ライフサイエンスコーパス: glucuronide

1 c anions such as 17beta-estradiol 17-(beta-d-glucuronide).

2 ide) and total NNAL (the sum of NNAL and its glucuronide).

3 otinate and quinate) and alcohol (with ethyl glucuronide).

4 reference standard, JWH-018 5-hydroxypentyl glucuronide.

5 ithin glucuronides, and indole-3-acetic acid glucuronide.

6 TCC in human urine was largely the N- or N'-glucuronide.

7 that was not induced by 4-nitrophenyl-beta-D-glucuronide.

8 L), NNAL-N-beta-glucuronide, and NNAL-O-beta-glucuronide.

9 a metabolite expressed in human sweat, Ethyl Glucuronide.

10 te in all volunteers was N-hydroxy-PhIP-N(2)-glucuronide.

11 norUDCA in bile and urine was the C-23 ester glucuronide.

12 in patients to a single metabolite [18F]FLT-glucuronide.

13 y of urinary GTC metabolite epigallocatechin glucuronide.

14 ings with the endogenous compound, bilirubin glucuronide.

15 GUS expression in response to small-molecule glucuronides.

16 d forms (79.4% +/- 3.9%) and as sulfates and glucuronides.

17 aluronan (HA), proteoglycans, and xenobiotic glucuronides.

18 environmental toxicants to highly excretable glucuronides.

19 ts binding to anionic and bulky ligands like glucuronides.

20 hem opioids, resulting in the formation of D-glucuronides.

21 es of CYP2C8 that allow potential binding to glucuronides.

22 thocyanins reached the circulation mainly as glucuronides.

23 1-hydroxypyrene (1-pyOH) and 1-hydroxypyrene-glucuronide (1-pyOglu) in phosphate buffer and artificia

24 a 5.1 mM solution of a synthetic model drug glucuronide, 1-beta-O-acyl (S)-alpha-methyl phenylacetyl

25 The amount of LTB4 glucuronide (16.7-29.4 pmol/ml) and 20-carboxy-LTB4 (18.

26 MS fragmentation matching with the synthetic glucuronide 26.

27 ansformed, respectively, into methyl alpha-O-glucuronide 3 and hydroxymethyl beta-C-glucuronide 9, wh

28 In addition, luteolin 7-O-glucuronide 3-O-glucoside was identified for the first t

29 metabolite, 3'-O-methyl-epicatechin-5-O-beta-glucuronide (3'-O-Me-EC-Gluc), one of the PAC metabolite

30 e method uses chemically synthesized 4-ABP-N-glucuronide (4-ABP-G) as a standard for method validatio

31 yl sulfamethoxazole, sulfamethoxazole beta-D-glucuronide, 4-nitroso sulfamethoxazole, and 4-nitro sul

32 AG), 4-methylumbelliferyl sulfate (4MUS) and glucuronide (4MUG), and harmol sulfate (HS) and glucuron

33 o other common opiates, morphine, morphine-3-glucuronide, 6-acetyl morphine, demonstrates an advantag

34 pha-O-glucuronide 3 and hydroxymethyl beta-C-glucuronide 9, which undergo decarboxylative elimination

35 id (an omega-3-fatty acid) and quercetin-3-O-glucuronide (a polyphenol metabolite) do not undergo sen

36 ng intensity and duration: cotinine plus its glucuronide, a biomarker of nicotine uptake; 4-(methylni

37 Finally, morphine-6-beta-D-glucuronide, a metabolite of morphine that was ineffecti

38 Conjugation of the MAC beta-glucuronide AE drug linker to the anti-CD30 antibody cAC

39 two T metabolites which remain conjugated as glucuronides after an enzymatic hydrolysis of the urine.

