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1 potent inhibitors of alpha-amylase and alpha-glucosidase.
2 tural inhibitors for alpha-amylase and alpha-glucosidase.
3 chanism-based covalent inhibitor of an alpha-glucosidase.
4 raldehyde-3-phosphate dehydrogenase and beta-glucosidase.
5 .2 nM) of the Thermotoga maritima TmGH1 beta-glucosidase.
6 coincubated with the recombinant human alpha-glucosidase.
7 l) displayed strong inhibition towards alpha-glucosidase.
8 e aglycones produced by hydrolysis with beta-glucosidase.
9 interpret the glucose dependence of GH1 beta-glucosidases.
10 the beetle myrosinase from other insect beta-glucosidases.
11 up to 76% sequence similarity to other beta-glucosidases.
12 for other glycoside hydrolase family 3 beta-glucosidases.
13 tly modify the nucleophile of retaining beta-glucosidases.
14 4.55, as found for most of the fungi of beta-glucosidases.
15 the extensive digestion by the mucosal alpha-glucosidases.
16 s of individual and collective mucosal alpha-glucosidases.
17 ding endoglucanases, exoglucanases, and beta-glucosidases.
19 n-degrading extracellular enzymes (beta-1, 4-glucosidase, 1, 4-beta-cellobiosidase, beta-D-xylosidase
27 Anthocyanin-rich extracts inhibited alpha-glucosidase (37.8%), alpha-amylase (35.6%), dipeptidyl p
28 enzymes with biological significance (alpha-glucosidase, acetylcholinesterase and butyrylcholinester
29 udy was to investigate how the mucosal alpha-glucosidases act with alpha-amylase to digest granular s
32 mbination of alpha-amylase and mucosal alpha-glucosidase activities, were applied to three granular m
38 -) mice, pharmacological inhibition of alpha-glucosidase activity almost completely abolished residua
40 noterpenes inhibited alpha-amylase and alpha-glucosidase activity and stimulated glucose uptake and l
41 al DeltaSPD0247 strain had reduced 6-phospho-glucosidase activity and was attenuated in growth on cel
42 ated changes in glycogen, glucose, and alpha-glucosidase activity are also found in spinal cord tissu
47 nd 17 muM, and also inhibited lysosomal beta-glucosidase activity in live cells at low-micromolar con
50 od-based assay to measure the level of alpha-glucosidase activity is the optimal initial test for con
55 l four subunits have alpha-1,4-exohydrolytic glucosidase activity, and the SI N-terminal subunit has
56 glucosidase enzymes (Delta3betaG) lacks beta-glucosidase activity, but efficiently induces cellulase
57 ne intracellular beta-glucosidase lacks beta-glucosidase activity, but efficiently induces cellulase
59 um and rye extracts inhibited (p<0.05) alpha-glucosidase activity, whereas barley and sorghum extract
62 tergent-independent membrane-associated beta-glucosidase activity; 3) was more variable among mouse t
63 lycosidase activity (GA) by 13.0%, alpha-1,4-glucosidase (AG) by 19.6%, beta-1,4-glucosidase (BG) by
64 vities of the three lysosomal enzymes (alpha-glucosidase (AG), beta-galactosidase (B-GAL) and beta-N-
65 the endoplasmic reticulum and vacuolar beta-glucosidases allows the rapid formation of free ABA in r
67 toprostanes (PhytoPs) on four enzymes: alpha-glucosidase, alpha-amylase, acetylcholinesterase, and bu
69 ted with metabolic syndrome, including alpha-glucosidase, amylase and lipase and exhibited antioxidan
70 ogical relevance of acid maltase (acid alpha-glucosidase, an enzyme that degrades lysosomal glycogen)
72 d the inhibitory effect of extracts on alpha-glucosidase and alpha-amylase activities were investigat
75 rdolino extracts exhibited the highest alpha-glucosidase and alpha-amylase inhibitory activity with I
76 antioxidant activities, inhibition of alpha-glucosidase and alpha-amylase, inhibition of angiotensin
77 mpare the levels of phenolic compounds, beta-Glucosidase and antioxidant activity during the ageing o
78 as selective competitive inhibitors of beta-glucosidase and are promising candidates as pharmacologi
79 al design to optimise the production of beta-glucosidase and convert glycosidic isoflavones in aglyco
80 green olives is due to the activity of beta-glucosidase and esterase during the first months of stor
83 e highest inhibition of alpha-amylase, alpha-glucosidase and lipase (IC50: 0.38mg/mL, 0.87mug/mL and
84 L-cholesterol peroxidation, as well as alpha-glucosidase and lipase activities were demonstrated, the
89 study was to monitor olive hydrolytic (beta-glucosidase) and oxidative (peroxydase, POX, and polyphe
90 nzyme, enzyme type (cellulase, pectinase, ss-glucosidase), and hydrolysis time (1, 4, 8, 24 h) on the
91 ritol B epoxide is an inhibitor of acid beta-glucosidase, and lowers glucosylceramide degradation.
