ライフサイエンスコーパス: globular

1 ns were observed: arteriolar, fern-like, and globular.

2 assembly was abrogated through reduction of globular actin (G-actin) levels and disturbed expression

3 58C monomer, which will increase the pool of globular actin (G-actin).

4 polymerization, increased the conversion of globular actin to the filamentous form, followed by incr

5 cifically, inner leaflet lateral mobility of globular actin-supported DMPC (1,2-dimyristoyl-sn-glycer

6 ynaptosomal F-actin accompanied by increased globular-actin (G-actin) at as early as 1 month of age i

7 eeding abolished the vasodilatory actions of globular adiponectin (gAd) and insulin on pre-constricte

8 attenuates cerebral ischemic/reperfusion via globular adiponectin (gAD).

9 cular adiponectin and insulin resistance but globular adiponectin administration can restore vascular

10 This suggests that globular adiponectin might have a therapeutic potential

11 ut is accompanied by the formation of large, globular aggregates.

12 olution and promoted the formation of larger globular aggregates.

13 reveals a novel structure comprising a small globular alpha/beta domain and an extended coiled-coil h

14 uccessful de novo 3D structure prediction of globular and alpha-helical membrane proteins from sequen

15 re is no significant interaction between the globular and disordered parts of NS5A.

16 P4 DNA recognition consensus sequence as the globular and disordered regions bind synergistically to

17 le (TSE) structures in Protein L folding are globular and extensive in agreement with the Psi-analysi

18 With any DFT functional, globular and planar structures coexist across the size r

19 Distinct yellow globular and red elongated crystalline chromoplasts were

20 Because the GRASP domain is globular and relatively small, but the gaps between stac

21 Many globular and structural proteins have repetitions in the

22 ying emergence of beta-propeller proteins, a globular and symmetric fold group with diverse functions

23 The globular and tail regions of rProtein uL23 are distincti

24 tripartite structure comprising N-terminal, globular, and long, unstructured C-terminal domains.

25 PZP has a globular architecture and forms a 2:1 stoichiometry comp

26 X21 show that these proteins adopt a compact globular architecture, and membrane interaction analyses

27 esults suggest that phosphorylation sites on globular, as distinct from disordered, parts of the prot

28 ssed by mutations within the coiled-coil and globular ATPase domains, suggesting a model in which con

29 The globular body of CX3CL1 is perched on top of the US28 ex

30 Globular bushy cells reliably and faithfully transfer sp

31 of ApoA1-POPC-cholesterol particles are not globular but instead an integrated part of the protein b

32 ling a "ball-and-chain" architecture, with a globular C-terminal domain (the ball) preceded by a long

33 we report the first crystal structure of the globular C-terminal domain of human CblD, which is suffi

34 isingly, this inhibitory effect required the globular C-terminal domain of PrP(C), which has not been

35 xible, expanding and contracting to pull the globular C-terminal domain up toward the membrane or pus

36 activity is tightly regulated in cis by the globular C-terminal domain.

37 The globular C-terminal Jab1/Mpn1-like domain of Prp8 increa

38 perstructures (filaments) assembled from its globular caspase activation and recruitment domain.

39 ains an off-pathway intermediate with molten globular characteristics.

40 Only yellow globular chromoplasts were observed in Newhall flesh.

41 solar masses when the dynamical state of the globular cluster is probed with pulsars.

42 icated observational campaigns have targeted globular clusters for many decades, searching for signat

43 If the massive metal-poor globular clusters in the halo of the Milky Way formed in

44 act with JIA positive serum, presented great globular clusters irregularly distributed.

45 e found two ultraluminous flaring sources in globular clusters or ultracompact dwarf companions of pa

46 ence of ancient massive bound star clusters (globular clusters) in the Milky Way suggests that effici

47 e ubiquitous multiple stellar populations in globular clusters.

48 frequent late-flash-mixing events in massive globular clusters.

49 ing either as field halo stars or grouped in globular clusters.