40 excretion of acetaminophen sulfate (AS) and glucuronide (AG), 4-methylumbelliferyl sulfate (4MUS) an

41 de, luteolin-7-O-rutinoside and luteolin-7-O-glucuronide against acridin were 21.8%, 22.4% and 23.6%,

42 de, luteolin-7-O-rutinoside and luteolin-7-O-glucuronide against ethyl methanesulfonate were 57.6%, 5

43 al acyl migration reactions of 1-beta-O-acyl glucuronides (AGs), which rearrange at neutral or slight

44 s, namely, indole-3-acetic acid and p-cresyl glucuronide, an increase in blood flow rate is advantage

45 onide, cortolone-3-glucuronide, testosterone-glucuronide and 17-hydroxyprogesterone), which belonged

46 he glucuronide conjugates ethinylestradiol-3-glucuronide and 17beta-estradiol-17-glucuronide stimulat

47 androstan-17-one (6beta-hydroxyandrosterone) glucuronide and 3alpha,6beta-dihydroxy-5beta-androstan-1

48 and two predominant metabolic conjugates-BPA glucuronide and BPA sulfate-in umbilical cord serum coll

49 to morphine and related opioids (morphine-6-glucuronide and buprenorphine) was blocked by JNK inhibi

50 nicotine metabolites, the levels of nicotine-glucuronide and cotinine-glucuronide were 42% (P < 0.000

51 Along with ethyl glucuronide and ethyl sulfate, N-acetyltaurine (NAT) was

52 ransport was inhibited by estradiol 17beta-d-glucuronide and fumitremorgin C.

53 HT-glucuronide, DOPAC-glucuronide, HVA-glucuronide and HVA-sulphate were also detected.

54 ity monitors that measured urinary estrone-3-glucuronide and luteinizing hormone (LH).

55 The reliability of ethyl glucuronide and other biomarkers for the detection of al

56 ed three metabolites RV 3-O-sulphate, RV 3-O-glucuronide and RV 4'-O-glucuronide, and studied their e

57 Flavonoids are conjugated with glucuronide and sulfate and are excreted in urine and bi

58 Following enzymatic cleavage of the glucuronide and sulfate conjugates, the phenolic metabol

59 S-MS) has been developed for the analysis of glucuronide and sulfate metabolites of seven anabolic-an

60 olic catabolites are included with flavanone glucuronide and sulfate metabolites, orange juice (poly)

61 Hesperetin-3'-O-glucuronide and the colonic microbiota-derived catabolit

62 Interestingly, the endobiotic estradiol-17-glucuronide and the xenobiotic indomethacin-acyl-glucuro

63 noside, luteolin 7-O-glucoside, apigenin 7-O-glucuronide and tricin 7-O-diglucuronide have been isola

64 We tentatively identified 1-methylpyrene glucuronides and 1-carbonylpyrene glycine as phase II me

65 thoroughly investigated for a wide range of glucuronides and for the reference standard, JWH-018 5-h

66 The factors affecting the separation of glucuronides and parent compounds were investigated by v

67 EG can be produced similarly to other simple glucuronides and should therefore be no more expensive.

68 nditions for enzyme hydrolysis of polyphenol glucuronides and sulfate esters, extraction, and dansyla

69 ed in human urine primarily as water-soluble glucuronides and sulfates that can dissociate in wastewa

70 beled metabolites, namely, (14)C- and (13)C6-glucuronides and sulfates.

71 morphine-like compounds (morphine and/or its glucuronides and/or codeine) in the adult mouse spinal c

72 ansport of [(3)H]17beta-estradiol-17-beta-(D-glucuronide) and doxorubicin efflux in AAV-293 cells.

73 total cotinine (the sum of cotinine and its glucuronide) and total NNAL (the sum of NNAL and its glu

74 (ii) dill: neochlorogenic acid and quercetin glucuronide, and (iii) parsley: apigenin-7-apiosylglucos

75 man (alpha-CEHC) glycine, alpha-CEHC glycine glucuronide, and alpha-CEHC taurine.

76 d circulating levels of APAP, APAP-GSH, APAP-glucuronide, and APAP-sulfate.

