ライフサイエンスコーパス: glucosyl

1 tal structure of BT3312 in complex with beta-glucosyl-1,6-deoxynojirimycin revealed a TIM barrel cata

2 nosyl)hexoside and quercetin-3-O-(6''-acetyl)glucosyl-2''-sinapic acid.

3 (beta-D-glucosyl)3 and (beta-D-galactosyl)3 Yariv phenylglycosid

4 l auxiliary containing 1-(tetracetyl-alpha-D-glucosyl)-3-pivaloxymethylpyridinium perchlorate undergo

5 We have focused on the glucosyl-3-phosphoglycerate synthase (GpgS), a "retainin

6 The natural product 7-O-glucosyl-4'-hydroxyisoflavone (daidzin), isolated from t

7 deoxyglucosone-3-ene (3,4-DGE) isomers and 4-glucosyl-5,6-dihydroxy-2-oxohexanal (4-G,3-DG) were foun

8 metabolic pathway to transform the 5hmC into glucosyl-5-hydroxymethyl-2'-deoxycytidine (5-gmC) and ac

9 ATP-stimulated REase activity on T4 DNA with glucosyl-5-hydroxymethyl-cytosines (glc-5hmC) and T4gt D

10 e efficient and consistent pull-down of beta-glucosyl-5-hydroxymethylcytosine (beta-glu-5hmC), and se

11 y strain AB-1 is cyclodecakis-(1-->3)-beta-D-glucosyl, a cyclic beta-(1-->3)-linked decasaccharide in

12 e enzyme was specific for glucose-6-P as the glucosyl acceptor, and the Km for this substrate was app

13 Glucosyl alkyl gallates were shown previously to be bett

14 the reversible interconversion of trehalose (glucosyl-alpha,alpha-1,1-glucose) and maltose (glucosyl-

15 ucosyl-alpha,alpha-1,1-glucose) and maltose (glucosyl-alpha1-4-glucose).

16 ncluding the first reported synthesis of the glucosyl analogue of the bacterial antigen BbGL-II.

17 Coupling of 3 with the peracetylated glucosyl and galactosyl halides 12a,b and 26 afforded, a

18 little difference between the reactivity of glucosyl and galactosyl iodides.

19 he differences in inhibitory potency between glucosyl and glucosaminyl derivatives and also for the d

20 Perbenzylated N-phenyl trifluoroacetimidate glucosyl and heptosyl derivatives served as alpha-select

21 ion between the C2-O2 and C3-O3 bonds in the glucosyl and mannosyl donors and of the influence of thi

22 he corresponding 4,6-O-benzylidene-protected glucosyl and mannosyl donors, which are alpha- and beta-

23 se (alpha-Gal A) hydrolyze the sphingolipids glucosyl- and globotriaosylceramide, respectively, and m

24 ne 1-phosphate (S1P), PAF, psychosine (Psy), glucosyl-beta1'1-sphingosine (Glu-Sph), galactosyl-beta1

25 o-2-1,3-benzoxadiazol-4-yl)amino)hexanoyl)-D-glucosyl-beta1-1'-sphin gosine, a fluorescent GlcCer ana

26 quirements: we propose that spsL codes for a glucosyl-(beta1-->4)-glucuronosyl transferase in Sphingo

27 by thioglycosylation of a 6-S-acetyl-alpha-D-glucosyl bromide with the isothiouronium salt of 2,3,4,6

28 suggested that it can potentially generate a glucosyl buffer between maltose and hexose phosphate bec

29 n chains on the heteroglycan that acts as a "glucosyl buffer" to ensure a constant rate of sucrose sy

30 echanism, in which NAD(+) initially oxidizes glucosyl C4 of dTDP-glucose to NADH and dTDP-4-ketogluco

31 , a simultaneous kinetic characterization of glucosyl C5((1)H/(2)H) solvent hydrogen and C6((16)OH/(1

32 iants is due to the loss of control over the glucosyl C5-C6 bond rotation in the active site.

