ライフサイエンスコーパス: glycerol 3-phosphate

1 1,1-difluorodeoxy analogues of (2R)-acyl-sn-glycerol 3-phosphate.

2 gulon mediate utilization of glycerol and sn-glycerol 3-phosphate.

3 ith NaCl plus an alpha subunit ligand, alpha-glycerol 3-phosphate.

4 d GuH(+)) and of an allosteric ligand, alpha-glycerol 3-phosphate.

5 tro by PRK2 in the presence of 1,2-diolyl-sn-glycerol 3-phosphate.

6 ted by the K(m) values for palmitoyl-CoA and glycerol 3-phosphate.

7 attached via ester bonds to enantiomeric sn-glycerol 3-phosphate.

8 droxyacetone phosphate (DHAP), glycerol, and glycerol-3-phosphate.

9 ysophospholipid species, including 1-acyl-sn-glycerol-3-phosphate.

10 and has profound effects on the Km(app) for glycerol-3-phosphate.

11 two molecules of CTP and then titrated with glycerol-3-phosphate.

12 duction by contributing to the production of glycerol-3-phosphate.

13 fic activity coupled with an elevated Km for glycerol-3-phosphate.

14 he ability of the cells to synthesize 1-acyl-glycerol-3-phosphate.

15 conversion of dihydroxyacetone phosphate to glycerol-3-phosphate.

16 Glycerol-3-phosphate 1-acyltransferase is a soluble chlo

17 c for the acyltransferase reaction involving glycerol 3-phosphate, 1-acylglycerol 3-phosphate, and di

18 thout significantly increasing the K(m) of L-glycerol-3-phosphate (10.0-14.5 mm).

19 ions, including [2,5-(13)C]glucose, [2-(13)C]glycerol 3-phosphate, [2-(13)C]phosphoenolpyruvate (PEP)

20 The enzyme CDP-diacylglycerol:sn-glycerol-3-phosphate 3-phosphatidyltransferase (phosphat

21 l conformational repair is provided by alpha-glycerol 3-phosphate, a ligand that binds to the alpha s

22 , urea, and TMAO on the mechanism of binding glycerol 3-phosphate, a substrate analogue, to yeast tri

23 tudied as a function of the concentration of glycerol 3-phosphate, a substrate surrogate.

24 ity of a mutant, gat1Deltagat2Delta, lacking glycerol-3-phosphate activity.

25 RAM2 encodes a glycerol-3-phosphate acyl transferase (GPAT) and is invo

26 ON1 (RAM1), which was reported to regulate a glycerol-3-phosphate acyl transferase that promotes cuti

27 RAM1 regulates the expression of RAM2, a glycerol-3-phosphate acyl transferase that promotes cuti

28 irst reaction of the pathway in the plastid, glycerol-3-phosphate acyl-acyl carrier protein acyltrans

29 ely used for the net synthesis of PC through glycerol 3-phosphate acylation.

30 o the sn-1 and sn-2 positions of DAG through glycerol-3-phosphate acylation.

31 provide most of the acyl chains for de novo glycerol-3-phosphate acylation.

32 Glycerol 3-phosphate acyltransferase (GPAT) catalyzes th

33 enzymes: glycerol 3-phosphate dehydrogenase, glycerol 3-phosphate acyltransferase and lysophosphatidi

34 oelii glycerol 3-phosphate dehydrogenase and glycerol 3-phosphate acyltransferase are expressed only

35 SF binds constitutively to the mitochondrial glycerol 3-phosphate acyltransferase promoter during fas

36 mutation in the soluble chloroplastic enzyme glycerol-3-phosphate acyltransferase (ACT1) completely r

37 -relevant key nodes, including mitochondrial glycerol-3-phosphate acyltransferase (GPAM), were expose

38 ansferases essential for cutin biosynthesis, glycerol-3-phosphate acyltransferase (GPAT) 4 and GPAT8.