77 Morphine, codeine, morphine-6-glucuronide, and morphine-3-glucuronide are synthesized

78 -1-(3-pyridyl)-1-butanol (NNAL), NNAL-N-beta-glucuronide, and NNAL-O-beta-glucuronide.

79 1-hydroxypyrene, pyrene-1-sulfate, pyrene-1-glucuronide, and pyrene glucoside sulfate, with pyrene-1

80 esveratrol-4'-O-sulfate, resveratrol sulfate glucuronide, and resveratrol disulfate were identified b

81 retinyl esters, 4-oxoretinol, retinoyl beta-glucuronide, and retinyl beta-glucuronide but not for re

82 ng MK-571, methotrexate, estradiol 17-beta-d-glucuronide, and S(2,4-dinitrophenyl)glutathione (DNP-SG

83 hydroepiandrosterone sulfate, androstanediol glucuronide, and sex hormone binding globulin).

84 trone, 5alpha-androstane-3alpha, 17beta-diol-glucuronide, and sex hormone-binding globulin.

85 3-O-sulphate, RV 3-O-glucuronide and RV 4'-O-glucuronide, and studied their effects on cell growth in

86 the levels of nicotine-glucuronide, cotinine-glucuronide, and trans-3'-hydroxycotinine (3HC)-glucuron

87 ude acyl glucuronides, ether glucuronides, N-glucuronides, and carbamoyl glucuronides, have been show

88 Hesperetin-O-glucuronides, naringenin-O-glucuronides, and hesperetin-3'-O-sulfate were the main

89 yphenyl-gamma-valerolactone, three urolithin glucuronides, and indole-3-acetic acid glucuronide.

90 tion of Gli1 reduced UGT1As, eliminated drug glucuronides, and renewed sensitivity to ribavirin and A

91 teers were glucuronides, sulfates, and sulfo-glucuronides, and the total excretion of flavanones incr

92 However, 20-fold higher accumulation of APAP-glucuronide (APAP-GLUC) was found in the liver of Mrp3-/

93 uronide and the xenobiotic indomethacin-acyl-glucuronide are found to exhibit markedly differential b

94 eine, morphine-6-glucuronide, and morphine-3-glucuronide are synthesized de novo in mammalian cells a

95 ect methods for the determination of steroid glucuronides are employed.

96 However, it was found that glucuronides are not stable, particularly in the case of

97 t Km values of >130 microM), suggesting that glucuronides are the preferred substrates for this trans

98 tructurally diverse lipophiles to excretable glucuronides are unknown.

99 egrees C and pH 6 using 4-nitrophenyl beta-D-glucuronide as an indicator.

100 and pyrene glucoside sulfate, with pyrene-1-glucuronide as the most prominent metabolite.

101 This review summarizes glucuronides as CYP2C8 ligands and the active-site struc

102 catechin and its metabolite, epicatechin-7-O-glucuronide, as independent predictors of the vascular e

103 19-NA in urine samples fortified with 19-NA glucuronide at three different concentrations (equivalen

104 reated rats showed the presence of bilirubin glucuronides at normal WT levels >2 yr after one injecti

105 transfer E. coli GusR's preferential DNA and glucuronide binding affinity to S. enterica GusR.

106 nding assay and shown that labeled ezetimibe glucuronide binds specifically to a single site in brush

107 retinoyl beta-glucuronide, and retinyl beta-glucuronide but not for retinoic acid.

