ライフサイエンスコーパス: gluconeogenic

1 Male LERKO mice displayed elevated hepatic gluconeogenic activity and fasting hyperglycemia.

2 se-6-phosphatase, and the neonate's pools of gluconeogenic alanine and lactate are each diminished by

3 To examine this possibility, we used the gluconeogenic amino acid proline, which is metabolized t

4 contributed to by decreased metabolism from gluconeogenic amino acids.

5 tically investigated factors influencing the gluconeogenic and anaplerotic reaction kinetics.

6 Overall, our data show that gluconeogenic and citric acid cycle intermediates cannot

7 vels, with evidence of altered expression of gluconeogenic and glycolytic enzymes.

8 en levels, and expressions of key regulatory gluconeogenic and glycolytic genes.

9 erse direction (pyruvate to PEP) during both gluconeogenic and glycolytic growth.

10 insulin signaling and reduced expression of gluconeogenic and lipogenic enzymes.

11 nd corrected excessive expression of hepatic gluconeogenic and lipogenic enzymes.

12 Similarly, a set of key gluconeogenic and lipogenic genes was regulated nearly n

13 glucose intolerance, decreased expression of gluconeogenic and lipogenic genes, and reduced hepatic s

14 signaling, and reduced hepatic expression of gluconeogenic and lipogenic genes.

15 a novel role for cyclin D1 as a regulator of gluconeogenic and oxidative phosphorylation (OxPhos) gen

16 sive activation of aPKC-dependent lipogenic, gluconeogenic and proinflammatory pathways increases the

17 aracrine/autocrine regulation of the hepatic gluconeogenic and/or lipogenic programs, respectively.

18 uitable tracer to assess hepatic glycolytic, gluconeogenic, and mitochondrial metabolism in vivo.

19 sensitivity, rapid normalization in hepatic gluconeogenic capacity and basal hepatic glucose product

20 to HF diet has the potential to program the gluconeogenic capacity of offspring through epigenetic m

21 cles, we show that a substantial fraction of gluconeogenic carbon leaves the liver as citric acid cyc

22 This cataplerotic efflux of gluconeogenic carbon may contribute to renal gluconeogen

23 The efflux of gluconeogenic carbon ranges from 10 to 200% of the rate

24 ectedly, an Mtb mutant lacking GLPX grows on gluconeogenic carbon sources and has detectable FBPase a

25 re differentially affected on glycolytic and gluconeogenic carbon sources, discriminating between the

26 the DeltaacuM mutant had impaired growth on gluconeogenic carbon sources.

27 se-1,6-bisphosphatase (FBPase) for growth on gluconeogenic carbon sources.

28 converting acetyl-CoA into anapleurotic and gluconeogenic compounds.

29 been shown to be necessary for growth under gluconeogenic conditions in Bacillus subtilis.

30 Under gluconeogenic conditions the E3 ligase is composed of si

31 ates the expression of virulence genes under gluconeogenic conditions, suggesting that colonization o

32 ng growth of a TIM-deficient bacterium under gluconeogenic conditions.

33 red the ability of B. subtilis to grow under gluconeogenic conditions.

34 evidence includes (a) the identification of gluconeogenic enzyme activities in various organs, espec

35 ffects of glucagon on stimulating hepatocyte gluconeogenic enzyme expression and glucose output and b

36 ERK inhibition restores FoxO1, gluconeogenic enzyme expression and glucose production.

37 ial ROS, ERK activation and increases FoxO1, gluconeogenic enzyme expression and hepatocyte glucose p

38 n methylation is required for both SEPP1 and gluconeogenic enzyme expression and that inhibition of p

39 and adipose tissue, and can in part suppress gluconeogenic enzyme expression in the liver.

40 l hepatic TG levels and partially normalized gluconeogenic enzyme expression, without changing matern

41 glucose output in hepatocytes by suppressing gluconeogenic enzyme expression.

