ライフサイエンスコーパス: glutamic acid

1 eptidase in which the third zinc ligand is a glutamic acid).

2 of tRNAs specific for lysine, glutamine and glutamic acid.

3 from glucose, guanine, and p-aminobenzoyl-l-glutamic acid.

4 tion of HMF from fructose in the presence of glutamic acid.

5 e digestion motifs flanked with aspartic and glutamic acid.

6 molecule was replaced by the side chain of a glutamic acid.

7 s associated with consumption of excess free glutamic acid.

8 r phenylalanine or to the negatively charged glutamic acid.

9 caspases can also hydrolyze substrates after glutamic acid.

10 ycine, l-proline, l-serine, l-alanine, and l-glutamic acid.

11 zolin-6-yl]amino]benzoyl]-l-gamma-glutamyl-d-glutamic acid 1 (BGC 945, now known as ONX 0801), is a s

12 ive mutagenesis analysis, we identified that glutamic acid 14 (E14) of vBcl-2 is critical for KSHV ly

13 to a chemical reaction, the deprotonation of glutamic acid 148 (E148).

14 he lumen-exposed residues, threonine 162 and glutamic acid 173, form stabilizing hydrogen bonds betwe

15 nd kinetics of (S)-4-(3-[18F]fluoropropyl)-l-glutamic acid ((18)F FSPG) in healthy volunteers and to

16 id derivative (S)-4-(3-(18)F-Fluoropropyl)-l-glutamic acid ((18)F-FSPG, alias BAY 94-9392), a new PET

17 interactions that include a lysine 113(K113):glutamic acid 195 (E195) salt bridge between actin subun

18 with 3-aminophenyl boronic acid (APB) and L-glutamic acid-(2,2,2)-trichloroethyl ester (GTE).

19 used significantly higher levels (p<0.05) of glutamic acids (343.0+/-22.09mg/100g), total FAAs (1720.

20 eins that are unusually rich in aspartic and glutamic acids [4-6], the role of these proteins in biom

21 he DOTAGA (1,4,7,10-tetraazacyclododecane-1-(glutamic acid)-4,7,10-triacetic acid) conjugate PSMA I&T

22 nT, tyrosine-43, lysine-69, arginine-254 and glutamic acid-493, were required for activity.

23 acids, L-aspartic acid 4-methyl ester and L-glutamic acid 5-methyl ester, is a convenient and sensit

24 External glutamic acid 623 (E623) is key for TMEM16A's ability to

25 ngs we propose that external protons titrate glutamic acid 623, which enables voltage activation of T

26 Previous conclusions on the involvement of glutamic acid 90 in channel opening are ruled out by dem

27 erred a small-plaque avirulent phenotype and glutamic acid a large-plaque virulent phenotype.

28 lyceraldehyde 3-phosphate dehydrogenase with glutamic acid, a malonyllysine mimic, suppressed its enz

29 feri and Burkholderia thailandensis bound to glutamic acid, a TrpRS from the eukaryotic pathogen Ence

30 to characterize the human aspartic acid- and glutamic acid-ADP-ribosylated proteome.

31 Glucose, trehalose and glutamic acid, alanine were the major sugars and amino a

32 andom copolymer of the amino acids tyrosine, glutamic acid, alanine, and lysine.

33 nificant effects were noticed in the case of glutamic acid, alanine, aspartic acid and proline betwee

34 We show that protonation of the conserved glutamic acid alters the peptide insertion depth in the

35 Glutamic acid and alanine make up more than 60 per cent

36 f glutamic acid (p < 0.05) and 200 mug/mL of glutamic acid and aspartic acid (p < 0.001) without affe

37 Free glutamic acid and free aspartic acid found in the PPI hy

38 m, were conjugated quickly and directly with glutamic acid and glutamine, and further with peptides,

39 PELP1 (proline, glutamic acid and leucine rich protein 1) is a nuclear r

40 rs containing the blocks of ethylene glycol, glutamic acid and phenylalanine (PEG-PGlu-PPhe) were suc

41 TPs calculated from delta (15)N values of glutamic acid and phenylalanine, which range from 8.3-33

42 s from wet solids were significantly rich in glutamic acid and proline.

43 ng 98% of ascorbic acid and 100% of glycine, glutamic acid and uric acid.

44 and size, such as arginine, serine, lysine, glutamic acid, and cysteine.