108 The method was developed using glucuronides, but it is adaptable to any compound that c

109 de, luteolin-7-O-rutinoside and luteolin-7-O-glucuronide) by using a eukaryotic cell system, Saccharo

110 The formation of beta-D-glucopyranosides (glucuronides) by the UDP-glucuronosyltransferases (UGTs)

111 f morphine-6-glucuronide (M6G) and codeine-6-glucuronide (C6G) were synthesized and evaluated with th

112 Apigenin-7-O-beta-d-glucuronide, caffeic and carnosic acids were quantitativ

113 re to NNN--the sum of NNN and its pyridine-N-glucuronide, called total NNN--was quantified in the uri

114 nt mouse models, we show here that sorafenib-glucuronide can be extruded from hepatocytes into the bi

115 cording to this model, hepatocytic bilirubin glucuronide can follow a liver-to-blood shuttling loop v

116 r, there is growing evidence to suggest that glucuronides can be ligands of human CYP2C8, making CYP2

117 ts of 19-NA yielded from hydrolysis of 19-NA glucuronide compared well with the theoretical values (c

118 Although the structures of CYP2C8-glucuronide complexes have not been determined, the stru

119 L) at 10 mg/kg was due to the formation of O-glucuronide conjugate by phase 2 metabolism.

120 y either bacteria-mediated hydrolysis of the glucuronide conjugate of the active metabolite 7-ethyl-1

121 ent glucuronidation to form a novel O-linked glucuronide conjugate, O-(beta-D-glucosidurony1)-2-hydro

122 ty is expected to reduce the reactivation of glucuronide-conjugated drugs in the intestine, thereby r

123 The glucuronide conjugates ethinylestradiol-3-glucuronide an

124 rase (UGT) enzymes catalyze the formation of glucuronide conjugates of phase II metabolism.

125 We hypothesized that glucuronide conjugates of xenobiotics, such as the antic

126 und decrease in the biliary clearance of the glucuronide conjugates was observed in Bcrp-deficient mo

127 Unlike in rats, where sulfate and glucuronide conjugates were excreted into bile predomina

128 roid conjugates in all sample types, whereas glucuronide conjugates were hydrolyzed in the presence o

129 se activity was stimulated by bile acids and glucuronide conjugates, reaching 170 +/- 28 nmol min-1 m

130 Because Mrp3 preferentially transports glucuronide conjugates, we investigated the in vivo disp

131 Several classes of glucuronide conjugates, which include acyl glucuronides,

132 a significant factor in renal elimination of glucuronide conjugates.

133 over-the-counter drugs as their sulfate and glucuronide conjugates.

134 widespread progressive accumulation of beta-glucuronide-containing glycosaminoglycans in lysosomes.

135 endocrine compounds (tetrahydroaldosterone-3-glucuronide, cortolone-3-glucuronide, testosterone-glucu

136 3'-hydroxycotinine (OH-COT), cotinine-N-beta-glucuronide (COT-GLUC), and trans-3'-hydroxycotinine-O-b

137 o significantly alter the levels of nicotine-glucuronide, cotinine-glucuronide, and trans-3'-hydroxyc

138 ble concentrations of COT, OH-COT, and their glucuronides, depending on sampling and storage time or

139 analysis showed that DHT was converted to a glucuronide, DHT-G, at a 6-fold higher level in androgen

140 educe conjugated steroids such as Dht-17beta-glucuronide (DhtG), Dht-17beta-sulfate (DhtS), and Tib-1

141 HT-glucuronide, DOPAC-glucuronide, HVA-glucuronide and HVA-

142 disruption of hepatic reuptake of bilirubin glucuronide due to coexisting OATP1B1 and OATP1B3 defici

143 CC10 transport substrates estrogen estradiol-glucuronide (E(2)17betaG) and leukotriene C4 (LTC(4)) si

144 te, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids gl

145 f E2-3G and its oxidized metabolite, estrone glucuronide (E1-3G), both of which were transformed into

146 fferent molecular weights: estradiol-17-beta-glucuronide (E17betaG), prostaglandin E2 (PGE2), cholecy

147 Estradiol-17ss-D-glucuronide (E17G) activates different signaling pathway

148 strogen levels, by measuring urinary estrone glucuronide (E1G) in the periovulatory and luteal phases

149 ects of a CYP3A haplotype on urinary estrone glucuronide (E1G) levels and tested for an association b

150 eled prototype conjugate, 17beta-estradiol-3-glucuronide (E2-3G).

