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1 sulfate to the iduronic acid but not to the glucuronic acid.
2 fated heparosan, a polysaccharide containing glucuronic acid.
3 DP-N-acetylglucosamine (UDP-GlcNAc), and UDP-glucuronic acid.
4 ansformed cells on minimal medium containing glucuronic acid.
5 h as hormones by reversible conjugation with glucuronic acid.
6 daily diet and environment by conjugation to glucuronic acid.
7 s two oxidations of UDP-glucose to yield UDP-glucuronic acid.
8 position 6 with glucuronic acid or rhamnosyl glucuronic acid.
9 d environmental chemicals via conjugation to glucuronic acid.
10 mediate that is synthesized by ArnA from UDP-glucuronic acid.
11 neurotoxic bilirubin by conjugating it with glucuronic acid.
12 a pathway for l-Ara4N biosynthesis from UDP-glucuronic acid.
13 e polysaccharide contained galactosamine and glucuronic acid.
14 the related IAG sequence, where G is alpha-D-glucuronic acid.
15 inked mannan substituted with D-xylose and D-glucuronic acid.
16 e HA or any other molecules known to contain glucuronic acid.
17 e hydroxyl groups in glycosidic linkage with glucuronic acid.
18 ha-D-glucose, beta-D-glucose, rhamnose and D-glucuronic acid.
19 lycyrrhizin (GL) by hydrolysing one terminal glucuronic acid.
20 polymer from UDP-N-acetylglucosamine and UDP-glucuronic acid.
21 cid, rhamnose, mannose, xylose and traces of glucuronic acid.
22 UDP-glycosyltransferase UGT co-substrate UDP-glucuronic acid.
23 applied to develop a synthesis of protected glucuronic acid 1, a key intermediate in the synthesis o
24 ed a rare sequence consisting of consecutive glucuronic acid 2-O-sulfate residues as selectively targ
26 ies against carbohydrate epitopes, including glucuronic acid 3-SO4 and chondroitins 6-SO4 and 4-SO4.
28 gh content of the nonsulfated disaccharide D-glucuronic acid-acetylated glucosamine (GlcA-GlcNAc).
29 metabolites (methylated and conjugated with glucuronic acid) across hCMEC/D3 cells (a blood-brain ba
31 Mutations in a previously identified UDP-glucuronic acid allosteric binding site decreased the bi
32 nd glycolipid, termed Gl-X (mannose-alpha1-4-glucuronic acid-alpha1-diacylglycerol), which function a
33 s for the sugar donors UDP-galactose and UDP-glucuronic acid, although UDP-glucose was always preferr
34 des UDP-glucose dehydrogenase which produces glucuronic acid, an essential component for the synthesi
35 ssive oxidations of UDP-glucose to yield UDP-glucuronic acid, an essential precursor for matrix polys
36 DP-glucose dehydrogenase (Ugd) generates UDP-glucuronic acid, an important precursor for the producti
37 shown to hydrolyze terminal alpha-1,2-linked glucuronic acid and 4-O-methylated glucuronic acid from
38 backbone of xylosyl residues substituted by glucuronic acid and 4-O-methylglucuronic acid (collectiv
39 that although wild-type xylans contain both glucuronic acid and 4-O-methylglucuronic acid residues,
40 ranosiduronic acids (glucuronides) using UDP-glucuronic acid and acceptor substrates such as drugs, s
42 es with low ratios of xylose to 4-O-methyl-D-glucuronic acid and appears to require two 4-O-methyl-D-
44 hesized in the assay was composed of Glc and glucuronic acid and could be degraded to a low molecular
45 dependent oxidation of the 4''-OH of the UDP-glucuronic acid and decarboxylation of the UDP-4-keto-gl
46 f acidic O-linked glycoconjugates containing glucuronic acid and galactose as well as a reduction of
47 microfibrils had a higher content of (methyl)glucuronic acid and galactose in tension wood than in no
49 o its ability to sequester intracellular UDP-glucuronic acid and inhibition of hyaluronan synthase tr
50 tabolites; quercetin-3'-sulfate, quercetin-3-glucuronic acid and isorhamnetin-3-glucuronic acid were
51 ed that the resulting mutant lacked both UDP-glucuronic acid and its downstream product, UDP-xylose,
52 ible for the oxidation of UDP-glucose to UDP-glucuronic acid and its subsequent decarboxylation to UD
54 ase responsible for the interconversion of d-glucuronic acid and l-iduronic acid residues encodes a t
55 DG42 encoded on a plasmid incorporated [14C]glucuronic acid and N-[3H]acetylglucosamine from exogeno
56 ide composed of repeating disaccharides of D-glucuronic acid and N-acetyl-D-glucosamine (GlcNAc).
