ライフサイエンスコーパス: glutamate dehydrogenase

1 ions of concurrent NADPH sources, especially glutamate dehydrogenase.

2 ation of L-glutamate catalyzed by beef liver glutamate dehydrogenase.

3 ding the key nitrogen metabolism enzyme NADP-glutamate dehydrogenase.

4 in gudB, which encodes an otherwise inactive glutamate dehydrogenase.

5 ism and may be through leucine activation of glutamate dehydrogenase.

6 specificity of ammonium-assimilating enzyme glutamate dehydrogenase.

7 lation of insulin secretion by modulation of glutamate dehydrogenase.

8 n products, into glutamate, using urease and glutamate dehydrogenase.

9 enzyme represents a novel class of microbial glutamate dehydrogenases.

10 ed significant similarity with mitochondrial glutamate dehydrogenases.

11 Here we report that the mitochondrial enzyme glutamate dehydrogenase 1 (GDH1) is commonly upregulated

12 Extended analysis of the glutamate dehydrogenase 1 (Gdh1) revealed that it regula

13 Here we report that a glutaminolytic enzyme, glutamate dehydrogenase 1 (GDH1), upregulated upon detac

14 Examining human gliomas, we find that glutamate dehydrogenase 1 (GLUD1) and GLUD2 are overexpr

15 lease in the CNS by introducing the gene for glutamate dehydrogenase 1 (Glud1) under the control of t

16 iated protein 1), citrate synthase, and GDH (glutamate dehydrogenase 1), are substrates of PARP-1 in

17 effect that is abrogated in the presence of glutamate dehydrogenase 2 (GLUD2), a hominoid-specific e

18 on of some key mitochondrial enzymes such as glutamate dehydrogenase 2 (GLUD2), adenylate kinase 2 (A

19 losuccinate lyase and to regulatory sites of glutamate dehydrogenase, 2) the use of affinity cleavage

20 tures of lactate dehydrogenase (145 kDa) and glutamate dehydrogenase (334 kDa), respectively.

21 secretion in response to glutamine plus the glutamate dehydrogenase activator 2-amino-2-norbornane c

22 by reductions in aspartate transaminase and glutamate dehydrogenase activities, suggesting additiona

23 We conclude that glutamate dehydrogenase activity affects the expression

24 We measured glutamate dehydrogenase activity in lymphoblasts from ei

25 mice exhibit increased glutamine uptake and glutamate dehydrogenase activity.

26 for the biomarkers of hepatocellular injury glutamate dehydrogenase, alanine aminotransferase, aspar

27 unit-subunit interactions for homo-hexameric glutamate dehydrogenase, allowing DeltaDeltaG of reversi

28 A-metabolizing enzymes glutamine synthetase, glutamate dehydrogenase, alpha-ketoglutarate dehydrogena

29 Irradiation of the complex of glutamate dehydrogenase and AMPS-Succ-BP at lambda >300

30 As a result of overexpressing the mutant glutamate dehydrogenase and Bacillus subtilis threonine

31 tridge assay determines the presence of both glutamate dehydrogenase and Clostridium difficile toxins

32 CFEs were suitable sources of peptidases, glutamate dehydrogenase and cystathionine gamma-lyase.

33 nd catalase as the primary autoantigens, and glutamate dehydrogenase and epoxide hydrolase-2 as addit

34 led by the nitrogen regulatory (Ntr) system, glutamate dehydrogenase and histidase.

35 interesting similarities to the structure of glutamate dehydrogenase and leucine dehydrogenase and al

36 conjunction with above average abundances of glutamate dehydrogenase and proline utilization protein

37 allel by a real-time PCR assay (PCR), a dual glutamate dehydrogenase and toxin A/B enzyme immunoassay

38 gene tcdB, and a 3-step algorithm detecting glutamate dehydrogenase and toxins A and B by enzyme imm

39 an enzyme immunoassay for toxins A and B or glutamate dehydrogenase, and a PCR for toxin B genes wer

40 rase, branched chain ketoacid dehydrogenase, glutamate dehydrogenase, and glutamic acid decarboxylase