42 tarved cells, substantial amounts of the key gluconeogenic enzyme fructose-1,6-bisphosphatase (FBPase

43 The key gluconeogenic enzyme fructose-1,6-bisphosphatase (FBPase

44 The gluconeogenic enzyme fructose-1,6-bisphosphatase (FBPase

45 ic gene set analysis and determined that the gluconeogenic enzyme fructose-1,6-bisphosphatase 1 (FBP1

46 The gluconeogenic enzyme fructose-1,6-bisphosphatase has bee

47 esult from 10-25-fold higher activity of the gluconeogenic enzyme fructose-1,6-bisphosphatase when gr

48 is by salidroside as the protein levels of a gluconeogenic enzyme G6Pase and a co-activator PGC-1alph

49 -CBP-TORC2 transcription complex and reduces gluconeogenic enzyme gene expression.

50 or complex controls transcription of hepatic gluconeogenic enzyme genes.

51 nished FoxO1-dependent expression of the key gluconeogenic enzyme glucose-6-phosphatase (G6pase).

52 e RNA, we demonstrate that repression of the gluconeogenic enzyme glucose-6-phosphatase in HepG2 cell

53 e, DYRK1B promoted the expression of the key gluconeogenic enzyme glucose-6-phosphatase.

54 et al. (2015) describe the unique role of a gluconeogenic enzyme in regulation of glucose catabolism

55 4 protein expression and upregulation of the gluconeogenic enzyme PCK2 in HCV-infected hepatocytes.

56 Here we report gluconeogenic enzyme phosphoenolpyruvate carboxykinase (

57 Recent structural studies of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase (

58 agonizing glucagon-induced expression of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase (

59 Moreover, the basal hepatic levels of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase 1

60 ion correlates with an increase in the liver gluconeogenic enzyme phosphoenolpyruvate carboxykinase e

61 Pck1, the fourth gluconeogenic enzyme, contains Pro at position 2; Gid4 d

62 he insulin-stimulated down regulation of the gluconeogenic enzyme, glucose-6-phosphatase.

63 The key gluconeogenic enzyme, phosphoenolpyruvate carboxykinase

64 is coincided with up-regulation of the first gluconeogenic enzyme, phosphoenolpyruvate carboxykinase,

65 athway genes (Phgdh, Psat1 and Psph) and the gluconeogenic enzyme, phosphoenolpyruvate carboxykinase-

66 thermore, OLZ-ICV rats had increased hepatic gluconeogenic enzymes and elevated hypothalamic neuropep

67 r methylation processes enable expression of gluconeogenic enzymes and metabolism of the nutrient sel

68 Initiating mechanisms that impair gluconeogenic enzymes and spare lipogenic enzymes in die

69 lso exhibited elevated hepatic expression of gluconeogenic enzymes and transcription factors.

70 Gluconeogenic enzymes are induced when Saccharomyces cer

71 Furthermore, GR-sensitive gluconeogenic enzymes are not induced in the prenatal pe

72 reversed the increased hepatic expression of gluconeogenic enzymes characteristic of rats with uDM.

73 ide concentrations and expression of hepatic gluconeogenic enzymes compared with vehicle (P < 0.05),

74 yeast Saccharomyces cerevisiae targeted the gluconeogenic enzymes Fbp1, Icl1, and Mdh2 for degradati

75 Increased expression of gluconeogenic enzymes glucose-6-phosphatase (G6PC) and p

76 patic glycogen content and activities of the gluconeogenic enzymes glucose-6-phosphatase and phosphoe

77 s accompanied by an up-regulation of the key gluconeogenic enzymes glucose-6-phosphatase and phosphoe

78 d through regulation by HNF-1beta of the key gluconeogenic enzymes glucose-6-phosphatase or PEPCK.

79 ns of G6pc, Pepck, and Fbp1 encoding the key gluconeogenic enzymes glucose-6-phosphatase, phosphoenol

80 e examined hepatic expression of these 2 key gluconeogenic enzymes in 2 rodent models of fasting hype

81 d the mRNA and protein expression of the key gluconeogenic enzymes in human liver biopsy specimens an

82 at certain types of cancer cells utilize the gluconeogenic enzymes phosphoenolpyruvate carboxykinase

83 glucose production and in the expression of gluconeogenic enzymes seen with variation of dietary iro

84 d of glucose for a prolonged period of time, gluconeogenic enzymes such as fructose-1,6-bisphosphatas

85 s where they associate with the promoters of gluconeogenic enzymes such as G6Pase.