57 nctional chondroitin synthase K4CP catalyzes glucuronic acid and N-acetylgalactosamine transfer activ
58 block, and the two monosaccharide components glucuronic acid and N-acetylglucosamine and identify mar
60 long linear polymer composed of alternating glucuronic acid and N-acetylglucosamine residues, is an
61 inear polysaccharide composed of alternating glucuronic acid and N-acetylglucosamine residues, is an
63 reaction of appropriately substituted azido-glucuronic acid and propargyluted N-acetyl glucosamine a
64 and two quercetin metabolites (quercetin-3-O-glucuronic acid and quercetin-3-O-sulfate) significantly
65 e propose a binding model for NAD(+) and UDP-glucuronic acid and the involvement of residues T(432),
66 catalyzes the conjugation of bilirubin with glucuronic acid and thus enhances bilirubin elimination;
67 eds in three chemical steps via UDP-4-keto-D-glucuronic acid and UDP-4-keto-pentose intermediates.
68 UXNAcS is specific and cannot utilize UDP-glucuronic acid and UDP-galacturonic acid as substrates.
69 at synthesize the building blocks of HA, UDP-Glucuronic acid and UDP-N-Acetyl-Glucosamine, as well as
70 ynthases (HAS1-3), which use cytoplasmic UDP-glucuronic acid and UDP-N-acetylglucosamine as substrate
71 Chondroitin sulfate type C (CSC) contains glucuronic acid, and 90% of the GalNAc residues are sulf
72 Chondroitin sulfate type A (CSA) contains glucuronic acid, and 90% of the GalNAc residues are sulf
73 xylosyl residues is decorated by occasional glucuronic acid, and approximately one-half of the xylos
74 dic, alpha-fucosidic, alpha-mannosidic, beta-glucuronic acid, and beta-glucosamine linkages upon acti
75 ow that hemicellulose branches of arabinose, glucuronic acid, and especially glucuronate strengthen t
76 al other monosaccharides, including glucose, glucuronic acid, and N-acetylmannosamine, do not express
77 gy, we used purified S. equisimilis HAS, UDP-glucuronic acid, and UDP[beta-32P]-Glc-NAc to radiolabel
79 s beta-glucuronidase enzymes that remove the glucuronic acid as a carbon source, effectively reversin
82 a variety of monodisperse hyaluronan (beta 4-glucuronic acid-beta 3-N-acetylglucosamine (HA)) oligosa
83 magnetic resonance studies confirmed that a glucuronic acid beta1,4-xylose disaccharide synthesized
85 uctions in the amount of [-3-xylose-alpha1,3-glucuronic acid-beta1-]n (hereafter referred to as LARGE
86 accharide repeating unit [-3-xylose-alpha1,3-glucuronic acid-beta1-]n by like-acetylglucosaminyltrans
87 ctive UDP-sugars to the non-reducing end of [glucuronic acid]beta1-3[galactose]beta1-O-naphthalenemet
88 with UDP and the acceptor substrate analog [glucuronic acid]beta1-3[galactose]beta1-O-naphthalenemet
89 resolution apo crystal structure of the UDP-glucuronic acid binding domain of human UGT isoform 2B7
90 ncoded protein is closely related to the UDP-glucuronic acid binding site consensus sequence, and the
92 n to grow with N-acetylglucosamine but not d-glucuronic acid (both components of HA) as a sole carbon
93 The deletion of either sequence abolishes glucuronic acid but not N-acetylgalactosamine transfer a
94 ectins, is produced from the precursor UDP-D-glucuronic acid by the action of glucuronate 4-epimerase
97 scovered that the published sequence for the glucuronic acid C5-epimerase responsible for the interco
99 residues predicted to interact with the UDP-glucuronic acid cofactor exhibited significantly impaire
101 or each analyte; a mixture of 1-pyOH and its glucuronic acid conjugate can be analyzed in 30 min.