45 l interference from ascorbic acid, cysteine, glutamic acid, and glucose was also studied, and the obt

46 Here, we identify proline, glutamic acid, and leucine-rich protein 1 (PELP1), a chr

47 thic and thin-film MIPs against Z-L-Phe, Z-L-glutamic acid, and penicillin G.

48 cted mutagenesis of the Env7 alanine-proline-glutamic acid (APE) motif Glu269 to alanine results in a

49 served when acidic amino acids, aspartic and glutamic acids, are present near the cleavage site.

50 We examined whether the intake of glutamic acid, arginine, cysteine, lysine, or tyrosine w

51 Our data do not suggest a major role for glutamic acid, arginine, lysine, tyrosine, or cysteine i

52 d with nontumor tissues (proline, threonine, glutamic acid, arginine, N1-acetylspermidine, xanthine,

53 as compared to adsorption of soy protein and glutamic acid as common ingredients.

54 complex with the Nix LIR peptide containing glutamic acids as phosphomimetic residues and NMR experi

55 here is no interference from d-glucose and l-glutamic acid, ascorbic acid and o-nitrophenol.

56 roline, glycine, serine, alanine, glutamine, glutamic acid, aspargine, aspartic acid were detected.

57 ant amino acids that contributed to flavour (glutamic acid, aspartic acid and alanine) were present a

58 ous lambda variable gene segments encoding a glutamic acid-aspartic acid (ED) motif for K169 recognit

59 tin-1, QHREDGS (glutamine-histidine-arginine-glutamic acid-aspartic acid-glycine-serine), as a therap

60 either the wild type (WT) or with alanine or glutamic acid/aspartic acid substitutions at the phospho

61 chemically well-defined amphoteric carriers, glutamic acid, aspartyl-histidine (Asp-His), cycloserine

62 For rat Glut5, a change of glutamine to glutamic acid at codon 166 (p.Q166E) has been reported t

63 n of the AIF-MIF interaction, or mutation of glutamic acid at position 22 in the catalytic nuclease d

64 with previous studies, we demonstrate that a glutamic acid at position 296 results in attenuation.

65 thin the C terminus of LukA, we identified a glutamic acid at position 323 that is critical for LukAB

66 In this study we found that KIR2DL2/L3 with glutamic acid at position 35 (E(35)) are functionally st

67 rily linked to HLA-DPB1 alleles possessing a glutamic acid at position 69 of the beta-chain.

68 ions not previously identified, specifically glutamic acid at positions 10 or 11 or lysine at positio

69 f-function mutation in which lysine replaced glutamic acid at residue 1021 (E1021K) in the p110delta

70 he combination of arginine at residue 11 and glutamic acid at residue 35 in KIR2DL3*005 were critical

71 associated with HLA-DP alleles possessing a glutamic acid at the 69th position of the beta-chain (be

72 71 mutant, containing lysine, glutamine, and glutamic acid at the respective residues 98, 145, and 16

73 k copolymers, poly(ethylene glycol)-b-poly(L-glutamic acid)-b-poly(L-phenylalanine), which effectivel

74 ely exoprotease production and poly-gamma-dl-glutamic acid biosynthesis.

75 We conjugate doxorubicin to poly(L-glutamic acid) by means of a pH-sensitive cleavable link

76 factor and protective antigen), and a poly-d-glutamic acid capsule.

77 tudy, we examined the efficacy of poly-gamma-glutamic acid/chitosan (PC) nanogel as an adjuvant for t

78 D-aas such as D-Asp (aspartic acid), D-Glu (glutamic acid), combined D-[Asp/Glu] and others were eac

79 nd non-coding regions explained aspartic and glutamic acid consumption differences, likely due to a p

80 ity but cleaved gamma-links in both d- and l-glutamic acid-containing polymers.

81 Glutamic acid contributed most to protein intake (21% of

82 ved DC were pulsed with preproinsulin (PPI), glutamic acid decarboxylase (65-kDa isoform; GAD65), and

83 gamma aminobutyric acid synthesizing enzyme glutamic acid decarboxylase (GAD) and choline acetyltran

84 High titers of autoantibodies to glutamic acid decarboxylase (GAD) are well documented in

85 is is controlled by enzymes derived from two glutamic acid decarboxylase (GAD) genes, GAD1 and GAD2,

86 f the rate-limiting GABA-synthesizing enzyme glutamic acid decarboxylase (GAD) is decreased in Brodma

87 of activation (Fos) of GABAergic neurons and glutamic acid decarboxylase (GAD) mRNA expression in the

88 probe for imaging the activity of the enzyme glutamic acid decarboxylase (GAD) present in neurons.

