ライフサイエンスコーパス: glutathione conjugate

1 ette protein C1, which effluxes arsenic as a glutathione conjugate.

2 cochromatographed with a synthetic atrazine-glutathione conjugate.

3 of metal thiolates, including the Pentostam-glutathione conjugate.

4 ssary only for the toxicity of the cisplatin-glutathione-conjugate.

5 , and greater MRP1-mediated efflux of NO2-OA-glutathione conjugates.

6 openoate and two mercapturate derivatives of glutathione conjugates.

7 ain and transports substrates in the form of glutathione conjugates.

8 pid peroxidation-derived aldehydes and their glutathione conjugates.

9 transporter of doxorubicin (DOX) as well as glutathione conjugates.

10 ding site for hydrophobic molecules or their glutathione conjugates.

11 olves the formation and active efflux of its glutathione conjugate, 15-d-PGJ(2)-SG.

12 iol 17-beta-D-glucuronide (E(2)17betaG), the glutathione conjugates 2,4-dinitrophenyl S-glutathione (

13 However, the much larger aflatoxin-glutathione conjugate, 8, 9-dihydro-8-(S-glutathionyl)-9

14 Recombinant TaGSTFs were assayed for glutathione conjugating activity towards xenobiotics inc

15 nitrobenzene (CDNB), but has relatively high glutathione-conjugating activity for 4-hydroxynonenal (4

16 ration calorimetry with a representative bis-glutathione conjugate and a monofunctional reference com

17 ne upon an electrophilic substrate to form a glutathione conjugate and contain a single glutathione b

18 te covalent attachment of a haloenol lactone-glutathione conjugate and suggest that an ester forms be

19 the Y9F substitution on binding affinity for glutathione conjugates and on rates of the order-disorde

20 movement of solute allocrites, which include glutathione conjugates and several natural product antin

21 gnal transduction, can catalyze transport of glutathione conjugates and xenobiotics, and may contribu

22 propyl atrazine, desethyl atrazine, atrazine-glutathione conjugate, and atrazine-mercapturate, using

23 binding domains-the first is a series of bis-glutathione conjugates, and the second is a series of co

24 t with broad substrate specificity, the drug glutathione conjugate APA-SG, oxidized glutathione, the

25 Leukotriene (LT) C4 and other glutathione conjugates are synthesized intracellularly a

26 thione, suggesting that the substrate is the glutathione conjugate, As(GS)3.

27 ic sequestration of these ligands, and their glutathione conjugates, away from their nuclear target,

28 athione reveals a third binding site for the glutathione conjugate besides the two in the active site

29 (Kd) of 59 +/- 17 microM while the aflatoxin-glutathione conjugate bound the enzyme with a Kd of 0.86

30 s are not only competent in the transport of glutathione conjugates but also folate monoglutamates an

31 y for optimal transport of anthracycline and glutathione conjugates by RLIP76, and that this peptide

32 en widely used for the in vitro screening of glutathione conjugates derived from reactive metabolites

33 From the export of the menadione-glutathione conjugate detected at a 1-microm-diameter el

34 By using the glutathione-conjugating dye monochlorobimane, in combina

35 PGJ(2), 15-d-PGJ(2)-SG, is formed and if the glutathione conjugate efflux pumps, MRP1 and MRP3, could

36 pastoris, exhibited low lipid peroxidase and glutathione-conjugating enzymatic activities but high he

37 ts comparing the kinetics of MLP- versus CHB-glutathione conjugate: formation, product inhibition of

38 Branched derivatives of acrolein or its glutathione conjugate (GS-propanal) were, however, reduc

39 ress-protective multispecific transporter of glutathione conjugates (GS-E) and xenobiotic toxins.

40 The equilibrium binding affinity of the glutathione conjugate, GS-NBD (NBD-Cl, 7-chloro-4-nitrob

41 hese results indicate that MRP can transport glutathione conjugates in vitro and in living cells and

42 sociated and cytoplasmic protein which binds glutathione conjugates including LTC4.

43 f nasal microsomal DCBN metabolites and DCBN-glutathione conjugates indicated that the major reactive

44 Inhibitors acting via the formation of glutathione conjugates induced a very pronounced stabili

45 the canalicular transport of glutathione and glutathione conjugates is deficient, although dibutyryl

46 oposide, and vincristine, as well as for the glutathione conjugate leukotriene C4 (LTC4).

47 was rapidly and quantitatively converted to glutathione conjugates (LNO(2)-SG) via Michael addition.