102 nantly excreted (>87%) in human urine as the glucuronic acid conjugate, whereas the relative abundanc
104 iver, intestine and kidney, and catalyze the glucuronic acid conjugation of both endogenous compounds
105 recombinant human UGT isoforms, we show that glucuronic acid conjugation of the model substrate, (-)-
107 e content of UDP-N-acetylhexosamines and UDP-glucuronic acid, correlating with the expression level o
110 iosynthesis of UDP-xylose is mediated by UDP-glucuronic acid decarboxylase, which converts UDP-glucur
114 uronic acid degradation at pH 5, poly-beta-D-glucuronic acid degradation at pH 7, and alginate degrad
115 enosine diphosphate-activated platelets, UDP-glucuronic acid-dependent bilirubin conjugation was dete
116 ndogenous and exogenous chemicals by linking glucuronic acid donated by UDP-glucuronic acid to a lipo
117 o glycoside (25) with a trichloroacetimidate glucuronic acid donor (13), using a catalytic amount of
118 The Glc-GlcA disaccharide, featuring the glucuronic acid donor moiety, proved to be the most prod
119 We demonstrated that lpsL encoded a UDP-glucuronic acid epimerase activity that was reduced in t
121 espect to chain length, sulfate content, and glucuronic acid epimerization content, resulting in a di
123 eactions revealed that the reactivity of the glucuronic acid esters studied is sufficient to provide
125 4" oxidation and C-6" decarboxylation of UDP-glucuronic acid, followed by the C-4" transamination of
126 and C-6" decarboxylation of [alpha-(32)P]UDP-glucuronic acid, followed by transamination to generate
127 ,2-linked glucuronic acid and 4-O-methylated glucuronic acid from the plant cell wall polysaccharide
128 ol g(-1)), whereas binding of the competitor glucuronic acid (GA) and other monosaccharides was consi
129 xtracts of the mutants completely lacked UDP-glucuronic acid:Galbeta1,3Gal-R glucuronosyltransferase
130 formation occurs by the copolymerization of glucuronic acid (GlcA) and N-acetylglucosamine (GlcNAc)
131 lcNAc) or N-sulfated glucosamine (GlcNS) and glucuronic acid (GlcA) as the primary sites and the link
132 uishing the epimers iduronic acid (IdoA) and glucuronic acid (GlcA) has been a long-standing challeng
133 corporation of radioactive glucose (Glc) and glucuronic acid (GlcA) into lipid-linked disaccharides i
134 ore-shell particles specifically recognizing glucuronic acid (GlcA) or N-acetylneuraminic acid (NANA)
135 glycan decorations that include a conserved glucuronic acid (GlcA) residue and various additional su
136 ries a pentose linked 1-2 to the alpha-1,2-d-glucuronic acid (GlcA) side chains on the beta-1,4-Xyl b
137 ta-glucuronidase (GUS) enzymes that liberate glucuronic acid (GlcA) sugars from small-molecule conjug
139 MIPs were prepared with the templates D-glucuronic acid (GlcA), a substructure of hyaluronan, an
140 The distribution of 13C in the Man, Xyl, glucuronic acid (GlcA), and O-acetyl constituents of nat
141 merase (Hsepi) catalyzes C5-epimerization of glucuronic acid (GlcA), converting it to iduronic acid (
144 6OSO3), but contained a higher proportion of glucuronic acid GlcUA-GlcNSO3(6OSO3) and IdUA-GlcNSO3(6O
145 is a membrane-bound enzyme that utilizes UDP-glucuronic acid (GlcUA) and UDP-GlcNAc to synthesize HA.