86 Substrates of this pathway include gluconeogenic enzymes that bear either the N-terminal Pr

87 esize glucose if deprived of it, and destroy gluconeogenic enzymes upon return to glucose-replete con

88 Furthermore, hormone-dependent induction of gluconeogenic enzymes was reduced by inhibition of prote

89 tocytes by inhibiting the mRNA expression of gluconeogenic enzymes, glucose-6-phosphatase and the cyt

90 In this report we show that two additional gluconeogenic enzymes, isocitrate lyase and phosphoenolp

91 tly increased the expression of two critical gluconeogenic enzymes, phosphoenolpyruvate carboxykinase

92 vity of key glucocorticoid-regulated hepatic gluconeogenic enzymes, phosphoenolpyruvate carboxykinase

93 rk that regulates the expression/activity of gluconeogenic enzymes.

94 ng a key role in promoting the expression of gluconeogenic enzymes.

95 b inhibited gluconeogenesis by targeting the gluconeogenic factor hepatocyte nuclear factor 4alpha (H

96 belonging to the ED, the EMP (operating in a gluconeogenic fashion), and the pentose phosphate pathwa

97 htly correlated with decreased expression of gluconeogenic, fatty acid oxidation and cholesterol degr

98 ciency on metabolic flux through the hepatic gluconeogenic, fatty acid oxidation, and tricarboxylic a

99 Gluconeogenic flux can be rapidly inhibited by high insu

100 C-1alpha(-/-) livers coincident with reduced gluconeogenic flux from phosphoenolpyruvate.

101 othesized HexR role as a master regulator of gluconeogenic flux from pyruvate via the transcriptional

102 ns and may represent a form of regulation of gluconeogenic flux in Salmonella enterica.

103 or the same enzymes, and (c) measurements of gluconeogenic flux in the small intestine.

104 lates energy consumption linked to increased gluconeogenic flux through cytosolic phosphoenolpyruvate

105 No further diminution in gluconeogenic flux to G6P occurred over the remaining 4.

106 Insulin reduced gluconeogenic flux to glucose-6-phosphate (G6P) but only

107 appear to have little or no acute effect on gluconeogenic flux.

108 to gluconeogenic products distinguished the gluconeogenic from glycogenolytic state in these functio

109 o methods to rapidly distinguish livers in a gluconeogenic from glycogenolytic state.

110 that the LKB1-SIK pathway functions as a key gluconeogenic gatekeeper in the liver.

111 disease, increased apoptosis, and changes in gluconeogenic gene expression and chromatin structure in

112 Furthermore, heme suppresses hepatic gluconeogenic gene expression and glucose output through

113 generally accepted model for suppression of gluconeogenic gene expression and glucose output.

114 predicted alterations in PGC-1alpha-mediated gluconeogenic gene expression and glucose production in

115 co-activators CRTC2/3 resulting in enhanced gluconeogenic gene expression and glucose production in

116 The ability of apoA-IV to lower gluconeogenic gene expression and glucose production was

117 rmone were preserved, including reduction of gluconeogenic gene expression and hepatic glucose produc

118 inhibitory mutant Nur77 receptor antagonizes gluconeogenic gene expression and lowers blood glucose l

119 ed the effect of a maternal HF diet on fetal gluconeogenic gene expression and potential regulation m

120 /EBPbeta, and pCREB in promoting HCV-induced gluconeogenic gene expression and suggest that increased

121 , the downstream signaling events repressing gluconeogenic gene expression are not as well understood

122 After glucagon induction, CRTC2 stimulated gluconeogenic gene expression by an association with p30

123 ight-day transition, when it reduced fasting gluconeogenic gene expression by blocking glucagon-media

124 utrient signals are also thought to modulate gluconeogenic gene expression by promoting epigenetic ch

125 After their activation, InsP(3)Rs enhanced gluconeogenic gene expression by promoting the calcineur

126 Here we show in mice that insulin inhibits gluconeogenic gene expression during re-feeding by promo

127 higher hepatic glucose production and higher gluconeogenic gene expression in apoA-IV(-/-) mice.

