ライフサイエンスコーパス: glucose-regulated protein

1 derived endoplasmic reticulum (ER) chaperone glucose-regulated protein 170 (grp170) elicits potent an

2 We found that glucose-regulated protein 170 (Grp170), the largest stre

3 a chain (IFN-gammaRalpha), and the chaperone glucose-regulated protein 58 (GRP58/ER-60/ERp57).

4 that the 74-78-kDa protein(s) is related to glucose-regulated protein 75 (GRP-75), a member of the h

5 the voltage-dependent anion channel (VDAC)-1/glucose-regulated protein 75 (Grp75)/inositol 1,4,5-trip

6 ndent anion channel 1), the GRP75 (chaperone glucose-regulated protein 75), and the IP3R1 (inositol-1

7 ion of cell surface heat shock protein (HSP) glucose regulated protein 78 kDa (GRP78) was utilized fo

8 rotein chaperones (heat shock protein 70 and glucose regulated protein 78), and the antioxidant enzym

9 ss pathway mediated by the protein chaperone glucose regulated-protein 78 (GRP78).

10 In contrast, the expression level of glucose-regulated protein 78 (GRP 78) in RAW and HARM ce

11 lation of X-box-binding protein 1 (XBP1) and glucose-regulated protein 78 (GRP 78), and nuclear trans

12 was evaluated by measuring the expression of glucose-regulated protein 78 (GRP78 [BiP]) and editing o

13 chaperones such as Ig binding protein (BiP)/glucose-regulated protein 78 (GRP78) and by attenuating

14 MT expression inhibited homocysteine-induced glucose-regulated protein 78 (GRP78) and C/EBP-homologou

15 Specifically, glucose-regulated protein 78 (Grp78) and spliced X-box b

16 CRIPTO and its signaling partner glucose-regulated protein 78 (GRP78) are highly expresse

17 Previously, we identified endothelial cell glucose-regulated protein 78 (GRP78) as a receptor for M

18 Here, we have identified glucose-regulated protein 78 (GRP78) as what we believe

19 High glucose-regulated protein 78 (GRP78) expression contribu

20 ors strongly induce the transcription of the glucose-regulated protein 78 (grp78) gene, which encodes

21 We investigated the potential role of glucose-regulated protein 78 (GRP78) in mediating estrog

22 This study is to investigate the role of glucose-regulated protein 78 (GRP78) in the pulmonary mi

23 The glucose-regulated protein 78 (GRP78) is a plasminogen (P

24 Glucose-regulated protein 78 (GRP78) is an endoplasmic r

25 Glucose-regulated protein 78 (GRP78) mRNA levels were co

26 50-kDa oxygen-regulated protein (ORP150) and glucose-regulated protein 78 (GRP78)) is induced by NSAI

27 s identified as the surface membrane form of glucose-regulated protein 78 (GRP78), a member of the he

28 Glucose-regulated protein 78 (GRP78), a molecular chaper

29 This screen led to our identification of glucose-regulated protein 78 (GRP78), an endoplasmic ret

30 psies, staining of 4-hydroxynonenal (4-HNE), glucose-regulated protein 78 (Grp78), and C/EBP-homologo

31 determined by mass spectrometry analysis as glucose-regulated protein 78 (Grp78), indicating the sur

32 Ig binding protein (BiP), also known as glucose-regulated protein 78 (GRP78), is a critical ER c

33 influence expression of ERSR genes, such as glucose-regulated protein 78 (GRP78), that contribute to

34 P1 induces certain ER-targeted proteins, eg, glucose-regulated protein 78 (GRP78), that help resolve

35 approach and cell biology techniques for the glucose-regulated protein 78 (GRP78), the spliced X-box-

36 Alpha2M* binds to cell surface-associated glucose-regulated protein 78 (GRP78), which activates do

37 es, glucose-regulated protein 94 (GRP94) and glucose-regulated protein 78 (GRP78).

38 elial cells (MvEC) in a manner that requires glucose-regulated protein 78 (GRP78).

39 endoplasmic reticulum (ER) chaperone protein glucose-regulated protein 78 (GRP78)/binding immunoglobu

40 Glucose-regulated protein 78 (GRP78)/BiP is a multifunct

41 forms a complex with the molecular chaperone glucose-regulated protein 78 (GRP78, also known as BiP),

42 volved in protein quality control, including glucose-regulated protein 78 (GRP78/BiP), a regulator of

43 ol intragastrically exhibited an increase in glucose-regulated protein 78 and inositol-requiring enzy

44 Glucose-regulated protein 78 and protein disulfide isome

45 the voltage-dependent anion channel and the glucose-regulated protein 78 have been identified as pla

46 ssion of heat shock protein 72 kDa (HSP-72), glucose-regulated protein 78 kDa (GRP-78), and GRP-94 in

47 e have previously demonstrated the role that glucose-regulated protein 78 kDa (GRP78) acetylation and

48 In such glioma cancer cells, the glucose-regulated protein 78 kDa (GRP78) is particularly

49 Overexpression of glucose-regulated protein 78 kDa in the liver abolished

50 and genetic (overexpression of the chaperone glucose-regulated protein 78 kDa) approaches.

