ライフサイエンスコーパス: glutamine residue

1 itive residues but also on a conserved polar glutamine residue.

2 whose methionine residue is replaced with a glutamine residue.

3 triplet within the coding region, encoding a glutamine residue.

4 at its place in the DNA stack was taken by a glutamine residue.

5 nvolved the gain or loss of an asparagine or glutamine residue.

6 xtended to peptides containing more than one glutamine residue.

7 ighly conserved histidine is replaced with a glutamine residue.

8 ge interactions, one of which is braced by a glutamine residue.

9 also abrogated by a change in the Drosophila glutamine residue.

10 active site causing hydrolysis of substrate glutamine residues.

11 huntingtin containing 20 (20Q) or 150 (150Q) glutamine residues.

12 35 (Q35-GFP), 56 (Q56-GFP), or 80 (Q80-GFP) glutamine residues.

13 in a region that contains clusters of serine-glutamine residues.

14 CAG/CAA repeats coding for a range of 25-300 glutamine residues.

15 transamidation of specific polypeptide-bound glutamine residues.

16 e SIVs exhibits an increase in the number of glutamine residues.

17 acids in length that is rich in proline and glutamine residues.

18 proteins containing abnormally long runs of glutamine residues.

19 ngles and secondary structural motifs of the glutamine residues.

20 ndividually mutated to alanine, arginine, or glutamine residues.

21 paragine rich but, unexpectedly, contains no glutamine residues.

22 epetitively anywhere within a stretch of ten glutamine residues.

23 while both release factors are methylated at glutamine residues.

24 old for fibril formation to approximately 15 glutamine residues.

25 glutamine expansion exceeds approximately 39 glutamine residues.

26 can occur at a threshold of approximately 40 glutamine residues.

27 eme-bound CO with the B10-tyrosine or the E7-glutamine residues.

28 mplicated in binding of hsp70s, PyJ contains glutamine residues.

29 the ester linkage formation used involucrin glutamine residues 107, 118, 122, 133, and 496 by conver

30 Substitution of the highly conserved glutamine residue 159 in the predicted ligand-binding po

31 , including one showing that substitution of glutamine residue 282 with arginine (Q282R) results in a

32 terminally derived 30-kDa fragment contains glutamine (residue 775) at the NH2-terminal end.

33 or the covalent crosslink reaction between a glutamine residue and a lysine residue.

34 rough mutational analysis, we identified two glutamine residues and a beta-hairpin within this putati

35 e, we synthesized poly(Q) peptides with 3-15 glutamine residues and a corresponding set of poly(Q) pe

36 e in length and rich in glycine, proline and glutamine residues and containing an unusual degenerate

37 ll Rho GTPases by deamidation of a conserved glutamine residue, and HlyA1 forms pores in eukaryotic c

38 corporate P1 lactam moieties in lieu of an L-glutamine residue are described.

39 resulting from expanded repeat sequences of glutamine residues are associated with the formation of

40 The results demonstrate that all three glutamine residues are very stable, with glutamine-50 un

41 sequence from ACBF contains a long repeat of glutamine residues as found in well characterized transc

42 amine, serine and threonine, and proline and glutamine residues, as shown in transient transfection e

43 The essential glutamine residue at position 17 resided in the dimer in

44 The presence of a glutamine residue at the -3 position was found to be imp

45 Similar motifs with glutamate or glutamine residues at that position are rare.

46 tamase containing non-canonical arginine and glutamine residues at the -3 position.

47 The glutamine residues at the reported in vivo deamidation s

48 lysine residues 5, 8, 12, and 16 changed to glutamine residues) background compared to the wild-type

49 between amino acids 7 and 74 and a group of glutamine residues between amino acids 75 and 84.

50 pe distribution for a peptide containing one glutamine residue coincides with the first peak of the i

51 CheD not only deamidates receptor glutamine residues contained within a conserved structur

52 ic layer consisting of an arginine and three glutamine residues contributed from each of the four alp

53 only the longest poly(Q)-poly(P) peptide (15 glutamine residues) did so.