39 Acyl-CoA:glycerol-3-phosphate acyltransferase (GPAT) catalyzes th

40 Glycerol-3-phosphate acyltransferase (GPAT) catalyzes th

41 Glycerol-3-phosphate acyltransferase (GPAT) catalyzes th

42 t that LpxL shares distant homology with the glycerol-3-phosphate acyltransferase (GPAT) family, incl

43 Arabidopsis (Arabidopsis thaliana) has eight glycerol-3-phosphate acyltransferase (GPAT) genes that a

44 tion, enzymatic activity of liver microsomal glycerol-3-phosphate acyltransferase (GPAT) increased 4-

45 Four glycerol-3-phosphate acyltransferase (GPAT) isoforms, ea

46 The topography of mitochondrial glycerol-3-phosphate acyltransferase (GPAT) was determin

47 We demonstrate that the mRNA levels of glycerol-3-phosphate acyltransferase (GPAT), a mitochond

48 Gene expression of sn-glycerol-3-phosphate acyltransferase (GPAT), diacylglyce

49 sequences from various acyltransferases [sn-glycerol-3-phosphate acyltransferase (GPAT), lysophospha

50 In addition, the activity of sn-glycerol-3-phosphate acyltransferase (GPAT), which like

51 fatty acid synthase (FAS) and mitochondrial glycerol-3-phosphate acyltransferase (GPAT)-involved in

52 d storage triacylglycerols is catalyzed by a glycerol-3-phosphate acyltransferase (GPAT).

53 t study, we show that AGPAT6 is a microsomal glycerol-3-phosphate acyltransferase (GPAT).

54 The expression of glycerol-3-phosphate acyltransferase (GPAT3) was examine

55 Microsomal and mitochondrial isoforms of glycerol-3-phosphate acyltransferase (GPAT; E.C. 2.3.1.1

56 ave previously shown rat liver mitochondrial glycerol-3-phosphate acyltransferase (mtGAT), which cata

57 epresentative members of this family, the sn-glycerol-3-phosphate acyltransferase (PlsB) and the bifu

58 The sn-glycerol-3-phosphate acyltransferase (plsB) catalyzes th

59 The sn-glycerol-3-phosphate acyltransferase (plsB) of Escherich

60 sD was most closely related to the 1-acyl-sn-glycerol-3-phosphate acyltransferase (plsC) gene family

61 in homology modeling of both the AGPATs with glycerol-3-phosphate acyltransferase 1 (GPAT1) revealed

62 ulating oleoyl-CoA utilization by microsomal glycerol-3-phosphate acyltransferase 3.2-fold and protec

63 Glycerol-3-phosphate acyltransferase 4 (GPAT4), which ca

64 in the model plant Arabidopsis thaliana: the glycerol-3-phosphate acyltransferase 6 (GPAT6) and a mem

65 loss of both dihydroxyacetone phosphate and glycerol-3-phosphate acyltransferase activities in yeast

66 AT resulted in a complete loss of Leishmania glycerol-3-phosphate acyltransferase activity and a majo

67 shmania major promastigotes express a single glycerol-3-phosphate acyltransferase activity important

68 However, glycerol-3-phosphate acyltransferase activity was not de

69 Furthermore, mitochondrial glycerol-3-phosphate acyltransferase activity was reduce

70 on of LPT1 had a minimal effect on 1-acyl-sn-glycerol-3-phosphate acyltransferase activity, but overe

71 iana GPAT5, encoding a protein with acyl-CoA:glycerol-3-phosphate acyltransferase activity.

72 alyses revealed that LmGAT is a low-affinity glycerol-3-phosphate acyltransferase and exhibits higher

73 In this study, we targeted the glycerol-3-phosphate acyltransferase GPAM along with cho

74 Glycerol-3-phosphate acyltransferase mRNA fell by 57% an

75 Second-site mutations in the ACT1-encoded glycerol-3-phosphate acyltransferase or GLY1-encoded gly

76 cooperative activation of the mitochondrial glycerol-3-phosphate acyltransferase promoter by USF and

77 xotrophs, and this lipid export requires the glycerol-3-phosphate acyltransferase RAM2, a direct targ

78 hesis is primarily mediated by the 1-acyl-sn-glycerol-3-phosphate acyltransferase reaction.

79 s based on competition between Ole1p and the glycerol-3-phosphate acyltransferase Sct1p/Gat2p for the

80 e PlsB26 protein had a significantly reduced glycerol-3-phosphate acyltransferase specific activity c

81 act1, which encodes the chloroplast acyl-ACP:glycerol-3-phosphate acyltransferase, and one in lpat1,

82 ose-6-phosphate dehydrogenase, malic enzyme, glycerol-3-phosphate acyltransferase, and stearoyl-CoA d

83 mice; however, the activities of microsomal glycerol-3-phosphate acyltransferase, diacylglycerol acy

84 The glycerol-3-phosphate acyltransferase, mitochondrial hapl

85 nzymes involved in both TAG synthesis, Gpam (glycerol-3-phosphate acyltransferase, mitochondrial), Dg