146 at transfer N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcUA) in alternative positions in the
148 atalyzes sugar transfer from UDP-Glc and UDP-glucuronic acid (GlcUA) to a polymer with the repeating
149 yltransferase that catalyzes the transfer of glucuronic acid (GlcUA) to the common growing linker reg
150 s comprising 3-sulfated rhamnose linked to d-glucuronic acid (GlcUA), l-iduronic acid (IdoUA), or d-x
157 w that the carboxyl group on nonreducing end glucuronic acid in dodecasaccharide motif is important f
158 o distinguish the epimers iduronic acid from glucuronic acid in heparan sulfate tetrasaccharides and
159 a1-4 linkage between N-acetylglucosamine and glucuronic acid in hyaluronan polymers via a substrate-a
160 s undergo detoxification by conjugation with glucuronic acid in the liver via the action of UDP-glucu
163 E, quercetin-3-O-glucoside and quercetin-3-O-glucuronic acid inhibited significantly (p<0.05) ACE act
167 ctivity of B3GAT1, we were able to show that glucuronic acid is present on antennae of plasma glycopr
170 at is specific for the l-rhamnose-alpha1,4-d-glucuronic acid linkage that caps the side chains of com
173 ranched surface structure containing glucose-glucuronic acid linked to a glucose-rhamnose-rhamnose-rh
174 vered that heparanase cleaves the linkage of glucuronic acid linked to glucosamine carrying 6-O-sulfo
175 n those measured on a mixture of pyruvic and glucuronic acids (logK = 2.2), which are the two constit
178 etraazacyclododecane) bearing a pendant beta-glucuronic acid moiety connected by a self-immolative li
180 cid hydrolysis, resulting in a Xyl:arabinose:glucuronic acid molar ratio of approximately 105:34:1.
181 fucose, d-mannose, d-galactose, d-glucose, d-glucuronic acid, N-acetyl-d-galactosamine, and N-acetyl-
183 ccus neoformans comprises manose, xylose and glucuronic acid, of which mannose is the major constitue
184 scribed, which arises due to the addition of glucuronic acid on the third heptose with a concomitant
188 highly sulfated polysaccharide consisting of glucuronic acid (or iduronic acid) linked to glucosamine
190 ctivity against hyaluronan (HA), poly-beta-d-glucuronic acid (poly-GlcUA), and poly-beta-d-mannuronic
191 lation of the bacterial N-acetylglucosaminyl-glucuronic acid polymer K5 under conditions where the ho
195 d from partial desulfation demonstrated that glucuronic acid rather than iduronic acid residues are i
196 lysaccharide composed of N-acetylglucosamine-glucuronic acid repeats, is found in the extracellular m
197 acid and appears to require two 4-O-methyl-D-glucuronic acid residues for substrate recognition and/o
198 on, BtGH115A, hydrolyzes terminal 4-O-methyl-glucuronic acid residues from decorated arabinogalactan
200 ily 2 glycosylhydrolases that cleaves beta-D-glucuronic acid residues from the nonreducing termini of
201 ly incorporated xylose (Xyl), arabinose, and glucuronic acid residues from their corresponding uridin
202 Odd-numbered oligosaccharides with terminal glucuronic acid residues isolated from hyaluronidase dig
204 iency, both contain a trisaccharide with two glucuronic acid residues that enabled the identification
205 ride of alternating N-acetyl-glucosamine and glucuronic acid residues, is ubiquitously expressed in v
206 ride units of N-acetyl-D-galactosamine and d-glucuronic acid residues, modified with sulfated residue
208 rface than thought previously, such that a D-glucuronic acid ring makes stacking and ionic interactio
209 ynthesis mutants, such as the replacement of glucuronic acid side chains with methylglucuronic acid s
210 (GXMT) that catalyzes 4-O-methylation of the glucuronic acid substituents of this polysaccharide.
