ライフサイエンスコーパス: glutamine-rich

1 acid composition: acidic, proline-rich, and glutamine-rich.

2 rminal 202 amino acids form a potent glycine/glutamine rich activation domain (GQ domain) that can tr

3 han transiently transfected, whereas the Sp1 glutamine-rich activation domain is more effective on in

4 One activator, however, derived from a glutamine-rich activation domain of Sp1, activated trans

5 ce similarities with each other and with the glutamine-rich activation domain of transcription factor

6 d by a heterologous acidic, proline-rich, or glutamine-rich activation domain.

7 vity, we show that the serine/threonine- and glutamine-rich activation domains A and B of Sp1 are req

8 ophila homolog dTAFII110, interacts with the glutamine-rich activation domains of the human transcrip

9 We observed that, unlike other glutamine-rich activation domains, the GQ domain activat

10 Four ARFs function as activators and contain glutamine-rich activation domains.

11 d Ela activation domains but not acidic- and glutamine-rich activation domains.

12 e GQ domain fundamentally differs from other glutamine-rich activators and may share some properties

13 est a novel mechanism by which the family of glutamine-rich activators promotes cellular gene express

14 ontrast, several studies have suggested that glutamine-rich activators such as human Sp1 are active i

15 el fold creating a cashew-shaped form with a glutamine-rich alpha helix packed against a beta-sheet f

16 The glutamine rich and WD-repeat domains are separated by a

17 In solution at acid pH, the glutamine-rich and asparagine-rich 18-residue Sup35 pept

18 otein into prions has been attributed to its glutamine-rich and asparagine-rich domain.

19 oteins during macrophage development via the glutamine-rich and PEST domains.

20 EBNA 3C contains glutamine-rich and proline-rich domains and a region in

21 ontains fourteen C2H2-type zinc fingers, and glutamine-rich and proline-rich domains, suggesting that

22 detected when flanking regions including the glutamine-rich and the basic regions that follow the HD

23 polymerase-1 and splicing factor proline and glutamine-rich, and is functional regarding haplotype-sp

24 tifs of the C2H2 type as well as proline and glutamine rich areas.

25 Here we identify SFPQ (splicing factor, poly-glutamine rich) as an RBP that binds and regulates multi

26 Notably, insertion of the glutamine-rich B trans-activation domain of SP1 into a m

27 ive RNA-binding domains, arginine/methionine/glutamine-rich C terminus and 3 potential membrane spann

28 minal region that is linked to two different glutamine-rich C-termini.

29 o fragments, the globular Cks domain and the glutamine-rich COOH terminus.

30 al protein VP16, the Drosophila fushi tarazu glutamine-rich domain (ftzQ), and yeast Gal4 were tested

31 are characterized by a conserved N-terminal glutamine-rich domain and a conserved C-terminal WD-repe

32 of three RNA recognition motifs (RRMs) and a glutamine-rich domain and binds to uridine-rich RNA sequ

33 zinc finger domain at the C terminus and the glutamine-rich domain at the N terminus of Sp1.

34 wed that RF2a interacts with TBP through the glutamine-rich domain but not the acidic domain.

35 The glutamine-rich domain compensates for otherwise deleteri

36 determined a high-resolution structure of a glutamine-rich domain from human histone deacetylase 4 (

37 We propose that the rodent glutamine-rich domain has (i) fostered accumulation of c

38 e the inherent transcriptional activity of a glutamine-rich domain in yeast S. cerevisiae from its ap

39 polymerase II via the coactivator CBP and a glutamine-rich domain interaction with TFIID via hTAF(II

40 The primary role of the glutamine-rich domain is apparently to mediate tetrameri

41 RM) domain have a minor contribution and the glutamine-rich domain is dispensable.

42 The glutamine-rich domain of HDAC4 (19 glutamines of 68 resi

43 r nutrient signaling, and the histidine- and glutamine-rich domain of TCP20, which is conserved acros

44 de-liganded AR could interact with the SRC-1 glutamine-rich domain that mediates AR NH(2)-terminal bi

45 four domains: a unique N-terminal domain, a glutamine-rich domain, an arginine-glycine (RGG) domain,

46 The long, glutamine-rich domain, which is located between the KD a

47 ncoding (as in mice) a CAG repeat-associated glutamine-rich domain.

48 ls lack a critical co-factor necessary for a glutamine-rich domain.

