ライフサイエンスコーパス: glucose homeostasis

1 1), a critical incretin that regulates blood glucose homeostasis.

2 eta cells producing glucagon and insulin for glucose homeostasis.

3 d adipose tissue is important in maintaining glucose homeostasis.

4 ed change in cellular metabolism to maintain glucose homeostasis.

5 lays a key role in the dynamic regulation of glucose homeostasis.

6 st postdieting food intake and showed normal glucose homeostasis.

7 ordinated control of body weight balance and glucose homeostasis.

8 g a role for GC/HIF cross-talk in regulating glucose homeostasis.

9 porter and characterized by altered glycogen/glucose homeostasis.

10 tributes to the role of SIRT6 in controlling glucose homeostasis.

11 a nuclear receptor central to fatty acid and glucose homeostasis.

12 and, remarkably, improves insulin action and glucose homeostasis.

13 t experiments suggest that oxytocin improves glucose homeostasis.

14 a TBK-1-dependent role for central Lin28a in glucose homeostasis.

15 lead to low-grade inflammation and impaired glucose homeostasis.

16 d play important roles in energy balance and glucose homeostasis.

17 t in insulin sensitivity and consequently in glucose homeostasis.

18 mselves by differential actions on lipid and glucose homeostasis.

19 epatic nutrient-sensing mechanism to control glucose homeostasis.

20 Glucose transporters are central players in glucose homeostasis.

21 nd long chain fatty acid sensing to regulate glucose homeostasis.

22 umans and rodents, including improvements in glucose homeostasis.

23 ally important role of ODC1 in regulation of glucose homeostasis.

24 learance to maintain physiologic insulin and glucose homeostasis.

25 issue communication and regulates energy and glucose homeostasis.

26 dipocytes, which is essential for whole-body glucose homeostasis.

27 els of insulin mRNA and other alterations in glucose homeostasis.

28 re beta cells impaired insulin secretion and glucose homeostasis.

29 evels of sensitivity to discrete elements of glucose homeostasis.

30 pancreatic islet beta-cells is critical for glucose homeostasis.

31 plays a critical role in regulating systemic glucose homeostasis.

32 f alpha- and beta-cells in order to maintain glucose homeostasis.

33 have unfavorable consequences for whole-body glucose homeostasis.

34 poor, and the mutant mice exhibited impaired glucose homeostasis.

35 Langerhans, disrupting insulin secretion and glucose homeostasis.

36 g physiological roles in insulin release and glucose homeostasis.

37 eurons rapidly coordinate hunger states with glucose homeostasis.

38 lammation is a positive regulator of hepatic glucose homeostasis.

39 ) signaling that results in dysregulation of glucose homeostasis.

40 anism by which sustained inflammation alters glucose homeostasis.

41 n glucose levels, play a significant role in glucose homeostasis.

42 y and the effects of anticancer therapies on glucose homeostasis.

43 an insulin-like hormone that is involved in glucose homeostasis.

44 gerhans plays a critical role in maintaining glucose homeostasis.

45 drial dynamics in VMH regulation of systemic glucose homeostasis.

46 ear hormone receptor that controls lipid and glucose homeostasis.

47 of IKKbeta-mediated hepatic inflammation in glucose homeostasis.

48 d sensing machinery in the ileum to regulate glucose homeostasis.

49 VMH and that this process regulates systemic glucose homeostasis.

50 findings extended to continuous measures of glucose homeostasis.

51 vitro and in vivo, coinciding with defective glucose homeostasis.

52 ering their activity also affects peripheral glucose homeostasis.

53 islet of Langerhans, which has a key role in glucose homeostasis.

54 as a single source of perforin in regulating glucose homeostasis.

55 equirement and severely compromised systemic glucose homeostasis.

56 investigate the effect of Cyp8b1 deletion on glucose homeostasis.

57 ssion undermines beta cell support of normal glucose homeostasis.

58 MSC transplantation results in better blood glucose homeostasis.

59 rogenism, chronic anovulation and defects in glucose homeostasis.

60 normal biphasic insulin secretion and blood glucose homeostasis.

61 enes involved in tissue barrier function and glucose homeostasis.

62 on, likely accounting for the differences in glucose homeostasis.

63 or by GLP-1 receptor agonists, which improve glucose homeostasis.