89 dinucleotide phosphate-diaphorase (NADPH-d), glutamic acid decarboxylase (GAD), cytochrome oxidase (C

90 ly detect somal immunoreactivity for GABA or glutamic acid decarboxylase (GAD), the enzyme that produ

91 e and some were parvalbumin-, calbindin-, or glutamic acid decarboxylase (GAD)-67-positive.

92 nobutyric acid (GABA) transporter (vGAT) and glutamic acid decarboxylase (GAD)65 in the GABAergic con

93 Additionally, glutamic acid decarboxylase (GAD)65-loaded tolDCs from w

94 on, with either green fluorescent protein or glutamic acid decarboxylase (GAD)65/67 immunoreactivity

95 Here, we study the distribution of glutamic acid decarboxylase (GAD)67 and GLY transporter

96 were triple-labeled for the 65 kD isoform of glutamic acid decarboxylase (GAD65), PV and the GABA(A)

97 Gad1 gene-encoded 67-kDa protein isoform of glutamic acid decarboxylase (GAD67) is a hallmark of sch

98 om the RVLM, were assessed for expression of glutamic acid decarboxylase (GAD67) or preproenkephalin

99 ntain normal levels of the 67 kDa isoform of glutamic acid decarboxylase (GAD67) protein, the enzyme

100 to lower expression of the 67-kDa isoform of glutamic acid decarboxylase (GAD67), a key enzyme for GA

101 ext, we produced conditional null alleles of Glutamic acid decarboxylase 1 (Gad1) and Resistant to di

102 nerated transgenic mouse lines that suppress glutamic acid decarboxylase 1 (GAD1) in either cholecyst

103 Levels of gamma-aminobutyric acid (GABA) and glutamic acid decarboxylase 1 (GAD1), the enzyme that sy

104 In contrast, the silencing of glutamic acid decarboxylase 2-positive interneurons, whi

105 x/klox) mice exhibited reduced expression of glutamic acid decarboxylase 65 (a GABA synthase), increa

106 n of T1D-related autoantigens [proinsulin or glutamic acid decarboxylase 65 (GAD)] delayed T1D onset,

107 tis Abs as well as thyroperoxidase (TPO) and glutamic acid decarboxylase 65 (GAD65) Abs.

108 Glutamic acid decarboxylase 65 (GAD65) and autoantibodie

109 r the development of insulin autoantibodies, glutamic acid decarboxylase 65 (GAD65) autoantibodies, i

110 been identified, including orexin cells and glutamic acid decarboxylase 65 (GAD65) cells, but their

111 gic knowledge on cerebellar ataxia (CA) with glutamic acid decarboxylase 65 antibodies (GAD65-Abs) is

112 id, beta-lactoglobulin, and the autoantigens glutamic acid decarboxylase 65, heat shock protein 60, a

113 globulin) and diabetes-related autoantigens (glutamic acid decarboxylase 65, insulin, heat shock prot

114 Serologic study results revealed glutamic acid decarboxylase 65-IgG in all cases (median

115 man syndrome (4 classic; 5 variant; 66% were glutamic acid decarboxylase 65-IgG positive) and 1 with

116 brane protein (PMP) antibody positivity; and glutamic acid decarboxylase 65-kDa isoform (GAD65) antib

117 atus of the second GABA-synthesizing enzyme, glutamic acid decarboxylase 65-kDa isoform (GAD65), rema

118 lation of the corresponding mRNAs, including glutamic acid decarboxylase 67 (GAD67) and reelin (RELN)

119 The expression of GABAergic marker glutamic acid decarboxylase 67 (GAD67) and the number of

120 pendent expression levels of parvalbumin and glutamic acid decarboxylase 67 (GAD67) in schizophrenia

121 dies have consistently found lower levels of glutamic acid decarboxylase 67 (GAD67) messenger RNA (mR

122 ter (VGLUT2), and the GABA synthetic enzyme, glutamic acid decarboxylase 67 (GAD67), in POMC neurons

123 eurons positively stained with antibodies to glutamic acid decarboxylase 67 was also reduced in the d

