiar receptor in the s

49 ing and signaling of the full and functional ghrelin receptor GHS-R1a.

50 Despite being unable to activate the cognate ghrelin receptor (GHS-R), unacylated ghrelin (UAG) posse

51 of food intake, and inverse agonists of the ghrelin receptor (GHS-R1a) are widely considered to offe

52 otein-coupled receptors (GPCRs), such as the ghrelin receptor (GHS-R1a), the melanocortin 3 receptor

53 The mechanism must accommodate noncanonical ghrelin receptor (GHS-R1a)-G-protein coupling to Galpha(

54 d weight gain in transgenic mice lacking the ghrelin receptor (Ghsr(-/-) mice).

55 hrelin action, we have examined the roles of ghrelin receptor (GHSR) expression in the mouse hindbrai

56 the distribution of neurons that express the ghrelin receptor (GHSR) in the medulla oblongata.

57 Genetic ablation of ghrelin or the ghrelin receptor (GHSR) increased SNpc DA cell loss and

58 hippocampal neurogenesis in depression-prone ghrelin receptor (Ghsr)-null mice to that in wild-type l

59 The G protein-coupled ghrelin receptor GHSR1a is a potential pharmacological t

60 The ghrelin receptor (GHSR1a) and dopamine receptor-1 (DRD1)

61 e dopamine receptor subtype-2 (DRD2) and the ghrelin receptor (GHSR1a).

62 tive and/or agonist-induced signaling of the ghrelin receptor, GPR119, the beta(2)-adrenergic recepto

63 -acyl ghrelin, although devoid of binding to ghrelin receptor (GRLN), exerts many biological effects,

64 The ghrelin receptor growth hormone secretagogue 1 receptor

65 The truncated non-signaling ghrelin receptor growth hormone secretagogue R1b (GHS-R1

66 are guided largely by the expression of the ghrelin receptor growth hormone secretagogue type 1a (GH

67 Here we demonstrate that Ghrl and ghrelin receptor (growth hormone secretagogue receptor (

68 Endogenous ghrelin receptors [growth hormone secretagogue receptor

69 reproghrelin gene, but not those lacking the ghrelin receptor, have impaired abilities to manifest an

70 s affect the conformational landscape of the ghrelin receptor in different ways.

71 phobic pocket between TM-III and TM-V in the ghrelin receptor in four of five positions impaired rece

72 ype levels by selective re-expression of the ghrelin receptor in the hindbrain.

73 Furthermore, to confirm the role of central ghrelin receptors in ghrelin's effect, ghrelin (1 nmol)

74 We recently identified ghrelin receptors in olfactory circuits in the brain.

75 Ghrelin treatment, mediated through ghrelin receptors in the brain, attenuates sepsis-induce

76 investigate the distribution and density of ghrelin receptors in the rodent hypothalamus.

77 o somatostatin receptors (sst2 and sst5) and ghrelin receptor, induction of cAMP and p38-mitogen-acti

78 bility compared to that of the highly stable ghrelin receptor inverse agonist.

79 d that the high constitutive activity of the ghrelin receptor is dependent upon flexibility in the C-

80 n function (r = 0.99) for both wild-type and ghrelin receptor knockout animals, with the latter havin

81 of cell proliferation via the mediation of a ghrelin receptor, likely a novel unidentified subtype.

82 a provide direct evidence of a mechanism for ghrelin receptor-mediated Gq signaling in which transiti

83 Ghrelin receptor mRNA and immunoreactivity were detected

84 elin promotes food intake, an action lost in ghrelin receptor null mice and also helps maintain fasti

85 in overnight-fasted, streptozotocin-treated ghrelin receptor-null mice that were administered GcgR m

86 Thus, the ghrelin receptor occurs in the medulla oblongata in 1) s

87 onstituted system, we show that the isolated ghrelin receptor per se activates G(q) in the absence of

88 growth hormone secretagogue receptor (GHSR) (ghrelin receptor) plays an important role in the regulat

89 pite its inability to activate the classical ghrelin receptor, preclinical studies suggest that UAG m

90 The Y2 receptor induces satiety, while the ghrelin receptor promotes hunger and weight gain.

91 ass A G protein-coupled receptor (GPCR), the ghrelin receptor, reconstituted as a monomer into lipid

92 e the authors show that MRAP2 also regulates ghrelin receptor signalling in the hypothalamus and star

93 block the fear-enhancing effects of repeated ghrelin receptor stimulation.

94 elease from amygdala neurons was enhanced by ghrelin receptor stimulation.

95 primer sequence of the previously identified ghrelin receptor subtypes detected no signal.

96 lin (a pentapeptide-selective agonist of the ghrelin receptor that speeds gastric emptying in patient

97 d rats, ghrelin activation of a postsynaptic ghrelin receptor, the growth hormone secretagogue recept

98 s occur mainly via binding to the only known ghrelin receptor, the growth hormone secretagogue recept

99 on of the high constitutive signaling of the ghrelin receptor, this loop was subjected to a detailed

100 Selectively targeting the ghrelin receptor using fluorine-18 tagged entities would