33 previously uncharacterized, enzyme-catalyzed glucosyl-C5 hydrogen-solvent exchange reaction of produc

34 demonstrate Asp135's role in protonating the glucosyl-C6(OH) during dehydration.

35 Our results show the glucosyl cap to have a single, well-defined conformation

36 be largely unaffected by the presence of the glucosyl cap.

37 wever, one is remarkably homologous to human glucosyl ceramidase, an enzyme involved in the ceramide

38 The mutant has an enrichment in glucosyl ceramide and cell surface glycoconjugates beari

39 se (GCase) leads to abnormal accumulation of glucosyl ceramide in lysosomes and the development of th

40 amides and a corresponding increase in their glucosyl ceramide precursors.

41 We report that inactivation of glucosyl ceramide synthase (GCS), either by RNAi or with

42 First, inhibition of glucosyl ceramide synthase by a new specific inhibitor o

43 ids sphingomyelin, lactosyl cerebroside, and glucosyl cerebroside tended to inhibit full pore enlarge

44 ic studies on ternary complexes in which the glucosyl component is substituted by the putative transi

45 The binding results using the O-linked glucosyl conjugate were consistent with a simple model i

46 nd subsequent hydrolysis of the five alpha-d-glucosyl-d-fructoses by K. pneumoniae.

47 e but also its five linkage-isomeric alpha-d-glucosyl-d-fructoses: trehalulose, turanose, maltulose,

48 nd phenyl derivatives induce weakly, but the glucosyl derivative does not.

49 nses with imino compounds (cyclo-DOPA or its glucosyl derivatives), or amines and/or their derivative

50 anylated polyglycerol-phosphate linked to di-glucosyl-diacylglycerol.

51 Cyclodecakis-(1-->3)-beta-D-glucosyl did not suppress the fungal beta-glucan-induced

52 Two ether glucosyl diglyceride analogs were synthesized, and their

53 ell-inhibitory profile of these ether-linked glucosyl diglycerides strengthens the hypothesis that su

54 The interaction of a C-glucosyl dihydrochalcone with a POPC membrane was modele

55 A library of C-glucosyl dihydrochalcones and their dihydrochalcone and

56 r assay to measure the decay rate of ([(14)C]glucosyl)-diphytanylglyceroldiether (GlcDGD) as an analo

57 toluene solvent mixture, ethyl 1-thio-beta-d-glucosyl disaccharide donors having 6-O-benzyl group(s)

58 bearing the peripheral L-vancosaminyl-1,2-D-glucosyl disaccharide that contain changes to a key sing

59 hing activity when incubated with sucrose as glucosyl donor and (oligo-)dextran as acceptor, transfer

60 approximately 7 mm when UDP-glucose was the glucosyl donor and approximately 4 mm with GDP-glucose.

61 The Km for UDP-glucose as the glucosyl donor was approximately 18 mm, and that for GDP

62 h cellulase and adding soluble starch as the glucosyl donor.

63 othiopyranoside were prepared and studied as glucosyl donors at -60 degrees C in dichloromethane with

64 med-disarmed coupling between two benzylated glucosyl donors by tuning their reactivity.

65 ently protected beta-linked 2-O-glycosylated glucosyl donors carrying bulky tert-butyldimethylsilyl g

66 ucleoside diphosphate glucose derivatives as glucosyl donors, i.e. ADP-glucose, CDP-glucose, GDP-gluc

67 banana lectin also recognizes beta1,6-linked glucosyl end groups (gentiobiosyl groups) as occur in ma

68 carbose-complexed, and trapped 5-fluoro-beta-glucosyl-enzyme intermediate forms revealed extended sub

69 y 3-fold, while accelerating turnover of the glucosyl-enzyme intermediate several hundredfold.

70 Abscisic acid glucosyl ester (ABA-GE) is a hydrolyzable ABA conjugate

71 ganelles (gut granules), as anthranilic acid glucosyl esters--not, as previously surmised, the damage

72 aring kinetic results obtained using alpha-D-glucosyl fluoride (GF) and maltooligosaccharides as subs

73 tain wild-type level activity toward alpha-D-glucosyl fluoride hydrolysis.