124 Levels of the GABA-synthesizing enzyme glutamic acid decarboxylase 67-kDa isoform (GAD67) in th

125 OFC), reduced gray matter volume and reduced glutamic acid decarboxylase 67kDa isoform (GAD67) messen

126 antibodies against the GABA synthetic enzyme glutamic acid decarboxylase and synaptophysin support th

127 Four patients also had high glutamic acid decarboxylase antibodies (>1000 U/ml), and

128 ms of pathology, many patients with SPS have glutamic acid decarboxylase antibodies (GAD-ab), but the

129 Little is known of glutamic acid decarboxylase antibodies (GAD-abs) in the

130 tions of SPS despite the persistence of anti-glutamic acid decarboxylase antibodies following auto-HS

131 Two anti-glutamic acid decarboxylase antibody-positive patients w

132 balanced for age, sex, disease duration, and glutamic acid decarboxylase autoantibody titers.

133 ain development through direct activation of glutamic acid decarboxylase enzyme isoforms that convert

134 he presence of the GABA-synthesizing enzyme, glutamic acid decarboxylase in EC were confirmed by immu

135 brillary acidic protein-immunocytochemistry, glutamic acid decarboxylase in situ hybridization, and p

136 Glutamic acid decarboxylase is the rate-limiting enzyme

137 hat specific promoter regulatory elements of glutamic acid decarboxylase isoforms (Gad1 and Gad2), wh

138 IgE responses to insulin, autoantibodies to glutamic acid decarboxylase or insulinoma-associated ant

139 gic neurons expressing different isoforms of glutamic acid decarboxylase were found to have different

140 (Hu, Yo, Ri, CV2, Tr, amphiphysin, and Ma2), glutamic acid decarboxylase, and mGluR1 antibodies.

141 Autoantibodies to insulin, glutamic acid decarboxylase, and the insulinoma-associat

142 re also immunopositive to antibodies against glutamic acid decarboxylase, suggesting that they use ga

143 ith SPS have antibodies directed against the glutamic acid decarboxylase, the rate-limiting enzyme fo

144 nel of immunocytochemical markers, including glutamic acid decarboxylase-67 (GAD67), somatostatin, an

145 lear layer and in the ganglion cell layer is glutamic acid decarboxylase-positive and shows the morph

146 etween PS and control rats, there were fewer glutamic acid decarboxylase-positive neurons in the form

147 actin-2, GlyR, D1R, D2R, AMPAR, GABA(B)R and glutamic acid decarboxylase.

148 e transporter 2; VGluT2) and GABA signaling (glutamic acid decarboxylase; GAD, and vesicular GABA tra

149 sporter 1 (VGLUT1) and the 65 kDa isoform of glutamic acid-decarboxylase (GAD65) as markers of, respe

150 o patients with novel de novo Tpm3.12 single glutamic acid deletions at positions DeltaE218 and Delta

151 A beta-glutamic acid dendron anchor was used to attach a PEG ch

152 With a protected glutamic acid derivate as the starting material, the pro

153 The glutamic acid derivative (S)-4-(3-(18)F-Fluoropropyl)-l-

154 toes resulted in robust GABA production from glutamic acid derived from blood protein digestion.

155 d-Alanine and d-glutamic acid derived from peptidoglycan decomposition e

156 d allylation of serine-, aspartic acid-, and glutamic acid-derived organozinc reagents, followed by c

157 His6-OPH) and poly(ethylene glycol)-b-poly(l-glutamic acid) diblock copolymer.

158 Arginine-glutamic acid dipeptide repeats (RERE) is located in the

159 at binding did not require the gamma-carboxy glutamic acid domain.

160 w potatoes and also thermally generated from glutamic acid during frying.

161 However, mutation that substituted glutamic acid (E) for glutamine (Q) at amino acid positi

162 The substitution of glutamic acid (E) for lysine (K) at position 627 of the

163 C-terminal domain of connexin43 (Cx43) into glutamic acid (E) or alanine (A) residues.

164 A glutamic acid (E)-to-glycine (G) difference at position

165 e show that a single hydrogen bond between a glutamic acid (E90) and an asparagine (N258) residue suf

166 e engaged, despite the lack of aspartic acid/glutamic acid encoded in the mouse repertoire.

167 arginine finger in conjunction with a novel glutamic acid finger, which forms a salt bridge with an

168 ting sequence of approximately 4 consecutive glutamic acids followed by approximately 4 consecutive b

169 uvignon, the light body of Xinomavro and the glutamic acid for Malvasia.