50 an do dynamical formation channels involving globular clusters; our predicted detection rate of these

51 However, massive, old 'globular' clusters--those with ages greater than ten bil

52 n important subset of membrane proteins have globular, cofactor-containing extracytoplasmic domains r

53 The more globular conformations correlate with cooperative bindin

54 show a preference for forming an ensemble of globular conformations, whereas the IDL from Plasmodium

55 Native alpha-conotoxins preferably adopt the globular connectivity, and previous studies of alpha-con

56 y FtsZ regulators, ZapC binds the large FtsZ globular core rather than C-terminal tail, and the prese

57 the residues extending C-terminally from the globular core, which are lacking in the Rad14 construct.

58 l of its dimeric binding partner against its globular core, without forming any distinct secondary st

59 adily into the FG-meshwork compared to their globular counterparts of identical volume and surface ch

60 ave three possible disulfide connectivities: globular (Cys(I)-Cys(III) and Cys(II)-Cys(IV)), ribbon (

61 requencies of neuronal inclusions, including globular cytoplasmic (Lewy body-like) neuronal inclusion

62 sis of individual lamin filaments resolves a globular-decorated fibre appearance and shows that A- an

63 of SAS-5: a trimeric coiled coil and a novel globular dimeric Implico domain.

64 cking further gamma rotation, while the zeta globular domain anchors it to the closed alphaDP/betaDP

65 architecture featuring a C-terminal soluble globular domain and a predicted N-terminal membrane-asso

66 is of deletion mutants demonstrated that the globular domain and middle region of eL19 are essential

67 disturbing specific contacts between the H1 globular domain and nucleosomal DNA.

68 We demonstrate that the globular domain and the proximal part of the C-terminal

69 uncated type I rMIP proteins that lacked the globular domain and the signal leader peptide (LP) signa

70 s primarily to a single linker, while the H1 globular domain contacts the nucleosome dyad and both li

71 The dimensions and stability of the globular domain do not support its potential passage thr

72 containing five transmembrane domains and a globular domain in periplasm has been recently identifie

73 The on-dyad binding mode of the H5 globular domain is different from the recently reported

74 is anchored on the cytosolic side, with the globular domain located on the extracellular end of the

75 ggest that a small number of residues in the globular domain of a linker histone can control its bind

76 role of its N-terminal domain, the so-called globular domain of ApoA1, in discoidal complexes with ph

77 measurements to identify residues within the globular domain of calreticulin, in proximity to the hig

78 Here, we report the crystal structure of the globular domain of chicken linker histone H5 in complex

79 rray condensed by either the GH5_pMut or the globular domain of Drosophila H1 displayed a similar sed

80 of H5 with the corresponding residues in the globular domain of Drosophila H1.

81 nucleosome array condensed by the wild-type globular domain of H5 showed a much larger sedimentation

82 des, we investigated the binding of a mutant globular domain of H5 to the nucleosome.

83 sequence conservation with the corresponding globular domain of H5, are consistent with an on-dyad bi

84 w that acetylation of lysine residues in the globular domain of histone H3 (lysine 64 (H3K64ac) and l

85 versatile modifications at Lys31 within the globular domain of histone H4 that crucially determine g

86 Although structures of the central globular domain of human XPA and data on binding of DNA

87 and solved the NMR solution structure of the globular domain of M2AP.

88 wo crystal structures of soluble periplasmic globular domain of PbgA from S. typhimurium and E. coli,

89 FKBPs) in residues 166 to 252 located in the globular domain of the protein.

90 X-ray crystal structures of the central globular domain of yeast XPA (Rad14) with lesion-contain

91 fate A, indicating binding to the N-terminal globular domain or type I repeats of hTSP-1.

92 med GH5_pMut, includes substitutions of five globular domain residues of H5 with the corresponding re

93 full-length human linker histone H1.0, whose globular domain shares high sequence conservation with t

94 The globular domain sits on the dyad of the nucleosome and i

95 e members of the ICP27 family is a predicted globular domain that has been termed the ICP27 homology

96 , full-length) rMIP proteins (containing the globular domain) with either an N- or C-terminal His tag

97 nce which indicated that, in addition to the globular domain, a flanking intrinsically disordered reg

98 otein eL19 that is composed of an N-terminal globular domain, a middle region, and a long C-terminal

99 mprises three distinct structural domains: a globular domain, an extended arm-like P-domain, and a C-

100 n complexes, such as linker DNA, the histone globular domain, and nucleosome spacing.