74 nism-based inhibitor 2-deoxy-2-fluoro-beta-D-glucosyl fluoride.

75 wild-type and Trp120-->Phe GAs using alpha-D-glucosyl fluoride.

76 -binding site in a hydrophobic cleft and the glucosyl function binding to a hydrophobic patch immedia

77 ne, or in the hydroxylysine-linked glycoside glucosyl-galactose in the diabetic kidneys.

78 ecretion and a decrease in hydroxylysine and glucosyl-galactosyl hydroxylysine.

79 ding interactions between the enzyme and the glucosyl group in subsite -1, particularly with the 4'-

80 The glucosyl group of the substrate is bound to the protein

81 IroB transfers glucosyl groups from uridine-5'-diphosphoglucose to C5 o

82 that this lectin also binds to the reducing glucosyl groups of beta-1,3-linked glucosyl oligosacchar

83 de for the interconversion of galactosyl and glucosyl groups.

84 grade both alpha-glucosy-HMC T4 DNA and beta-glucosyl-HMC T4 DNA, whereas no activity was observed ag

85 fied thymidine residue termed base J (beta-d-glucosyl-HOMedU).

86 ked but not by a soluble beta-(1-->3)-linked glucosyl homopolysaccharide (pustulan and laminarin, res

87 By using various soluble glucosyl homopolysaccharides as inhibitors of SP-D carbo

88 e and proton donor, with endoglucanases from glucosyl hydrolase family 12.

89 clude infection by T4 ip1(-) phage and other glucosyl-hydroxymethylcytosine (glc-HMC) Tevens lacking

90 at the glucosylated thymine DNA base (beta-d-glucosyl-hydroxymethyluracil or base J) is present withi

91 Base J (beta-D-glucosyl-hydroxymethyluracil) replaces 1% of T in the Le

92 Base J (beta-D-glucosyl-hydroxymethyluracil) was discovered in the nucl

93 Beta-D-Glucosyl-hydroxymethyluracil, also called base J, is an

94 Base J, beta-d-glucosyl-hydroxymethyluracil, is an epigenetic modificat

95 ynthesis of the modified thymine base beta-D-glucosyl-hydroxymethyluracil, or J, within telomeric DNA

96 We identified 4-O-beta-D-glucosyl-indol-3-yl formamide (4OGlcI3F) as a pathogen-i

97 ipids containing alpha-linked galactosyl and glucosyl moieties have been shown to possess unique immu

98 sferase activity, DPE2, believed to transfer glucosyl moieties to a complex heteroglycan prior to the

99 ucuronate to the 2''-hydroxyl group of the 3-glucosyl moiety of cyanidin 3-O-6''-O-malonylglucoside w

100 ese pockets in stacking interaction with one glucosyl moiety.

101 W1065 provides stacking interactions to the glucosyl moiety.

102 s of cellobiose, CbpA releases one activated glucosyl molecule while conserving one ATP molecule per

103 of binding of the two groups (galactosyl and glucosyl) of oligosaccharides to the two respective sets

104 reducing glucosyl groups of beta-1,3-linked glucosyl oligosaccharides (e.g. laminaribiose oligomers)

105 preferred conformation for alpha(1-4)-linked glucosyl polymers.

106 analogues with different substituents at the glucosyl position.

107 dentified as branched trisaccharides, with a glucosyl residue alpha-(1 --> 2)-linked to the acceptor'

108 ntially hydrolyzes the non-reducing terminal glucosyl residue from (1-->3)-beta-D-glucans, but also h

109 .1.25), this enzyme strictly transferred one glucosyl residue from alpha(1-->4)-glucans in disproport

110 ptor, the enzyme efficiently transferred the glucosyl residue from sucrose to linear alpha-(1-->6) de

111 dded the first xylosyl residue to the fourth glucosyl residue from the reducing end of both acceptors

112 The presence of a second alpha-linked glucosyl residue is also critical for strong inhibition

113 nteractions with the protein, whereas the +3 glucosyl residue makes relatively few contacts with the

114 forming subsite -1, involved in binding the glucosyl residue of sucrose and catalysis, are strictly

115 e I in Arabidopsis, which trims the terminal glucosyl residue of the oligosaccharide chain of nascent

116 Nss catalyzed the direct transfer of the glucosyl residue to the GlcNAc-modified Fap1 substrate i

117 rbon atom of the covalently bound subsite -1 glucosyl residue, thus explaining the unique lyase activ

118 ed affinity for the second covalently linked glucosyl residue.

