ライフサイエンスコーパス: glucuronate

1 genase (UGDH) catalyzes the formation of UDP-glucuronate.

2 etermined in the presence of the substrate D-glucuronate.

3 )) for galacturonate was lower than that for glucuronate.

4 erates in a pathway distinct from that for d-glucuronate.

5 mination of fluoride from 3-deoxy-3-fluoro-D-glucuronate.

6 lohexan-(1,2,3,4,5,6-hexa)-ol substrate to d-glucuronate.

7 e [myo-inositol (MI)] by four electrons to d-glucuronate.

8 talyzes the formation of UDP-xylose from UDP-glucuronate.

9 but grew on the more oxidized carbon source glucuronate.

10 to identify and functionally express a UDP-D-glucuronate 4-epimerase (GAE1) from Arabidopsis.

11 ssays on cell extracts localized total UDP-D-glucuronate 4-epimerase and recombinant GAE1 activity ex

12 ursor UDP-D-glucuronic acid by the action of glucuronate 4-epimerases (GAEs).

13 h) (EC 1.1.1.22) converts UDP-glucose to UDP-glucuronate, a critical component of the glycosaminoglyc

14 drogenase (UGDH) oxidizes UDP-glucose to UDP-glucuronate, an essential precursor for production of hy

15 uperfamily, catalyzes the isomerization of D-glucuronate and D-fructuronate.

16 hat unlike Bh0705, Bh0493 can utilize both d-glucuronate and d-galacturonate as substrates.

17 P2 controls eda induction on glucuronate and galacturonate and is regulated by KdgR.

18 to Escherichia coli and Erwinia chrysanthemi glucuronate and galacturonate metabolic genes were found

19 t grow on fructuronate but grows normally on glucuronate and gluconate.

20 was reduced to 25-35 mM by replacement with glucuronate and may, therefore, be attributed to Cl(-)-H

21 fects on the kinetic constants with [2-2H]-D-glucuronate and the effects of changes in solvent viscos

22 rms UDP-d-xylose by decarboxylation of UDP-d-glucuronate, and has therefore been named UDP-d-apiose/U

23 ose, not glucose 6-phosphate; therefore, UDP-glucuronate arose predominantly by the action of UDP-glu

24 e enzymes, the turnover number (k(cat)) with glucuronate as a substrate was higher than that with gal

25 cherichia coli mutant incapable of consuming glucuronate as the sole carbon source but capable of gro

26 gulated by the availability of activated UDP-glucuronate, as determined by relative Udpgdh expression

27 Glucuronate, because it proceeds through a fructuronate

28 ibrium between UDP-D-galacturonate and UDP-D-glucuronate but did not epimerize UDP-D-Glc or UDP-D-Xyl

29 d-apiose (UDP-d-apiose) is formed from UDP-d-glucuronate by decarboxylation and re-arrangement of the

30 being located adjacent to genes involved in glucuronate catabolism, gntP does not encode a glucurona

31 Based on the determination of the OccK2-glucuronate co-crystal structure, we identify the channe

32 t in the transport of GS conjugates but also glucuronate conjugates after heterologous expression in

33 anticancer drugs and efflux glutathione and glucuronate conjugates from the cell.

34 ione and the cyclopentapeptide BQ123 but not glucuronate conjugates such as 17beta-estradiol 17-(beta

35 cocholate as well as several glutathione and glucuronate conjugates.

36 UDP-glucuronate decarboxylase (UGD) catalyzes the formation

37 r polypeptide identified it as a form of UDP-glucuronate decarboxylase and functionality was establis

38 The UDP-glucuronate decarboxylase was purified as polypeptides o

39 6-hexa)-ol substrate (myo-inositol, MI) to d-glucuronate (DG).

40 er via conjugation of ethanol with activated glucuronate, EtG remains detectable in serum, plasma, an

41 of XynC crystal soaks with the simple sugar glucuronate (GA) and the tetrameric sugar 4-O-methyl-ald

42 E. coli K-12 eda mutants (unable to utilize glucuronate, galacturonate, and gluconate) were construc

43 cetylglucosamine > N-acetylneuraminic acid = glucuronate > mannose > fucose > ribose.