64 oA-TXNIP axis that we propose contributes to glucose homeostasis.

65 ce, and the lowering of RBP4 levels improves glucose homeostasis.

66 g to improvement of fasting and postprandial glucose homeostasis.

67 ty acid receptor linked to MAPK networks and glucose homeostasis.

68 betes-reaffirm the critical role of APPL1 in glucose homeostasis.

69 pancreatic beta-cell is required for normal glucose homeostasis.

70 cemic index diet as a constant challenge for glucose homeostasis.

71 g nonesterified fatty acid levels and normal glucose homeostasis.

72 e beneficial effects of exercise on systemic glucose homeostasis.

73 mechanism is essential for insulin-regulated glucose homeostasis.

74 ated with deregulation of systemic lipid and glucose homeostasis.

75 anase (hep-tg) was the discovery of improved glucose homeostasis.

76 ta-cell insulin secretion and helps maintain glucose homeostasis.

77 on, in vivo insulin sensitivity, and overall glucose homeostasis.

78 metabolic status is a fundamental aspect of glucose homeostasis.

79 ion on iron traits and their connection with glucose homeostasis.

80 on studies but without a clear connection to glucose homeostasis.

81 as an important target of insulin action on glucose homeostasis.

82 and disease processes, including cancer and glucose homeostasis.

83 tant for maintaining cellular and organismal glucose homeostasis.

84 paths of metabolites in type 2 diabetes and glucose homeostasis.

85 y in hepatocytes did not show any changes in glucose homeostasis.

86 metabolic regulation of fat accumulation and glucose homeostasis.

87 ulator that plays major roles in maintaining glucose homeostasis.

88 pha activation, leading to impaired systemic glucose homeostasis.

89 Targeted temperature management alters blood glucose homeostasis.

90 mportant regulators of bile acid, lipid, and glucose homeostasis.

91 suggests TFG to have an important role(s) in glucose homeostasis.

92 R signaling, leading to striking deficits in glucose homeostasis.

93 chondrial cell energy metabolism but also of glucose homeostasis.

94 s in CD4(+) T cells and B cells; 2) improved glucose homeostasis; 3) higher circulating insulin; and

95 s as a key metabolic regulator that controls glucose homeostasis across the circadian cycle or under

96 secretion and increased capacity to maintain glucose homeostasis after transplantation.

97 h as hyperphagia, hypermetabolism, disturbed glucose homeostasis, altered hematological parameters, i

98 nce has linked sleep duration and quality to glucose homeostasis, although the mechanistic pathways r

99 In examining iron variant associations with glucose homeostasis, an iron-raising variant of TMPRSS6

100 Aging is accompanied by impaired glucose homeostasis and an increased risk of type 2 diab

101 eptin also plays a role in the regulation of glucose homeostasis and as a gating factor in reproducti

102 ion of feeding behavior, energy expenditure, glucose homeostasis and autonomic outflow.

103 We examined glucose homeostasis and beta-cell function of these mice

104 is downstream target is a major regulator of glucose homeostasis and beta-cell mass, proliferation, a

105 ted, and evaluated their ability to modulate glucose homeostasis and body weight in chronic mouse mod

106 We examined the relationship between glucose homeostasis and comprehensive measures of cardia

107 oendocrine cells plays a fundamental role in glucose homeostasis and could be targeted for the treatm

108 lucose-6-phosphatase-alpha activity maintain glucose homeostasis and display physiologic features mim

109 Impaired glucose homeostasis and energy balance are integral to t

110 Supplementation with UT improved plasma glucose homeostasis and enhanced skeletal muscle insulin

111 ads to decreased body and fat mass, improved glucose homeostasis and extended lifespan, despite incre

112 e to study central nervous system control of glucose homeostasis and feeding in mice.

113 , a brain nucleus involved in the control of glucose homeostasis and feeding.

114 potentially in partnership to help maintain glucose homeostasis and guard against hypoglycemia.

115 ventions, such as regulation of body weight, glucose homeostasis and gut microbiome.

116 ced glycosuria elicits adaptive responses in glucose homeostasis and hormone release.

117 t loss of liver glycogen impaired whole-body glucose homeostasis and increased hepatic expression of

118 ation of N-acyl amino acids to mice improves glucose homeostasis and increases energy expenditure.