119 risaccharides can be bound by their internal glucosyl residues and that binding also occurs through i

120 e consistent with a model in which alternate glucosyl residues are transiently or permanently twisted

121 removal may prevent the misincorporation of glucosyl residues for mannosyl residues into the glycoco

122 sidic bonds to release non-reducing terminal glucosyl residues from glycosides and oligosaccharides,

123 and a beta-(1 --> 2)-linked side chain of d-glucosyl residues in disaccharide repeating units.

124 nt extraction, associates with it to add the glucosyl residues that complete the cellotriosyl and hig

125 d that GtfC catalyzed the direct transfer of glucosyl residues to Srr2-GlcNAc.

126 nd (oligo-)dextran as acceptor, transferring glucosyl residues to the acceptor via a ping-pong bi-bi

127 n lectins recognize internal alpha1,3-linked glucosyl residues, which occur in the linear polysacchar

128 the final glycosylation step by transferring glucosyl residues.

129 through differential binding to nonterminal glucosyl residues.

130 the final glycosylation step by transferring glucosyl residues.

131 e of unbranched (1,3)- and (1,4)-linked beta-glucosyl residues.

132 3-acetic acid and the disaccharide rutinose (glucosyl-rhamnose).

133 lactosyl-rhamnosyl-glucoside, kaempferol-3-O-glucosyl-rhamnosyl-glucoside, theaflavin, and theobromin

134 ut not in GH7 endoglucanases, at the leading glucosyl ring provide the thermodynamic driving force fo

135 ith the 2- and 3-equatorial OH groups on the glucosyl ring.

136 ily as the SA 2-O-beta-D-glucoside (SAG) and glucosyl salicylate (GS).

137 ated by standard quantitative PCR (qPCR) and glucosyl-sensitive restriction enzyme digestion (gRES-qP

138 ear beta-(1,6)-glucan chains with beta-(1,3)-glucosyl side chain with an average of 1 branch point ev

139 hyl cellulose (CM-cellulose), with K259H (in glucosyl subsite -2) creating the highest activity (370%

140 sidic linkages of glycogen and related alpha-glucosyl substrates within lysosomes.

141 he hysteresis of freezing in the presence of glucosyl sugars, namely glucose, maltose, and trehalose.

142 Recently, the use of glucosyl sulfamate inhibitors has shown promise as selec

143 neered hCA IX-mimic in complex with selected glucosyl sulfamates and structurally rationalize mechani

144 chip6 expressed in E. coli catalyses glucosyl transfer from UDP-glucose to cholesterol.

145 ich are known to serve as donors in acyl and glucosyl transfer reactions in the vacuole, where Os9BGl

146 se the plant heteroglycan as an acceptor for glucosyl transfer.

147 Glycosylation of 5-hmC residues by beta-glucosyl transferase (beta-GT) can make CCGG residues in

148 talyzed by the enzyme, UDPG-indol-3-ylacetyl glucosyl transferase (IAA-glucose-synthase).

149 yanin-related gene UDP glucose:flavonoid 3-O-glucosyl transferase (UFGT), which was dependent of the

150 Conversely, in E. amylovora, the homologous glucosyl transferase activity appears to be relatively i

151 ne, which encodes a protein with homology to glucosyl transferase enzymes, is expressed within 15 min

152 ignificantly attenuated by the inhibition of glucosyl transferase in tumor cells, suggesting that tum

153 wartii is non-functional, while the terminal glucosyl transferase is catalytically active.