128 Under fasting conditions, FOXO1 increases gluconeogenic gene expression in concert with the cAMP r

129 ttenuate the inhibitory effect of CARHSP1 on gluconeogenic gene expression in hepatocytes.

130 recruits a co-repressor complex to regulate gluconeogenic gene expression in HepG2 cells.

131 mechanism, suppresses glucose production and gluconeogenic gene expression in primary hepatocytes at

132 and allows for normal suppression of HGP and gluconeogenic gene expression in response to insulin, de

133 Metformin also inhibits gluconeogenic gene expression in the liver of mice admin

134 PGC-1alpha's activation of gluconeogenic gene expression is dependent upon its acet

135 llel decreases in insulin signalling augment gluconeogenic gene expression through the dephosphorylat

136 Triggering of the cAMP pathway stimulates gluconeogenic gene expression through the PKA-mediated p

137 r data suggest that CARHSP1 inhibits hepatic gluconeogenic gene expression via repression of PPARalph

138 iggering of the cyclic AMP pathway increases gluconeogenic gene expression via the de-phosphorylation

139 gnaling in the liver, and suppressed hepatic gluconeogenic gene expression without altering EGP or gl

140 MP analog to stimulate CREB phosphorylation, gluconeogenic gene expression, and HGP in primary hepato

141 Plasma hormone and substrate levels, hepatic gluconeogenic gene expression, and measures of tissue in

142 at increase PGC-1alpha acetylation, suppress gluconeogenic gene expression, and reduce glucose produc

143 Depletion of KAT2B or WDR5 decreased gluconeogenic gene expression, consequently breaking the

144 pite the known role of CRTC2 in coordinating gluconeogenic gene expression, CRTC2 KD in a rodent mode

145 antly, LTCFDN hepatocytes displayed elevated gluconeogenic gene expression, gluconeogenesis, and loss

146 tiating hepatic insulin signaling with lower gluconeogenic gene expression, higher glycogen storage a

147 anides to regulate AMPK, glucose production, gluconeogenic gene expression, mitochondrial respiration

148 state, which could be attributed to reduced gluconeogenic gene expression, resulting in reduced basa

149 PRMT5 lowers hepatic glucose production and gluconeogenic gene expression, these results demonstrate

150 Inhibition of CDK4 enhances the gluconeogenic gene expression, whereas cyclin D1-mediate

151 ssion of both hepatic glucose production and gluconeogenic gene expression, with no change of glucose

152 uce the nuclear FOXO1 abundance and suppress gluconeogenic gene expression.

153 ay control substrate availability as well as gluconeogenic gene expression.

154 We now show that YAP can also suppress gluconeogenic gene expression.

155 ize the role of CARHSP1 in the regulation of gluconeogenic gene expression.

156 n from inhibiting glucose output or reducing gluconeogenic gene expression.

157 in liver and a marked suppression of hepatic gluconeogenic gene expression.

158 rough reduction of hepatic FOXO1 protein and gluconeogenic gene expression.

159 lucose appearance (Ra), or increased hepatic gluconeogenic gene expression.

160 d-type TCF7L2, increased gluconeogenesis and gluconeogenic gene expression.

161 oteasome-dependent degradation and, in turn, gluconeogenic gene expression.

162 vation of p38 enhances expression of hepatic gluconeogenic gene phosphoenolpyruvate carboxykinase (PE

163 patic PGC-1alpha acetylation, suppressed the gluconeogenic gene program, and lowered glycemia, indica

164 etion in primary hepatocytes potentiates the gluconeogenic gene response to glucagon and dexamethason

165 the insulin-mediated suppression of hepatic gluconeogenic gene transcription but blunted the inducti

166 how that MAPK phosphatase-3 (MKP-3) promotes gluconeogenic gene transcription in hepatoma cells, but

167 A key mediator of gluconeogenic gene transcription is PGC-1alpha.

168 D1-mediated activation of CDK4 represses the gluconeogenic gene-expression program in vitro and in vi

169 Abnormal expression of the hepatic gluconeogenic genes (glucose-6-phosphatase [G6Pase] and

170 tylation at Lys 9 (H3K9Ac) was elevated over gluconeogenic genes and contributed to increased hepatic

171 on of FXR in WT mice repressed expression of gluconeogenic genes and decreased serum glucose.