44 to be formed by the 4-epimerization of UDP-D-glucuronate; however, no coding regions for the epimeras

45 e metabolism (P=9.0x10(-6)), and pentose and glucuronate interconversions (P=3.0x10(-6)) in pathogene

46 noid and flavonoid biosynthesis, pentose and glucuronate interconversions and starch and sucrose meta

47 reported using anomeric hydroxy and imidate glucuronate intermediates.

48 D-Glucuronate is a key metabolite in the process of detoxi

49 The loss of fluoride from 3-deoxy-3-fluoro-D-glucuronate is consistent with a stabilized carbanion at

50 ubstrate and product the hydrogen at C2 of D-glucuronate is transferred to the pro-R position at C1 o

51 O-6''-O-malonylglucoside, 19 microM) and UDP-glucuronate (Km, 476 microM).

52 heparinase III-like, cleaving at hexosamine-glucuronate linkages.

53 Glucuronate, mannose, fucose, and ribose appeared to be

54 H would then catalyze the addition of methyl glucuronate (MeGlcA) to complete the first instance of t

55 nization, including L-fucose, D-gluconate, D-glucuronate, N-acetyl-D-glucosamine, D-mannose, and D-ri

56 fter abstraction of the proton from either D-glucuronate or D-fructuronate during the isomerization r

57 Polyphenols are present as conjugates of glucuronate or sulfate, with or without methylation of t

58 synthesis is induced by growth on gluconate, glucuronate, or methyl-beta-D-glucuronide; phosphate lim

59 p62/Sqstm1 at Ser349 directs glucose to the glucuronate pathway, and glutamine towards glutathione s

60 The glucuronate probe was used to measure the turnover and s

61 , as would be predicted from a defect in UDP-glucuronate production.

62 de followed by base-mediated cleavage of the glucuronate protective groups.

63 Glucuronate represents an integral component of the glyc

64 he role of the free carboxylate group on the glucuronate residue, the enzymatic behavior on chondroit

65 ogen-dependent cells by treatment with a UDP-glucuronate scavenger.

66 se and apiose residues (all produced via UDP-glucuronate) stemmed from UDP-glucose, not glucose 6-pho

67 f arabinose, glucuronic acid, and especially glucuronate strengthen the primary cell wall by strongly

68 Sodium glucuronate substitution did not inhibit cytokine proces

69 metabolized and circulate in the organism as glucuronated, sulphated and methylated metabolites, disp

70 ant enzyme catalyzed the conversion of UDP-d-glucuronate to a mixture of UDP-d-apiose and UDP-d-xylos

71 hat utilizes a proton transfer from C-2 of D-glucuronate to C-1 that is initiated by the combined act

72 ichia coli, catalyzes the isomerization of d-glucuronate to d-fructuronate and d-galacturonate to d-t

73 catalyzes the reversible isomerization of D-glucuronate to D-fructuronate and of D-galacturonate to

74 latively specific for the isomerization of d-glucuronate to d-fructuronate, confirming this functiona

75 site base abstracts the proton from C2 of D-glucuronate to form a cis-enediol intermediate.

76 the enzymes responsible for conversion of D-glucuronate to L-gulonate, a key step in the ascorbate (

77 fic transfer of a glucuronosyl unit from UDP-glucuronate to the 2''-hydroxyl group of the 3-glucosyl

78 o induce the ExuR regulon, which encodes the glucuronate transporter, ExuT, and the first step in its

79 ucuronate catabolism, gntP does not encode a glucuronate transporter.

80 Galacturonate and glucuronate, two abundant hexuronic acids in pectin and

81 he 4e(-) oxidation of myo-inositol (MI) to D-glucuronate using a substrate activated Fe(II)Fe(III) si

82 s found in an operon for the metabolism of d-glucuronate, whereas Bh0493 is in an operon for the meta

83 rate constant (k(cat) = 1.9 x 10(2) s(-1) on glucuronate), which was more than twofold higher than th

84 ium tumefaciens, we developed an assay for D-glucuronate with a detection limit of 5 microM.

85 A simple and specific assay of D-glucuronate would be useful for studying these processes

86 In mammals, XK is the last enzyme in the glucuronate-xylulose pathway, active in the liver and ki

87 one of the products of MI catabolism via the glucuronate-xylulose pathway, induces an overexpression

88 id is further metabolized to xylitol via the glucuronate-xylulose pathway.