41 For 51 CDI patients, PCR, glutamate dehydrogenase, and toxigenic culture results c

42 rase chain reaction (PCR) for toxin B genes, glutamate dehydrogenase, and toxigenic culture, from pos

43 life function in cases such as G to F-actin, glutamate dehydrogenase, and tubulin and flagella format

44 tridium difficile: an enzyme immunoassay for glutamate dehydrogenase antigen (Ag-EIA) and then, for a

45 ce of the rapid C. diff Quik Chek Complete's glutamate dehydrogenase antigen (GDH) and toxin A/B (CDT

46 stal structures of glutathione reductase and glutamate dehydrogenase are now available; another drug

47 The Vidas C. difficile glutamate dehydrogenase assay had performance comparable

48 ct effect is the stimulation of succinate or glutamate dehydrogenase by decreasing matrix Mg2+.

49 Glutamate dehydrogenase catalyses the oxidative deaminat

50 d nucleotide absorbance time courses for the glutamate dehydrogenase catalyzed oxidative deamination

51 intermediate complexes of the bovine liver l-glutamate dehydrogenase-catalyzed reaction.

52 e glutamate dehydrogenase gene by sequencing glutamate dehydrogenase complementary DNA prepared from

53 on glutamine synthesis, we hypothesize that glutamate dehydrogenase complements mitochondrial ammoni

54 Glutamate dehydrogenase covalently attached on tip of VA

55 reaction catalyzed by Clostridium symbiosum glutamate dehydrogenase (csGDH) producing the real-time

56 Here, we used mice with beta-cell-selective glutamate dehydrogenase deletion (betaGlud1(-/-)), lacki

57 , TSC1/2-/- cells become highly dependent on glutamate dehydrogenase-dependent glutamine metabolism v

58 and tandem mass spectrometry to investigate glutamate dehydrogenase dodecamers and serum amyloid P d

59 odelling study using sequences of a range of glutamate dehydrogenases drawn from species which span a

60 fixation genes and represses a gene encoding glutamate dehydrogenase during nitrogen fixation.

61 homolog of the ryanodine receptor type-2 and glutamate dehydrogenase (EC 1.4.1.3), were further inves

62 o examples: the TATA-box binding protein and glutamate dehydrogenase families.

63 balanced by a NAC-independent activation of glutamate dehydrogenase formation during nitrogen-limite

64 s also showed a loss of a weak repression of glutamate dehydrogenase formation.

65 The sHSP also prevented bovine glutamate dehydrogenase from aggregating at 56 degrees C

66 Glutamate dehydrogenase from beef liver (bl GDH) and the

67 The recent structure determination of glutamate dehydrogenase from the hyperthermophile Pyroco

68 stal structure of the extremely thermostable glutamate dehydrogenase from Thermococcus litoralis has

69 direct structure comparison on the hexameric glutamate dehydrogenases from the hyperthermophiles Pyro

70 mitochondria by either PDG (from 5-(15)N) or glutamate dehydrogenase (from 2-(15)N) enjoys the same p

71 o-sector ATPase, syntaxin binding protein 1, glutamate dehydrogenase, gamma-actin, and elongation fac

72 ondrial GTP (mtGTP)-insensitive mutations in glutamate dehydrogenase (GDH(H454Y)) result in fasting a

73 uses NAD to ADP-ribosylate and downregulate glutamate dehydrogenase (GDH) activity.

74 assay, which tests for the presence of both glutamate dehydrogenase (GDH) and C. difficile toxins A

75 lating enzymes glutamine synthetase (GS) and glutamate dehydrogenase (GDH) and the ammonium-evolving

76 neously detecting both Clostridium difficile glutamate dehydrogenase (GDH) and toxin A/B antigens aga

77 ed for toxigenic Clostridium difficile using glutamate dehydrogenase (GDH) and toxin immunoassays com

78 mino acid polymorphisms in the NAD-dependent glutamate dehydrogenase (Gdh) and trehalase (Treh) genes

79 ls were screened for C. difficile-associated glutamate dehydrogenase (GDH) antigen and, if positive,

