ライフサイエンスコーパス: glucuronosyltransferase

1 me P450 or phase II conjugating enzymes (UDP-glucuronosyltransferase).

2 ficiency of the hepatic enzyme bilirubin-UDP-glucuronosyltransferase.

3 plained by deletion of a uridine diphosphate glucuronosyltransferase.

4 GUX2 and GUX4, have activity as xylan alpha-glucuronosyltransferases.

5 nsferases, glutathione transferases, and UDP-glucuronosyltransferases.

6 onic acid in the liver via the action of UDP-glucuronosyltransferases.

7 osyltransferase, INOSITOL PHOSPHORYLCERAMIDE GLUCURONOSYLTRANSFERASE 1 (IPUT1), which is the first en

8 The human UDP-glucuronosyltransferase 1 (UGT1) locus spans nearly 200

9 A polymorphism in the promoter of the UDP-glucuronosyltransferase 1 (UGT1A1) gene has been shown t

10 Alternative splicing at the human glucuronosyltransferase 1 gene locus (UGT1) produces alt

11 01A1, glutathione S-transferase Ya1, and UDP-glucuronosyltransferase 1*6 are apparently potentiated t

12 (pfu) intravenously) in adult bilirubin-UDP-glucuronosyltransferase-1 (BUGT1)-deficient Gunn rats re

13 ance to adenoviral antigens in bilirubin-UDP-glucuronosyltransferase-1 (BUGT1)-deficient Gunn rats.

14 gastroduodenostomy tubes into bilirubin-UDP-glucuronosyltransferase-1 (BUGT1)-deficient jaundiced Gu

15 In humanized UDP glucuronosyltransferase-1 (hUGT1) mice that express the

16 ransferase (pSV2-CAT) or human bilirubin-UDP-glucuronosyltransferase-1 (pSVK3-hBUGT1) genes were comp

17 ns of bilirubin-uridine-diphosphoglucuronate glucuronosyltransferase-1 (UGT1A1) completely or partial

18 x promoter spanning 218 kb, the phase II UDP-glucuronosyltransferase 1A (UGT1) gene encodes at least

19 esult in part from delayed expression of UDP-glucuronosyltransferase 1A1 (UGT1A1) and the inability t

20 UDP-glucuronosyltransferase 1A1 (UGT1A1) catalyzes the glucu

21 To study the association between UDP-glucuronosyltransferase 1A1 (UGT1A1) genotypes and sever

22 In mammals, UDP-glucuronosyltransferase 1A1 (UGT1A1) is the sole enzyme

23 UDP-glucuronosyltransferase 1A1 (UGT1A1) plays an important

24 ), CAR, cytochrome P-450 2b10 (Cyp2b10), UDP-glucuronosyltransferase 1a1 (Ugt1a1), sulfotransferase 2

25 in turn is detoxified primarily through UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed glucuroni

26 P7A1), CYP27A1, CYP8B1, uridine 5'-diphospho-glucuronosyltransferase 1A1, 1A3, 1A4, 1A6, hydroxystero

27 expressing human uridinediphosphoglucuronate glucuronosyltransferase-1A1 (pSB-hUGT1A1).

28 Uridine diphosphate-glucuronosyltransferase-1A1 deficiency, causing Gilbert'

29 Uridine diphosphate-glucuronosyltransferase-1A1 deficiency, causing Gilbert'

30 uted isozymes encoded at the UGT1 locus, UDP-glucuronosyltransferase 1A10 (UGT1A10) metabolizes a num

31 tutive or ligand-induced CYP1A1; CYP1A2; UDP glucuronosyltransferase 1A2; NAD(P)H dehydrogenase, quin

32 UDP-glucuronosyltransferase 1A7 (UGT1A7) is a major UGT cont

33 The UDP-glucuronosyltransferase 2 family, polypeptide B15 (UGT2B

34 Members of the human UDP-glucuronosyltransferase 2B family are located in a clust

35 Uridine diphospho glucuronosyltransferase 2B17 (UGT2B17) glucuronidates an

36 UDP-glucuronosyltransferase 2B17 (UGT2B17) is a key enzyme t

37 EPI is primarily inactivated by UDP-glucuronosyltransferase 2B7 (UGT2B7) in the liver.

38 Whereas UDP-glucuronosyltransferase-2B7 is widely distributed in dif

39 n permethrin resistant mosquitoes included a glucuronosyltransferase (AAEL014279-RA) and the glutathi

40 ly due to interindividual differences in UDP-glucuronosyltransferase activity and/or excretion pathwa

41 increase or a decrease, respectively, in IPC glucuronosyltransferase activity in vitro.