151 estosterone, androstenedione, androstanediol glucuronide, estradiol, and sex hormone-binding globulin

152 ency management intervention using the ethyl glucuronide (EtG) alcohol biomarker resulted in increase

153 tification of a metabolite of ethanol, ethyl glucuronide (EtG).

154 f glucuronide conjugates, which include acyl glucuronides, ether glucuronides, N-glucuronides, and ca

155 Ethyl glucuronide (ethyl-beta-D-6-glucosiduronic acid, EtG), a

156 We further demonstrate that sorafenib-glucuronide excreted into the gut lumen can be cleaved b

157 onide lower plasma cholesterol; however, the glucuronide exhibits greater potency.

158 KD values of ezetimibe glucuronide for mouse, rat, rhesus monkey, and human NPC

159 19-NA exists mainly as the glucuronide form in human urine.

160 interindividual variability in urinary NNAL glucuronide formation has been observed in smokers and t

161 6-fold lower level of nicotine- and cotinine-glucuronide formation, respectively, was observed in HLM

162 In the liver, Mrp2 transports bilirubin-glucuronide, glutathione (GSH), and drug conjugates into

163 : BPA (GM 0.16, range <LOD-52.26 ng/mL), BPA glucuronide (GM 0.14, range <LOD-5.41 ng/mL) and BPA sul

164 ut severely impaired by the presence of a 17-glucuronide group for AKR1C1-3 isoforms.

165 d high levels of urinary N-hydroxy-PhIP-N(2)-glucuronide had the lowest level of colon PhIP-DNA adduc

166 onides, suggesting that the preponderance of glucuronides had dissociated prior to reaching the treat

167 ansport of anticancer drugs, bile acids, and glucuronides has been controversial.

168 glucuronides, N-glucuronides, and carbamoyl glucuronides, have been shown to be substrates or time-d

169 lavanone metabolites, mainly hesperetin-3'-O-glucuronide, hesperetin-3'-sulfate, naringenin-4'-O-gluc

170 curonide (4MUG), and harmol sulfate (HS) and glucuronide (HG) was studied in Abcc2(-/-), Abcg2(-/-),

171 HT-glucuronide, DOPAC-glucuronide, HVA-glucuronide and HVA-sulphate were also

172 curonide, and trans-3'-hydroxycotinine (3HC)-glucuronide in human liver microsomes in vitro.

173 acid, 5-O-caffeoylquinic acid, apigenin 7-O-glucuronide in primary heads as well 1,5-di-O-caffeoylqu

174 pendent transport of [(3)H]estradiol-beta-17-glucuronide in vitro as compared with wild-type Ycf1p.

175 e presence of morphine, codeine, or morphine glucuronides in gamma-aminobutyric acid (GABA)-ergic neu

176 of morphine in case of fragmentation of the glucuronides in the atmospheric-to-vacuum interface of t

177 Here, we focus on glucuronides in the gut and the microbial proteins that

178 an methods for the open detection of steroid glucuronides in urine samples.

179 , lamotrigine, and its major metabolite (2-N-glucuronide), in environmental water samples using a new

180 MRP1-mediated uptake of tritiated estradiol glucuronide into inside-out membrane vesicles, their aff

181 t of leukotriene C(4) and estradiol-17beta-d-glucuronide into vesicles derived from MRP1 CK2alpha(-)

182 tate is an effective prodrug, and the O-aryl glucuronide is a major metabolite.

183 some organic anions by PB treatment: 1) PBOH-glucuronide is a substrate for Mrp2 and may compete with

184 ICUP) technique, we found that quercetin-3-O-glucuronide is also capable of interfering with the init

185 The low SN-38 glucuronide is attributed to low hepatic uptake of SN-38

186 de, luteolin 7-O-rutinoside and luteolin 7-O-glucuronide) isolated from Mentha longifolia (L.) Huds.

