ライフサイエンスコーパス: global

1 At baseline and follow-up, patient-reported global AD severity significantly correlated with oSCORAD

2 Valvuloarterial impedance (ie, global afterload) and myocardial oxygen consumption were

3 mportant agronomic trait in a major crop for global agriculture.

4 While global analysis approximates the data to the sum of a sm

5 y maps that agree with published results and global ancestry estimates in humans.

6 rennial allergic rhinitis (PAR) represents a global and public health problem, due to its prevalence,

7 report a chemical proteomic platform for the global and quantitative analysis of lysine residues in n

8 elated to DN involvement were independent of global and regional brain atrophy.

9 ate residual effects of cannabis use whereby global and regional brain metabolism are altered in thos

10 for burden estimation and present first WHO global and regional estimates of the annual number of ne

11 y and understand prevalence variation at the global and regional levels.

12 ast and cervical cancer, with an emphasis on global and regional trends in incidence, mortality, and

13 This indicates that global areal maps cannot fully account for orientation i

14 , a decline 46-76% greater than estimated by global assessments.

15 The total mechanical energy of the global atmosphere basically remains constant with time,

16 nificantly among different ecosystems with a global average of 2.21, ranging from the highest found i

17 asically remains constant with time, but the global-average eddy energies show significant positive t

18 Halting global biodiversity loss is central to the Convention on

19 capitulated the hemochromatosis phenotype of global Bmp6 knockout mice, whereas hepatocyte and macrop

20 We propose that TDW identifies a discrete global brain activity mode that is regulated by context-

21 disorders, one of the leading causes of the global burden among men worldwide.

22 The global burden of dengue and its geographic distribution

23 Using the Global Burden of Disease study data and methods, we also

24 We found that global burned area declined by 24.3 +/- 8.8% over the pa

25 ent, humans emerge as a driver with dominant global C cycle impacts only in the most recent three mil

26 ntribute to a more complete understanding of global carbon and nitrogen cycling and a reduction in th

27 is vital for the development of regional and global carbon budgets.

28 annual variability and greening trend of the global carbon cycle given their mean lower productivity

29 on in the surface ocean is a key step in the global carbon cycle, with almost half of marine primary

30 microbial respiration are a key component of global carbon cycling, resulting in the transfer of 40-7

31 aryotic algal CCM, a key process that drives global carbon fixation.

32 each spreader determines its contribution to global cascades.

33 Infectious keratitis is a major global cause of visual impairment and blindness, often a

34 Human paramyxoviruses include global causes of lower respiratory disease like the para

35 uence C storage under combined anthropogenic global change drivers.

36 rstanding and predicting the consequences of global change over evolutionary and ecological timescale

37 changes describe an important phenomenon in global change research.

38 nding of how these forests are responding to global change.

39 severe transformations due to pressures from global change.

40 Ancestral TBT exposure induces global changes in DNA methylation and altered expression

41 We examined the global changes in mRNA abundance in healthy lung and lun

42 as cellular redox homeostasis, resulting in global changes in protein glycosylation, expression and

43 However, other global changes-especially climate change and elevated at

44 Linear alkyl benzenes (LAB) are global chemicals that are produced by acid-catalyzed rea

45 O:C ratio of SOA components, and we used the global chemistry climate model EMAC with the organic aer

46 Here, we present results from a global circRNA expression and functional analysis of pat

47 Global climate change drives sea-level rise, increasing

48 In the face of global climate change, organisms may respond to temperat

49 nscaled climate models and a high-resolution global climate model, and create a generalized additive

50 impact is one of the largest challenges for global climate models.

51 We apply this framework to map different global climate regimes and identify where coarse climate

52 an Seaway closure a strengthened AMOC with a global climate signature.

53 for incident parkinsonism per SD decrease in global cognition, adjusted for age, sex, and study subco

54 Outcomes assessed included measures of global cognitive function, verbal episodic memory, seman

55 nalysis, we built a prediction algorithm for global cognitive impairment (defined as Mini Mental Stat

56 itive risk score had an increased hazard for global cognitive impairment compared with those in the l

57 A 2016 Lancet global collaboration to review the health implications o

58 ating awareness and political commitment via global communications and advocacy; (2) informing nation

59 gender cooperative behavior with the broader global community.

60 ecently developed for probabilistic pairwise global comparison of biological networks, and it has bee

61 dual partition level and at the level of the global concentration.