92 xhibited specificity for almond-derived beta-glucosidase, and the 1-nonylazetidine 25 inhibited alpha
97 ribes novel preparations of immobilized beta-glucosidase as highly stable and active catalysts for in
99 y-2-fluoro-beta-glucosides react with a beta-glucosidase at rates differing by 10(6)-fold, despite th
101 owed promising results as inhibitor of alpha-glucosidase, being almost 9 times more effective than ac
102 ur) are both produced by E. coli, while beta-glucosidase (beta-gluco) is produced by Enterococcus spp
103 aucher disease is caused by mutations in the glucosidase, beta, acid gene that encodes glucocerebrosi
105 Case) due to biallelic mutations in the GBA (glucosidase, beta, acid) gene causes the classic manifes
108 lpha-1,4-glucosidase (AG) by 19.6%, beta-1,4-glucosidase (BG) by 11.1%, beta-1,4-xylosidase (BX) by 2
109 erms) against the potential activity of beta-glucosidase (BG), N-acetyl-glucosaminidase (NAG), and pe
110 d, we designed a chimeric cohesin-fused beta-glucosidase (BglA-CohII) that binds directly to the cell
113 primarily of stereochemistry-retaining beta-glucosidases but also contains a subfamily of beta-N-ace
114 opsis thaliana contain large amounts of beta-glucosidases, but the physiological functions of ER bodi
116 fy both catalytic residues of retaining beta-glucosidases by the combined use of cyclophellitol beta-
117 copyranoside hydrolysis by sweet almond beta-glucosidase can be generated based on 24 time-courses ta
119 zymes of intact heterotrophic biofilms, beta-glucosidase (carbon-cycling) and l-leucin aminopeptidase
120 to non-homologous (putative) retaining beta-glucosidases categorized in GH1 and GH116: GBA2, GBA3, a
121 on of both enzymes, as a membrane-bound beta-glucosidase could specifically digest soluble xyloglucan
122 D) is a metabolic myopathy due to acid alpha-glucosidase deficiency and characterized by extensive gl
123 iated uptake of recombinant human acid-alpha-glucosidase during ERT in mice with Pompe disease follow
124 lises the diglycosidase alpha-rhamnosyl-beta-glucosidase (EC 3.2.1.168) to quantitatively hydrolyse h
125 ntrations were associated with enhanced beta-glucosidase enzyme activities (V max ) but short-term dr
126 showed more than 80% inhibition of the alpha-glucosidase enzyme at a concentration of 40mg/mL (dry sa
127 tors of glucocerebrosidase (GCase), the beta-glucosidase enzyme deficient in Gaucher disease (GD).