49 in RE and RS dipeptides, and a proline- and glutamine-rich domain.

50 a transcriptional repressor that contains a glutamine-rich domain.

51 ain at its N terminus, followed by a proline/glutamine-rich domain.

52 it encodes a novel protein with at least two glutamine-rich domains and a highly conserved domain tha

53 Interestingly, we found that glutamine-rich domains are considerably less potent when

54 A truncated CBF that lacked the glutamine-rich domains did not activate transcription fr

55 ne expression, although the proline-rich and glutamine-rich domains each played a role in this functi

56 CREMalpha lacks the glutamine-rich domains found in CREB that are essential

57 sults is supported by our finding that yeast glutamine-rich domains from HAP2 and MCM1 are also trans

58 We also find that the amino-terminal glutamine-rich domains of hGrg and TLE1 are sufficient t

59 taQ1 and CREMDeltaQ2), which lack one of the glutamine-rich domains, Q1 and Q2 respectively, and six

60 many native yeast activator proteins contain glutamine-rich domains.

61 to 675 of EBNA3C flanked by the proline- and glutamine-rich domains.

62 contrast to PU.1, which contains acidic and glutamine-rich domains.

63 tream region of genes and the ability to use glutamine-rich enhancers such as Sp1.

64 Here, we have investigated the activity of a glutamine-rich GAL4-Sp1 domain A (Sp1A) hybrid protein i

65 Glutamine-rich gliadin peptides from ingested cereals, a

66 Proteolytically resistant, proline- and glutamine-rich gluten peptides from wheat, rye, and barl

67 Bioinformatics analysis identified a glutamine-rich, heptad-repeat region; a feature of aggre

68 ortion of the molecule is characterized by 7 glutamine-rich hexapeptide repeats similar to those foun

69 m of the first PAS domain resides a putative glutamine-rich hinge (residues 127 to 136) that connects

70 network of hydrogen bonds within a conserved glutamine-rich layer of poorly understood function.

71 nes in Arabidopsis thaliana encode ARFs with glutamine-rich middle domains.

72 Although the glutamine-rich middle region (Q) was not sufficient to a

73 We propose that a general role of glutamine-rich motifs be to mediate protein-protein inte

74 lp-1-mediated signaling, and that SEL-8 is a glutamine-rich nuclear protein.

75 th the VP16 activation domain but not with a glutamine-rich or proline-rich activation domain.

76 y GAL4 derivatives containing either acidic, glutamine-rich, or proline-rich activation domains.

77 recognition motifs of TIA-1 are linked to a glutamine-rich prion-related domain (PRD).

78 s, have been identified in yeast; asparagine/glutamine-rich 'prion domains' within these proteins can

79 We hypothesize that this novel glutamine-rich protein participates in a protein complex

80 Here we identify LAG-3, a glutamine-rich protein that forms a ternary complex toge

81 ), which encodes a novel 90 kDa proline- and glutamine-rich protein that interacts with a highly cons

82 DPY-22 is a glutamine-rich protein that is most similar to human TRA

83 ed approach and showed that LEUNIG encodes a glutamine-rich protein with seven WD repeats and is simi

84 at the putative MS8 protein was similar to a glutamine-rich protein, of unknown function, from the fu

85 repeats and the relocalization of a nuclear glutamine-rich protein.

86 the level of expression of a suite of other glutamine-rich proteins profoundly affect polyQ toxicity

87 CREMalpha lacks two glutamine-rich Q regions that, in CREB, are thought to b

88 or the length and sequence of the C-terminal glutamine-rich (Q) domain.

89 A recognition motifs (RRMs) and a C-terminal glutamine-rich (Q-rich) domain.

90 sis has revealed specific regions within the glutamine-rich (Q1 to Q4) central region of hTAFII130 th

91 in-7 interaction domain was localized to its glutamine-rich region and ataxin-7's Crx binding domain

92 A region of MEX-3 containing a glutamine-rich region and potential ubiquitination and p

93 the amino terminus, the homeodomain and the glutamine-rich region at the carboxyl terminus.

94 Thus, the glutamine-rich region contributes to specificity of this

95 ne-rich region of the N terminus and a short glutamine-rich region in the C terminus.