62 an epidemic and a public health emergency of global concern due to its association with microcephaly

63 Forest resilience to climate change is a global concern given the potential effects of increased

64 enhancer, we constructed a three-dimensional global connectivity map of promoters and enhancers, reve

65 arochialism and ultimately is detrimental to global cooperation.

66 s) were calculated from PET scans and a mean global cortical SUVR was calculated.

67 This network of global coverage requires substantial investments in labo

68 The discrete voids do not change the global current density distribution, but they induce the

69 s between urban form and air pollution for a global data set of 1274 cities.

70 Here, we compile a global database of 108753 trees for which stem diameter,

71 s balsamifera, with variation represented in global databases of foliar isotopes.

72 rvations in June-August from 2006 to 2011, a global dataset for the cirrus cloud lateral boundary (CC

73 Using a global dataset of mammalian species, Mazel and colleague

74 n is an important ecosystem function and the global decline in pollinators attenuates the resistance

75 s, and mangrove forests, all of which are in global decline.

76 Moreover, we identified a significant global decrease in effective interactions during slow-wa

77 sults potentially explain the convergence of global deep water mass properties at the Plio-Pleistocen

78 Upwelling of global deep waters to the sea surface in the Southern Oc

79 23 levels in wild-type mice and in mice with global deficiency of the Cyp27b1 gene encoding 25-hydrox

80 Selective inhibition of T-channels and global deletion of CaV 3.1 channels completely suppresse

81 Protodestannylation and global deprotection then yield these sterically encumber

82 lder missense variants presented with severe global developmental delay, syndactyly of 2(nd) and 3(rd

83 Proteomic analysis of the liver reveals global differences in hepatic proteins when comparing di

84 d mortality, and is a leading contributor to global disease burden.

85 The global distribution and large variations of morphology o

86 Global distribution of hepatocellular carcinomas (HCCs)

87 Genome-wide analyses further revealed global DNA hypomethylation and enriched dysregulation of

88 Global DNMT-dependent epigenetic modifications lead to c

89 -driven transcriptional activity, leading to global downregulation of STAT5-regulated genes in patien

90 This TCR-mediated feedback is a global effect on the intercellular junction.

91 The global EFFORTLESS S-ICD (Evaluation oF FactORs ImpacTing

92 Recently, the global efforts to collect subjects with Mendelian disord

93 filing of an eIF5A-depleted strain reveals a global elongation defect, with abundant ribosomes stalli

94 Global environmental change is altering temperature, pre

95 ity to project the response of the Arctic to global environmental change.

96 ize the importance of measures to reduce the global epidemic of childhood obesity and encourage mecha

97 In the mouse embryo, global epigenetic changes occur during zygotic genome ac

98 Overall our results reveal substantial global epigenomic change in mammalian sperm methylomes a

99 Here we provide a global estimate of microbial loads and air-sea exchanges

100 representing 19.7 million (54%) of the 2015 global estimate of PLHIV.

101 We do not derive global estimates to measure the depth of impoverishment

102 untargeted" method is required that captures global exposures to chemicals, by simultaneously detecti

103 The potentially global extent of animal-induced regularity in vegetation

104 forestation rates and to avert a new wave of global extinctions.

105 exists between this intensity spike and the global field produced by the core geodynamo.

106 pecific binding of proteins and modulate the global folding and interactions of double helices with h

107 ing biomass is a key strategy to meet rising global food demands.

108 negative impact of heat stress and increase global food productivity, benefiting from [CO2] rich env

109 This increases current estimates of global forest cover by at least 9%.

110 aily activity is a measure of HF-related and global functional status in HF with preserved ejection f

111 neural crest-derived cells (CNCCs) to define global gene expression along the dorsoventral axis of th

112 ct of genome-wide cardiac DNA methylation on global gene expression in myocardial samples from end-st

113 archical clustering of participants based on global gene expression profiles revealed that participan

114 Compensatory roles for global-genome (XPC-1) and transcription-coupled (CSB-1)

115 to the mantle and are a major gateway in the global geochemical water cycle.

116 Here, based on novel global geodynamic models and the joint interpretation of

117 e early Paleoproterozoic in association with global glaciations and continued until the end of the Lo

118 erosis (arteriosclerosis/arteriolosclerosis, global glomerulosclerosis, interstitial fibrosis, and tu

119 ncreasing soil carbon, adequately reproduced global GPP distributions.

120 Rapid Arctic warming is expected to increase global greenhouse gas concentrations as permafrost thaw

121 rse, resulting in large uncertainties in the global H2 budget.