172 d an HI diet, due to decreased expression of gluconeogenic genes and decreased substrate (lactate) fr

173 lucose production, hepatic expression of key gluconeogenic genes and glucose uptake in skeletal muscl

174 ssion (GRbeta-Ad) resulted in suppression of gluconeogenic genes and hyperglycemia in mice on a regul

175 ation of FXR in db/db mice repressed hepatic gluconeogenic genes and increased hepatic glycogen synth

176 MUP1 inhibited the expression of both gluconeogenic genes and lipogenic genes in the liver.

177 rt6 levels; ectopic re-expression suppresses gluconeogenic genes and normalizes glycemia.

178 D suppression of glucose output, NAD(+), and gluconeogenic genes and stabilized PGC1alpha.

179 Insulin represses the expression of gluconeogenic genes at the mRNA level, but the hormone a

180 IL-13 inhibited transcription of gluconeogenic genes by acting directly on hepatocytes th

181 tivator 2 (CRTC2) regulates transcription of gluconeogenic genes by specifying targets for the transc

182 ain glucose homeostasis through induction of gluconeogenic genes by the CREB coactivator CRTC2.

183 resulting in decreased transcription of the gluconeogenic genes glucose-6-phosphatase (G6pase) and p

184 genesis and reduced transcript levels of key gluconeogenic genes glucose-6-phosphatase (G6Pase) and p

185 ms had significantly higher mRNA contents of gluconeogenic genes in addition to the elevated plasma g

186 XR-mediated trans-activation of promoters of gluconeogenic genes in human liver cells, thereby enhanc

187 phorylatable CREB allele failed to attenuate gluconeogenic genes in response to DNA damage or fully a

188 Altered AKT signaling and expression of gluconeogenic genes in the fed state contributed to an i

189 In addition, PST peptides activated gluconeogenic genes in the following order: PST-297S app

190 ng (CREB) phosphorylation, and expression of gluconeogenic genes in the liver and primary hepatocytes

191 HNPs also suppressed expression of key gluconeogenic genes including phosphoenoylpyruvate carbo

192 Down-regulation of apoA-IV on gluconeogenic genes is mediated through NR1D1, as illust

193 c insulin signaling, decreased expression of gluconeogenic genes PEPCK and G-6-Pase, enhanced insulin

194 Induction of the gluconeogenic genes Ppargc1a, Pck1, and G6pc by glucagon

195 ound 17beta-estradiol (E2) inhibited hepatic gluconeogenic genes such as phosphoenolpyruvate carboxyk

196 glucose levels and the expression of hepatic gluconeogenic genes was first examined.

197 The expression of gluconeogenic genes was measured by quantitative real-ti

198 ion levels of several critical lipogenic and gluconeogenic genes were significantly decreased in HFD-

199 in the paradoxically increased expression of gluconeogenic genes while concomitantly inducing express

200 e promoter of FOXO1 (transcription factor of gluconeogenic genes).

201 re triglyceride, expression of lipogenic and gluconeogenic genes, and activity of protein kinases dow

202 and -2 on glucose production, expression of gluconeogenic genes, and phosphorylation of Akt, c-Src,

203 ritical role in FFA-induced transcription of gluconeogenic genes, and the known gluconeogenic regulat

204 translocation of FoxO1 and activation of key gluconeogenic genes, glucose-6-phosphatase and phosphoen

205 not significant] vs. w0) by reducing hepatic gluconeogenic genes, including G6Pase, PEPCK, and FOXO1.

206 transcriptional level to negatively regulate gluconeogenic genes, including the glucose-6-phosphatase

207 c in liver and downregulation of the hepatic gluconeogenic genes, Pepck and G6pase.