128 matic activities, results show that the beta-glucosidase enzyme is the key enzyme responsible for the
130 assa mutant carrying deletions of three beta-glucosidase enzymes (Delta3betaG) lacks beta-glucosidase
131 mutant lacking genes encoding both the beta-glucosidase enzymes and cellodextrin transporters (Delta
132 ons of two genes encoding extracellular beta-glucosidase enzymes and one intracellular beta-glucosida
133 -4B is an iminosugar that inhibits the alpha-glucosidase family of enzymes and subsequently the foldi
136 que and shared roles of the individual alpha-glucosidases for alpha-glucans persisting after starch i
137 me and the immobilised cells containing beta-glucosidase, for 2h at 40 degrees C, promoted efficient
138 most potent (IC50: 0.25mug/mL) against alpha-glucosidase; Fraction IV from black turtle bean was the
140 to be low micromolar inhibitors of the alpha-glucosidase from baker's yeast with Ki's near to 2 muM.
143 expressed OeGLU, an oleuropein-specific beta-glucosidase from olive (Olea europaea), had enzymatic ki
144 i-casuarine is a strong inhibitor of alpha-d-glucosidase from rice and of rat intestinal sucrase.
145 n in the active site of the homologous alpha-glucosidase from Sulfolobus solfataricus resulted in a s
147 somal glycogen-hydrolyzing enzyme acid alpha-glucosidase (GAA) activity, which results in lysosomal g
148 or gene replacement therapy with acid alpha-glucosidase (GAA) has achieved only partial efficacy in
149 d to and degraded in lysosomes by acid alpha-glucosidase (GAA) in mammals, but it is unclear why and
150 disorder characterized by lack of acid-alpha glucosidase (GAA) resulting in ubiquitous lysosomal glyc
151 to improve lysosomal delivery of acid alpha-glucosidase (GAA), the enzyme deficient in patients with
152 d enzyme replacement therapy with acid alpha-glucosidase (GAA), which has been attributed to ineffici
155 dated the method by using the retaining beta-glucosidase GBA (CAZy glycosylhydrolase family GH30) and
157 -glucosidase GBA1 and the non-lysosomal beta-glucosidase GBA2 degrade glucosylceramide (GlcCer) to gl
158 xide (CBE), as well as the nonlysosomal beta-glucosidase (GBA2) inhibitor N-butyldeoxygalactonojirimy
161 caused by insufficient activity of acid beta-glucosidase (GCase) and the resultant glucosylceramide (
164 CBE-N2a) was created by inhibiting acid beta-glucosidase (GCase) in N2a cells with conduritol B epoxi
167 ion of exogenous noncellulosomal enzyme beta-glucosidase; however, because the cellulosome is adsorbe
168 his pathway in maize smut (Ustilago maydis), glucosidase I (Gls1) and glucosidase II beta-subunit (Ga
169 lacking Erv41-Erv46 function, the ER enzyme glucosidase I (Gls1) was mislocalized and degraded in th
171 e glucosidase (OsMOGS), an ortholog of alpha-glucosidase I in Arabidopsis, which trims the terminal g
172 nce capacity and effectively inhibited alpha-glucosidase (IC(50): 0.83 mg/ml) and pancreatic lipase (
173 pea showed inhibitory activity against alpha-glucosidase (IC50 6967 +/- 343 and 2885 +/- 85.4 mug/ml,
174 (bran) and 148.23 mug/ml (hulls)] and alpha-glucosidase [IC50, 62.1 mug/ml (bran) and 68.14 mug/ml (
176 structures of the main ERQC enzyme, ER alpha-glucosidase II (alpha-GluII; from mouse), alone and in c
177 and genetic approaches, we demonstrate that glucosidase II (GII) mediates glycan trimming of TRPP2.