96 osphorylation of the ICD and p300 requires a glutamine-rich region of MAM (TAD2) that is essential fo

97 Deletion constructs confirm that the glutamine-rich region of Sp1 is required to enhance vime

98 ic domain between the two zinc-fingers and a glutamine-rich region upstream of the first zinc-finger

99 ptor coactivator/p160-binding region and the glutamine-rich region) were each found to be important f

100 ion has been shown to require the C-terminal glutamine-rich region, this region is dispensable for in

101 ontains three putative activation domains: a glutamine-rich region, which interacts in vitro with TAF

102 complex and contains six BRCT domains and a glutamine-rich region.

103 omeodomain transcription factor containing a glutamine-rich region.

104 (bHLH) and PER-ARNT-SIM (PAS) domains and a glutamine-rich region.

105 ral domain of human TAF(II)130 contains four glutamine-rich regions Q1-Q4 that interact with transcri

106 he central domain of hTAFII130 contains four glutamine-rich regions, designated Q1 to Q4, that are in

107 CREMDelta(C-G) lacks both the KID and the glutamine-rich regions.

108 A 26-amino-acid peptide from the proline-glutamine-rich repetitive N-terminal region was identifi

109 Moreover, a truncated variant lacking the glutamine-rich sequence did not form fibrils under the s

110 evisiae Cks protein Cks1 has a COOH-terminal glutamine-rich sequence not present in other homologues.

111 and 3) a 176-residue-long, poorly conserved, glutamine-rich sequence.

112 t species present within the fibrils was the glutamine-rich sequence.

113 to high molecular weight multimers through a glutamine-rich sequence.

114 ng domains and the C-terminal half possesses glutamine-rich sequences characteristic of transcription

115 Glutamine-rich sequences exist in a wide range of protei

116 A subset of glutamine-rich sequences has been shown to form amyloid

117 ee host proteins splicing factor proline and glutamine rich (SFPQ), non-POU domain-containing octamer

118 Glutamine-rich Sp1 and proline-rich CTF1, two extensivel

119 ors (i.e., the tumor suppressor p53 protein, glutamine-rich Sp1 and the oncoprotein c-Jun) and compar

120 kworm TBP exhibits characteristics such as a glutamine-rich stretch and three imperfect Pro-Met-Thr-l

121 acid residues 277-543), which consists of a glutamine-rich subdomain and two acidic subdomains.

122 Finally, we demonstrate that the glutamine-rich subdomain of the transcriptional activati

123 e identified three acidic subdomains and one glutamine-rich subdomain.

124 d Ssa on [PSI(+)] are modulated by the small glutamine-rich tetratricopeptide cochaperone Sgt2.

125 Small glutamine-rich tetratricopeptide repeat-containing prote

126 le and identify a pivotal role for the small glutamine-rich tetratricopeptide repeat-containing prote

127 reported Vpu-interacting host factor, small glutamine-rich tetratricopeptide repeat-containing prote

128 tail-anchored substrate transfer from small glutamine-rich tetratricopeptide repeat-containing prote

129 and a putative ortholog of a mammalian small glutamine-rich tetratricopeptide repeat-containing prote

130 Small glutamine-rich tetratricopeptide repeat-containing prote

131 ative C. elegans ortholog of the human small glutamine-rich tetratricopeptide-repeat-containing prote

132 Small, glutamine-rich, tetratricopeptide repeat protein 2 (Sgt2

133 of Socs3 and Sfpq (splicing factor, proline/glutamine rich) that attenuate optic nerve regeneration.

134 basic region/leucine zipper (bZIP) domain, a glutamine-rich trans-activation domain in CREB called Q2

135 ribe the use of the previously characterized glutamine-rich transactivation domain of Sp1 (B-c) as a

136 affinity binding region colocalizes with the glutamine-rich transactivation domain of the receptor.

137 r assay system, we have established that the glutamine-rich transactivation domain, a portion of the

138 3) Both zinc finger and glutamine-rich transactivation domains of Sp1 are involv

139 mains include multiple N-terminal acidic and glutamine-rich transactivation domains, a PEST domain, s

140 alization of the polyglutamine-containing or glutamine-rich transcription factors TBP, CBP and Sp1 in

141 e tracts alter transcription by sequestering glutamine rich transcriptional regulatory proteins, ther

142 Although each peptide was glutamine-rich, tTGase exhibited a high degree of regios

143 Sti1 also suppresses cytotoxicity of the glutamine-rich yeast prion [RNQ+] while reorganizing spe