42 This paralleled the hepatic bilirubin-UDP-glucuronosyltransferase activity, which was above 50% of

43 binant adenovirus (Ad), adenovirus human UDP-glucuronosyltransferase (Ad-hBUGT1) carrying the hBUGT1

44 Polymorphisms in UDP-glucuronosyltransferases and sulfotransferases may contr

45 , we quantified androgen dependence of UGDH, glucuronosyltransferase, and HA synthase expression.

46 eme oxygenase, biliverdin reductase, and UDP-glucuronosyltransferases, and there was concordance with

47 a normal form of uridinediphosphoglucuronate glucuronosyltransferase because of a defect in the promo

48 human bilirubin-uridine-diphosphoglucuronate-glucuronosyltransferase (BUGT) genes, into BUGT-deficien

49 noviral antigens, we immunized bilirubin-UDP-glucuronosyltransferase (BUGT)-deficient jaundiced Gunn

50 ll as other enzymes (eg, uridine diphosphate-glucuronosyltransferases, cytochrome P450 isozymes, nico

51 as injected intravenously into bilirubin-UDP-glucuronosyltransferase-deficient Gunn rats.

52 fam 03016 that is the hallmark of the beta-d-glucuronosyltransferase domain of exostosins, a class of

53 he enzyme shows sequence similarities to the glucuronosyltransferase domain of exostosins, a class of

54 mes P-450) and phase II (uridine diphosphate glucuronosyltransferases) drug-metabolizing enzymes are

55 Uridine diphosphate glucuronosyltransferase (EC 2.4.1.17) containing microso

56 ng developmental effects of a microsomal UDP-glucuronosyltransferase-encoding gene from pea (Pisum sa

57 he prostate may be to provide precursors for glucuronosyltransferase enzymes, which inactivate and so

58 one transferases, NAD(P)H:quinone reductase, glucuronosyltransferases, epoxide hydrolase) is a major

59 eterogeneity in uridine 5'-diphosphate (UDP) glucuronosyltransferase expression across the human hepa

60 resulted in a reduced level of bilirubin UDP-glucuronosyltransferase expression in the liver.

61 rved across a 200 kb region spanning the UDP-glucuronosyltransferase family, including UGT1A1, an enz

62 of the bilirubin uridinediphosphoglucuronate glucuronosyltransferase gene.

63 se (XylT), arabinosyltransferase (AraT), and glucuronosyltransferase (GlcAT).

64 y lacked UDP-glucuronic acid:Galbeta1,3Gal-R glucuronosyltransferase (GlcAT-I) activity, as measured

65 thought to encode UDP-GlcUA:Galbeta1,3Gal-R glucuronosyltransferase (GlcUAT-I), involved in the form

66 tical to the UDP-GlcUA:glycoprotein beta1, 3-glucuronosyltransferase (GlcUAT-P) involved in forming H

67 the position-specific activity of the xylan glucuronosyltransferase GUX1, and so the even pattern of

68 Relocating either galactosyltransferase I or glucuronosyltransferase I had no effect on the other's l

69 d B3GAT3, B4GALT7, and SLC35B2, which encode glucuronosyltransferase I, galactosyltransferase I, and

70 nthetic enzymes: galactosyltransferase I and glucuronosyltransferase I, required for the formation of

71 udy the expression and regulation of beta1,3-Glucuronosyltransferase-I (GlcAT-I), a key enzyme regula

72 We recently discovered an Arabidopsis GIPC glucuronosyltransferase, INOSITOL PHOSPHORYLCERAMIDE GLU

73 e hydrolase, NAD(P)H: quinone reductase, and glucuronosyltransferases] is a powerful strategy for ach

74 -103-G) predominantly by uridine diphosphate glucuronosyltransferase isoform 1A1 (UGT1A1).