119 However, glucose homeostasis and insulin secretion in IRS2(5A)-be

120 studies confirmed the marked improvement of glucose homeostasis and insulin sensitivity in AC5KO mic

121 r compromised insulin secretion and maintain glucose homeostasis and insulin sensitivity in wild-type

122 metabolism can strongly influence whole-body glucose homeostasis and insulin sensitivity.

123 rate that apelin controls fetal and neonatal glucose homeostasis and is altered by fetal growth restr

124 Betaine administration failed to improve glucose homeostasis and liver fat content in Fgf21(-/-)

125 ype Ia (GSD-Ia) is characterized by impaired glucose homeostasis and long-term risks of hepatocellula

126 of blood pressure) and metabolic (improving glucose homeostasis and lowering body weight).

127 ells (MSCs) have great potential to maintain glucose homeostasis and metabolic balance.

128 n adipose tissue (BAT) metabolism influences glucose homeostasis and metabolic health in mice and hum

129 these proteins have a physiological role in glucose homeostasis and metabolism in vivo.

130 ir knock-in controls (S/S) exhibited similar glucose homeostasis and muscle insulin signaling.

131 rimary mechanism by which salsalate improves glucose homeostasis and NAFLD is via salicylate-driven m

132 However, its function in glucose homeostasis and obesity has been unknown.

133 carbohydrates, have been related to impaired glucose homeostasis and obesity.

134 rprisingly, the beneficial effects of SRT on glucose homeostasis and of both compounds on energy expe

135 he long-term effects of JNK1 inactivation on glucose homeostasis and oxidative stress in obese mice w

136 gnals that contributes to the maintenance of glucose homeostasis and peripheral tissue energy balance

137 Atrial natriuretic peptide (ANP) influences glucose homeostasis and possibly acts as a link between

138 HIP2 is required to maintain normal systemic glucose homeostasis and prevent oxidative stress-induced

139 verts iWAT to brown-like fat, which improves glucose homeostasis and prevents obesity and hepatic ste

140 substantial effects than LR on body mass and glucose homeostasis and reduced hepatic lipogenic gene e

141 ed systemic health, including maintenance of glucose homeostasis and reduced white adipose tissue inf

142 portunity to develop therapies that modulate glucose homeostasis and separately slow the development

143 ks of exercise training increased whole-body glucose homeostasis and skeletal muscle Akt signaling an

144 weeks and investigated the effects of MS on glucose homeostasis and sleep.

145 ovalent analogues with respect to control of glucose homeostasis and suppression of food intake.

146 ht, liver and adipose tissue function, blood glucose homeostasis and survival in adult mice.

147 cells to produce a change in food intake and glucose homeostasis and that these effects depend on the

148 pled receptor family and plays a key role in glucose homeostasis and the pathophysiology of type 2 di

149 We compared markers of glucose homeostasis and their association with diabetes

150 tic indications including insulin secretion, glucose homeostasis and weight gain.

151 % of normal hepatic G6PT activity maintained glucose homeostasis and were protected against age-relat

152 pancreatic islet beta cells is critical for glucose homeostasis, and a blunted beta cell secretory r

153 ced food intake, lower body weight, improved glucose homeostasis, and activation of CNS stress axes.

154 hondrial metabolism to insulin secretion and glucose homeostasis, and could represent a therapeutic t

155 The circadian rhythm of the liver maintains glucose homeostasis, and disruption of this rhythm is as

156 le acids regulate triglyceride, cholesterol, glucose homeostasis, and energy expenditure.

157 dy metabolism, we examined body composition, glucose homeostasis, and fatty acid metabolism in Sost(-

158 Increased anxiety-like behavior, impaired glucose homeostasis, and higher body weight and abdomina

159 ts, the role of apelin in fetal and neonatal glucose homeostasis, and its modulation by maternal food

160 Elafibranor improves insulin sensitivity, glucose homeostasis, and lipid metabolism and reduces in

161 ipates in regulation of bile acid, lipid and glucose homeostasis, and liver protection.

162 periphery and the CNS to change food intake, glucose homeostasis, and metabolic rate while playing a

163 ry for normal pancreatic beta-cell function, glucose homeostasis, and prevention of diabetes.