101 evolutionarily conserved nucleosome-binding globular domain, GH1.

102 er, Mre11 complex functions specified by the globular domain, including Tel1 (ATM) activation, nonhom

103 an structures functional for binding laminin globular domain-containing proteins.

104 s, via a second, lower-affinity P-domain and globular domain-dependent, but calcium-independent bindi

105 sites in the influenza A virus hemagglutinin globular domain.

106 ificity of DNA interactions in tandem with a globular domain.

107 its a characteristic dumbell shape, with two globular domains (N- and C-terminal lobe) joined by a li

108 HP1BP3 contains three globular domains and a highly positively charged C-termi

109 which conformational changes in the hook and globular domains are transmitted via the extended coils

110 acterial flagellar filament, where the outer globular domains make no contact with each other and are

111 econd we have discovered that the C-terminal globular domains of BclA from both species are substitut

112 We have previously shown that the globular domains of chicken H5 and Drosophila H1 linker

113 ted by interactions between protease and the globular domains of Gag and that the sites of transient

114 transient encounter complexes involving the globular domains of Gag may play a role in guiding and f

115 rinsically disordered linkers connecting the globular domains of Gag to one another), suggesting that

116 rinsically disordered linkers connecting the globular domains of Gag, remains unclear.

117 one face by PB2 and clamped between the two globular domains of P3.

118 imurium and E. coli, which revealed that the globular domains of PbgA resemble the structures of the

119 nt signalling events, and consist of several globular domains that together form a large assembly.

120 PB2 C-terminus (residues 536-759) reveal two globular domains, 627 and NLS, that form a tightly packe

121 arin-binding sites of laminin, including the globular domains, and also attached to laminin expressed

122 structures are better understood than large globular domains.

123 n which stretch induces the unfolding of its globular domains.

124 ectively, characterized by flexibly tethered globular domains.

125 e than 400 proteins via one or more of their globular domains.

126 cule serves to modulate its affinity for the globular, electron-rich guest that resides within its mo

127 alyzed gene expression patterns in the early globular embryo and how this relates to expression in em

128 pression foci for each expressed gene in the globular embryo, which revealed the importance of phytoh

129 apical-basal and dorsal-ventral axes in the globular embryo, which tended to fluctuate in later deve

130 During valvulogenesis, globular endocardial cushions elongate and remodel into

131 ssociated with an abnormally low filamentous/globular (F/G)-actin ratio that may be the underlying ca

132 anofibrils display a complex linear array of globular features spaced at varying distances, indicatin

133 Both proteins adopt a globular fold with mixed alpha and beta secondary struct

134 ino acid and later on its compatibility with globular folding in water.

135 charge states, indicative of a predominantly globular form and some population in more extended state

136 ically have lower potency at nAChRs than the globular form.

137 -hand motifs of MlcC pack together to form a globular four-helix bundle that opens up to expose a cen

138 his interaction was mapped in the N-terminal globular GTPase domain of GBP1.

139 by a repetitive collagen-like neck bearing a globular head (C-terminal domain) that promotes glycopro

140 ted in a region located near the base of the globular head and its junction with the alpha-helical st

141 a-biased Ab response directed against the HA globular head and stem regions.

142 o G7); one in the stalk (G2) and five in the globular head domain (G3 to G7).

143 The HA is composed of a globular head domain for receptor binding and a stem dom

144 ng mAbs targeted a new antigenic site on the globular head domain of F, designated here antigenic sit

145 suggest that antibody targets other than the globular head domain of the HA may be efficacious in pre

146 cavity, the data suggest that H binds the F globular head domain sideways.

147 Mutations in the globular head domain that decrease enzymatic activity bu

148 of MAbs that have targets other than the HA globular head domain will provide insight into novel ant

149 ition of the major antigenic sites in the HA globular head domain.