187 Urinary pregnanediol glucuronide levels were measured weekly for two 3-month

188 d (RA), lithospermic acid (LA), luteolin-7-O-glucuronide (Lgr), luteolin-7-O-rutinoside (Lr), eriodic

189 and Salmonella enterica in complexes with a glucuronide ligand.

190 d that its human metabolite lamotrigine-N(2)-glucuronide (LMG-N2-G) is the actual source of OXO-LMG i

191 Both ezetimibe and the glucuronide lower plasma cholesterol; however, the glucu

192 Among them, apigenin-glucuronide, lucenin-2 and lithospermic acid were tentat

193 -glucoside (cosmosiin), luteolin 3'-O-beta-d-glucuronide, luteolin, apigenin, cirsimaritin, isokaempf

194 on, the morphine metabolite morphine-3beta-D-glucuronide (M3G) elicited hyperalgesia in WT but not in

195 es due to TLR4 active metabolite, morphine-3-glucuronide (M3G) exposure in vivo.

196 e for the residual heroin and morphine-6beta-glucuronide (M6G) analgesia in the exon 1 knockout mice.

197 -beta-thiosaccharide analogues of morphine-6-glucuronide (M6G) and codeine-6-glucuronide (C6G) were s

198 e concentrations for morphine and morphine-6-glucuronide (M6G) were observed in stable expression cel

199 ntified apigenin-7-O-glucoside, luteolin-3-O-glucuronide, malonyl caffeoylquinic acid, trans-resverat

200 Brain-targeted quercetin-3-O-glucuronide may simultaneously modulate multiple indepen

201 response and cytokine release syndrome, and glucuronide metabolite AUC correlated with tumor lysis s

202 A gram scale synthesis of the glucuronide metabolite of ABT-724 is reported.

203 The structure of the glucuronide metabolite was confirmed by retention time a

204 samples analyzed and lamotrigine and its 2-N-glucuronide metabolite were mostly detected in both wast

205 on for propranolol and its hydroxyproranolol glucuronide metabolite within specific organs of the tis

206 s dapagliflozin's major systemic circulating glucuronide metabolite, BMS-801576, concentrations in hu

207 The increases in beta-glucuronide metabolites and 4-oxoretinol suggest a preve

208 was enzymatically hydrolyzed to convert the glucuronide metabolites into the original pharmaceutical

209 the relative abundance of hydroxypropranolol glucuronide metabolites were recorded and found to be co

210 DMS also separates morphine from its glucuronide metabolites, which allows for preventing the

211 e patients to receive morphine with 3- and 6-glucuronide metabolites, which are known to be neurotoxi

212 a major role in the biliary excretion of the glucuronide metabolites, with some minor contribution fr

213 r magnetic resonance using the acetaminophen glucuronide method.

214 ear magnetic resonance and the acetaminophen glucuronide method.

215 ose, deuterated water, and the acetaminophen glucuronide methods, respectively.

216 A series of MAC beta-glucuronide model constructs were prepared to evaluate s

217 fenac, it has been shown that removal of the glucuronide moieties from drug metabolites by bacterial

218 (FITC)], by utilizing a difluoromethylphenol-glucuronide moiety (TrapG) to trap the fluorochromes in

219 1-beta-O-acyl (S)-alpha-methyl phenylacetyl glucuronide (MPG) in 0.1 M sodium phosphate buffer in D2

220 ydroflavonol derivatives; myricetin hexoside-glucuronide, myricetin O-di-hexoside, syringetin O-di-he

221 tosterone (N = 4678), 3 alpha-androstanediol-glucuronide (N = 4767) and 17beta-estradiol (N = 2014) i

222 ates, which include acyl glucuronides, ether glucuronides, N-glucuronides, and carbamoyl glucuronides

223 nide, hesperetin-3'-sulfate, naringenin-4'-O-glucuronide, naringenin-7-O-glucuronide, was equivalent

224 Hesperetin-O-glucuronides, naringenin-O-glucuronides, and hesperetin-

225 a unique biomarker, N-acetyltyramine-O,beta-glucuronide (NATOG), a neurotransmitter-derived secretio