164 lenges, enhanced respiration rates, improved glucose homeostasis, and reduced weight gain, demonstrat

165 ptin in the regulation of beta-cell mass and glucose homeostasis appears to be conserved across verte

166 ased CMRglu in areas of the brain related to glucose homeostasis, appetite, and food reward, despite

167 Disorders of glucose homeostasis are common in chronic kidney disease

168 119 agonists regulate metabolic hormones and glucose homeostasis as efficiently as human ligands, alt

169 DC was shown to play an important role in glucose homeostasis as well as other key physiological r

170 After the 8-week experiment, glucose homeostasis, blood biochemistry, tissue triglyce

171 nvolved in pathways that modulate short-term glucose homeostasis, but casts doubt on the general usef

172 normally produce adequate insulin to control glucose homeostasis, but in obesity-related diabetes, th

173 rowth factor (IGF) axis may be implicated in glucose homeostasis, but its longitudinal profile across

174 etic animal model, exogenous Pref-1 improved glucose homeostasis by accelerating pancreatic ductal an

175 ecretion and accounts for the improvement of glucose homeostasis by GLP-1.

176 trate that osteoblast-derived LCN2 maintains glucose homeostasis by inducing insulin secretion and im

177 Regulation of glucose homeostasis by insulin depends on beta-cell grow

178 ortant role in regulating energy balance and glucose homeostasis by promoting leptin expression and s

179 Kidneys contribute to glucose homeostasis by reabsorbing filtered glucose in t

180 body and insulin-producing cells to maintain glucose homeostasis by supporting a developmental switch

181 schizophrenia already exhibit alterations in glucose homeostasis compared with controls.

182 s factor-alpha (TNF-alpha) mRNA and impaired glucose homeostasis compared with those administered VEH

183 r worsening of the insulin secretion defect, glucose homeostasis deteriorates in aging LP descendants

184 cate aPKC as a novel regulator of energy and glucose homeostasis downstream of the leptin-PI3K pathwa

185 AMPKalpha1alpha2 is required for maintaining glucose homeostasis during an acute bout of exercise.

186 The adequate control of glucose homeostasis during both gestation and early post

187 agon plays a major role in the regulation of glucose homeostasis during fed and fasting states.

188 ting beta-cell proliferation and maintaining glucose homeostasis during obesity development.

189 ys an important role in maintaining a normal glucose homeostasis during pregnancy and beyond.

190 ancreatic islet maturation, and consequently glucose homeostasis, during the larval to juvenile trans

191 Indices of anxiety-like behavior, glucose homeostasis, endocrine and molecular markers of

192 llectively establish a physiological role in glucose homeostasis for VMN(SF1) neurons and suggest tha

193 important signalling-node kinase involved in glucose homeostasis, from the membrane into the cytoplas

194 lues and found some genes involved in plasma glucose homeostasis (GLP1R) and lipid metabolism as well

195 omitant to enhanced regulatory components of glucose homeostasis (GLUT-4, G6PDH, Hk-2 and Gly-Syn-1).

196 erse processes including insulin signalling, glucose homeostasis, glycogen biosynthesis and chromatin

197 Glucose homeostasis greatly depends on the match between

198 le of SERCA2 in the regulation of whole-body glucose homeostasis has remained uncharacterized.

199 ural circuits controlling energy balance and glucose homeostasis have rekindled the hope for developm

200 in synaptic plasticity and insulin signaling/glucose homeostasis (ie, Akt, extracellular signal-regul

201 w effect on gallbladder volume, and improves glucose homeostasis in a preclinical murine model of die

202 efective islet development and disruption of glucose homeostasis in adult mice.

203 e range of tissues, exert important roles in glucose homeostasis in adults.

204 a differential role of a ghrelin agonist on glucose homeostasis in an Alzheimer's disease mouse mode

205 enicity and can be used to optically-control glucose homeostasis in anesthetized mice following deliv

206 y searched for studies examining measures of glucose homeostasis in antipsychotic-naive individuals w

207 FMD cycles restore insulin secretion and glucose homeostasis in both type 2 and type 1 diabetes m

208 flammation has been implicated in control of glucose homeostasis in cases of infection, obesity, and

209 es hepatic insulin sensitivity, and improves glucose homeostasis in dietary and genetic mouse models

210 suggests it may play a range of roles beyond glucose homeostasis in different cells and tissues.