122 -regulation of Fbxl19 increases the level of global H2Bub1 in mouse ES cells, while down-regulation o

123 an metapneumovirus, represent a considerable global health burden, as recognised by WHO's Battle agai

124 ction of biomarkers would drastically impact global health by enabling decentralized disease diagnosi

125 mortality and morbidity continue to be major global health challenges strongly associated with premat

126 We propose criteria on which the global health community can judge the success or failure

127 zation and industrialization causes a severe global health concern to both ecosystem and humanity.

128 Tuberculosis remains a global health problem with an enormous burden of disease

129 sensing technique can find numerous uses in global health related applications in resource-limited e

130 The primary HRQoL endpoint was the global health scale, with the predefined hypothesis of n

131 Global health systems are shifting toward value-based ca

132 New emerging pathogens can quickly become a global health threat in this era.

133 -borne flavivirus that emerged recently as a global health threat, causing a pandemic in the Americas

134 Despite its significance in global health, the mechanisms of pathogenesis associated

135 n a species geographic range), we identified global hotspots of species at risk from climate change t

136 neralised estimating equations (GEE) for the global (ie, any) pathogen analyses, with adjustments mad

137 Global IL-6 inhibition in the early phase after fracture

138 to object motion, but remained silent during global image motion.

139 ides have previously been described, but the global immune response to in vivo gluten exposure in CD

140 re seen for almost all vaccines contained in global immunization programs and influence immune respon

141 Global implementation of this highly effective multidrug

142 This has significant global implications for our understanding of soil N cycl

143 dromes Parkinson Plus Score and the Clinical Global Impression Disease Severity Score but not sex (mu

144 The global incidence of catastrophic spending at the 10% thr

145 We investigated the global incidence of infant invasive GBS disease and the

146 ors (TF) is a key feature of cancer, but its global influence on drug sensitivity has not been examin

147 bution of non-respiratory causes of death to global influenza-associated mortality should be investig

148 Based on Global Initiative for Chronic Obstructive Lung Disease g

149 Mechanistically, global knockout of PLD4 modulated innate and adaptive im

150 he usefulness and value of a multifunctional global laboratory database is far reaching, with uses in

151 Although tonotopically organized at a global level, we found that the frequency selectivity of

152 wealth-equalizing institutions emerge at the global level.

153 re of the transsulfursome and thus enables a global long-range channeling of tRNA(Cys) between SepRS

154 Left ventricular (LV) global longitudinal strain (GLS) is a marker of subclini

155 baseline GDF-15 was associated with improved global longitudinal strain at 1 year (hazard ratio=0.29;

156 4 months post-treatment, we measured (1) LV global longitudinal strain, twisting, and percent differ

157 We report extensive, global loss of c-Fos and Arc/Arg3.1 immunoreactive neuro

158 Investigate whether the Global Lung Initiative (GLI-2012) reference values for s

159 rgic (TH(VTA)) neurons, as well as from more global maladaptation in neurocircuit function.

160 ce of nondestructive modalities to provide a global mapping of the stratigraphy, information that is

161 substances (PFASs) are, or have been, on the global market, yet most research and regulation continue

162 D2-type BPnd was negatively associated with global mean cortical gray-matter thickness in the metham

163 the most recent time in Earth's history when global mean sea level was substantially higher than it i

164 to improve our understanding of the role of global methylation in human diseases, especially cancer.

165 rmentable (SWI/SNF) chromatin remodeling and global methylation patterns that may allow for future th

166 umber of candidate structures to compute the Global Minimum Energy Conformation (GMEC).

167 Recent global models estimate that light absorption by brown ca

168 Here we combine four global models to estimate premature mortality caused by

169 cting Rs and is the dominant driver of Rs in global models; however, within certain biomes soil moist

170 ss the likely trajectory of incorporation of global molecular profiling platforms into the routine cl

171 We analyzed global monitoring data reported during the first two dec

172 itable trait that contributes to substantial global morbidity and mortality.

173 With an ACE-Inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure) trial r

174 IF4G and rates of cell population growth and global mRNA translation, with peak rates occurring at no

175 tational framework to accurately predict the Global Multidimensional Poverty Index (MPI) at a finest

176 N compounds is an important component of the global N-cycle.

177 Global Names Parser (gnparser) is a fast, high precision

178 from tropical wetlands contribute 60%-80% of global natural wetland CH4 emissions.