154 charide glycosyl transferase G) encoding the glucosyl transferase of GC that initiates the beta chain

155 xpression of CsbB, a putative membrane-bound glucosyl transferase that is partially controlled by the

156 d 5' to 3' DNA exonuclease), alpha-gt (alpha-glucosyl transferase), gp47.1 (uncharacterized), and Nrd

157 Starch-branching enzyme (SBE), a glucosyl transferase, is required for the highly regular

158 ine at position 304 (F304S) of the alpha 1,3 glucosyl transferase.

159 id sequence are with members of family 31 of glucosyl transferase.

160 t completely lacks base J but still contains glucosyl-transferase activity.

161 An Arabidopsis mutant lacking the glucosyl-transferase, STARCH SYNTHASE 4 (SS4) is impaire

162 identified as encoding glucuronosyl-(B1-->4)-glucosyl transferases based on reciprocal genetic comple

163 hyl transfers (SAM), prenyl transfers (IPP), glucosyl transfers (UDP-glucose), and electron and ADP-r

164 >6)-linked but not alpha/beta-(1-->3)-linked glucosyl trisaccharides can be bound by their internal g

165 beta-(1-->4)-, and alpha/beta-(1-->6)-linked glucosyl trisaccharides into the SP-D carbohydrate recog

166 5-O-glucosyl-tylactone was also obtained, showing that endog

167 The extent of [4,5,6-(13)C(3)]glucosyl unit enrichment in glycogen was enhanced by ins

168 we show that DPE2 transfers the non-reducing glucosyl unit from maltose to glycogen by a ping-pong me

169 ferent glucansucrases and is close to the +1 glucosyl unit in the crystal structure of GTF180-DeltaN

170 The glycogen (glucosyl unit) concentration was 38.1 mmol/kg wet weight

171 red with Con (117 +/- 39 vs. 240 +/- 32 mmol glucosyl units (kg DM)(-1), respectively; P < 0.01), but

172 = 9.2 +/- 1.1 vs. 3 min = 22.3 +/- 4.0 mmol glucosyl units (kg dry muscle)(-1) min(-1), P < 0.05).

173 co-oligosaccharides in which alpha1,3-linked glucosyl units are joined sequentially to maltose.

174 eared in glycogen in carbon positions 4-6 of glucosyl units but none in positions 1-3.

175 ly 70 (GH70) that catalyzes the transfer ofd-glucosyl units from sucroseto dextrans or gluco-oligosac

176 , the transmembrane subunit MalF binds three glucosyl units from the nonreducing end of the sugar.

177 lyzes (1-->2)-, (1-->6)-, and (1-->4)-beta-D-glucosyl units in decreasing order of activity.

178 he peak intensity of the C1 resonance of the glucosyl units in muscle glycogen during a 6-h hyperglyc

179 wed to synthesize variable amounts of 1-[13C]glucosyl units of glycogen.

180 activity, capable of transferring one of the glucosyl units of maltose to glycogen or amylopectin and

181 hat consists essentially of only xylosylated glucosyl units, with no further substitutions.

182 t hydrolyzed CMC to fragments averaging 10.7 glucosyl units.

183 lZ hydrolyzed CMC to fragments averaging 3.6 glucosyl units.

184 elY hydrolyzed CMC to products averaging 2.3 glucosyl units.

185 an agent with R = isopropyl and R' = beta-D-glucosyl was prepared and shown to generate nitric oxide

186 rminated and grown in medium containing beta-glucosyl Yariv reagent (beta GlcY), a synthetic phenyl g

187 rentiating xylem of pine trees by using beta-glucosyl Yariv reagent (beta-glcY) and was recognized by

188 e arabinogalactan-protein (AGP) binding beta-glucosyl Yariv reagent (betaGlcY) that disrupts cell elo

189 l/Ara-rich motifs not recognized by the beta-glucosyl Yariv reagent but interacting with the peanut a

190 the traditional AGP-diagnostic reagent beta-glucosyl Yariv reagent, and they are also recognized by

191 -protein complex that binds poorly with beta-glucosyl Yariv reagent, and two glycoproteins.