80 Diff Chek-60 glutamate dehydrogenase (GDH) antigen assay followed by

81 algorithm which includes the C. Diff Chek-60 glutamate dehydrogenase (GDH) antigen assay followed by

82 p algorithm which includes a C. Diff Chek-60 glutamate dehydrogenase (GDH) antigen assay followed by

83 n this study we identify a novel activity of glutamate dehydrogenase (GDH) as a histone H3-specific p

84 s from symptomatic patients were tested by a glutamate dehydrogenase (GDH) assay, a toxin A and B enz

85 pecimens that were positive for C. difficile glutamate dehydrogenase (GDH) by Wampole C Diff Quik Che

86 Glutamate dehydrogenase (GDH) catalyzes the oxidative de

87 The glutamate dehydrogenase (GDH) enzymes of 19 Streptococcu

88 gnostic algorithm, an enzyme immunoassay for glutamate dehydrogenase (GDH) followed by the cytotoxin

89 Two linked mutations affecting glutamate dehydrogenase (GDH) formation (gdh-1 and rev-2

90 ment of the Giardia genome that contains the glutamate dehydrogenase (GDH) gene and a portion of a se

91 The structure of human glutamate dehydrogenase (GDH) has been determined in the

92 Glutamate dehydrogenase (GDH) has been shown to play a r

93 Glutamate dehydrogenase (GDH) has been shown to play a r

94 Identification of regulatory mutations of glutamate dehydrogenase (GDH) in a form of congenital hy

95 Mammalian glutamate dehydrogenase (GDH) is a homohexameric enzyme

96 is of beta-cells is partly turned on because glutamate dehydrogenase (GDH) is activated by a decrease

97 Glutamate dehydrogenase (GDH) is allosterically activate

98 Glutamate dehydrogenase (GDH) is found in all organisms

99 Glutamate dehydrogenase (GDH) is found in all organisms

100 Glutamate dehydrogenase (GDH) is regulated by both posit

101 Glutamate dehydrogenase (GDH) is ubiquitous to all organ

102 In pancreatic beta-cells, glutamate dehydrogenase (GDH) modulates insulin secretio

103 ) operon and to repress transcription of the glutamate dehydrogenase (gdh) operon in K. aerogenes.

104 erate glutamate and the second occurring via glutamate dehydrogenase (GDH) or transaminases.

105 The glutamate dehydrogenase (GDH) pathway is important durin

106 Glutamate dehydrogenase (GDH) plays an important role in

107 ng, and two- and three-step algorithms using glutamate dehydrogenase (GDH) screening followed by eith

108 The role of NADH-dependent glutamate dehydrogenase (GDH) was investigated by studyi

109 gluD was highly conserved and glutamate dehydrogenase (GDH) was readily expressed in v

110 Tag cells and in vivo, whereas activation of glutamate dehydrogenase (GDH) was required to stimulate

111 cyl-coenzyme A dehydrogenase short chain and glutamate dehydrogenase (GDH) were decreased by 68% and

112 he GTP and ADP binding sites of bovine liver glutamate dehydrogenase (GDH) were identified using phot

113 We illustrate this here using glutamate dehydrogenase (GDH), a 336-kDa metabolic enzym

114 noassays (EIAs), an EIA for the detection of glutamate dehydrogenase (GDH), and culture of C. diffici

115 We have previously shown that glutamate dehydrogenase (GDH), mitochondrial DNA (mtDNA)

116 ong them, GDH2, which encodes one subunit of glutamate dehydrogenase (GDH), was chosen for further st

117 on that encodes a catabolic NAD(+)-dependent glutamate dehydrogenase (GDH), which converts l-glutamat

118 From 2-step testing, all glutamate dehydrogenase (GDH)-positive specimens, regard

119 synthetase, glutamate synthase (GOGAT), and glutamate dehydrogenase (GDH).

120 e derived from nonglycolytic sources; and 3) glutamate dehydrogenase (GDH).

121 decarboxylation and allosteric activation of glutamate dehydrogenase (GDH).

122 S/GOGAT cycle) or the action of biosynthetic glutamate dehydrogenase (GDH).

123 -CoA was formed from glutamine downstream of glutamate dehydrogenase (GDH).