51 tion with the SR/ER-resident protein, GRP78 (glucose-regulated protein 78 kDa).

52 nvolved in adiponectin maturation, including glucose-regulated protein 78 kDa, protein disulfide isom

53 The chaperone GRP78/BiP (glucose-regulated protein 78 kDa/binding immunoglobulin

54 did not induce HO-1 mRNA expression, whereas glucose-regulated protein 78 mRNA was increased.

55 between voltage-dependent anion channel and glucose-regulated protein 78 on the surface of 1-LN huma

56 ess response, the unfolded protein response (glucose-regulated protein 78 pathway), and the ER overlo

57 endoplasmic reticulum (ER) chaperones GRP78 (glucose-regulated protein 78) and GRP94 (glucose-regulat

58 In addition, we identified GRP78 (glucose-regulated protein 78) and protein-disulfide isom

59 SERCA expression and increased expression of glucose-regulated protein 78, C/EBP homologous protein,

60 Here, we report that glucose-regulated protein 78, exposed on cell surfaces o

61 n-containing protein 2, elongation factor 2, glucose-regulated protein 78, transketolase, and succiny

62 on localized in the N-terminal domain of the glucose-regulated protein 78, whereas microplasminogen d

63 caspase-7, consistent with the disruption of glucose-regulated protein 78-procaspase-7 complexes.

64 channel and microplasminogen does so via the glucose-regulated protein 78.

65 does so through the C-terminal domain of the glucose-regulated protein 78.

66 ild-type gB, gB deltaI, and gB KNPm, but the glucose-regulated proteins 78 (BiP) and 94 formed stable

67 R, the ER-targeted cytoprotective chaperones glucose-regulated proteins 78 and 94 (GRP78 and GRP94),

68 g immunoglobulin heavy chain-binding protein/glucose-regulated protein, 78 kDa and CCAAT/enhancer bin

69 atrix identified several proteins, including glucose regulated protein-78 kDa (GRP-78), heterogeneous

70 Glucose-regulated protein-78 (GRP-78) is an endoplasmic

71 process is initiated by DMP1 binding to the glucose-regulated protein-78 (GRP-78) localized on the p

72 doplasmic reticulum stress signals including glucose-regulated protein-78 (GRP78), activating transcr

73 s by binding to the stress response protein, glucose-regulated protein-78 (GRP78), expressed at the s

74 surface complex with the HSP70 family member glucose-regulated protein-78 (GRP78).

75 sed expression of chaperone proteins such as glucose-regulated protein-78 and activation of caspase-1

76 Glucose regulated protein 94 (Grp94) is the endoplasmic

77 ons of the utility of peptide complexes with glucose regulated protein 94 (GRP94, also known as gp96)

78 6 (ATF6) and induction of the ER chaperones, glucose-regulated protein 94 (GRP94) and glucose-regulat

79 roles of the endoplasmic reticulum chaperone glucose-regulated protein 94 (GRP94) are poorly understo

80 duction of both IGF-I and IGF-II, we ablated glucose-regulated protein 94 (GRP94) in murine striated

81 Glucose-regulated protein 94 (GRP94) is a major endoplas

82 Glucose-regulated protein 94 (GRP94) is an endoplasmic r

83 zed that the ER-resident molecular chaperone glucose-regulated protein 94 (GRP94) is part of this qua

84 pliced X-box-binding protein 1 (sXBP-1), the glucose-regulated protein 94 (GRP94), and the calreticul

85 The ER-resident Hsp90 isoform, glucose-regulated protein 94 (Grp94), promotes the aggre

86 The human HSP90 isoform, glucose-regulated protein 94 (GRP94), resides in the end

87 ted knockdown strategies, we determined that glucose-regulated protein 94 (Grp94), the ER equivalent

88 Tumor-derived glucose-regulated protein 94 (GRP94/gp96) has shown grea

89 Glucose-regulated protein 94 (GRP94/gp96), the endoplasm

90 78 (glucose-regulated protein 78) and GRP94 (glucose-regulated protein 94), and the ER lectins calnex

91 The 78 kDa-glucose regulated protein, a chaperone molecule, was kno

92 and interactions with the cochaperone 78-kDa glucose-regulated protein (binding immunoglobulin protei

93 Notably, ER stress markers glucose-regulated protein, C/EBP homolog protein, splice

94 For example, cancer progression requires glucose regulated protein (GRP) 78 for cancer cell survi

95 Glucose Regulated Protein (GRP) 94 and GRP78 are critica

96 s proteins, heat shock protein (hsp) 110 and glucose-regulated protein (grp) 170, have shown them to

97 Glucose-regulated protein (Grp) 94 depletion reduces mut

98 epend on the endoplasmic reticulum chaperone glucose-regulated protein (GRP) 94.

