ライフサイエンスコーパス: glutathione reductase

1 tioxidant defense (thioredoxin reductase and glutathione reductase).

2 drogenase and reoxidation to N(tz) ADP(+) by glutathione reductase.

3 y of both serine acetyltransferase (SAT) and glutathione reductase.

4 id residues that are different from those in glutathione reductase.

5 oth the mitochondrial and cytosolic forms of glutathione reductase.

6 n dipteran insects, where it substitutes for glutathione reductase.

7 reductase, which shares common ancestry with glutathione reductase.

8 e in the presence of reduced glutathione and glutathione reductase.

9 yl] propionic acid (2-AAPA), an inhibitor of glutathione reductase.

10 of unmodified and bisnitrated P. falciparum glutathione reductase.

11 etase and glutathione synthetase, as well as glutathione reductase.

12 vin, just as with lipoamide dehydrogenase or glutathione reductase.

13 in titrations of lipoamide dehydrogenase or glutathione reductase.

14 M-45 and M-90 were resistant to reduction by glutathione reductase.

15 xins with the small molecule glutathione and glutathione reductase.

16 7, as suggested for the analogous residue in glutathione reductase.

17 ld increased expression of transketolase and glutathione reductase.

18 per-zinc superoxide-dismutase, catalase, and glutathione-reductase.

19 ermine if two of the genes, glyoxalase 1 and glutathione reductase 1, have a causal role in the genes

20 ione synthesis (L-buthionine-sulfoximine) or glutathione reductase (1,3-bis(2-chloroethyl)-1-nitrosou

21 protein content, whereas the rice plastidial glutathione reductase 3 mutant showed increased sensitiv

22 National survey data of erythrocyte glutathione reductase activation coefficient (EGRac) ind

23 pe groups (8% to 12% response in erythrocyte glutathione reductase activation coefficient; P<0.01 in

24 Both superoxide dismutase and glutathione reductase activities were increased early (4

25 In addition, thioredoxin reductase and glutathione reductase activities were measured, where th

26 le to show that EGRac (14 studies) and basal glutathione reductase activity (5 studies) were effectiv

27 method is described for the determination of glutathione reductase activity (GR; EC 1.6.4.2) in plant

28 eactive oxygen species levels, and decreased glutathione reductase activity and a corresponding incre

29 Glutathione reductase activity did not increase signific

30 Glutathione reductase activity does not appear to be a r

31 ONOO- decreased glutathione reductase activity in a concentration depend

32 lutathione peroxidase activity and increased glutathione reductase activity in the liver.

33 ave measured the effects of GSH depletion on glutathione reductase activity of the rat brain.

34 Brain glutathione reductase activity was dose-dependently inhi

35 Glutathione reductase activity was found to be inducible

36 d with SSM in both young and old rats, while glutathione reductase activity was not different with ag

37 with buthionine sulfoximine or inhibition of glutathione reductase activity with BCNU inhibited nitri

38 ion, an effect partly mediated via increased glutathione reductase activity.

39 However, there was no change in glutathione reductase activity.

40 y results from cyanate-induced inhibition of glutathione reductase activity.

41 est that GSH is important in the maintenance glutathione reductase activity.

42 nal requirement mediating selection for high glutathione reductase activity.

43 Similarly, glutathione reductase (an H-TrxR homologue lacking Sec)

44 activities of catalase hydroperoxidase I and glutathione reductase and an increased sensitivity to ex

45 he mechanisms of lipoamide dehydrogenase and glutathione reductase and differs fundamentally from the

46 modium falciparum, the crystal structures of glutathione reductase and glutamate dehydrogenase are no

47 amily that includes lipoamide dehydrogenase, glutathione reductase and mercuric reductase, thioredoxi

48 Expression of quinone reductase, glutathione reductase and methionine sulfoxide reductase

49 However, expressions of only glutathione reductase and methionine sulfoxide reductase

50 (GSSG), except in the presence of the enzyme glutathione reductase and NADPH which enabled 1.Tb to be

51 on HPLC, with enzymatic reduction of GSSG by glutathione reductase and NADPH, appear to be valid but

52 Similarly, RNA levels of glutathione reductase and ribonucleotide reductase were

53 ), and activities of glutathione peroxidase, glutathione reductase and superoxide dismutase were meas

54 ynthase, EF hands, haemoglobins, lipocalins, glutathione reductase and the alpha/beta hydrolases.