180 sylation of N-glycans, and oppositely acting glucosidase II (GlucII), and that vIL-6 can promote prot
181 (Ustilago maydis), glucosidase I (Gls1) and glucosidase II beta-subunit (Gas2), are essential for it
183 unctions as the noncatalytic beta subunit of Glucosidase II, an endoplasmic reticulum (ER)-resident e
184 e we show that PYK10, the most abundant beta-glucosidase in A. thaliana root ER bodies, hydrolyzes in
187 Interestingly, expression of individual beta-glucosidases in Escherichia coli K-12 enabled this non-c
188 lpha-Amylase combined with the mucosal alpha-glucosidases in the intestinal extract showed higher glu
189 reatic alpha-amylases and four mucosal alpha-glucosidases, including N- and C-terminal subunits of bo
190 range of dietary NSP intake, although alpha-glucosidase increased on a resistant starch-enriched die
193 his study was to evaluate the in vitro alpha-glucosidase inhibition and antioxidant activity of hexan
194 his study was to evaluate the in vitro alpha-glucosidase inhibition and antioxidant activity of hexan
196 al platform based on a high-resolution alpha-glucosidase inhibition assay in combination with hyphena
197 variate data analysis, high-resolution alpha-glucosidase inhibition assays and HPLC-HRMS-SPE-NMR with
198 xtract of H. biflora (HBMe) showed 50% alpha-glucosidase inhibition at the concentration of 480.20 +/
199 ore investigated using high-resolution alpha-glucosidase inhibition profiling combined with high-perf
202 anticancer activity, alpha-amylase and alpha-glucosidase inhibition, angiotensin-converting-enzyme (A
205 ter fraction (WF) of ME was a stronger alpha-glucosidase inhibitor (EC50 2.9 mug/mL) than quercetin,
206 SMD, 0.33 [95% CI, 0.13 to 0.52]), and alpha-glucosidase inhibitor (SMD, 0.35 [95% CI, 0.12 to 0.58])
208 l" analogue would be a potent retaining beta-glucosidase inhibitor for those enzymes reacting through
209 tive synthesis of nectrisine, a potent alpha-glucosidase inhibitor, was carried out starting from but
213 phenolic sub-classes were more potent alpha-glucosidase inhibitors than the clinical drug, acarbose
215 litol aziridine-both covalent retaining beta-glucosidase inhibitors-we postulated that the correspond
220 lues following fermentation, while the alpha-glucosidase inhibitory activities ranged from 95.2 to 19
223 X2C gave a subfraction, with enhanced alpha-glucosidase inhibitory activity (IC50=6.15mug/mL), with
224 -bioassay/HPLC-HRMS-SPE-NMR showed the alpha-glucosidase inhibitory activity of A. nodosum, F. vesocu
226 oside-A showed concentration-dependent alpha-glucosidase inhibitory activity with IC50=35.01 mug/ml.
227 identification of three analytes with alpha-glucosidase inhibitory activity, and subsequent HPLC-HRM
232 d stronger antioxidant activity and an alpha-glucosidase inhibitory property than positive controls.
233 lemon myrtle fractions had pronounced alpha-glucosidase-inhibitory activities (IC(50): 0.30 and 0.13
235 In the present work Aspergillus niger beta-glucosidase is immobilized within nanoscale polymeric ma
236 Inhibition of alpha-amylase and/or alpha-glucosidases is a strategy for treatment of type 2 diabe
237 s found that only one of four predicted beta-glucosidases is required in a physiological context.
