ライフサイエンスコーパス: gliosarcoma

1 e to treat glioblastoma multiforme (GBM) and gliosarcoma.

2 eukocyte populations infiltrating the rat 9L gliosarcoma.

3 estricted to the mesenchymal tumor area of a gliosarcoma.

4 of 125IUdR in rats bearing intracerebral 9L gliosarcomas.

5 n in glial and mesenchymal tumor areas of 13 gliosarcomas.

6 ions derived from normal animals and from 9L gliosarcomas.

7 2.1% +/- 0.3 (standard error of mean) for 9L gliosarcoma, 3.1% +/- 0.4 for DU4475 mammary adenocarcin

8 Rat gliosarcoma 9L cells stably expressing ETR (ETR+) were u

9 opoietic lineage (bladder carcinoma BC47 and gliosarcoma 9L).

10 mes extravasate in tumors such as the rat 9L gliosarcoma and accumulate in perivascular areas.

11 barrier in both the 9L (6-fold improvement) gliosarcoma and invasive F98 (28-fold improvement) gliom

12 om p-boronophenylalanine (BPA) in the 9L rat gliosarcoma and the F98 rat glioma brain tumor models.

13 cal resection, and histology (glioblastoma v gliosarcoma) and then randomly assigned to arm A (BCNU p

14 within glioma cells, collagen deposition in gliosarcoma, and irregularity and disruption of myelinat

15 and mesenchymal tumor areas, suggesting that gliosarcomas are genetically monoclonal, and mesenchymal

16 increased tumor capillary permeability in 9L gliosarcoma-bearing rats with no significant increase in

17 phenylalanine-fructose (BPA-F) in the rat 9L gliosarcoma brain tumor model.

18 Recently, we showed that the rat 9L gliosarcoma cell line, which does not express BEHAB/brev

19 immunization of rats with IL-4 transduced 9L gliosarcoma cells (9L-IL-4) induced a potent antitumor i

20 The 9L gliosarcoma cells assays showed that 4b is mainly a subs

21 The kinetics of viral infection of rat 9L gliosarcoma cells by the replication-conditional HSV-1 v

22 Amino acid transport assays using 9L gliosarcoma cells demonstrated that both compounds are s

23 We have found that vaccination with rat 9L gliosarcoma cells expressing interleukin 4 (9LmIL4) indu

24 es for amino acid transport and enter 9L rat gliosarcoma cells in vitro at least in part by system A

25 es the cytotoxic events induced by CPA in 9L gliosarcoma cells retrovirally transduced with CYP2B6, o

26 Rat 9L gliosarcoma cells stably expressing either basal or elev

27 Here, we transformed rat 9L gliosarcoma cells to express cel-miR-67, a miRNA that la

28 9L gliosarcoma cells transduced with the CPA-activating enz

29 9L gliosarcoma cells were implanted in both hemispheres in

30 The 9L gliosarcoma cells were implanted in the brain of eight r

31 inant retroviruses were used to transduce 9L gliosarcoma cells with the genes encoding P450 2B6 and N

32 Three days after implantation of 9L gliosarcoma cells, 125IUdR was administered intrathecall

33 transport assays performed in vitro using 9L gliosarcoma cells, both [18F]16 and [18F]17 were substra

34 In rats implanted intracranially with 9L gliosarcoma cells, the retention of radioactivity in tum

35 of glioblastoma, anaplastic astrocytoma, and gliosarcoma cells.

36 cytotoxicity in a population of infected 9L gliosarcoma cells.

37 a concentration of 10 muM against rat 9L-SF gliosarcoma cells.

38 ated the antitumor effect of ErPC3 in 9L rat gliosarcoma cells.

39 ecal (i.t.) implantation of 5 x 10(5) 9L rat gliosarcoma cells.

40 A- or IFA-metabolizing human CYP genes to 9L gliosarcoma cells: 2B6, 2C8, 2C9, 2C18 (Met385 and Thr38

41 MCF7 (breast), DU145 (prostate), and SF539 (gliosarcoma) cells were exposed to a total radiation dos

42 Active Cy annexin was used to image a 9L gliosarcoma, constitutively expressing green fluorescent

43 83), anaplastic glioma (U-87MG and U-138MG), gliosarcoma (D-32GS), or normal human astrocytes demonst

44 differing degrees of angiogenesis-9L rodent gliosarcoma, DU4475 human mammary adenocarcinoma, HT1080

45 lioblastoma multiforme, gliomatosis cerebri, gliosarcoma, ependymoma, and subependymoma, for their po

46 6; anaplastic oligodendroglioma [AO], n = 2; gliosarcoma [GS], n = 1; and metastatic adenocarcinoma,

47 FDG) in which the uptake of each agent in 9L gliosarcoma (implanted intracerebrally in Fisher 344 rat

48 ion of 123IUdR/125IUdR into intracerebral 9L gliosarcomas in rats results in selective uptake of the

49 mas (intratumoral injection), or intrathecal gliosarcomas (intrathecal injection).

50 cer (*IUdR by intravesical injection), brain gliosarcomas (intratumoral injection), or intrathecal gl

51 Gliosarcoma is a rare glioblastoma variant characterized

52 esenchymal components in a small fraction of gliosarcomas may be derived from glial cells with additi

53 l fibroblasts) as well as in tumor cells (9L gliosarcoma, MCF7 adenocarcinoma, and HT-1080 fibrosarco

54 tial for this disease in a 9L rat orthotopic gliosarcoma model using a combination of noninvasive ima

55 umor mass and increased survival in a rat 9L gliosarcoma model, whereas individual monotherapies were

56 Experiments were performed with the 9L gliosarcoma rat model using a needle oxygen electrode to

57 b locally in the brain in an intracranial 9L gliosarcoma rat model.

58 nsgenic SF/HGF expression by intracranial 9L gliosarcomas reduced tumor cell sensitivity to gamma irr

59 i.p. injection of BPA in the 9L gliosarcoma resulted in a tumor-to-brain (T:Br) boron-10

60 s 3- and 6-h i.v. infusions of BPA in the 9L gliosarcoma resulted in similar high boron-10 concentrat

61 A gliosarcoma rodent model was established to determine th

62 Like human gliomas, the rat 9L gliosarcoma secretes the immunosuppressive transforming

63 experiments with cannulated rats bearing 9L gliosarcoma showed a preferential localization of the TA

64 In the 9L gliosarcoma, this ratio was 2.9:1 after i.p. administrat

65 ischer rats implanted intracranially with 9L gliosarcoma tumor cells were also performed.

66 2-h i.v. infusion of BPA in rats with the 9L gliosarcoma, tumor boron-10 concentrations were 2.7 time

67 ow-derived dendritic cells (DCs) into rat 9L gliosarcoma tumors and into 9L tumors induced to undergo

68 rats and mice orthotopically implanted with gliosarcoma tumors or glioma stem-like cells, respective

69 In rats bearing 9L gliosarcoma tumors, 4b displayed high tumor to brain rat

70 Further analyses of 64 cases of gliosarcoma using quantitative PCR showed amplification

71 eligible adults with newly diagnosed GBM or gliosarcoma were enrolled.

72 Forty-eight male rats bearing a 9L gliosarcoma were randomized in untreated and treated (so

73 Using a model of gliosarcoma with stably green fluorescence protein-expre

74 of orthotopic glioma (SF188/V+ glioma and 9L gliosarcoma) with a model of radiation necrosis in rats,

75 not always achieved, as shown here, when 9L gliosarcoma xenografts were treated over a range of dose