75 hydrophobic region in the bilirubin-type UDP-glucuronosyltransferase isozyme was first uncovered as a

76 rs6742078 located in the uridine diphosphate-glucuronosyltransferase locus as an instrumental variabl

77 In all 3 treatment phases, a glucuronosyltransferase polymorphism predicted hyperbili

78 Consistent with the UDP-glucuronosyltransferase requirement for regulated phosph

79 related detoxification enzymes, notably UDP-glucuronosyltransferases, suggesting a network of associ

80 -HexUA were tested as substrates for various glucuronosyltransferases to better understand enzyme spe

81 The human major bilirubin UDP glucuronosyltransferase (transferase), HUG-Brl, and its

82 e as substrate, we showed that LNCaP had UDP-glucuronosyltransferase (UDPGT) activity.

83 stosterone/4-nitrophenol uridine diphosphate glucuronosyltransferase (UDPGT), and aryl sulfotransfera

84 emical and genetic information on vertebrate glucuronosyltransferases (UGATs), only limited informati

85 The human UDP-glucuronosyltransferase (UGT) 1A (UGT1A) locus is regula

86 s associated with a reduction in hepatic UDP glucuronosyltransferase (UGT) 1A1 activity that can lead

87 ecessive inherited deficiency of hepatic UDP-glucuronosyltransferase (UGT) 1A1 activity.

88 constitutional genetic variation at the UDP-glucuronosyltransferase (UGT) 1A1 locus in breast cancer

89 olized solely through glucuronidation by UDP-glucuronosyltransferase (UGT) 1A1, it is now known that

90 nduce the bilirubin-metabolizing enzyme--UDP-glucuronosyltransferase (UGT) 1A1--to prevent the onset

91 quires the expression of uridine diphosphate glucuronosyltransferase (UGT) 1A1; we investigated its r

92 the rabbit liver dexamethasone-inducible UDP-glucuronosyltransferase (UGT) 2B13 RNA is related in seq

93 Because human prostate-distributed UDP-glucuronosyltransferase (UGT) 2B15 metabolizes 5alpha-di

94 tigate the inhibitory effects of TKIs on UDP-glucuronosyltransferase (UGT) activities, and to quantit

95 dinavir-mediated impairment of bilirubin UDP-glucuronosyltransferase (UGT) activity and would be most

96 en glucuronidation, catalyzed by the two UDP-glucuronosyltransferase (UGT) enzymes UGT2B15 and UGT2B1

97 f the UGT1A gene, encoding half of human UDP-glucuronosyltransferase (UGT) enzymes, undergo alternati

98 endoxifen, is by glucuronidation via the UDP-glucuronosyltransferase (UGT) family of enzymes.

99 metabolism is by glucuronidation via the UDP-glucuronosyltransferase (UGT) family of enzymes.

100 A reduced hepatic bilirubin UPD- glucuronosyltransferase (UGT) is associated with this sy

101 A1) encoding the uridinediphosphoglucuronate glucuronosyltransferase (UGT) isoform bilirubin-UGT1 wer

102 ein-protein interactions between several UDP-glucuronosyltransferase (UGT) isoforms and cytochrome P4

103 The UDP-glucuronosyltransferase (UGT) isozyme system is critical

104 UDP-glucuronosyltransferase (UGT) isozymes catalyze detoxifi

105 UDP-glucuronosyltransferase (UGT) isozymes detoxify metaboli

106 In humans, uridine 5'-diphosphate glucuronosyltransferase (UGT) operates in opposition to

107 Microsomal uridine diphosphate (UDP)-glucuronosyltransferase (UGT) protein expression and UGT

108 (NQO1), glutathione S-transferase (GST), UDP-glucuronosyltransferase (UGT), and phenol sulfotransfera

109 hepatic glutathione S-transferase (GST), UDP-glucuronosyltransferase (UGT), and sulfotransferase (ST)

110 UDP-glucuronosyltransferase (UGT)-mediated glucuronidation o

111 ained at least partly by upregulation of UDP-glucuronosyltransferase (UGT).