150 ed on chimeric hemagglutinins, consisting of globular head domains from exotic influenza A viruses an

151 and/or expressing antigenically distinct HA globular head domains.

152 libraries possessing random mutations in the globular head of the haemagglutinin protein (which inclu

153 rmational epitopes in antigenic sites on the globular head of the hemagglutinin protein, on the basis

154 ion of neutralizing antibodies targeting the globular head of the viral hemagglutinin (HA).

155 The globular head of Uso1 binds to Ypt1 and its coiled-coil

156 jor antigenic sites of HA are located in the globular head subdomain, which is highly tolerant of ami

157 The HN protein has a globular head that is attached to a membrane-anchored fl

158 ng of a transmembrane region, a stalk, and a globular head with sialidase activity.

159 by glycan accumulation on the hemagglutinin globular head, and hemagglutinin receptor binding has ch

160 en bond network at the base of the F-protein globular head.

161 ND resembles an elongated, asymmetric Y; two globular heads project from a coiled-coil shaft.

162 ly unresolved 17-residue segment linking the globular heads to the tetrameric stalk of the measles vi

163 Sds3 engages a globular, helical region of the HDAC interaction domain

164 More recently, modifications affecting the globular histone core have been uncovered as being cruci

165 Nitrocellulose membrane functionalized with globular hydroxyaminodendrimers was used to covalently c

166 pid degradation of misfolded ATZ and lack of globular inclusions in cells from patients who have esca

167 l individuals with ATD, not in controls, but globular inclusions that are partially covered with ribo

168 n isomers of GeXIVA are more potent than the globular isomer, with low nanomolar half-maximal inhibit

169 dies of alpha-conotoxins have focused on the globular isomers as the ribbon and bead isomers typicall

170 ]2 sub-complexes to the surface results in a globular macromolecule with a diameter of approximately

171 sically disordered human protein tau and the globular maltose binding protein.

172 Our data reveal that CYK4 binds to a globular mass in the atypically long MKLP1 neck domain b

173 cyanic vacuolar inclusions (AVIs), from more globular, membrane-bound anthocyanoplasts.

174 Four globular MeV H heads are connected to a tetrameric stalk

175 perform localized indentation of Al-15wt.%Cu globular microstructures, with an average grain size of

176 ssisted transgranular cracking of semi-solid globular microstructures.

177 Fluorine NMR data on the 7-kDa globular N-terminal SH3 domain of Drosophila signal tran

178 ith a peripheral rim of globules (peripheral globular nevi [PGN]) observed with dermoscopy are associ

179 Each SSB subunit contains an N-terminal globular oligonucleotide/oligosaccharide binding fold (O

180 ometers long that occasionally are capped by globular particles, likely representing PttCesA8 complex

181 ctivities are associated with the C-terminal globular parts in the absence of the flexible N terminus

182 Nevi displaying a peripheral globular pattern enlarged symmetrically with apparent gr

183 consist of a membrane domain on which sits a globular periplasmic domain.

184 hat derives from increased prominence of the globular polyQ domain.

185 ses that drive the directional growth of the globular process of the FNP toward the lateral nasal pro

186 comprises a signal peptide, a 60-90-residue globular prodomain with a conserved sequence motif inclu

187 from Sulfolobus solfataricus (Sso AcP) is a globular protein able to aggregate in vitro from a nativ

188 the Protein Data Bank contains some 100,000 globular protein and 3,000 membrane protein structures,

189 etween the overall structural integrity of a globular protein and the local destabilization of its am

190 It utilizes a model of a globular protein connected, through a single point (smal

191 -ligand binding affinities, mutation induced globular protein folding free energy changes, and mutati

192 ortable to heterologous proteins such as the globular protein GFP (green fluorescent protein) via a p

193 In this study, we show that a typical globular protein is able to undergo significant changes

194 o those of lysozyme that is taken as a model globular protein of similar molecular mass.

195 y bimodal while those obtained by trapping a globular protein or individual fluorophores are not.

196 Recent studies of globular protein solutions have uniformly adopted a coll

197 ded volume effect, similar to that found for globular protein solvents.