124 promotes glutamine anaplerosis by activating glutamate dehydrogenase (GDH).

125 gnaling functions via its metabolism through glutamate dehydrogenase (GDH).

126 le, with a large increase in the activity of glutamate dehydrogenase (GDH).

127 a strategy of treating nobody, lateral-flow glutamate dehydrogenase (GDH)/odPCR generated 831 true-p

128 nia through reductive amination catalyzed by glutamate dehydrogenase (GDH); secondary reactions enabl

129 ST, GLT-1 and EAAT-1), glutamate metabolism (glutamate dehydrogenase [GDH] and glutamine synthetase [

130 evels of biomarkers of mitochondrial damage (glutamate dehydrogenase [GDH] and mitochondrial DNA [mtD

131 The protein complex also contains glutamate dehydrogenase (GDH1), 4-nitrophenylphosphatase

132 Notably, expression of glutamate dehydrogenase GDH2, a hominoid-specific enzyme

133 addition to its known regulation by NCR, NAD-glutamate dehydrogenase (GDH2) gene expression is down-r

134 The gene encoding an NAD(P)H-dependent glutamate dehydrogenase (gdhA) in Bacteroides thetaiotao

135 ation in the structural gene for NADP-linked glutamate dehydrogenase, gdhA, which disrupts metabolism

136 We identified mutations in the glutamate dehydrogenase gene by sequencing glutamate deh

137 nemia syndrome is caused by mutations in the glutamate dehydrogenase gene that impair the control of

138 The expression of the am (glutamate dehydrogenase) gene is dependent upon two upst

139 ona fide C. difficile promoters for rRNA and glutamate dehydrogenase genes.

140 Urease (Urs) and glutamate dehydrogenase (GLDH) are covalently attached t

141 K18; markers of necrosis and apoptosis), and glutamate dehydrogenase (GLDH; marker of mitochondrial d

142 K18], high mobility group box-1 [HMGB1], and glutamate dehydrogenase [GLDH]).

143 Whereas most cells use glutamate dehydrogenase (GLUD1) to convert glutamine-der

144 Comparisons of the structures of glutamate dehydrogenase (GluDH) and leucine dehydrogenas

145 ive, as revealed by the activity profiles of glutamate dehydrogenase, glutamate synthase, and glutami

146 tains two genes with the potential to encode glutamate dehydrogenase (GlutDH) enzymes.

147 ory pathway, we determined that biosynthetic glutamate dehydrogenase has an inverse isotope effect in

148 Studies of new serum biomarkers such as glutamate dehydrogenase, high mobility group box protein

149 e following: (i) GDH2 encoding NAD-dependent glutamate dehydrogenase; (ii) AAT1 and AAT2 encoding mit

150 the gene (gdh) that encodes the biosynthetic glutamate dehydrogenase in Salmonella.

151 d by a loss of interaction between SCHAD and glutamate dehydrogenase in the pancreatic beta-cells.

152 een tea polyphenols are potent inhibitors of glutamate dehydrogenase in vitro and can efficaciously b

153 etion stimulates succinate dehydrogenase (or glutamate dehydrogenase) in state 4 without decreasing m

154 ia, and NADH) and L-leucine (an activator of glutamate dehydrogenase) in the standard assay mixture,

155 dependent valine dehydrogenases, the evolved glutamate dehydrogenase increased the conversion yield o

156 eticulum and in leakage of the mitochondrial glutamate dehydrogenase into the plasma, reflecting mito

157 Glutamate dehydrogenase is covalently attached to the ti

158 Glutamate dehydrogenase is found in all organisms and ca

159 Bovine liver glutamate dehydrogenase is known to be allosterically ac

160 nt of BCAT activity in tissue homogenates by glutamate dehydrogenase is observed.

161 e of Bacillus subtilis, encoding a catabolic glutamate dehydrogenase, is transcribed by SigL (sigma(5

162 ere found not to be detectable substrates of glutamate dehydrogenase, L-leucine dehydrogenase, L-phen

163 nd development as well as a 50% reduction in glutamate dehydrogenase levels.

