ライフサイエンスコーパス: ginkgolide

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1 pha1beta2 and alpha1beta2gamma2 receptors to ginkgolides.

2 required for glycine receptor inhibition by ginkgolides.

3 onally, the antioxidants ginsenoside Rb1 and ginkgolide A effectively reversed HAART drug-induced vas

4 modulating Abeta oligomeric species, and (3) ginkgolide A has therapeutic potential for prevention an

5 ss is not the mechanism by which EGb 761 and ginkgolide A suppress Abeta-induced paralysis because th

6 port that EGb 761 and one of its components, ginkgolide A, alleviates Abeta-induced pathological beha

7 These acetyl derivatives, as well as ginkgolides A and B acetates have been investigated for

8 Both ginkgolides and bilobalide inhibit GABA(A) receptors, wi

9 Terpene trilactones (ginkgolides and bilobalide) are unique constituents of G

10 Their active components (ginkgolides and bilobalide) have structures similar to t

11 The terpene trilactones (TTLs), ginkgolides and bilobalide, are structurally unique cons

12 nd demonstrate a striking similarity between ginkgolides and picrotoxinin, a GABA(A) and recombinant

13 emonstrates a strong interaction between the ginkgolides and the 2' residue, a result supported by in

14 Ginkgolides are known antagonists of the platelet-activa

15 We find that most of the ginkgolides are selective and potent antagonists of the

16 Ginkgolides are structurally unique constituents of Gink

17 n with the PAF inhibitors WEB 2086 (WEB) and ginkgolide B (GB).

18 Ginkgolide C is 25-fold less potent than ginkgolide B as a PAF receptor antagonist, due to the pr

19 ein we describe the synthesis of a series of ginkgolide B derivatives with modifications at the 7-pos

20 thermore, standard reduction of 7alpha-azido ginkgolide B did not give the expected primary amine, bu

21 es nucleophilic attack on a 7beta-O-triflate ginkgolide B did not lead to the expected products, but

22 d PAF receptor, confirming that of the TTLs, ginkgolide B is the most potent PAF receptor antagonist.

23 7alpha-fluoro ginkgolide B was equipotent to ginkgolide B underlining the critical importance of the

24 Recently, we found that 7alpha-fluoro ginkgolide B was equipotent to ginkgolide B underlining

25 Conversely, vitamin C and ginkgolide B were not efficient quenchers of singlet oxy

26 tivating factor receptor (PafR) antibody and Ginkgolide B, a well-defined PafR antagonist, demonstrat

27 ta-substituents, in particular 7alpha-chloro ginkgolide B, the most potent nonaromatic ginkgolide der

28 locked when platelets were preincubated with Ginkgolide B.

29 antibodies against PAFR and PAFR antagonist, ginkgolide B.

30 harmacologically active terpene trilactones (ginkgolides, bilobalide) from the tissues of Ginkgo bilo

31 Ginkgolides, but not vitamin E, inhibited the Abeta-indu

32 hese acetylations have given rise to various ginkgolide C acetates and iso-ginkgolide C acetates, the

33 ise to various ginkgolide C acetates and iso-ginkgolide C acetates, the latter having a rearranged sk

34 ective acetylation of the hydroxyl groups of ginkgolide C have been developed.

35 Ginkgolide C is 25-fold less potent than ginkgolide B as

36 ro ginkgolide B, the most potent nonaromatic ginkgolide derivative described to date with a K(i) valu

37 Ginkgolide derivatives carrying photoactivatable and flu

38 Ginkgolide derivatives incorporating both fluorescent an

39 These studies have shown that ginkgolide derivatives with aromatic photoactivatable su

40 products, but gave rise to two unprecedented ginkgolide derivatives, one with a novel rearranged skel

41 the critical importance of the 7-position of ginkgolides for PAF receptor activity.

42 Four ginkgolides (GA, GB, GC, GJ) and bilobalide (BB) from bo

43 e GABA(A) receptor alpha-subunits, decreases ginkgolide potency by up to 10,000-fold.

44 Pretreatment of the cells with isolated ginkgolides, the anti-oxidant component of Ginkgo biloba

45 ellent ligands for clarifying the binding of ginkgolides to PAF receptor by photolabeling studies.

46 esting with cloned PAF receptors showed that ginkgolides with 7alpha-substitutents had increased affi

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