198 other existing methods in the predictions of globular protein stability changes upon mutation.

199 The structure of Der p 23 is a small, globular protein stabilized by two disulphide bonds, whi

200 kinase PINK1 phosphorylates the well-folded, globular protein ubiquitin (Ub) at a relatively protecte

201 idering bovine serum albumin because it is a globular protein whose solution properties have also bee

202 Finally, we also encapsulate a model globular protein, bovine serum albumin, and calculate it

203 like short oligonucleotide and a sphere-like globular protein.

204 ate internal long-range contacts in this non-globular protein.

205 we extend the consensus strategy to design a globular protein.

206 il reaching 20% at 10h with disappearance of globular proteins and generation of low molecular weight

207 endencies to appear in interior positions in globular proteins and in deeply buried positions of memb

208 etween the Mr and EM diameter for a range of globular proteins and the intact virions.

209 Globular proteins are not permanently folded but spontan

210 a wide range of food products with gluten or globular proteins as functional agents.

211 The functional native states of globular proteins become unstable at low temperatures, r

212 tudy the effects of pH on the charge of four globular proteins by expanding their surface charge dist

213 The dynamics of globular proteins can be described in terms of transitio

214 co-protein effects in mixtures of gluten and globular proteins during heating at 100 degrees C.

215 Most globular proteins exhibit a characteristic sigmoidal wat

216 Numerous methods for docking globular proteins exist, however few have been developed

217 ted in the literature shows that well-packed globular proteins follow a scaling relation between the

218 We conclude that NIS competes with globular proteins for association with SDS, making it po

219 olymorph are similar to what is observed for globular proteins for the core residues, whereas M35 exh

220 Although the interfacial behavior of globular proteins has been extensively studied, experime

221 ractions between pre-formed coiled coils and globular proteins have not been systematically analyzed.

222 s is caused by misfolding and aggregation of globular proteins in vivo for which effective treatments

223 ic volumes significantly larger than typical globular proteins of similar mass, thus imparting a bulk

224 iposome surfaces and find the DW dynamics on globular proteins to be significantly more heterogeneous

225 Globular proteins typically fold into tightly packed arr

226 f amyloid aggregate formations by structured globular proteins under conditions close to physiologica

227 dodecyl sulfate (SDS) denatures and unfolds globular proteins under most conditions.

228 Here, we investigate whether globular proteins unfolded by SDS can be refolded upon a

229 s and the surface hydrophobicity of unfolded globular proteins were the main characteristics in deter

230 The intrinsic protein characteristics of globular proteins which enhance polymerization in mixtur

231 ophobic collapse for an unstructured and two globular proteins while directly measuring initial cotra

232 rating the potential for consensus design of globular proteins with increased stability, these result

233 able objects (e.g., nanoparticles, micelles, globular proteins) that can adapt their shape to the loc

234 r repetitive construction means that, unlike globular proteins, a repeat protein's equilibrium foldin

235 In contrast to globular proteins, a single protein sequence can aggrega

236 ul in rationalizing the folding behaviour of globular proteins, as this representation provides intui

237 e average solvent exposure of amino acids in globular proteins, as well as with polarity indices and

238 ystem for understanding the encapsulation of globular proteins, enzymes, or antibodies for potential

239 Globular proteins, such as cytochrome c (cyt c), display

240 so designed to encapsulate and release bulky globular proteins, such as mCherry, in a light-dependent

241 It is also observed that for almost all globular proteins, the quality of contact prediction dic

242 In contrast to globular proteins, the structure of repeat proteins is d

243 of complete secondary-structure elements in globular proteins-molecular events that have previously

244 omogeneous nucleation typically observed for globular proteins.

245 packed tertiary structure of natively folded globular proteins.

246 forces that are the highest yet reported for globular proteins.

247 e tested the approach on a diverse set of 28 globular proteins.

248 itting sensing and characterization of small globular proteins.

249 understand the folding process of many small globular proteins.