211 to the hypothalamic regulation of energy and glucose homeostasis in divergent ways.

212 This first evaluation of glucose homeostasis in DKO pigs for two major xenoantige

213 rnal protein intake in pregnancy may improve glucose homeostasis in GDM-exposed and male offspring.

214 n of endosomal insulin receptor activity and glucose homeostasis in hepatocytes.

215 rol AT-LSK improves both AT-inflammation and glucose homeostasis in HFD mice.

216 ted that CDKN2A is an important regulator of glucose homeostasis in humans, thus supporting its candi

217 class B GPCR involved in the maintenance of glucose homeostasis in humans.

218 r GLUT1 (SLC2A1) is an important mediator of glucose homeostasis in humans.

219 e the impact of CDKN2A haploinsufficiency on glucose homeostasis in humans.

220 interacting protein (Txnip), which regulates glucose homeostasis in mammals, binds to fructose transp

221 id Fenretinide inhibits obesity and improves glucose homeostasis in mice and has pleotropic effects o

222 duced adipose inflammation and impairment of glucose homeostasis in mice.

223 henylalanine at position 508 (DeltaF508), on glucose homeostasis in mice.

224 ose tissue leads to weight loss and improves glucose homeostasis in obese animals.

225 nistration of resveratrol is able to improve glucose homeostasis in obese individuals.

226 trol-fed donor mice is sufficient to improve glucose homeostasis in obese mice, suggesting that the r

227 n1 could provide novel avenues to ameliorate glucose homeostasis in obese patients and improve the ef

228 T1 to reverse insulin resistance and improve glucose homeostasis in obesity and diabetes.

229 insulin resistance is necessary to maintain glucose homeostasis in obesity.

230 TRs directly contribute to the regulation of glucose homeostasis in response to glucose ingestion is

231 pressing human G6Pase-alpha normalizes blood glucose homeostasis in the global G6pc knockout (G6pc(-/

232 retion and insulin sensitivity that preserve glucose homeostasis in the setting of cold exposure.

233 , which is believed to be due alterations in glucose homeostasis in the skeletal muscle.

234 P1 results in impaired insulin signaling and glucose homeostasis in vivo Collectively, these data rev

235 However, the role of beta-cell PKD1 in glucose homeostasis in vivo is essentially unknown.

236 factor 2) contributes to the maintenance of glucose homeostasis in vivo Nrf2 suppresses blood glucos

237 dioica L. (UT) has been reported to improve glucose homeostasis in vivo, but definitive studies on e

238 cal NF-kappaB-inducing kinase (NIK) disrupts glucose homeostasis in zebrafish in vivo.

239 ed and curtailed the development of impaired glucose homeostasis independently of obesity and food in

240 metabolism characterized by altered systemic glucose homeostasis, inflammation, and hepatic steatosis

241 intermediate phenotypes characterizing basal glucose homeostasis (insulin resistance and HOMA of insu

242 estigated the utility of dynamic measures of glucose homeostasis (insulin sensitivity [SI] and acute

243 We measured the temporal trends of glucose homeostasis, insulin secretion, beta cell morpho

244 strength protocol exerted greater effects on glucose homeostasis, insulin sensitivity, and liver lipi

245 e and control db/db mice were phenotyped for glucose homeostasis, insulin sensitivity, insulin secret

246 Maintenance of glucose homeostasis is achieved via functional interacti

247 These findings show that glucose homeostasis is altered from illness onset in sch

248 Maintenance of whole-body glucose homeostasis is critical to glycemic function.

249 adipocyte GLUT4 translocation on whole-body glucose homeostasis is driven by a near complete failure

250 Maintenance of glucose homeostasis is essential for normal physiology.

251 Its involvement in glucose homeostasis is less clear, although pilot experi

252 The role of hepatitis virus infection in glucose homeostasis is uncertain.

253 icant role in whole body energy balance, and glucose homeostasis, it is predicted that both obesity a

254 ly enhancing insulin secretion and improving glucose homeostasis, making FoxM1 an attractive therapeu

255 tered to 29 healthy, fasted male subjects on glucose homeostasis measured by means of an oral glucose

256 etwork involving carbohydrate metabolism and glucose homeostasis mediated by GLD4.