54 the htt(NT) sequence, with or without added glutamine residues, exists in solution as an equilibrium

55 owed that, while poly(Q) peptides with >or=6 glutamine residues formed beta-sheet-rich fibrils, only

56 A withdrawal of a phylogenetically invariant glutamine residue from contact with the gamma-phosphate

57 ith a chloride ion coordinated by one buried glutamine residue from each monomer.

58 Remarkably, the deletion of just one glutamine residue from the middle of the peptide leads t

59 In addition, a central, highly conserved glutamine residue (Gln-48) is buried within the interfac

60 GTPases and specifically deamidates a single glutamine residue (Gln-63 in RhoA) required for GTP hydr

61 inding sites, in part, by a highly conserved glutamine residue (Gln194 in Escherichia coli RecA) that

62 by catalyzing the deamidation of a specific glutamine residue (Gln40) in NEDD8 and the related prote

63 acement of an extracellular histidine with a glutamine residue (H508Q) abolished the slowing of recov

64 ric coiled coils, buried asparagine, but not glutamine, residues have been shown to confer specificit

65 Above a threshold of 37 glutamine residues, htt(e1) starts to aggregate in a nuc

66 erminal amino acids of TonEBP/OREBP, (ii) 17 glutamine residues, (iii) the TAD of c-Jun, or (iv) no T

67 s also synthesized by modifying a single key glutamine residue in A15.

68 ed that FXIIIa displays a preference for the glutamine residue in an xQAxBxPx sequence, where Q repre

69 The surrounding residues anchor the glutamine residue in different orientations for cAMP and

70 degree of regioselectivity for a particular glutamine residue in each peptide.

71 were suggested by the absence of a conserved glutamine residue in human S3 that usually resides at th

72 Mutation of histidine H452 to a glutamine residue in Kv1.5 yields a channel that no long

73 e hinge by the introduction of a hydrophilic glutamine residue in place of isoleucine 260 results in

74 as target substrates, both modify a specific glutamine residue in RhoA, Rac1 and Cdc42, which renders

75 oxins catalyze the deamidation of a specific glutamine residue in RhoA, Rac1, and Cdc42 and consist o

76 ling pathways via deamidation of a conserved glutamine residue in the alpha subunit of heterotrimeric

77 It has been proposed that a conserved glutamine residue in the first membrane-spanning region

78 transferase activity, and they methylate the glutamine residue in the GGQ motif of ribosomal translat

79 nd to be approximately 50% methylated at the glutamine residue in the normal strain but completely un

80 We have placed a glutamine residue in the otherwise hydrophobic interior

81 Analysis of the cleavage sites identified a glutamine residue in the P2 position of all WDSV sites,

82 The glutamine residue in this segment, Gln102, is the site o

83 pentane) was used to study the reactivity of glutamine residues in acidic large and small proline-ric

84 es of huntingtin exon 1 (HDx1) containing 46 glutamine residues in its polyglutamine (polyQ) region.

85 e at greater lengths, our data indicate that glutamine residues in monomeric polyglutamine have a sig

86 almodulin (CaM) were individually changed to glutamine residues in order to investigate their roles i

87 ecent computational study suggested that the glutamine residues in polyglutamine tracts have a signif

88 ptide crosslinks between reactive lysine and glutamine residues in proteins.

89 his study, we investigated the role of these glutamine residues in SIVmac239 replication.

90 ence leading to an increase in the number of glutamine residues in the encoded protein.

91 that mutation of the equivalent arginine and glutamine residues in the Escherichia coli F1 gamma subu

92 polyQ amyloid vary with the chirality of the glutamine residues in the polyQ.

93 Conserved arginine and glutamine residues in the tail are required for high aff

94 Arginine or glutamine residues in the tail were substituted by alani

95 ergy can be decreased by about 0.2 eV if two glutamine residues in the vicinity of the cofactor are m

96 came increasingly collapsed as the number of glutamine residues increased.