48 iate vacuolar accumulation of the quorescent glutathione-conjugate, monochlorobimane-GS.

49 e accumulation of the harderoporphyrin(ogen)-glutathione conjugate observed in the expression studies

50 ent and was associated with formation of the glutathione conjugate of 15-d-PGJ(2), 15-d-PGJ(2)-SG, an

51 We examined whether a glutathione conjugate of 15-d-PGJ(2), 15-d-PGJ(2)-SG, is

52 contrast, ATP-dependent accumulation of the glutathione conjugate of a chlorsulfuron analog, chlorim

53 f ZmGSTU1 led to the accumulation of a novel glutathione conjugate of harderoporphyrin(ogen) (2,7,12,

54 d one of its putative metabolites, i.e., the glutathione conjugate of p-XSC (p-XSe-SG), and determine

55 act heart, AR catalyzes the reduction of the glutathione conjugate of the lipid peroxidation product

56 s not contribute in vivo to the formation of glutathione conjugates of acetaminophen but plays a nove

57 tic efficiency of AR in the reduction of the glutathione conjugates of acrolein, trans-2-hexenal, tra

58 ductase (AR) reduces cytotoxic aldehydes and glutathione conjugates of aldehydes derived from lipid p

59 h a possible role of AR in the metabolism of glutathione conjugates of aldehydes.

60 Measurement of glutathione conjugates of BPDE indicated that the total

61 an important role of AR in the metabolism of glutathione conjugates of endogenous and xenobiotic alde

62 ed to the heart, was identified to be due to glutathione conjugates of HNE.

63 These results raise the possibility that the glutathione conjugates of lipid peroxidation products ar

64 Accumulation of the glutathione-conjugate of CDNB, DNP-SG, and of doxorubici

65 tes are generally amphiphilic anions such as glutathione conjugates or require the presence of physio

66 rate or route of metabolism, particularly to glutathione conjugates, or in the levels of covalent bin

67 s the reduction of lipid aldehydes and their glutathione conjugates, prevents human colon cancer cell

68 ne transporter catalyzed the accumulation of glutathione-conjugated probes, and another transported p

69 ated transport demonstrate that the vacuolar glutathione conjugate pump of yeast bears a strong mecha

70 These results indicate that MRP6 is a glutathione conjugate pump that is able to confer low le

71 of menadione and that the efflux through the glutathione-conjugate pump was at least an order of magn

72 ted by reduced and oxidized glutathione, the glutathione conjugates S-(p-azidophenacyl)-glutathione (

73 Whereas SFN and its glutathione conjugate (SFN-GSH) had little or no effect,

74 quinone is attacked by glutathione to form a glutathione conjugate that, in the absence of Cys13, dec

75 ch could increase the formation of cisplatin-glutathione conjugates that may be metabolized to toxic

76 is activation begins with the formation of a glutathione-conjugate that is metabolized to a cysteinyl

77 s to menadione and detecting the menadione-S-glutathione conjugate (thiodione) that is formed during

78 te, for the first time, efficient binding of glutathione conjugates to an aldo-keto reductase.

79 (p-nitrobenzyl glutathione and the aflatoxin-glutathione conjugate) to mouse glutathione S-transferas

80 Here, we show marked reduction in glutathione conjugate transport capacity and stepwise in

81 t in human erythrocytes, its relationship to glutathione conjugate transport, and possible mediation

82 elationship between this process and organic glutathione-conjugate transport are known.

83 It represents the predominant glutathione-conjugate transporter in cells, and our prev

84 RLIP76 (RALBP1) is a glutathione-conjugate transporter that is a critical com

85 treated with antibodies directed against the glutathione conjugate transporters RLIP76 (Ral-binding p

86 injury but did induce RNA expression of the glutathione-conjugate transporters encoded by AtMRP1, At

87 H(+) antiporter, whereas vanadate-sensitive glutathione conjugate uptake is mediated by an ATP-bindi

88 protein, or sequester it in vacuoles as the glutathione conjugate using Ycf1p, an ABC transporter.

89 Both 4ONE and its glutathione conjugate were found to be substrates for CR

90 olished the mitogenic effects of HNE and its glutathione conjugates, whereas ablation of RLIP76 using

91 mitogenic effects of HNE are mediated by its glutathione conjugate, which has to be reduced by aldose

92 st glutathione is involved in formation of a glutathione conjugate, while the second is involved in t

93 lutathione S-transferases (GSTs), which form glutathione conjugates with lipid peroxidation products