112 in vitro studies have suggested that the UDP-glucuronosyltransferases (UGT) 2B10 and 2B17 play major

113 Human UDP-glucuronosyltransferases (UGT) are the dominant phase II

114 UDP-glucuronosyltransferases (UGT) catalyze the conjugation

115 gamma-glutamylcysteine synthetase (GCS), UDP-glucuronosyltransferases (UGT),epoxide hydrolase, as wel

116 similarity to the rat CGT enzyme and to UDP-glucuronosyltransferases (UGT).

117 iable exons arrayed in tandem, including UDP glucuronosyltransferase (UGT1), plectin, neuronal nitric

118 The human UDP-glucuronosyltransferase UGT1A locus encodes up to 12 uni

119 ioma-associated protein 1 (GLI1) and the UDP glucuronosyltransferase (UGT1A) family of enzymes are el

120 ncodes hepatic bilirubin uridine diphosphate-glucuronosyltransferase (UGT1A1).

121 The UDP-glucuronosyltransferase, UGT1A1, is the critical enzyme

122 uired for hepatic bilirubin elimination, UDP-glucuronosyltransferase, UGT1A1.

123 UDP-glucuronosyltransferase UGT1A7 catalyzes the glucuronida

124 f two androgen-inactivating enzymes, the UDP-glucuronosyltransferases UGT2B15 and UGT2B17, was assess

125 The UDP-glucuronosyltransferase UGT2B7 is an important human UGT

126 The UDP-glucuronosyltransferase UGT2B7 is an important human UGT

127 Family 1 UDP-glucuronosyltransferases (UGTs) (UGT1A) are encoded by a

128 ficient in drug conjugation catalyzed by UDP-glucuronosyltransferases (UGTs) and now report on the ro

129 UDP-glucuronosyltransferases (UGTs) are critical to the deto

130 UDP-glucuronosyltransferases (UGTs) are highly expressed in

131 UDP-glucuronosyltransferases (UGTs) are important enzymes th

132 UDP-glucuronosyltransferases (UGTs) are membrane-bound prote

133 Among the 19 functional UDP-glucuronosyltransferases (UGTs) in humans, UGT2B7 is inv

134 ity label [beta-32P]5-azido-UDP-GlcUA to UDP-glucuronosyltransferases (UGTs) in intact, but not in de

135 pid, reversible down-regulation of human UDP-glucuronosyltransferases (UGTs) in LS180 cells following

136 D-glucopyranosides (glucuronides) by the UDP-glucuronosyltransferases (UGTs) is a significant metabol

137 tor-activated receptor alpha (PPARalpha)-UDP-glucuronosyltransferases (UGTs) signalling is an importa

138 n liver microsomes and human recombinant UDP-glucuronosyltransferases (UGTs) was characterized and co

139 The UGT1A cluster encodes a family of UDP-glucuronosyltransferases (UGTs), which facilitate cellul

140 tion of cytoprotective genes such as the UDP-glucuronosyltransferases (UGTs).

141 lucuronidated by hepatic uridine diphosphate glucuronosyltransferases (UGTs).

142 carried out by the Super gene family of UDP-glucuronosyltransferases (UGTs).

143 and catalytic activity of human hepatic UDP-glucuronosyltransferases (UGTs).

144 e to identify the phenol binding site of UDP-glucuronosyltransferases (UGTs).

145 ory patterns of the phase II superfamily UDP-glucuronosyltransferases (UGTs).

146 PsUGT1, which encodes a microsomal UDP-glucuronosyltransferase, was cloned from root tips of Pi

147 cyclodeaminase, and the uridine diphosphate glucuronosyltransferases, whereas alleles such as DRB1*0

148 az both induce an unidentified rat liver UDP-glucuronosyltransferase with activity toward benzo(a)pyr