170 line for enamine formation on one side and a glutamic acid for nitronate protonation on the other sid

171 for Ser2 and/or Ser7 and the phosphomimetic glutamic acid for Ser7.

172 Substitution of glutamic acid for tyrosine between the Syk SH2 domains (

173 /pvdN double mutant produced exclusively the glutamic acid form of pyoverdine.

174 The peptide, which contains a photocaged glutamic acid, forms a solid-like gel in a syringe and c

175 igh-level activity in humans compared to the glutamic acid found at this position in avian isolates.

176 This mutation ('DeltaE') removes a single glutamic acid from the encoded protein, torsinA.

177 Poly-gamma-glutamic acid (gamma-PGA) is an important biochemical pr

178 e pgsBCA cluster (responsible for poly-gamma-glutamic acid (gamma-PGA) synthesis), were intentionally

179 n (CBP)/p300 interacting transactivator with glutamic acid (Glu) and aspartic acid (Asp)-tail 2 (Cite

180 ve methods for measuring glutamine (Gln) and glutamic acid (Glu) in cell cultures and other biologica

181 the source (phenylalanine, Phe) and trophic (glutamic acid, Glu) AAs were 4.1 (muscle) and 5.4 (red b

182 n the soluble structure that comprised three glutamic acids (Glu92, Glu94, and Glu97) that we hypothe

183 xidase (GmOx) microelectrode for measuring l-glutamic acid (GluA) in oxygen-depleted conditions, whic

184 spartic acid, cystathionine, total cysteine, glutamic acid, glutamine, glycine, histidine, total homo

185 n we report self-assembly behavior of poly(l-glutamic acid)-grafted gold NPs in solution and describe

186 l-aspartic acid (IA-Asp) and indole-3-acetyl-glutamic acid (IA-Glu) conjugates.

187 rtic acid (IAA-Asp) and indole-3-acetic acid glutamic acid (IAA-Glu) of 438- and 240-fold, respective

188 rus, cancer, human papillomavirus, dopamine, glutamic acid, IgG, IgE, uric acid, ascorbic acid, acetl

189 Several studies have advocated the role of glutamic acid in cancer therapy.

190 transamination of the three acids to produce glutamic acid in cancerous cells.

191 rearrangements that expressed aspartic acid/glutamic acid in CDR L2.

192 und that a single change of aspartic acid to glutamic acid in CW3 NS1/2 was sufficient for persistenc

193 he E2 envelope glycoprotein (lysine in SFV4, glutamic acid in SFV6).

194 Replacement of a glutamic acid in the central gate with a positively char

195 Importantly, determination of free glutamic acid in the daily diet could also prevent vario

196 Point mutation of either glutamic acid in the Galpha13-binding (767)EKE motif in

197 ons of the arginine and lysine to alanine or glutamic acid in the receptor-binding region ablated the

198 avian influenza virus isolates have carried glutamic acid in this position (PB2 627E), commonly desc

199 The oral introduction of glutamic acid increased virus acquisition by mosquitoes

200 2, one cancer-derived ECRG2 mutant harboring glutamic acid instead of valine at position 30 (V30E) fa

201 The data suggest that glutamic acid is a nitrogen acceptor while alanine, aspa

202 Furthermore, we also found that when the glutamic acid is adjacent to the alkyl tail the supramol

203 lin autoregulatory MREI (methionine-arginine-glutamic acid-isoleucine) domain, highly expressed in th

204 he common C-terminal epitope of neuropeptide glutamic acid-isoleucine/alpha-melanocyte-stimulating ho

205 replacing this lysine with alanine (K265A), glutamic acid (K265E) or glutamine (K265Q), and the func

206 Cytoplasmic localization of proline, glutamic acid, leucine-rich protein 1 (PELP1) is observe

207 Here, we examined the role of non-glutamic acid-leucine-arginine CXC chemokine CXCL9 for T

208 plantation and has been shown to up-regulate glutamic acid-leucine-arginine-positive (ELR(+)) CXC che

209 important and unexpected result is that the glutamic acid ligand to FeB is not essential for functio

210 side chains amino acids that were aspartate, glutamic acid, lysine and tyrosine on the negative side

211 hese findings demonstrated that three buried glutamic acid-lysine pairs, in concert with hydrophobic

212 he CREKA-peptide-modified (Cysteine-Arginine-Glutamic-acid-Lysine-Alanine) omega-3-fatty acid oil con

213 n sources (L-Asparagine, L-Aspartic Acid, L- Glutamic Acid, m- Erythritol, D-Melezitose, D-Sorbitol)

214 out diabetes and was functionally related to glutamic acid metabolism, suggesting a mechanistic link.