86 s impair insulin signaling, we overexpressed glycerol-3-phosphate acyltransferase-1 (GPAT1) in primar

87 osis by upregulating target genes, including glycerol-3-phosphate acyltransferase-1 (Gpat1), which ca

88 vitro studies suggest that the mitochondrial glycerol-3-phosphate acyltransferase-1 (mtGPAT1) isoform

89 Overexpressing glycerol-3-phosphate acyltransferase-1 or -4 inhibited i

90 Glycerol-3-phosphate acyltransferase-4 (GPAT4) null pups

91 l-3-phosphate dehydrogenase, and plsB, an sn-glycerol-3-phosphate acyltransferase.

92 acid synthase, acetyl-CoA carboxylase 1, and glycerol-3-phosphate acyltransferase.

93 c enzymes, including fatty acid synthase and glycerol-3-phosphate acyltransferase.

94 e homozygous mutant deficient of the plastid glycerol-3-phosphate acyltransferase; both mutations blo

95 erichia coli, LPA acyltransferase (1-acyl-sn-glycerol-3-phosphate acyltransferase; EC 2.3.1.51) catal

96 nnotated as lysophosphatidic acid (1-acyl-sn-glycerol-3-phosphate) acyltransferase (AGPAT).

97 In the plastidic glycerol-3-phosphate acyltransferase1 mutant, which is d

98 (lacs2), permeable cuticle1 (pec1), cyp77a6, glycerol-3-phosphate acyltransferase6 (gpat6), and defec

99 cy in a mutant thereafter named gpat6-a (for glycerol-3-phosphate acyltransferase6).

100 vo pathway for TAG synthesis is catalyzed by glycerol-3-phosphate acyltransferases (GPATs).

101 Lysophosphatidic acid (LPA; 1-acyl-sn-glycerol-3-phosphate), an abundant constituent of serum,

102 tochondria and microsomes, incubated with sn-glycerol 3-phosphate and an immobilized substrate palmit

103 production depends on the concentrations of glycerol 3-phosphate and calcium and correlates positive

104 depend upon tissue source, concentrations of glycerol 3-phosphate and calcium, and the presence of di

105 respectively, by 1.0 M phosphite dianion, d-glycerol 3-phosphate and d-erythritol 4-phosphate.

106 Both glycerol 3-phosphate and fatty acyl-CoA increased the GP

107 hesis of PG-P from CDP-diacylglycerol and sn-glycerol 3-phosphate and functions as the committed and

108 Replacement of Pi with sn-glycerol-3-phosphate and 2-aminoethylphosphonate yielded

109 recombinant EDI3 protein cleaves GPC to form glycerol-3-phosphate and choline.

110 GDPDs metabolize glycerophosphodiesters into glycerol-3-phosphate and corresponding alcohols, but whe

111 Herein we describe the sn-glycerol-3-phosphate and dihydroxyacetone phosphate tran

112 roxyacetonephosphate at the sn-1 position by glycerol-3-phosphate and dihydroxyacetonephosphate acylt

113 a virulence, initiates with the acylation of glycerol-3-phosphate and dihydroxyacetonephosphate at th

114 ut significant, sequence similarity with the glycerol-3-phosphate and fucose permeases from Escherich

115 s of epidermal cell glycerol, its metabolite glycerol-3-phosphate, and ATP were found in AQP3 deficie

116 imulate insulin secretion, glucose flux into glycerol-3-phosphate, and esterification of long chain C

117 anisms for catalyzing the dehydrogenation of glycerol-3-phosphate are envisioned, based on the confor

118 ride synthesis in mammalian tissues requires glycerol 3-phosphate as the source of triglyceride glyce

119 ed based on its ability to complement the sn-glycerol-3-phosphate auxotrophic phenotype of a plsB mut

120 if 2 to alanines resulted in a Km defect for glycerol 3-phosphate binding leading to the conclusion t

121 nclusion that this motif corresponded to the glycerol 3-phosphate binding site.

122 ting the potential role of these residues in glycerol 3-phosphate binding.