250 extension of capsid protein VP3 folds into a globular protruding (P) domain, exposed on the virion su

251 ibosome every 200 to 900 nucleotides and are globular rather than elongated in shape.

252 Given the binding promiscuity of C1q's globular region (gC1q), we hypothesized that C1q concurr

253 particle EM nanostructure of the N-terminal globular region of the alpha4 chain confirmed the C-shap

254 For the globular region of the rProtein, folding is independent

255 meric, and the periplasmic domain contains a globular region that binds to the OM in a PhoPQ-dependen

256 PbgA globular region-deleted mutant bacteria are severely att

257 y, the alpha1, alpha2, and alpha4 C-terminal globular regions dimerize.

258 N- and C-terminal globular regions of collagen VI were recombinantly expre

259 Moreover, SAXS models of the C-terminal globular regions of the alpha1, alpha2, alpha4, and alph

260 Ab initio models of the N-terminal globular regions of the alpha4, alpha5, and alpha6 chain

261 Particularly, motions between the globular rotational correlation time (tauc ) and 40 mus

262 s resulted from an evolutionary radiation of globular S-crystallin proteins.

263 f the sequence and by destabilization of the globular segment of the protein.

264 A portion of the non-globular Sgf73 subunit lies between the Ubp8 catalytic d

265 second generation dendrimer with persistent globular shape and well-defined cavities.

266 evolving traits such as the acquisition of a globular shape may be the result of direct or indirect s

267 cle to a multiply folded 8 + 8 macrocycle of globular shape.

268 teristics of the dendrimers, including their globular shapes, excellent solubility, and demonstrated

269 classical two-state model as found for many globular soluble proteins.

270 soybean and Arabidopsis methylomes from the globular stage through dormancy and germination to under

271 ntly, embryo development was arrested at the globular stage.

272 utagenesis experiments in transgenic tobacco globular-stage embryos to identify two additional cis-re

273 nding interactions, holding it in its native globular state.

274 peptides derived from the vicilin-class(7S) globular storage protein are required for the generation

275 ental scientific interest owing to planar to globular structural transformation at an anomalously hig

276 intrinsically disordered with extended, non-globular structure in solution.

277 ke quadruplexes in which every two repeats a globular structure is stabilized by two hemiprotonated C

278 gp17.1 does not exhibit a stable globular structure when monomeric in solution, even if i

279 n, the inner side of the procuticle showed a globular structure with vesicle-like particles in the ce

280 ins are typically characterized by a defined globular structure, along with a peptide-binding site lo

281 llerene C60-with a unique symmetrical and 3D globular structure-as biocompatible carbon platforms for

282 tribution, is not compromised to accommodate globular structure.

283 side chains that give it a rigid polycyclic globular structure.

284 s, the p53 rescue motif described here and a globular-structured SUMO-binding catalytic domain, to st

285 nes, and therefore, backbones form collapsed globular structures in aqueous solvents.

286 brills in the self-assembly of Abeta1-40 and globular structures in the short fragment Abeta15-21 in

287 We found that telomeres form compact globular structures through a complex network of interac

288 tein EAP, which resulted in the formation of globular structures within the nucleus.

289 mal protein EAP resulted in the formation of globular structures within the nucleus.

290 s interactions, on the other hand, stabilize globular structures.

291 tack together into quasi one-dimensional non-globular structures.

292 hSesn2 is twofold pseudo-symmetric with two globular subdomains, which are structurally similar but

293 The myosin V globular tail domain (MyoV-GTD) interacts directly with

294 n structures, which we call "oligomers", are globular throughout all stages of cooperative assembly a

295 The planar-globular transition is gradual at room temperature rathe

296 n PsIAA4 from pea (Pisum sativum) revealed a globular ubiquitin-like beta-grasp fold with homologies

297 protein carbonylation than soy proteins and globular were more susceptible than fibrillar proteins.

298 4T) quadruplex is discrete and approximately globular, whereas the G-quadruplex complex with poly(G)

299 rial EPS in the presence of calcium ions was globular, while that with magnesium ions was rod-shaped.

300 inactive orange form (OCP(o)) is compact and globular, with the carotenoid spanning the effector and