ライフサイエンスコーパス: glutaminyl

1 This hydrolysis of glutaminyl adenylate represents a novel reaction that is

2 negative charge on the phosphorus center of glutaminyl-adenylate plays an important role in the tigh

3 l aldimine complexes, cysteinyl aldimine and glutaminyl aldimine.

4 Ks evolved from a common ancestor related to glutaminyl aminoacyl-tRNA synthetases, which may have be

5 for measurement of the deamidation rates of glutaminyl and asparaginyl residues in peptides and prot

6 The spontaneous nonenzymatic deamidation of glutaminyl and asparaginyl residues of peptides and prot

7 iscussed with respect to the hypothesis that glutaminyl and asparaginyl residues serve, through deami

8 constructed and evaluated as substrates for glutaminyl and cysteinyl-tRNA synthetases.

9 formation of amide bonds between endo-gamma-glutaminyl and endo-epsilon-lysyl residues of proteins,

10 transglutaminase-catalyzed reaction between glutaminyl and lysyl side-chains, leading to a covalent

11 y are responsible for essentially all of the glutaminyl- and glutamyl-tRNA synthetase activity detect

12 This work identifies genes encoding glutaminyl- and glutamyl-tRNA synthetase in the closely

13 of C73 brings about mischarging by glycyl-, glutaminyl-, and leucyl-tRNA synthetases.

14 Glutaminyl cyclase (hQC) has emerged as a new potential

15 e, we assess the antiarthritic efficiency of glutaminyl cyclase (QC) inhibitors.

16 Glutaminyl cyclase (QC, EC 2.3.2.5) catalyzes the format

17 monooxygenase (PAM), peptidase cleavage, and glutaminyl cyclase.

18 Mammalian glutaminyl cyclases may, therefore, have structural and

19 in vitro expanded polyglutamine repeats are glutaminyl-donor substrates of tissue transglutaminase (

20 ign and synthesis of dipeptidyl N,N-dimethyl glutaminyl fluoromethyl ketones (fmk) as severe acute re

21 terial peptidoglycan contains L-alanyl-D-iso-glutaminyl-meso-diaminopimelyl-D-alanyl-D-alanine peptid

22 An alternative approach of using glutaminyl-peptide cyclotransferase to convert the N-ter

23 vacuolar SNAREs requires the wild-type three glutaminyl (Q) and one arginyl (R) residues for optimal

24 Deamidation of asparaginyl and glutaminyl residues causes time-dependent changes in cha

25 sopeptide bonds by transfer of an amine onto glutaminyl residues of a protein.

26 e can also form ester bonds between specific glutaminyl residues of human involucrin and a synthetic

27 CheD catalyzes amide hydrolysis of specific glutaminyl side chains of the B. subtilis chemoreceptor

28 hylaminonaphthalene sulfonyl)diamidopentane (glutaminyl substrate) is cross-linked to dansyl cadaveri

29 is (glutamyl-prolyl-transfer RNA synthetase, glutaminyl-transfer RNA synthetase, elongation factor 2,

30 ombination of discriminating asparaginyl and glutaminyl tRNA synthetase (AARS) together with the amid

31 base frequencies for the seryl, aspartyl and glutaminyl tRNA-synthetase and U1 RNA-protein complexes.

32 Archaea make glutaminyl-tRNA (Gln-tRNA(Gln)) in a two-step process; a

33 Asparaginyl-tRNA (Asn-tRNA) and glutaminyl-tRNA (Gln-tRNA) are essential components of p

34 synthetase to synthesize Glu-tRNA(Gln) and a glutaminyl-tRNA amidotransferase to convert Glu-tRNA(Gln

35 alysis of the x-ray crystal structure of the glutaminyl-tRNA aminoacyl synthetase (GlnRS)-tRNA2Gln co

36 y prokaryotes form the amide aminoacyl-tRNAs glutaminyl-tRNA and asparaginyl-tRNA by tRNA-dependent a

37 "21st synthetase-tRNA pairs" include E. coli glutaminyl-tRNA synthetase (GlnRS) along with an amber s

38 ependent on coexpression of Escherichia coli glutaminyl-tRNA synthetase (GlnRS) along with the E. col

39 e free state, and for tRNAGln complexed with glutaminyl-tRNA synthetase (GlnRS) are in good agreement

40 The crystal structure of E. coli glutaminyl-tRNA synthetase (GlnRS) bound to native tRNA1

41 Helicobacter pylori does not have a glutaminyl-tRNA synthetase (GlnRS) but has two divergent

42 alter amino acid specificities of TrpRS and glutaminyl-tRNA synthetase (GlnRS) by mutagenesis withou

43 Eukaryotic glutaminyl-tRNA synthetase (GlnRS) contains an appended

44 The glutaminyl-tRNA synthetase (GlnRS) enzyme, which pairs g

45 Glutaminyl-tRNA synthetase (GlnRS) evolved later and is

46 alysis of aminoacylation of Escherichia coli glutaminyl-tRNA synthetase (GlnRS) has revealed that the

47 due from glutamyl-tRNA synthetase (GluRS) to glutaminyl-tRNA synthetase (GlnRS) improves the K(M) of

48 The structure of Escherichia coli glutaminyl-tRNA synthetase (GlnRS) in complex with tRNAG

49 in the crystal structure of Escherichia coli glutaminyl-tRNA synthetase (GlnRS) in complex with tRNAG