164 Glutamate dehydrogenase mRNA and activity remained uncha

165 The NAD(+)-dependent glutamate dehydrogenase (NAD-GDH) from Pseudomonas aerug

166 stinct cDNA clones encoding NAD(H)-dependent glutamate dehydrogenase (NAD[H]-GDH) in Arabidopsis thal

167 onium-inducible, chloroplastic NADP-specific glutamate dehydrogenase (NADP-GDH) isozymes composed of

168 DIFF CHEK, a new screening test that detects glutamate dehydrogenase of C. difficile.

169 of lack of the glutamate-synthesizing enzyme glutamate dehydrogenase on glucose-limited growth is alt

170 lebsiella aerogenes, the gdhA gene codes for glutamate dehydrogenase, one of the enzymes responsible

171 latory system (Ntr), which in turn represses glutamate dehydrogenase, one pathway of glutamate produc

172 increasing alpha-ketoglutarate production by glutamate dehydrogenase or mitochondrial aspartate amino

173 cellular metabolic signal transduction, with glutamate dehydrogenase playing a key role in the amplif

174 fficile infection and indeterminate results (glutamate dehydrogenase positive, toxin A and B negative

175 the assay mixture, the interference from the glutamate dehydrogenase reaction is minimized.

176 creatic islets suggest that flux through the glutamate dehydrogenase reaction is quiescent during glu

177 Therefore, we propose that glutamate dehydrogenase regulation of insulin secretion

178 The glutamate dehydrogenase RocG of Bacillus subtilis is a b

179 hesis of the other glutamate-forming enzyme, glutamate dehydrogenase, severalfold, but this is still

180 Due to the presence of glutamate dehydrogenase substrates (alpha-ketoglutarate,

181 t has fewer than 3 loose stools per day; the glutamate dehydrogenase test for CDI is sensitive and th

182 ls, as did the activities of glutaminase and glutamate dehydrogenase, the enzymes needed to convert g

183 ulin release is associated with flux through glutamate dehydrogenase, the flux is in the direction of

184 The metabolic activity of glutamate dehydrogenase thus has important and previousl

185 The sensitivity of glutamate dehydrogenase to inhibition by guanosine 5'-tr

186 both glutamate-oxaloacetate transaminase and glutamate dehydrogenase to maintain Gln homeostasis and

187 ate, the data suggest that P. mirabilis uses glutamate dehydrogenase to monitor carbon-nitrogen balan

188 Single molecular or multistep assays (glutamate dehydrogenase, toxin A/B, +/- molecular) are r

189 argets for C difficile detection: bacterium (glutamate dehydrogenase), toxins, or toxin genes.

190 ive glutamate biosensor is prepared based on glutamate dehydrogenase/vertically aligned carbon nanotu

191 Weak inhibition of aminotransferases and glutamate dehydrogenase was found with some of the alpha

192 In addition, high activity of glutamate dehydrogenase was incompatible with activity o

193 Glutamate dehydrogenase was more resistant (K(i)(app) =

194 the Roc pathway indicated that rocG-encoded glutamate dehydrogenase was required for such repression

195 ocitrate dehydrogenase-2, malic enzymes, and glutamate dehydrogenase) was assessed.

196 nthetase) was repressed in vivo, while gdhA (glutamate dehydrogenase) was upregulated in vivo.

197 illus subtilis rocG gene, encoding catabolic glutamate dehydrogenase, was found to be subject to dire

198 ments of the genes encoding beta-giardin and glutamate dehydrogenase were sequenced and their alignme

199 s positioned within the crystal structure of glutamate dehydrogenase, where it should also mark the A

200 sterically activate glutamate deamination by glutamate dehydrogenase, which can supply alpha-ketoglut

201 mmonemia was caused by excessive activity of glutamate dehydrogenase, which oxidizes glutamate to alp

202 late the activity of a large NAD(+)-specific glutamate dehydrogenase with an unusually low affinity f

203 ia is transferred to alpha-ketoglutarate via glutamate dehydrogenase, yielding glutamate and the oxid