215 erved in NuoL (LLys(399)) but is replaced by glutamic acid (MGlu(407)) in NuoM.

216 A previous study documented a glycine to glutamic acid mutation (G4946E) in ryanodine receptor (R

217 In 09HA_mut, a lysine-to-glutamic-acid mutation leads to the loss of both salt br

218 transmitters glutamate and N-acetyl-aspartyl-glutamic acid (NAAG) and their precursor glutamine.

219 Glutamic acids, NGlu(133), MGlu(144), and LGlu(144), are

220 ations involved replacements by glutamine or glutamic acid of E2 glycoprotein amino acids in the acid

221 form the active site, by the new N-terminal glutamic acid of mature SplB is observed.

222 sp70EEVD was restored upon substitution of a glutamic acid of the J-domain.

223 d on both the grafting density of the poly(l-glutamic acid) on the NPs and the size of the NPs.

224 nctional artificial metalloenzyme in which a glutamic acid or aspartic acid residue engineered into s

225 he nonhelical tailpiece or their mutation to glutamic acid or aspartic acid.

226 mutation of these residues to phosphomimetic glutamic acid or transfection with the Src kinases Lyn o

227 mug/mL histidine (p < 0.001), 100 mug/mL of glutamic acid (p < 0.05) and 200 mug/mL of glutamic acid

228 (EnvD) which rapidly hydrolysed poly-gamma-d-glutamic acid (PDGA), the constituent of the anti-phagoc

229 activation is reversed by the removal of the glutamic acid penultimate to the tyrosine.

230 tilayers ~700nm thick fabricated from poly-l-glutamic acid (PGA) and poly-l-lysine (PLL) can be loade

231 A skin prick test for poly-gamma-glutamic acid (PGA) which is a component of jellyfish st

232 eimer's disease, covalently linked to poly-l-glutamic acid (PGA).

233 hybrid hydrogels consisting of a poly(gamma-glutamic acid) polymer network physically cross-linked v

234 is work, we demonstrate that proline-proline-glutamic acid (PPE)17 protein of Mycobacterium tuberculo

235 nts in complex with L-aspartic acid versus L-glutamic acid provide insights into their differential s

236 atural amino acid termed a proline-templated glutamic acid (ptE) that constrained both the backbone a

237 cing of the ALMS1 coding region identified a glutamic acid repeat polymorphism in exon 1, which was s

238 The glutamic acid repeat polymorphism of ALMS1 identified in

239 ion (DeltaGAG), which causes a deletion of a glutamic acid residue (DeltaE) in the C-terminal region

240 acid substitutions at this highly conserved glutamic acid residue and illustrates the value of syste

241 hemically identical carboxylate group on the glutamic acid residue and on the glycine residue shows a

242 ous missense substitutions in the paralogous glutamic acid residue in TWIST2 (p.Glu75Ala, p.Glu75Gln

243 , and a strictly conserved fluorophore-bound glutamic acid residue is converted to a range of variant

244 17Val and p.Glu117Gly) at a highly conserved glutamic acid residue located in the basic DNA binding d

245 th a constitutively phosphorylated mimicking glutamic acid residue or a phosphorylation-dead mimickin

246 ing a calcium ion-binding site and chelating glutamic acid residue that mediate the formation of HC.T

247 304 was replaced with either an alanine or a glutamic acid residue was also affected.

248 enesis of any of the two conserved catalytic glutamic acid residues (Glu(200) and Glu(414)) of the ac

249 by a central tryptophan flanked by aspartic/glutamic acid residues (W-acidic).

250 ution of Ala, Gly, Cys, or Gln for these two glutamic acid residues abrogated all capacity to stimula

251 Interestingly, introduction of three glutamic acid residues alone was not sufficient to estab

252 etal ion bridge, confirm that the serine and glutamic acid residues anchor the bridge, demonstrate th

253 ned oligoarginine peptides equipped with six glutamic acid residues and an anionic pyranine at the N-

254 pecific amino acid substitutions: lysine and glutamic acid residues are replaced by arginine and aspa

255 These peptides possess aspartic and glutamic acid residues at p4 and p7, respectively, that

256 arboxylic groups of various key aspartic and glutamic acid residues by monitoring their C=O stretchin

257 Three glutamic acid residues in epsin UIM were found to intera

258 ouble dehydration and decarboxylation of two glutamic acid residues in the 30-residue precursor PaaP.