179 y evaluate the alignment scoring schemes and global network aligners on large scale PPI data and obse

180 etworks, and it has been applied to pairwise global network alignment, where the framework was shown

181 ulation protocol often produced increases in global network excitability or depression of the conditi

182 e Bind condition is less integrated with the global network than in the Shape condition in occipital

183 tegories: (1) ataxia, (2) spasticity and (3) global neurodevelopmental impairment.

184 ay important roles in ecosystem functioning, global nutrient cycling and climate regulation, but are

185 The current global obesity pandemic is clearly linked to both the in

186 icated sunflower, Helianthus annuus L., is a global oil crop that has promise for climate change adap

187 The initiation of the combs requires global or local anomalous dispersion which leads to many

188 However, coefficients for associations with global or memory-related cognitive function were non-sig

189 The global organization of protein binding sites is analyzed

190 n and SLP-2, and further, tissue-specific or global overexpression of SLP-2 transgenes rescued parkin

191 sea surface in the Southern Ocean closes the global overturning circulation and is fundamentally impo

192 This supplement focuses on efforts by global partners to successfully launch polio endgame act

193 Translation through space produces one global pattern of retinal image motion (optic flow), rot

194 While the environmental correlates of global patterns in standing species richness are well un

195 Understanding global patterns of biodiversity change is crucial for co

196 The models fit global patterns of isotope data and may explain features

197 Using the Global Peace Index to measure conflict, a curvilinear (q

198 require individual characterization and that global peptide-S/N relationships are difficult to identi

199 homeostatic we show that it does not achieve global perfect homeostasis-a condition where internal nu

200 Our findings thus unveil a global physical mechanism that sustains tissue separatio

201 ay allow plant biologists to unlock powerful global plant predictions from a handful of open-access f

202 es and territories affected, and to quantify global plaque burden defined as the sum of all plaque vo

203 ndgame Strategic Plan 2013-2018 (PEESP), the Global Polio Eradication Initiative identified 1 indicat

204 omes from FTA cards will aid in facilitating global poliovirus surveillance.

205 823, and now account for one in seven of the global population of stateless people.

206 By 2020, among the global population who are blind (38.5 million [13.2 mill

207 HP) infection is present in about 50% of the global population, and is associated with chronic gastri

208 to improve health and longevity for an aging global population.

209 patient's smartphone, specifically, step and global position system data, to quantify physical activi

210 ated, daily production will enable efficient global predictions of picophytoplankton productivity inc

211 with considerably less attention paid to its global prevalence or its consequences for patients and p

212 right anterior hippocampal activity reflects global properties of the street entered.

213 dence suggests that the daily oscillation in global protein accumulation depends on a similar fluctua

214 ation water to play a role beyond modulating global protein solubility or stability, the thermodynami

215 In acute/transient ER stress, decreased global protein synthesis and increased uORF mRNA transla

216 an increase in cytoplasmic TDP-43 represses global protein synthesis, an effect which is rescued by

217 karyotic initiation factor 2alpha to inhibit global protein translation.

218 By global proteomic and phosphoproteomic profiling, we show

219 ENV), and Zika virus (ZKV), all of which are global public health concerns.

220 s that the adoption of strategies addressing global public health threats at the country level reinfo

221 contributed to polio eradication by building global public health workforce capacity.

222 In HF, PH is associated with global pulmonary vascular remodeling, but the severity o

223 apillary 3D RNFL volumes were calculated for global, quadrant, and sector regions, using 4 different-

224 Global quality-of-life change after three cycles was wor

225 ions concerning a technology that could have global ramifications.

226 The primary endpoint was a composite global rank score (hierarchy of death, cardiovascular ho

227 Both local and global reactivity descriptors were used to study the reg

228 a (MM) patients and normal individuals using global reasoning on the RN causality to identify key-nod

229 pulations by fear or safety cues and robust, global recruitment of most cells by strong aversive stim

230 g the memory task, which correlated with the global reduction in brain modularity.

231 Global reductions in translation initiation resulting fr

232 This study estimates the potential for global, regional, and country-level resource recovery to

233 hanges in gene expression, often mediated by global regulators of transcription.

234 Our results indicate that VSG induces global regulatory changes that impact hepatic inflammato

235 However, intracellular drivers of global reprogramming of the inflammatory gene networks i

236 We assessed global RNA expression levels in whole blood samples from

237 -seq, analysis of nascent transcription from Global-Run On (GRO-seq) data, and characterization of ch

238 so quantifying this amplified response at a global scale is important.

239 ion space on Facebook by characterizing on a global scale the news consumption patterns of 376 millio

240 At the global scale, the apparent temperature sensitivity of CU

241 rimental air pollutant for vegetation at the global scale, with negative consequences for both provis

242 s have proved difficult to characterize at a global scale.