208 (TR) to induce the expression of the hepatic gluconeogenic genes, phosphoenolpyruvate carboxykinase (

209 epatic glucose production, expression of key gluconeogenic genes, phosphoenolpyruvate carboxykinase (

210 lved in catabolic pathways and activation of gluconeogenic genes, was for the first time predicted by

211 etylates and inhibits PGC-1alpha activity on gluconeogenic genes.

212 ma glucagon levels and hepatic expression of gluconeogenic genes.

213 and disassembling the CREB-CBP complex from gluconeogenic genes.

214 a participates in the hormonal regulation of gluconeogenic genes.

215 content, and impaired insulin suppression of gluconeogenic genes.

216 bsequent recruitment to the promoters of key gluconeogenic genes.

217 omitant with decreased expression of hepatic gluconeogenic genes.

218 yte cultures by inhibiting the expression of gluconeogenic genes.

219 and thereby inhibiting CRTC2 occupancy over gluconeogenic genes.

220 on via gluconeogenesis and expression of key gluconeogenic genes.

221 ral parts of FFA-stimulated transcription of gluconeogenic genes.

222 omponent in FFA-induced transcription of key gluconeogenic genes.

223 sponsive elements and thereby down-regulates gluconeogenic genes.

224 creased insulin levels, and elevated hepatic gluconeogenic genes.

225 G2 cells also causes similar upregulation of gluconeogenic genes.

226 ced expression of hepatic glycogenolytic and gluconeogenic genes.

227 lso reflected by the decreased expression of gluconeogenic genes.

228 in vivo by increasing the expression of key gluconeogenic genes.

229 llular signaling and molecular inhibition of gluconeogenic (GNG) enzyme mRNA expression.

230 s; however, in vivo regulation of PK flux by gluconeogenic hormones and substrates is poorly understo

231 ription factor FoxO1 activates expression of gluconeogenic, including phosphoenolpyruvate carboxykina

232 iple crossover analyses of concentrations of gluconeogenic intermediates and redox measurements expan

233 ependent enzymes that convert amino acids to gluconeogenic intermediates, suggesting that it may cont

234 carboxylic acid cycle-derived metabolites to gluconeogenic intermediates.

235 These gluconeogenic, lipogenic, and inflammatory pathway trans

236 o N-deprived conditions turning on a largely gluconeogenic metabolic state, which then transitions to

237 osphate, an essential step in glycolytic and gluconeogenic metabolism.

238 e and stationary phase yeast switched into a gluconeogenic mode in which metabolism was reoriented to

239 The gluconeogenic module operates through assisted loading,

240 ding E. coli EDL933 uses both glycolytic and gluconeogenic nutrients and needs the ability to perform

241 strain that outcompetes O157:H7 strains for gluconeogenic nutrients could render them nonpathogenic.

242 nd 5 days postfeeding, appears to stop using gluconeogenic nutrients thereafter in a large, long-term

243 a probiotic strain, uses both glycolytic and gluconeogenic nutrients to colonize the mouse intestine

244 starve the O157:H7 E. coli strain EDL933 of gluconeogenic nutrients, even though E. coli Nissle 1917

245 nditions were designed to establish either a gluconeogenic or a glycogenolytic state.

246 7 increases the expression of enzymes of the gluconeogenic pathway in HepG2 cells.

247 hat PEPCK has poor control strength over the gluconeogenic pathway in vivo.

248 Here we investigated whether the gluconeogenic pathway is significantly modulated in hepa

249 nly regulatory step of the common glycolytic-gluconeogenic pathway that appears to exert significant

250 , with feeding, and assemble glucose via the gluconeogenic pathway, in response to fasting, are criti

251 ing the expression of enzymes in the hepatic gluconeogenic pathway, thereby reducing gluconeogenesis

252 lar probe that allows measurement of hepatic gluconeogenic pathways in vivo and in a noninvasive mann

253 s VirF and VirB, and both the glycolytic and gluconeogenic pathways influence steps in S. flexneri in

254 e extraction is important, and later reduced gluconeogenic precursor availability plays a role.