55 oxidation, and calcium levels along with the glutathione reductase and thioltransferase enzyme activi

56 An Escherichia coli mutant lacking both glutathione reductase and thioredoxin reductase cannot g

57 vitro resulted in the decreased activity of glutathione reductase and thioredoxin reductase, but not

58 one, NOV-002 was an equivalent substrate for glutathione reductase and was an inhibitor of protein di

59 of glucose-6-phosphate dehydrogenase (G6PD), glutathione reductase, and glutathione peroxidase.

60 ysteine ligase modulatory subunit, catalase, glutathione reductase, and superoxide dismutase were low

61 shed from the collective activities of ArsB, glutathione reductase, and the global regulator Crc.

62 Leishmania and other trypanosomatids lack glutathione reductase, and therefore rely on the novel t

63 nd structures of lipoamide dehydrogenase and glutathione reductase are alike irrespective of the sour

64 oxin reductase, lipoamide dehydrogenase, and glutathione reductase are members of the pyridine nucleo

65 Cells lacking both thioredoxins and glutathione reductase are not viable under aerobic condi

66 closely similar to the FAD-binding domain of glutathione reductase but with NAD+ replacing FAD.

67 sitioned for electron transfer to the FAD in glutathione reductase, but in TrR, these two components

68 Reduction of yeast glutathione reductase by glutathione and reoxidation of

69 Transgenic animals stably overexpressed glutathione reductase by up to 100% throughout adult lif

70 cluding glutathione, glutathione peroxidase, glutathione reductase, catalase, and superoxide dismutas

71 nolic content, ascorbic acid and the enzymes glutathione reductase, catalase, ascorbate peroxidase an

72 The flavoenzyme glutathione reductase catalyzes the NADPH-dependent redu

73 Glutathione reductase catalyzes the reduction of glutath

74 reductase activity in vitro by the method of glutathione reductase-coupled spectrophotometric assay.

75 of this family, lipoamide dehydrogenase and glutathione reductase, cycle between the two electron-re

76 uctase (DSOR) family of enzymes that include glutathione reductase, dihydrolipoamide dehydrogenase, t

77 vin status was assessed with the erythrocyte glutathione reductase (EC 1.6.4.2) activity coefficient.

78 ion continuously by studying the kinetics of glutathione reductase (EC 1.8.1.7), an enzyme that catal

79 Cr(VI)-induced apoptosis, whereas NADPH and glutathione reductase, enhancers of Cr(VI)-induced ROS g

80 nificantly higher levels of malondialdehyde, glutathione reductase enzyme activity, and calcium level

81 ng plants, improved heavy metal tolerance in glutathione reductase expressing lines, and improved tol

82 VioA belongs to the glutathione reductase family 2 of FAD-dependent oxidored

83 Similarity of Pdr to the enzymes of the glutathione reductase family is discussed.

84 zymes, antioxidants (glutathione peroxidase, glutathione reductase, ferritin, and haptaglobin), and b

85 edoxin 5), and unchanged levels of catalase, glutathione reductase, gamma-glutamyl transpeptidase, an

86 ensatory increase in expression of catalase, glutathione reductase, gamma-glutamyl transpeptidase, an

87 ess response genes (e.g., gadB, ctc, and the glutathione reductase gene lmo1433) and virulence genes

88 a P element construct containing the genomic glutathione reductase gene of Drosophila, with 4 kb upst

89 Complementation experiments in yeast lacking glutathione reductase glr1 show that human PYROXD1 has r

90 Yeast mutants that lack glutathione reductase (glr1 delta) accumulate high level

91 ygenase-1, NAD(P)H dehydrogenase, quinone 1, glutathione reductase, glutamate-cysteine ligase catalyt

92 of glutathione-associated enzymes, including glutathione reductases, glutaredoxins, and glutathione S

93 s encoding glutathione biosynthetic enzymes, glutathione reductases, glutaredoxins, thioredoxins, and

94 , ALR islets expressed constitutively higher glutathione reductase, glutathione peroxidase, and highe

95 Glutathione reductase, glutathione peroxidase, and manga

96 not mediated by changes in the activities of glutathione reductase, glutathione peroxidase, catalase,

97 atalase, superoxide dismutase (SOD)-1, SOD3, glutathione reductase, glutathione S-transferase and ald

98 in, and the glutaredoxin system, composed of glutathione reductase, glutathione, and three glutaredox

99 ide dismutase (MnSOD) or an Escherichia coli glutathione reductase (gor) gene.

100 in spite of the homologous nature of E3 and glutathione reductase (goR) in sequence and structure, E

101 nts lacking thioredoxin reductase (trxB) and glutathione reductase (gor) or glutathione biosynthesis

102 abolite repression control protein (Crc), or glutathione reductase (Gor) were more sensitive to As(II

103 levation was followed by marked decreases in glutathione reductase (GR) activity in mitochondria, and

104 hione consistent with a 1.6-fold increase in glutathione reductase (GR) activity.