259 etween histidine 64 in CAII and a cluster of glutamic acid residues in the C terminus of the transpor

260 of different species with varying numbers of glutamic acid residues in the side chain ranging from 12

261 Second, two glutamic acid residues located on the distal side of the

262 dopted to probe solvent-exposed aspartic and glutamic acid residues on the CP43 protein.

263 lanine, arginine, glycine, aspartic acid and glutamic acid residues represented the major amino acids

264 Notably, the glutamic acid residues were not solely gamma-linked, as

265 ted by the gamma-carboxylase (GGCX) on three glutamic acid residues, a cellular process requiring red

266 s, Hec1 possessed an unusual distribution of glutamic acid residues, Glu-334, Glu-341, and Glu-348, b

267 sensitive to the protonation state of buried glutamic acid residues.

268 rod cGMP-gated cation channel and associated glutamic acid rich proteins (GARPs) are required for pho

269 dominant negative termed A-ZIP53 that has a glutamic acid-rich amphipathic peptide sequence attached

270 ARF) encodes a KSHV LANA-like glutamine- and glutamic acid-rich protein, whereas KSHV LANA1(ARF) enco

271 overy of Src homology 3 (SH3) domain-binding glutamic acid-rich-like protein (SH3BGRL), a novel c-Src

272 Glutamic acid, serine, and glycine concentrations are kn

273 appaBalpha C-terminal PEST (rich in proline, glutamic acid, serine, and threonine residues) sequence

274 ontains PEST sequences (enriched in proline, glutamic acid, serine, and threonine) and is normally su

275 ein tyrosine phosphatases from the proline-, glutamic acid-, serine- and threonine-rich (PEST) family

276 mutations causing deletions of the proline-, glutamic acid-, serine-, and threonine-rich (PEST) domai

277 y, p66 with Thr(206) and Ser(213) mutated to glutamic acid showed a gain-of-function phenotype with s

278 a photolabile dimethoxynitrobenzyl-protected glutamic acid side chain used to impede hydrolysis of th

279 Charge reversal by glutamic acid substitution at Arg-I or Arg-II has opposi

280 The simulations also show why glutamic acid substitution at either serine does not con

281 Furthermore, neither alanine nor glutamic acid substitutions had a significant effect on

282 The alanine and glutamic acid substitutions reduced actin-activated ATPa

283 Serine-to-glutamic acid substitutions that mimicked the phosphoryl

284 amily contains an unnatural 4,4-disubstitued glutamic acid, the synthesis of which provides a key cha

285 cation as a transformation of the N-terminal glutamic acid to a succinamide.

286 to be responsible for the conversion of the glutamic acid to alpha-ketoglutaric acid.

287 two amino acid mutations in the PB2 protein (glutamic acid to lysine at position 627 and aspartic aci

288 to alanine to prevent phosphorylation or to glutamic acid to mimic phosphorylation had no effect on

289 an internal proton transfer from a conserved glutamic acid to the proton-loading site of the pump.

290 a revealed three novel mutations including a glutamic acid to valine substitution (E1338D), a glutami

291 nin still can form pores, but mutating these glutamic acids to glutamines rendered the toxin pH-insen

292 ediated trafficking of the aspartic acid and glutamic acid transporter Dip5 to the vacuole, but it do

293 ulting variant, which has cysteine-histidine-glutamic acid triads on each helix, hydrolyses p-nitroph

294 lutamyl cycle intermediates pyroglutamic and glutamic acid was also shown in risk allele homozygotes

295 atural language (NL) largely untapped (e.g. 'glutamic acid was substituted by valine at residue 6').

296 ythro-beta-d-methylaspartic acid and gamma-d-glutamic acid were key for an isomerization-free synthes

297 er-tasting caffeine, and the umami-tasting l-glutamic acid were the main contributors to the taste of

298 Molecular modeling analysis reveals that the glutamic acid, which is negatively charged, interacts wi

299 Structural analysis revealed that this key glutamic acid, which is not present in Ydj1, forms a sal

300 , but there is a negatively charged residue (glutamic acid) within the transmembrane domain.