255 Here we use the gluconeogenic precursor dihydroxyacetone (DHA) to delive

256 in addition to serving as a fuel source and gluconeogenic precursor, lactate anion (La-) is a signal

257 of carbohydrate restriction on the origin of gluconeogenic precursors (GNG from glycerol [GNG(glycero

258 methylcitrate cycle intermediates, depletes gluconeogenic precursors, and results in defects of memb

259 rption from the gut and by providing hepatic gluconeogenic precursors.

260 GK in the nucleus, which removes GK from the gluconeogenic process and prevents a futile cycle of glu

261 ancy, we demonstrate that TrmB regulates the gluconeogenic production of sugars incorporated into the

262 A ratio of glycolytic to gluconeogenic products distinguished the gluconeogenic f

263 ed genes are largely involved in the hepatic gluconeogenic program and lipid metabolism.

264 of obese mice reversed CRTC2 effects on the gluconeogenic program and lowered hepatic glucose output

265 Glucagon stimulates the gluconeogenic program by triggering the dephosphorylatio

266 Whether ER stress also modulates the gluconeogenic program directly, however, is unclear.

267 hibiting the CREB-mediated activation of the gluconeogenic program in response to glucagon.

268 KAT2B and WDR5 stimulated the gluconeogenic program through a self-reinforcing cycle,

269 iggering of the cAMP pathway upregulates the gluconeogenic program through the phosphorylation of cAM

270 mia because of constitutive induction of the gluconeogenic program.

271 glucose production through induction of the gluconeogenic program.

272 in diabetes, leading to upregulation of the gluconeogenic program.

273 ns during fasting, due to attenuation of the gluconeogenic program.

274 n and when FOXO1 supported expression of the gluconeogenic program.

275 d to the nucleus, in which it stimulates the gluconeogenic programme by binding to CREB.

276 uitment of CREB and its coactivator CRTC2 to gluconeogenic promoters by up-regulating ATF3, a transcr

277 ion that enhanced chromatin accessibility at gluconeogenic promoters.

278 ulin and glucagon concentrations and hepatic gluconeogenic protein expression.

279 r->asp)) exhibited apparent correlation with gluconeogenic pyruvate carboxylase (PC) activity in hepa

280 However, fasting increased the fluxes in gluconeogenic reactions whereas it decreased fluxes asso

281 ing poor control strength for this enzyme in gluconeogenic regulation in canines.

282 r results illustrate how the exchange of two gluconeogenic regulators during fasting maintains energy

283 iption of gluconeogenic genes, and the known gluconeogenic regulators, PGC-1alpha and CREB, are also

284 ne the relative importance of its effects on gluconeogenic regulatory sites, and 3) to correlate thos

285 , our model simulations predict a restricted gluconeogenic response of the liver under impaired hormo

286 protein expression and impairs FOXO1-driven gluconeogenic response.

287 In eukaryotes only one gluconeogenic route has been described from organic acid

288 iron homeostasis, showing that Hepcidin is a gluconeogenic sensor in mice during starvation.

289 We investigated whether gluconeogenic signals directly control Hepcidin, an impo

290 This gluconeogenic statin-PXR-SGK2 signal is not present in m

291 e gene that encodes Hepcidin) in response to gluconeogenic stimuli using small interfering RNA, lucif

292 There is a switch of gluconeogenic substrate preference to glycerol that quan

293 oles of lactate in delivery of oxidative and gluconeogenic substrates as well as in cell signalling.

294 The reduction in key gluconeogenic substrates in the postprandial state may c

295 nucleus in cells grown on methanol or other gluconeogenic substrates.

296 verse hepatic metabolic responses, including gluconeogenic suppression and induction of glycogen synt

297 PK-related kinase family, play a key role as gluconeogenic suppressors downstream of LKB1 in the live

298 vate transcription from the promoters of its gluconeogenic targets, and the effects of YAP are blunte

299 PEPCK-M was acutely silenced in gluconeogenic tissues of rats using antisense oligonucle

300 ever, PEPCK-M is present in a variety of non-gluconeogenic tissues, including tumors of several origi