105 ts were correlated with an early increase in glutathione reductase (GR) and GST activities.

106 substrate complexes of the flavoenzyme human glutathione reductase (GR) at nominal resolutions betwee

107 cose-6-phosphate dehydrogenase (G6PDH), and, glutathione reductase (GR) by UV spectrophotometry and d

108 strated herein that the FAD-dependent enzyme glutathione reductase (GR) catalyzes the NADPH-dependent

109 Glutathione reductase (GR) catalyzes the reduction of gl

110 Glutathione reductase (GR) catalyzes the reduction of ox

111 A second glutathione reductase (GR) cDNA has been cloned and sequ

112 phila melanogaster (DmTR) is a member of the glutathione reductase (GR) family of pyridine nucleotide

113 ne (GSH), over its oxidized form (GSSG), and glutathione reductase (GR) in human serum.

114 y tested as thioredoxin reductase (TrxR) and glutathione reductase (GR) inhibitors, directly against

115 Glutathione reductase (GR) is a critical enzyme in the h

116 laria, we show that the antioxidative enzyme glutathione reductase (GR) is inactivated by peroxynitri

117 Glutathione reductase (GR) is one of important antioxida

118 G also showed increased glutathione reductase (GR) levels vs. C, but reduced the

119 investigates whether the salivary levels of glutathione reductase (GR) may be linked with periodonta

120 oxidase (APX), guaiacol peroxidase (GPX) and glutathione reductase (GR) were significantly higher in

121 Furthermore, inhibition of glutathione reductase (GR) with 1,3-bis[2-chloroethyl]-1

122 ioxidant enzymes superoxide dismutase (SOD), glutathione reductase (GR), and catalase (CAT) as well a

123 oxidant enzymes ascorbate peroxidase (APOX), glutathione reductase (GR), and superoxide dismutase (SO

124 atalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), Glutathione-S-Transferase (G

125 power to thioredoxin reductase-1 (TrxR1) and glutathione reductase (GR), thereby supporting fundament

126 seventh decades and analyzed for TTase, TRx, glutathione reductase (GR), thioredoxin reductase (TR),

127 Cu/Zn-superoxide-dismutase (Cu/Zn-SOD), and glutathione reductase (GR), were quantified using qRT-PC

128 ysis of human lens resulted in a 70% loss in glutathione reductase (GR)-specific activity and a 24% l

129 Glutathione reductase (GR; EC 1.6.4.2) activity was assa

130 tive stress, and thus the antioxidant enzyme glutathione reductase (GR; NADPH+GSSG+H(+) <==> NADP(+)+

131 in that lacks both thioredoxin reductase and glutathione reductase grows extremely poorly.

132 Glutathione reductases (GRs) are important components of

133 eracts suppression of glutathione peroxidase/glutathione reductase (GSH-Px/GSSG-R) functions, protein

134 atalase, glutathione peroxidase (GSH-Px) and glutathione reductase (GSH-Rd) in the liver.

135 hyde (MDA), DNA fragmentation, caspase-3 and glutathione reductase (GSR) activities, while the level

136 Glutathione reductase (Gsr) catalyzes the reduction of g

137 ntig was initiated by isolating YACs for the glutathione reductase (GSR) gene and extended in either

138 al genes that are linked to anxiety, such as glutathione reductase (Gsr), exhibited altered expressio

139 ds to i) reduction in glyoxalase (GLO)-1 and glutathione reductase (GSR)-1 expression; ii) calpain me

140 le the protein levels of glyoxalase (GLO)-1, glutathione reductase (GSR)-1, calcium/calmodulin-depend

141 se (GPX), glucose 6-phosphate dehydrogenase, glutathione reductase, GST, catalase (CAT), and superoxi

142 Under normoxic conditions, overexpression of glutathione reductase had no effect on longevity, protei

143 yme), for yeast, Escherichia coli, and human glutathione reductase have been determined between pH 6.

144 H forms of protein tyrosine phosphatases and glutathione reductase have been suggested to play key ro

145 3H-xanthene-9-propionic acid (XAN) and human glutathione reductase (hGR).

146 nhanced enzymatic activities of catalase and glutathione reductase in a dose-dependent manner.

147 ever, to date the activity and regulation of glutathione reductase in conditions such as PD have not

148 The role of thioltransferase and glutathione reductase in the cellular reduction of disul

149 fide (GSSG) formed can be recycled to GSH by glutathione reductase in the presence of NADPH.