226 ion with the stable isotopes 2H and 13C, the glucuronide of acetaminophen isolated from urine provide

227 It is also the first report of a glucuronide of an antidepressant surviving wastewater tr

228 res of 36 phenolic conjugates, including the glucuronides of 3',4'-di- and 3',4',5'-trihydroxyphenyl-

229 As interaction perpetrators with CYP2C8, glucuronides of gemfibrozil and clopidogrel showed marke

230 The results of this study suggest that glucuronides of pharmaceuticals might also be sources of

231 T-GLUC), and trans-3'-hydroxycotinine-O-beta-glucuronide (OH-COT-GLUC) are excreted in urine followin

232 de, luteolin 7-O-rutinoside and luteolin 7-O-glucuronide on TA1537 strain were 84.03%, 87.63% and 67.

233 In this study, free, conjugated (BPA glucuronide or BPAG and BPA disulfate or BPADS), and sub

234 nd animals, conjugation of BPA molecule with glucuronide or sulfate is considered as a mechanism for

235 chroman (CEHC) and CEHC conjugates (sulfate, glucuronide, or glucoside).

236 acetyl-l-glutamine, 5-hydroxyindole, indoxyl glucuronide, p-cresol sulfate, and indoxyl sulfate.

237 ones characterized by urinary pregnanediol-3-glucuronide (PdG) and estrone conjugate (E(1)C) levels.

238 is of propranolol and its hydroxypropranolol glucuronide phase II metabolites from a rat thin tissue

239 on gluconate, glucuronate, or methyl-beta-D-glucuronide; phosphate limitation; and carbon starvation

240 However, NIR glucuronide probes are not yet available.

241 of reporter expression and for personalized glucuronide prodrug cancer therapy in preclinical studie

242 y in mice compared to HMR 1826, a well-known glucuronide prodrug of doxorubicin that cannot bind cova

243 tin metabolites in human plasma, quercetin 3-glucuronide (Q3G), quercetin 3'-sulphate (Q3'S) and isor

244 tradiol levels, and testosterone:17beta-diol-glucuronide ratio are associated with reduced BPH risk,

245 one, estradiol, and testosterone:17beta-diol-glucuronide ratio were 0.64 (95% confidence interval (CI

246 ites of (epi)catechin and (epi)gallocatechin glucuronide reach peak nanomolar per liter plasma concen

247 t the residues essential for DNA binding and glucuronide recognition.

248 tive chromogenic substrate, resorufin beta-d-glucuronide (REG), which is exceptionally sensitive and

249 peron under the transcriptional control of a glucuronide repressor, GusR.

250 esveratrol-3-O-glucuronide, resveratrol-4'-O-glucuronide, resveratrol-3-O-sulfate, resveratrol-4'-O-s

251 ompound plus its metabolites resveratrol-3-O-glucuronide, resveratrol-4'-O-glucuronide, resveratrol-3

252 r time scale to yield a series of positional glucuronide ring isomers and alpha/beta anomers from the

253 (-6)) and SRD5A2 with 3 alpha-androstanediol-glucuronide (rs2208532, mean difference = 11.8%, P = 1.8

254 de, luteolin 7-O-rutinoside and luteolin 7-O-glucuronide showed antimutagenic effects on TA1537 and T

255 rgeted polyphenol metabolites, quercetin-3-O-glucuronide, significantly reduced the generation of bet

256 ation in APC (a metabolite of CPT-11), SN-38 glucuronide (SN-38G), and SN-38G/SN-38 AUCs, respectivel

257 ne samples spiked with alpha-naphthyl beta-d-glucuronide sodium salt (1-NAP-GLU) and pyrene-1-sulfate

258 radiol-3-glucuronide and 17beta-estradiol-17-glucuronide stimulated the ATPase with relatively high a

259 viors were observed depending on the steroid glucuronide structure.

