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1 ive to caspofungin, an inhibitor of beta-1,3-glucan synthase.
2 nd for activity and regulation of beta(1-->3)glucan synthase.
3 h the cell wall biosynthesis enzyme beta-1,3-glucan synthase.
4 ene, ags1(+), which encodes a putative alpha-glucan synthase.
5 activation of FKS2, which encodes a beta-1,3 glucan synthase.
6 se resistant mutants may have alterations in glucan synthase.
7 r aspergilli by targeting cell wall 1,3-beta-glucan synthases.
8 over a wide range of related processive beta-glucan synthases.
9 ce blocks conserved in 28 known or predicted glucan synthases.
11 ent report that pgs1Delta cells have reduced glucan synthase activity and diminished levels of Fks1p,
14 entified and implicated in the regulation of glucan synthase activity from Candida albicans, Aspergil
16 ylation of Rho1p by exoenzyme C3 inactivates glucan synthase activity specified by FKS1 and FKS2 as d
17 ty to other antifungal agents; (ii) in vitro glucan synthase activity that is more resistant to pneum
19 ding protein Rho1 is required for beta(1-->3)glucan synthase activity, for activation of protein kina
24 cooperation between the alpha- and beta(1-3)glucan synthases Ags1 and Bgs for cell wall and septum a
25 ponent of the yeast cell wall, beta(1-->3)-D-glucan synthase (also known as 1,3-beta-glucan synthase)
26 ts roles as a positive regulator of 1,3-beta-glucan synthase and of the cell integrity MAP kinase cas
27 y with the well-characterized yeast beta-1,3-glucan synthase and transgenic plant cells over-expressi
28 rified with plasma membrane markers 1,3 beta-glucan synthase and vanadate-sensitive ATPase, indicatin
29 ed sequence homology with the yeast 1,3-beta-glucan synthases and is distinct from plant cellulose sy
30 major cell wall-related genes such as FKS1 (glucan synthase) and mutations in any of the Golgi glyco
31 mutants were defective in GTP stimulation of glucan synthase, and the defect was corrected by additio
32 i-associated synthases, (1-->3),(1-->4)-beta-glucan synthase behaves as a topologic equivalent of cel
33 Sid2p/Mob1p and Clp1p phosphatase, and beta-glucan synthase Bgs1p accumulated slowly at the cleavage
34 involve allosteric activation of the ML beta-glucan synthase BgsA by c-di-GMP binding to its C-termin
36 up of antifungal agents that target 1,3-beta-glucan synthase, causing disruption of mold growth at ce
37 idopsis (Arabidopsis thaliana), the 1,4-beta-glucan synthase, Cellulose Synthase-Like C4 (CSLC4), and
38 KS1 and FKS2 are alternative subunits of the glucan synthase complex, which is responsible for synthe
39 reduced maximum catalytic capacity of their glucan synthase complexes and thicker cell walls attribu
40 bor an S645Y mutation in the CaFks1 beta-1,3 glucan synthase drug target, suggesting potential therap
41 he biochemical activity of membrane spanning glucan synthases encoded by the CSLH and CSLF cellulose
42 ts identify the membrane-spanning subunit of glucan synthase, encoded by the FKS genes, as the molecu
43 Post-transcriptional inhibition of alpha-1,3-glucan synthase expression, using double-stranded RNA in
44 specifically defective in activation of the glucan synthase Fks1/2 does not internalize alpha-factor
46 to regulate the accumulation and dynamics of glucan synthases for successful septum formation in cyto
48 We functionally characterized the beta-1,3-glucan synthase gene GLS1 of the maize (Zea mays) pathog
49 Cryptococcal cells disrupted in their alpha glucan synthase gene were sensitive to stresses, includi
50 able putative catalytic subunits of 1,3-beta-glucan synthase (GS), an enzyme that synthesizes an esse
51 functional P. carinii kre6 (Pckre6) beta-1,6 glucan synthase in Pneumocystis that, when expressed in
54 ynthesis, exhibits synergy with the beta-1,3 glucan synthase inhibitor caspofungin or the calcineurin
55 ce were treated with caspofungin, a beta-1,3-glucan synthase inhibitor that is known to reduce the nu
56 synthase inhibitor), caspofungin (a beta-1,3-glucan synthase inhibitor), or FK506 (a calcineurin inhi
58 fficient, new, and scalable semisynthesis of glucan synthase inhibitors 1 and 2 from the fermentation
60 glucan, and treatment of PcP with beta-1,3-D-glucan synthase inhibitors, such as anidulafungin, resul
61 ing (i) cross-resistance to other 1,3-beta-D-glucan synthase inhibitors, such as papulacandin and ech
62 mple, the mixed-linkage (1-->3)(1-->4)beta-D-glucan synthase is found specifically in grasses and pos
65 CHOR encodes a putative callose synthase, GLUCAN SYNTHASE-LIKE 8 (GSL8), that is required for call
66 polymerase chain reaction of transcripts for GLUCAN SYNTHASE-LIKE, Cellulose Synthase, and CELLULOSE
69 zymatic properties of the mixed-linkage beta-glucan synthases not only provide special insight into t
70 from reduced activity against C. neoformans glucan synthase or from yet undiscovered mechanisms of a
71 1 also serves as a regulatory subunit of the glucan synthase, our results define a regulatory circuit
72 of FKS2, the alternate catalytic subunit of glucan synthase, partially restoring glucan synthase act
73 3)-D-glucan synthase (also known as 1,3-beta-glucan synthase), requires a guanosine triphosphate (GTP
75 Rho1p was found to copurify with Fks1p, a glucan synthase subunit, in preparations of the enzyme p
76 re similar to the effects of inhibiting beta-glucan synthase, suggesting that the abnormal cell wall
77 catalytic domain of the (1-->3),(1-->4)-beta-glucan synthase synthesizes cellotetraosyl units and hig
78 ho1, is required for activity of beta (1-->3)glucan synthase, the enzyme that catalyzes the synthesis
81 ed RNAi targeting AGS1 (encoding alpha-(1,3)-glucan synthase) to deplete levels of alpha-(1,3)-glucan
82 aydis class VII chitin synthase and 1,3-beta-glucan synthase travel in Mcs1-containing vesicles, and
83 s1p were co-immunoprecipitated from purified glucan synthase under conditions that maintained enzyme
84 hot spot" regions of FKS-encoded subunits of glucan synthase, which decreases the sensitivity of enzy
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