150 o test the hypothesis that overexpression of glutathione reductase in transgenic Drosophila melanogas

151 The genetic analysis of thioredoxin and glutathione reductase in yeast runs counter to previous

152 nly minimal contributions: 25% decrease with glutathione reductase inhibition and no effect by glutat

153 igh sensitivity of mature gametocytes to the glutathione reductase inhibitor and redox cycler drug me

154 r redox homeostasis in D. melanogaster where glutathione reductase is absent.

155 The enzyme glutathione reductase is also important in GSH homeostas

156 Glutathione reductase is the principal enzyme involved i

157 The enzyme, glutathione reductase, is highly specific to glutathione

158 he only enzyme affected by GSH depletion was glutathione reductase; its activity being reduced by app

159 This method of subcellular distribution of glutathione reductase may be conserved in mammalian cell

160 cluding glutathione, glutathione peroxidase, glutathione reductase, metallothionein, and superoxide d

161 superoxide dismutase mimetic CuDIPs and the glutathione reductase mimetic ebselen, TPA-stimulated TN

162 base catalyst, both the EH2 and EH- forms of glutathione reductase must be catalytically active, in c

163 including catalase, glutathione synthetase, glutathione reductase, NADPH-cytochrome P450 reductase,

164 A glutathione reductase null mutant of Saccharomyces cerev

165 ase in catalytic efficiency (k(cat)/K(m)) of glutathione reductase observed at physiologic pH.

166 uced glutathione (GSH) by supplying NADPH to glutathione reductase or thioredoxin reductase.

167 iting either GSH uptake, the NADPH-dependent glutathione reductase, or the NADH/NADPH transhydrogenas

168 the activity of ascorbic acid peroxidase and glutathione reductase over the experimental storage dura

169 is associated with increased levels of alpha-glutathione reductase protein expression.

170 structure with that of two-electron reduced glutathione reductase provides an insight into the sulfe

171 In contrast to H-TrxR and glutathione reductase, recombinant Escherichia coli L-Tr

172 al concentrations of glutathione, NADPH, and glutathione reductase reduced the non-active site disulf

173 al concentrations of glutathione, NADPH, and glutathione reductase reduced Trx1 in vitro and that the

174 oxidation is also not observed, although the glutathione reductase SelH is upregulated, likely to mai

175 ning (VS) of Schistosoma mansoni thioredoxin glutathione reductase (SmTGR) inhibitors and high conten

176 3-bis(2-chloroethyl)-1-nitrosourea (BCNU) or glutathione reductase-specific siRNA, results in diminis

177 ing to a well defined site that is unique to glutathione reductase suggests that noncompetitive inhib

178 that cells that utilize primarily the GSHPx-glutathione reductase system for degrading H2O2 would be

179 Treatment with the glutathione reductase system led to 80% reduction in PSS

180 ere done before and after reduction with the glutathione reductase system.

181 tivity of the glutathione peroxidase (GSHPx)-glutathione reductase system.

182 Thioredoxin/glutathione reductase (TGR) is a recently discovered mem

183 Thioredoxin/glutathione reductase (TGR) is a third member of this en

184 In addition, thioredoxin/glutathione reductase (TGR) was identified, which is a f

185 ntly identified as inhibitors of thioredoxin glutathione reductase (TGR), a selenocysteine-containing

186 wn to inhibit a parasite enzyme, thioredoxin glutathione reductase (TGR), with activities in the low

187 parison of the crystal structures of TrR and glutathione reductase, the latter being a well-understoo

188 insects such as Drosophila melanogaster lack glutathione reductase, their TrxRs are particularly impo

189 ipteran insects such as D. melanogaster lack glutathione reductase, thioredoxin reductase (DmTrxR) is

190 ther thiol-disulfide oxidoreductase enzymes, glutathione reductase, thioredoxin, and thioredoxin redu

191 ell as catalase, glutathione peroxidase, and glutathione reductase tissue activity, were determined.

192 GSF acts as an alternative substrate to glutathione reductase to decrease NADPH levels and enhan

193 rapidly reduced back to glutathione (GSH) by glutathione reductase to maintain redox status.

194 itionally investigated the susceptibility of glutathione reductase to ONOO- in vitro, using purified

195 Concomitantly expression of glutathione reductase was reduced leading to an increase

196 Nonprotein sulfhydryl groups and glutathione reductase were not affected by Mn or light t

197 r in a strain lacking both thioredoxin-A and glutathione reductase, which maintains reduced glutaredo

198 Glutathione reductase, which regenerates the reduced for

199 so down-regulated glutathione peroxidase and glutathione reductase, which together constitute a key e