97 The glutamine residue is important both for decarboxylase ac

98 om the results that the primary role of this glutamine residue is in interdomain signal communication

99 o nonenzymatic deamidation of asparagine and glutamine residues may be an important determinant of pr

100 tional methylation of release factors on the glutamine residue of a conserved GGQ motif is required f

101 A glutamine residue of Rab proteins (cis-glutamine) that i

102 of primary amines at selected peptide-bound glutamine residues of cytosolic proteins (including acti

103 Essentially only one lysine and two glutamine residues of involucrin and two glutamines of e

104 Conversion of the isoleucine and glutamine residues of the IQ motif to alanines in the ch

105 the possible replacement of the proline and glutamine residues of this lead compound were obtained b

106 alyzes the posttranslational modification of glutamine residues on protein or peptide substrates.

107 uten T-cell epitopes by deamidating specific glutamine residues on the basis of their spacing to prol

108 Lys9 and an N-terminal lactam formed from a glutamine residue (Pca1), could also contribute to catal

109 g beta-strand/beta-turn structure with seven glutamine residues per beta-strand.

110 we use NMR spectroscopy to demonstrate that glutamine residues possess a high propensity to adopt th

111 presence of oligosaccharide structures on a glutamine residue present in the V(L) domain sequence of

112 also observed, but a maximum of only 14% of glutamine residues present in acidic PRPs and statherin

113 of a glutamate within VP3 (VP3-234E) with a glutamine residue (Q), conferred upon CB3-Nancy the capa

114 Previous studies found that a conserved glutamine residue [Q513 in the Avena sativa phototropin

115 ic differences, some of which are due to its glutamine residue rather than leucine at position 105.

116 licated in substrate binding and a conserved glutamine residue required for catalysis, demonstrating

117 d C-terminal regions are rich in proline and glutamine residues, respectively.

118 histidine residues 81, 90, 94, and 208 with glutamine residues resulted in a significant loss of cat

119 tingtin exon 1 fusion proteins with 16 to 46 glutamine residues reveal extended structures with rando

120 hile the longer poly(Q) peptides (nine or 15 glutamine residues) showed a beta-sheet conformation by

121 orter soluble poly(Q) peptides (three or six glutamine residues) showed polyproline type II-like (PPI

122 or threonines when positioned adjacent to a glutamine residue (SQ/TQ).

123 acing Trp-48 in the FRC active site with the glutamine residue that occupies an equivalent position i

124 The glutamine residue that serves as a substrate for activat

125 ng-lived proteins can contain asparagine and glutamine residues that are extremely resistant to in vi

126 hese basic residues and adjacent beta strand glutamine residues that may prevent assembly of intact v

127 We found that N-terminal cyclization of glutamine residues to pyroglutamate on the light and hea

128 d the structural and functional roles of the glutamine residue using site-directed mutagenesis, kinet

129 When a glutamine residue was introduced at the N terminus, whic

130 t from one allele of the LPL gene in which a glutamine residue was substituted for a glycine (gly 188

131 sines and also a mutant in which a conserved glutamine residue was substituted with an arginine to in

132 y terminus (aa 325 to 419), which is rich in glutamine residues, was dispensable for the EICP0 trans-

133 ntingtin containing tracts of 2, 75, and 120 glutamine residues were expressed in photoreceptor neuro

134 imian immunodeficiency viruses use arrays of glutamine residues, which can form hydrogen bonds effici

135 e diseases are linked to expanded repeats of glutamine residues, which lead to the formation of amylo

136 ring by inclusion (or exclusion) of a single glutamine residue, whose relative levels of expression c

137 Four mutants were made: Q114P replaced the glutamine residue with proline; K115G replaced lysine wi

138 scherichia coli proteinases, were mutated to glutamine residues with the goal of producing more stabl

139 r site-specific IL-15 antagonist by mutating glutamine residues within the C terminus of IL-15 to asp

140 lent modifications of specific glutamate and glutamine residues within the cytoplasmic domains of met