243 to gene expression in Escherichia coli on a global scale.

244 ncreases in coastal flooding on a continuous global scale.

245 We provide the first global-scale analysis investigating the diversification

246 atmospheric CO2 concentrations rise, having global-scale implications for water balance, carbon stor

247 Global-scale nitrogen budgets developed to quantify anth

248 Global-scale studies suggest that dryland ecosystems dom

249 On global scales, such changes in terrestrial water storage

250 munities will be seriously endangered as the global sea level rises.

251 r contained in the ocean and can manifest as global sea level variations.

252 suggest that the EAIS contribution to future global sea-level projections may be under-estimated.

253 -HT) neuronal precursors, leading to altered global serotonergic neuroarchitecture and increased spon

254 2 countries has been delayed because of the global shortage of IPV, making it unavailable to select

255 e propose that this regulation constitutes a global 'silent code' mechanism that controls the functio

256 We have performed a set of turbulent global simulations that exhibit magnetic cycles varying

257 ous oxide reductase, potentially acting as a global sink for the greenhouse gas nitrous oxide.

258 y 1.1M individuals who ran over 350M km in a global social network over 5 years.

259 etic analysis to investigate the patterns of global spread and population structure of 277 RT017 isol

260 ix family to determine if it had exceptional global stability, backbone dynamics, or amide hydrogen e

261 leaching for 1900-2000, we quantify the peak global storage of nitrate in the vadose zone as 605-1814

262 Chinese population and warrants broad-based, global strategy, such as greater efforts in prevention,

263 icular hypothalamic circuit coordinating the global stress response.

264 ords, networks that differ markedly in their global structure can look quite similar locally.

265 ce of appropriate drought measures and, as a global study that focuses on temperate drylands, highlig

266 (Global Study to Assess the Safety and Effectiveness of E

267 on-classical monocytes in conjunction with a global suppression of type I interferon-signalling pathw

268 sduction of erythroid progenitor cells, with global surface proteomic profiling.

269 t features and specificities that can aid in global surveillance of such viruses for potential spread

270 In many ways, the experience with the global switch from trivalent OPV (tOPV) to bivalent OPV

271 ngs lend support to a hypothesis implicating global systemic inflammation in HF with preserved ejecti

272 However, reconstructions of LIG global temperature remain uncertain, with estimates rang

273 However, the global terrestrial response to this cooling is uncertain

274 itchable molecules can be used to escape the global thermodynamic minimum by populating metastable st

275 Overall, these data provide a timeline of global thermogenic metabolism in adipose depots during a

276 ted with PLTX-like molecules illustrates the global threat to human health.

277 fisheries is clearly among the most serious global threats for marine ecosystems, affecting a wide r

278 stly located in Asia, account for 67% of the global total.

279 's economic development patterns and role in global trade in the post-financial-crisis era.

280 Overall, this is the first global transcriptomic analysis of the human host respons

281 opposes full-length eIF2Bepsilon to inhibit global translation.

282 Rising income inequality is a global trend.

283 x (RV1) and RotaTeq (RV5), were licensed for global use in 2006.

284 t that pheromone-based technology will be of global utility for the monitoring of this important inva

285 e conclude that the heterogeneous pattern of global vegetation change has been controlled by a combin

286 However, biogeographical theory and global vegetation models poorly represent recent forest

287 The role of the S. agalactiae global virulence regulator, CovR, in UTI pathogenesis is

288 Global volumes and ejection fraction showed no differenc

289 and CH4 into the atmosphere, causing severe global warming and subsequent mass extinction.

290 imates of county-level opinion about whether global warming is happening.

291 the region, and rising seas associated with global warming on long timescales and exacerbated by shi

292 As global warming progresses, the need for species to compe

293 Since Chaney's report, the range of global warming projections in response to a doubling of

294 e supporting that soil N availability, under global warming scenarios, is expected to increase strong

295 the international community pledged to limit global warming to below 2 degrees C above preindustrial

296 the atmosphere that has led to the so-called global warming.

297 rces could have significant implications for global warming.

298 d these contagion effects by combining daily global weather data, which creates exogenous variation i

299 these emerging strains, which pose a risk to global wheat production, because the fungal spores trans

300 observed soot is believed to originate from global wildfires ignited after the impact of a 10-km-dia

301 lent OPV (bOPV) can inform the eventual full global withdrawal of OPV.