211 xylan, generating products with a 4-O-methyl-glucuronic acid-substituted xylose residue one position
214 ernating beta1,3-N-acetylglucosamine-beta1,4-glucuronic acid sugar chain by the sequential addition o
217 ects observed for amino acids closest to the glucuronic acid sugar transferred to the acceptor molecu
218 ansport rate for N-acetylneuraminic acid and glucuronic acid, suggesting that it may be directly invo
221 charides containing terminal 4,5-unsaturated glucuronic acid, the nonreducing end disaccharide moiety
222 found in natural polysaccharides containing glucuronic acid, the oxidation of the primary alcohol at
223 nts may be linked to the availability of UDP-glucuronic acid; therefore UGDH is an intriguing therape
224 ls by linking glucuronic acid donated by UDP-glucuronic acid to a lipophilic acceptor substrate.
225 "reversible" catalytic mode by converting a glucuronic acid to an iduronic acid residue, and vice ve
226 lso serve as a one-way catalyst to convert a glucuronic acid to an iduronic acid residue, displaying
229 precedented oxidative decarboxylation of UDP-glucuronic acid to form uridine 5'-(beta-l-threo-pentapy
230 )-dependent oxidative decarboxylation of UDP-glucuronic acid to generate a UDP-4'-keto-pentose sugar
232 ylgalactosamine may precede epimerization of glucuronic acid to iduronic acid during dermatan sulfate
233 san with C(5)-epimerase converts some of the glucuronic acid to iduronic acid, thus becoming a substr
235 fication reactions is the epimerization of D-glucuronic acid to its C5-epimer L-iduronic acid, which
238 3)-glucuronyltransferases, one of which adds glucuronic acid to protein-linked galactose-beta(1, 4)-N
239 the NAD(+)-dependent decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and (ii) the N-1
242 neoformans gene catalyzed conversion of UDP-glucuronic acid to UDP-xylose, as confirmed by NMR analy
245 +-dependent oxidative decarboxylation of UDP-glucuronic acid to yield the UDP-4''-ketopentose, uridin
247 into two single-action glycosyltransferases (glucuronic acid transferase and N-acetylglucosamine tran
248 ) to the key metabolic precursor UDP-alpha-d-glucuronic acid (UDP-GlcA) and display specificity for U
249 e authentic sugar nucleotide precursors, UDP-glucuronic acid (UDP-GlcA) and UDP-N-acetylglucosamine (
250 together with UDP-xylose is formed from UDP-glucuronic acid (UDP-GlcA) by UDP-Api synthase (UAS).
253 ing (1) the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcA) to the UDP-4' '-ketopentose [
254 ) catalyzes the epimerization of UDP-alpha-D-glucuronic acid (UDP-GlcA) to UDP-alpha-D-galacturonic a
256 nverts UDP-2-acetamido-3-amino-2,3-dideoxy-d-glucuronic acid (UDP-GlcNAc3NA) to UDP-2,3-diacetamido-2
258 ed nucleotide sugars UDP-2-acetamido-2-deoxy-glucuronic acid (UDP-GlcNAcA) and UDP-2-acetamido-2-deox
260 accharide units from the donor molecules UDP-glucuronic acid (UDP-GlcUA) and UDP-N-acetylglucosamine
261 oniae requires UDP-glucose (UDP-Glc) and UDP-glucuronic acid (UDP-GlcUA) for production of the [3)-be
262 resence of protein-mediated transport of UDP-glucuronic acid (UDP-GlcUA) in rat liver endoplasmic ret
263 lcUA-(1-] from UDP-glucose (UDP-Glc) and UDP-glucuronic acid (UDP-GlcUA) is catalysed by the type 3 s
264 nic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region
265 trate for all glucuronidation reactions, UDP-glucuronic acid (UDP-GlcUA), was determined using a rapi
266 cerevisiae expressing SQV-7 transported UDP-glucuronic acid, UDP-N-acetylgalactosamine, and UDP-gala
268 use steroid hormones are often conjugated to glucuronic acid, we hypothesized that Chst10 sulfates gl
269 ercetin-3-glucuronic acid and isorhamnetin-3-glucuronic acid were effective at physiological concentr
270 synthase for UDP-N-acetylglucosamine and UDP-glucuronic acid were estimated to be approximately 75 an
271 talyzes the conversion of UDP-glucose to UDP-glucuronic acid, which is essential for the biosynthesis
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