238 rological legacy alters the response of beta-glucosidase kinetics (i.e. type of inhibition) to short-
239 ucosidase enzymes and one intracellular beta-glucosidase lacks beta-glucosidase activity, but efficie
241 l-NBDNJ is able to enhance lysosomal alpha-glucosidase levels in Pompe disease fibroblasts, either
242 lic syndrome, including alpha-amylase, alpha-glucosidase, lipase and hydroxyl methyl glutaryl CoA red
243 compounds did not affect inhibition of alpha-glucosidase (maltase) activity, which remained relativel
244 n hydrolyzed to glucose by the mucosal alpha-glucosidases, maltase-glucoamylase (MGAM) and sucrase-is
245 and biallelic MOGS (mannosyl-oligosaccharide glucosidase) mutations (GenBank: NM_006302.2; c.[65C>A;
246 l synthase 2, 12-oxophytodienoate reductase, glucosidase, MYB transcription factor, and alcohol dehyd
248 at coded a putative mannosyl-oligosaccharide glucosidase (OsMOGS), an ortholog of alpha-glucosidase I
249 ties and inhibitory activities against alpha-glucosidase, pancreatic lipase and angiotensin I-convert
250 ct and its inhibiting activity against alpha-glucosidase, pancreatic lipase and hyaluronidase were de
251 e insect but can be cleaved by a spruce beta-glucosidase, PgbetaGLU-1, which releases the active agly
252 surfaces with OM inputs had the highest beta-glucosidase, phosphatase, NAGase and cellobiohydrolase a
253 The ability of olive endogenous enzymes beta-glucosidase, polyphenol oxidase (PPO) and peroxidase (PO
257 , and benzaldehyde by the action of the beta-glucosidase prunasin hydrolase (PH) and mandelonitirile
258 -bound drug for recombinant human alpha acid glucosidase (rhGAA) in plasma from patients suffering fr
259 y leaves was resistant to conversion by beta-glucosidase-rich ingredients, but was converted to apige
260 and the 1-nonylazetidine 25 inhibited alpha-glucosidase (Saccharomyces cerevisiae) with an IC(50) of
263 The IC(50) values show that the four alpha-glucosidase subunits could be differentially inhibited.
266 o-component defense system comprising a beta-glucosidase that activates oleuropein into a toxic gluta
267 ered was JMB19063, a novel three-domain beta-glucosidase that belongs to the GH3 (glycoside hydrolase
268 ) is an intestinal membrane-associated alpha-glucosidase that breaks down di- and oligosaccharides to
269 ropose to redefine GBA2 activity as the beta-glucosidase that is sensitive to inhibition by N-butylde
270 ta-glucanase, BT3312, and a periplasmic beta-glucosidase that targets primarily 1,6-beta-glucans.
271 on by mechanism-based inhibitors of GH1 beta-glucosidases that utilize a double displacement retainin
272 , the gene encoding mannosyl-oligosaccharide glucosidase (the first enzyme in the processing pathway
273 rients involves the action of 6-phospho-beta-glucosidase to convert them into usable monosaccharaides
275 ion of ICHO and ICOOH derivative pools after glucosidase treatment revealed that, in response to AgNO
277 resence of active polyphenoloxidase and beta-glucosidase was determined by HPLC and UV-Visible spectr
278 activity of pectin methyl esterase and beta-glucosidase was enhanced in ET-treated berry skins, sugg
281 tarch by mammalian recombinant mucosal alpha-glucosidases was observed which shows that these enzymes
285 mutation(s) in GBA, which encodes acid beta-glucosidase, were recruited at the SZMC Gaucher Clinic.
286 osomal acid maltase, two major hepatic alpha-glucosidases, were unaltered in L-G6pc(-/-) mice, pharma
288 er is known to secrete large amounts of beta-glucosidases, which have a variety of biotechnological a
289 se tolerance and stimulation of the GH1 beta-glucosidases will be crucial to improve their applicatio
290 highly specific inhibition of mammalian beta-glucosidase with a marked dependence of the potency upon
291 lted in the thermo-stabilization of the beta-glucosidase with an increase in optimum temperature and
292 lack currant and rowanberry, inhibited alpha-glucosidase with IC(50) values respectively of 20 and 30
293 were found to be potent inhibitors of alpha-glucosidase with IC50 values of 0.32 and 0.49 mug/ml.
294 found to be potent inhibitors of rice alpha-glucosidase with K(i) and IC(50) values in the nanomolar
296 mary and tertiary structures of two GH1 beta-glucosidases with distinct glucose dependence, some puta
297 ommercial samples were able to inhibit alpha-glucosidase, with EC(50) values lower than that found fo
298 ractions X1C and X2C notably inhibited alpha-glucosidase, with IC50=9.89 and 8.05mug/mL, respectively
300 s of volatiles released enzymatically with a glucosidase, (Z)-3-hexenyl beta-D-glucopyranoside and li
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