99 Another SDK activity was copurified with glucose-regulated protein (GRP) and heat shock proteins

100 ion of stress proteins or chaperones such as glucose-regulated protein (GRP) and protein-disulphide i

101 uding stress response genes belonging to the glucose-regulated protein (grp) family.

102 tion block, the transcription of a family of glucose-regulated protein (GRP) genes encoding endoplasm

103 (2+) store, the transcription of a family of glucose-regulated protein (GRP) genes encoding ER chaper

104 y, can constitutively induce the promoter of glucose-regulated protein (grp) genes through activation

105 nitiation factor-2alpha (phospho-eIF2alpha), glucose-regulated protein (GRP)-78, and GRP94; and (b) t

106 ases in the mRNA levels of the ER chaperones glucose-regulated protein (grp)78/immunoglobulin-binding

107 Of 1176 toxicology-related genes, glucose-regulated proteins (GRP-78 and -94), growth arre

108 The 170 kDa glucose-regulated protein (grp170) is an endoplasmic ret

109 he other as its mitochondrial homologue, the glucose-regulated protein grp75.

110 tracts of irradiated glioma cells identified glucose-regulated protein GRP78 as the receptor target f

111 The glucose-regulated protein GRP78, a major endoplasmic ret

112 Upregulation of UPR proteins, such as the glucose-regulated protein Grp78, induced the formation o

113 that BIK selectively forms complex with the glucose-regulated protein GRP78/BiP, a major ER chaperon

114 he MDA-7/IL-24 and PERK chaperone BiP/78-kDa glucose regulated protein (GRP78), and overexpression of

115 ostate cancer patients identified the 78-kDa glucose-regulated protein (GRP78) as one such target.

116 This study is to explore the role of 78 kD glucose-regulated protein (GRP78) in the development of

117 c supplementation of the ER chaperone 78-kDa glucose-regulated protein (GRP78) in the SFO.

118 78 kDa glucose-regulated protein (Grp78) is a heat shock protei

119 We show that the cell surface 78-kDa glucose-regulated protein (GRP78), a receptor that binds

120 corresponded to a M(r) approximately 78,000 glucose-regulated protein (GRP78), was observed.

121 pha-2-macroglobulin, and for SNTRVAP, 78-kDa glucose-regulated protein (GRP78).

122 h resulted in the upregulation of the 78-kDa glucose-regulated protein (GRP78).

123 Glucose-regulated protein (GRP78)/BiP, a major chaperone

124 damage-inducible protein 34 (GADD34), 78-kDa glucose-regulated protein (GRP78)/BiP, inositol-requirin

125 -regulation of chaperones such as the 78-kDa glucose-regulated protein (GRP78, also referred to as Bi

126 erone calreticulin, but not calnexin, 78 kDa glucose-regulated protein (Grp78/BiP) or protein disulfi

127 , we report that the stress-inducible 78-kDa glucose-regulated protein (GRP78/HSPA5), a key regulator

128 plasmic reticulum (ER) homologue, the 94 kDa glucose regulated protein (Grp94).

129 complex between p185c-erbB-2 and the 94-kDa glucose-regulated protein, GRP94, to which geldanamycin

130 Although the induction of the glucose-regulated proteins (GRPs) is commonly used as an

131 s with binding immunoglobulin protein/78-kDa glucose-regulated protein, in drug combination-treated c

132 xpressed in the endoplasmic reticulum, is a "glucose-regulated protein" induced by stress responses t

133 es encoding adaptive functions including the glucose-regulated proteins is induced.

134 PAS kinase (PASK) is a glucose-regulated protein kinase involved in the control

135 eptor-related protein (LRP) and cell surface glucose-regulated protein [Mr approximately 78000 (GRP78

136 ER also possesses a single large Hsp70, the glucose-regulated protein of 170 kDa (Grp170).

137 by the nucleotide exchange factors, Grp170 (glucose-regulated protein of 170kDa) and Sil1, both of w

138 Circulating autoantibodies against the glucose-regulated protein of 78 kDa (GRP78) are present

139 C/EBP-homologous protein), as well as GRP78 (glucose-regulated protein of 78 kDa) was examined in sev

140 Glucose-regulated protein of 94 kDa (GRP94), the endopla

141 MTJ-1 associates with a glucose-regulated protein of Mr approximately 78,000(GRP

142 cluding protein di-sulfide isomerase, 78 kDa glucose-regulated protein precursor, heat shock protein

143 ithelial cells (A549), keratin 18, the 78-kD glucose-regulated protein, trans-1, 2-dihyrobenzene-1,2-

144 onitis exhibited increased expression of the glucose-regulated proteins upregulated during ER stress

145 ulator binding immunoglobulin protein/78-kDa glucose-regulated protein was down-regulated, activating

146 endoplasmic reticulum stress marker, 78 kDa glucose-regulated protein, was up-regulated, whereas ant