50 The N-terminal appended domain (NTD) of glutaminyl-tRNA synthetase (GlnRS) is intriguing since G

51 Glutaminyl-tRNA synthetase (GlnRS) is one noteworthy exc

52 Cytosolic glutaminyl-tRNA synthetase (GlnRS) is the singular enzym

53 previously described mutant Escherichia coli glutaminyl-tRNA synthetase (GlnRS) proteins that incorre

54 eady-state and transient kinetic analyses of glutaminyl-tRNA synthetase (GlnRS) reveal that the enzym

55 rom the catalytic domain of Escherichia coli glutaminyl-tRNA synthetase (GlnRS) were replaced with th

56 karyotes and some bacteria employ a specific glutaminyl-tRNA synthetase (GlnRS) which other Bacteria,

57 nthesis, which in eukaryotes is catalyzed by glutaminyl-tRNA synthetase (GlnRS), while most bacteria,

58 aminoacyl-tRNA synthetase, including E. coli glutaminyl-tRNA synthetase (GlnRS), yet functions with t

59 glutamine binding pocket in Escherichia coli glutaminyl-tRNA synthetase (GlnRS).

60 acent to the active site of Escherichia coli glutaminyl-tRNA synthetase (GlnRS).

61 on by asparaginyl-tRNA synthetase (AsnRS) or glutaminyl-tRNA synthetase (GlnRS).

62 Most bacteria and all archaea lack a glutaminyl-tRNA synthetase (GlnRS); instead, Gln-tRNA(Gl

63 Here we show for Escherichia coli glutaminyl-tRNA synthetase (GlnRS; EC 6.1.1.18) that the

64 dentification of mutations in QARS (encoding glutaminyl-tRNA synthetase [QARS]) as the causative vari

65 -tRNAGln, functionally replacing the lack of glutaminyl-tRNA synthetase activity in Gram-positive eub

66 However, it was previously shown that glutaminyl-tRNA synthetase activity is present in Leishm

67 Glutaminyl-tRNA synthetase and asparaginyl-tRNA syntheta

68 eria lack genes encoding asparaginyl- and/or glutaminyl-tRNA synthetase and consequently rely on an i

69 ecific interactions between Escherichia coli glutaminyl-tRNA synthetase and tRNA(Gln) have been shown

70 Archaebacteria lack glutaminyl-tRNA synthetase and utilize a two-step pathwa

71 as those for asparaginyl-tRNA synthetase and glutaminyl-tRNA synthetase are absent.

72 undwork for the acquisition of the canonical glutaminyl-tRNA synthetase by lateral gene transfer from

73 different from that reported for the tRNAGln-glutaminyl-tRNA synthetase complex.

74 dy-state kinetic studies of Escherichia coli glutaminyl-tRNA synthetase conclusively demonstrate the

75 d that residues Asp66, Tyr211, and Phe233 in glutaminyl-tRNA synthetase could potentially facilitate

76 either the cytoplasmic nor the mitochondrial glutaminyl-tRNA synthetase distinguishes between the imp

77 y perturb the enzyme-tRNA interface, E. coli glutaminyl-tRNA synthetase does not charge yeast tRNA.

78 Because glutaminyl-tRNA synthetase does not possess a spatially

79 The binding of glutaminyl-tRNA synthetase from Escherichia coli to seve

80 ells by regulating expression of the E. coli glutaminyl-tRNA synthetase gene in an inducible, cell-ty

81 Concomitant expression of the E. coli glutaminyl-tRNA synthetase gene results in aminoacylatio

82 Glutaminyl-tRNA synthetase generates Gln-tRNA(Gln) 10(7)

83 2.5 A crystal structure of Escherichia coli glutaminyl-tRNA synthetase in a quaternary complex with

84 n) that may be preventing the acquisition of glutaminyl-tRNA synthetase in Archaea.

85 Glutaminyl-tRNA synthetase is thought to be absent from

86 gical activity of an essential RNA.Bacterial glutaminyl-tRNA synthetase poorly aminoacylates yeast tR

87 structure of the complex between tRNAGln and glutaminyl-tRNA synthetase shows that the enzyme interac

88 gly, T. brucei uses the same eukaryotic-type glutaminyl-tRNA synthetase to form mitochondrial and cyt

89 dues were randomly mutated and the resulting glutaminyl-tRNA synthetase variants were screened in viv

90 The cocrystal structure of the class I glutaminyl-tRNA synthetase with tRNAGln revealed an unco

91 A is dependent upon the expression of E.coli glutaminyl-tRNA synthetase, indicating that none of the

92 nsamidation, and the eukaryal cytoplasm uses glutaminyl-tRNA synthetase, it appears that the three do

93 The monomeric yeast Saccharomyces cerevisiae glutaminyl-tRNA synthetase, like several other class I e

94 catalysed by asparaginyl-tRNA synthetase and glutaminyl-tRNA synthetase, respectively.

95 inoacylated in vitro by the Escherichia coli glutaminyl-tRNA synthetase, suggesting that the lack of

96 Glutaminyl-tRNA(Gln) and asparaginyl-tRNA(Asn) were like

97 e and glutamine amidotransferase to generate glutaminyl-tRNA.