123 bsaturating amounts of a substrate analogue, glycerol 3-phosphate, both NMR peaks were present, with

124 Consistent with the specificity of LmGAT for glycerol-3-phosphate but not dihydroxyacetonephosphate,

125 sfer of the acyl group from acylphosphate to glycerol 3-phosphate by an integral membrane protein, Pl

126 The oxidation of sn-glycerol 3-phosphate by mitochondrial sn-glycerol 3-phos

127 ic acid that begins with the acylation of sn-glycerol-3-phosphate by PlsY using an acyl-phosphate (ac

128 CTP:glycerol-3-phosphate cytidylyltransferase (GCT) catalyze

129 The CTP:glycerol-3-phosphate cytidylyltransferase (GCT) of Bacil

130 The bacterial enzyme, glycerol-3-phosphate cytidylyltransferase (GCT), is a mo

131 otein family and was previously annotated as glycerol-3-phosphate cytidylyltransferase (GCT).

132 hain cation of R269 lies at the surface of l-glycerol 3-phosphate dehydrogenase (GPDH) and forms an i

133 ate decarboxylase (ScOMPDC), and human liver glycerol 3-phosphate dehydrogenase (hlGPDH) for catalysi

134 sn-glycerol 3-phosphate by mitochondrial sn-glycerol 3-phosphate dehydrogenase (mGPDH) is a major pa

135 truncated substrate glycolaldehyde (GLY) by glycerol 3-phosphate dehydrogenase (NAD (+), GPDH) satur

136 ncluding pyruvate dehydrogenase kinase 4 and glycerol 3-phosphate dehydrogenase 1, was acutely induce

137 ons of Escherichia coli encode the anaerobic glycerol 3-phosphate dehydrogenase and glycerol 3-phosph

138 s that apicoplast-targeted Plasmodium yoelii glycerol 3-phosphate dehydrogenase and glycerol 3-phosph

139 Gpd1p is a cytosolic NAD(+)-dependent glycerol 3-phosphate dehydrogenase that also localizes t

140 rogenase, glucose 6-phosphate dehydrogenase, glycerol 3-phosphate dehydrogenase, and glucose oxidase.

141 three-step reaction utilizing three enzymes: glycerol 3-phosphate dehydrogenase, glycerol 3-phosphate

142 plasmic reticulum Ca2+-ATPase, mitochondrial glycerol 3-phosphate dehydrogenase, PGC1alpha, CoxII, an

143 uncoupling protein (Ucp1) and mitochondrial glycerol-3-phosphate dehydrogenase (Gdm) result in mice

144 Sn-glycerol-3-phosphate dehydrogenase (GlpD) is an essentia

145 stabilize the integral membrane flavoenzyme, glycerol-3-phosphate dehydrogenase (GlpD), and the solub

146 osphoserine phosphatase (PSP) motif fused to glycerol-3-phosphate dehydrogenase (GPD) domains.

147 r glycerol levels because of a defect in the glycerol-3-phosphate dehydrogenase (GPD1) gene: deletion

148 ion and activity (P<0.02), a 61% increase in glycerol-3-phosphate dehydrogenase (GPDH) activity (P<0.

149 Here we evaluate the effects of glycerol-3-phosphate dehydrogenase (Gpdh) and cytosolic

150 An extensive investigation of two proteins, glycerol-3-phosphate dehydrogenase (GPDH) and superoxide

151 We find that glycerol-3-phosphate dehydrogenase (GPDH) is localized a

152 nd hence their glycolytic enzymes, including glycerol-3-phosphate dehydrogenase (GPDH), are considere

153 n extensive investigation of three proteins, glycerol-3-phosphate dehydrogenase (GPDH), superoxide di

154 ehyde-3-phosphate dehydrogenase (GAPDH), and glycerol-3-phosphate dehydrogenase (GPDH).

155 The R269A mutation of glycerol-3-phosphate dehydrogenase (hlGPDH) results in a

156 triosephosphate isomerase (EC 5.3.1.1), and glycerol-3-phosphate dehydrogenase (NAD+)(EC 1.1.1.8).

157 In yeast glycerol-3-phosphate dehydrogenase 1 is essential for sy

158 , both the malate/oxaloacetate shuttle and a glycerol-3-phosphate dehydrogenase 1(Gpd1p)-dependent sh

159 co-imported with the PTS2-containing enzyme Glycerol-3-phosphate dehydrogenase 1, Gpd1.

160 ion (A280V) in a conserved amino acid of the glycerol-3-phosphate dehydrogenase 1-like (GPD1-L) gene.

161 Here, we identify the enzyme glycerol-3-phosphate dehydrogenase 1-like (GPD1L) as a n

162 production of the mature miRNA, derepresses glycerol-3-phosphate dehydrogenase 1-like enzyme (GPD1L)

163 Recently, a novel mutation in the glycerol-3-phosphate dehydrogenase 1-like gene (GPD1-L)

164 azepam also blocked the mutant A280V GPD1-L (glycerol-3-phosphate dehydrogenase 1-like) effect on red

165 luted and identified by mass spectrometry as glycerol-3-phosphate dehydrogenase 2 (Gpd2).