260 one 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(

261 s of the inactive metabolite buprenorphine-3-glucuronide suggested that darunavir-ritonavir and fosam

262 and experimental CCS obtained for mycotoxin glucuronides suggested the potential of the CCS matching

263 greater than that of the respective steroid glucuronides, suggesting that the preponderance of glucu

264 Glucuronide, sulfate, and methyl metabolites of (epi)cat

265 anthocyanins and 12 metabolites (methylated, glucuronided, sulfated).

266 etabolites in both groups of volunteers were glucuronides, sulfates, and sulfo-glucuronides, and the

267 mino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronides (sum of which is denoted as total NNAL) are

268 ahydroaldosterone-3-glucuronide, cortolone-3-glucuronide, testosterone-glucuronide and 17-hydroxyprog

269 -nor-9-carboxy-Delta(9)-tetrahydrocannabinol glucuronide (THC-COO-glu).

270 xtended periods, and forms very little SN-38 glucuronide (the precursor of enterotoxic SN-38).

271 iderable renal elimination of the C-23 ester glucuronide, the dominant metabolite.

272 idases, and by understanding which substrate glucuronides they process, molecular insights into mamma

273 ues (calculated from the conversion of 19-NA glucuronide to 19-NA) with absolute relative differences

274 curonides (total NNAL), and cotinine and its glucuronides (total cotinine), validated biomarkers of u

275 nitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides (total NNAL), a biomarker of the tobacco ca

276 nitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides (total NNAL), and cotinine and its glucuron

277 Lastly, we found that quercetin-3-O-glucuronide treatment, compared to vehicle-control treat

278 behavior of thirteen representative steroid glucuronides, used as model compounds, was studied.

279 mation of beta-d-glucopyranosiduronic acids (glucuronides) using UDP-glucuronic acid and acceptor sub

280 ramework toward understanding the control of glucuronide utilization by opportunistic pathogens in th

281 d to its metabolite 3alpha-androstanediol-17-glucuronide via the previously unrecognized "conjugation

282 mg/kg APAP were elucidated as 3-methoxy-APAP glucuronide (VII) and three novel APAP metabolites, incl

283 The level of 3HC-glucuronide was 42% (P < 0.001) lower in the urine from

284 The 19-NA glucuronide was enzymatically hydrolyzed, and the 19-NA

285 Only one flavonoid, luteolin-3'-O-glucuronide was found in all the samples, ranging from 8

286 naringenin-4'-O-glucuronide, naringenin-7-O-glucuronide, was equivalent to 4.2% of OJ flavanone inta

287 notype; the levels of nicotine- and cotinine-glucuronide were 21% to 30% lower in specimens from subj

288 levels of nicotine-glucuronide and cotinine-glucuronide were 42% (P < 0.0005) and 48% (P < 0.0001),

289 ntration and urinary excretion of naringenin glucuronide were both significantly higher after the con

290 tions of protein unbound, total RAL, and RAL glucuronide were determined by liquid chromatography-tan

291 rostan-17-one (6beta-hydroxyetiocholanolone) glucuronide were established as the structures for these

292 metabolites, except sulfamethoxazole beta-D-glucuronide were found to be more photostable than SMX u

293 The levels of urinary N-hydroxy-PhIP-N(2)-glucuronide were negatively correlated to colon DNA addu

294 Serum free-BPA and BPA-glucuronide were quantitated in sera of individual PND 3

295 Resveratrol and resveratrol-3-O-glucuronide were recovered from tissues at maximal mean

296 In contrast, epicatechin glucuronides were dominant in plasma, bile, and urine.

297 bin was reduced by 40% +/- 5%, and bilirubin glucuronides were excreted into bile.

298 onalized 2-acetamido-2-deoxy-Delta(4)-beta-D-glucuronides were synthesized to explore noncharge inter

299 hormone binding globulin, and androstenediol glucuronide, were analyzed.

300 -binding studies, as shown by morphine-6beta-glucuronide, which was the most efficacious agent agains