257 se 1 (PGM1) plays a central role in cellular glucose homeostasis, mediating the switch between glycol

258 pacity after adjusting for age, sex, fasting glucose, homeostasis model assessment of insulin resista

259 sporter (G6PT), is characterized by impaired glucose homeostasis, myeloid dysfunction, and long-term

260 s rate does not elicit detectable effects on glucose homeostasis or EGP in healthy men, which may ref

261 arby genes with roles in the nervous system, glucose homeostasis or hypoxia.

262 Preoperative impaired glucose homeostasis (OR, 10.8) and initial poor graft fu

263 iation between genetic variants of PCSK2 and glucose homeostasis parameters and incident diabetes.

264 binding to the Mas receptor (MasR) improves glucose homeostasis, partly by enhancing glucose-stimula

265 The brain influences glucose homeostasis, partly by supplemental control over

266 As several anticancer therapies alter glucose homeostasis, physicians need to be aware of thes

267 Control of glucose homeostasis plays a critical role in health and

268 d beige/brite adipocytes can affect systemic glucose homeostasis, potentially through a neuroendocrin

269 n mice with diabetes, this leads to improved glucose homeostasis, providing an unexpected functional

270 obesity prevents the development of impaired glucose homeostasis, reduces hepatic lipid accumulation,

271 NAD + dependent Sirtuin 6 (SIRT6) is a glucose homeostasis regulator in animals and humans and

272 sms by which this nuclear receptor regulates glucose homeostasis remain unclear.

273 ways in skeletal muscle to maintain systemic glucose homeostasis remains largely unexplored.

274 tion of energy balance; however, its role in glucose homeostasis remains less clear.

275 eocalcin, which regulate kidney function and glucose homeostasis, respectively.

276 knockout mice exhibited paradoxical superior glucose homeostasis resulting from an enhanced insulin s

277 and the monogenic contributions to perturbed glucose homeostasis, the complexity of genetic events th

278 mmation markers, blood pressure, and insulin-glucose homeostasis.The results of our study suggest tha

279 c beta cells are responsible for maintaining glucose homeostasis; their absence or malfunction result

280 Hence, osteocytes coregulate bone and glucose homeostasis through a PPARgamma regulatory pathw

281 ese data indicate that DPD promotes improved glucose homeostasis through an NEAA insufficiency-induce

282 Glucagon-like peptide 1 (GLP-1) regulates glucose homeostasis through the control of insulin relea

283 oughout diet-induced progression from normal glucose homeostasis, through compensation of insulin res

284 eserves oxidative mitochondrial function and glucose homeostasis, thus preventing death at the fetal-

285 gated how endothelial FcgammaRIIB influences glucose homeostasis, using mice with elevated CRP expres

286 oncentrations were inversely associated with glucose homeostasis variables and inflammation variables

287 ch prevents developing strategies to improve glucose homeostasis via altering the brain-liver pathway

288 y, our data suggest that vitamin D regulates glucose homeostasis via the paraventricular nuclei and e

289 standard) diet or a high-fat diet (HFD), and glucose homeostasis was assessed 20 weeks after surgery.

290 facilitative glucose transporters (GLUTs) in glucose homeostasis was studied in mice using fluorine-1

291 ymatic activity in beta-cell development and glucose homeostasis, we generated mice overexpressing ei

292 which Nrf2 contributes to the maintenance of glucose homeostasis, we generated skeletal muscle (SkM)-

293 ed metabolic inefficiency and improvement of glucose homeostasis were independent of uncoupling prote

294 Body composition, food intake and glucose homeostasis were measured throughout the study a

295 ice on a standard chow diet, body weight and glucose homeostasis were not affected in Lin28aKI(VMH) o

296 ermore, the adverse effects of ATB2 cells on glucose homeostasis were partially dependent upon T cell

297 mating and on GD18.5, with no difference in glucose homeostasis, whereas the insulin sensitivity was

298 Thus, GBP surgery causes a resetting of glucose homeostasis, which reduces symptoms and neurohor

299 r islet development, and hence for postnatal glucose homeostasis, with some functional redundancy.

300 ing variant of apelin-36 that could modulate glucose homeostasis without impacting blood pressure (or