166 nthase activity (P<0.001), a 48% increase in glycerol-3-phosphate dehydrogenase activity (P<0.01) and

167 ve effects by inducing maximal mitochondrial glycerol-3-phosphate dehydrogenase activity in rat liver

168 d by 12 +/- 0.4 % in TG SOL and single fibre glycerol-3-phosphate dehydrogenase activity was decrease

169 dulated formation of a complex between alpha-glycerol-3-phosphate dehydrogenase and l-lactate dehydro

170 The activation of pure glycerol-3-phosphate dehydrogenase by either L-ascorbic

171 ol kinase encoded by glpK and suggest that a glycerol-3-phosphate dehydrogenase encoded by the upstre

172 Glycerol-3-phosphate dehydrogenase from pig brain mitoch

173 xpress the gene for the conserved aerobic sn-glycerol-3-phosphate dehydrogenase GlpD.

174 The glycerol-producing PTS2 protein glycerol-3-phosphate dehydrogenase Gpd1p shows a tripart

175 robic conditions, increasing the activity of glycerol-3-phosphate dehydrogenase induces complex dynam

176 letion within the glpD gene encoding aerobic glycerol-3-phosphate dehydrogenase might account for the

177 ally linked to the gpdC gene of the putative glycerol-3-phosphate dehydrogenase operon (gpdABC), base

178 -3-phosphate acyltransferase or GLY1-encoded glycerol-3-phosphate dehydrogenase restored 18:1 levels

179 n upstream gene, gpdA, encoding a homolog of glycerol-3-phosphate dehydrogenase subunit A, were upreg

180 equire GPD1, which encodes an NADH-dependent glycerol-3-phosphate dehydrogenase that is important for

181 Homogeneous pig brain mitochondrial glycerol-3-phosphate dehydrogenase was activated by eith

182 rom NADL to glycolaldehyde (GA) catalyzed by glycerol-3-phosphate dehydrogenase were determined over

183 and the glycerol-3-phosphate shuttle (Gut2, glycerol-3-phosphate dehydrogenase) are novel longevity

184 sure and a glycerol synthesis gene, gpd1(+) (glycerol-3-phosphate dehydrogenase), and is independent

185 They encode glycerol-3-phosphate dehydrogenase, an ABC transporter,

186 rug tolerance loci, glpABC, the anaerobic sn-glycerol-3-phosphate dehydrogenase, and plsB, an sn-glyc

187 mology, the closest structural neighbors are glycerol-3-phosphate dehydrogenase, N-(1-d-carboxylethyl

188 e glycerol facilitator, glycerol kinase, and glycerol-3-phosphate dehydrogenase, respectively, all of

189 s a physiological activator of mitochondrial glycerol-3-phosphate dehydrogenase, that the enzyme is p

190 GPD1-L has >80% amino acid homology with glycerol-3-phosphate dehydrogenase, which is involved in

191 ng the activity of its ancillary subunit-the glycerol-3-phosphate dehydrogenase-like protein.

192 e and suppression of GLUT2, glucokinase, and glycerol-3-phosphate dehydrogenase.

193 acetone phosphate transport system and an sn-glycerol-3-phosphate dehydrogenase.

194 nergy metabolism (triosephosphate isomerase, glycerol-3-phosphate-dehydrogenase, alpha enolase and L-

195 Saccharomyces cerevisiae has two homologous glycerol-3-phosphate dehydrogenases, Gpd1 and Gpd2, that

196 nal, the lysine catabolite pipecolic acid, a glycerol-3-phosphate-dependent factor and the dicarboxyl

197 Lysophosphatidic acid (LPA, 1- or 2-acyl-sn-glycerol 3-phosphate) displays an intriguing cell biolog

198 Lysophosphatidic acid (LPA, 1- or 2-acyl-sn-glycerol 3-phosphate) displays an intriguing cell biolog

199 utation causes an intracellular depletion of glycerol-3-phosphate due to constitutive synthesis of Gl

200 Modeling a ternary complex glycerol 3-phosphate (G3P) and NAD(+) with LmGPDH identi

201 es phosphorylation of [3H]glycerol to sn-[3H]glycerol 3-phosphate (G3P) by glycerokinase,acylation of

202 ajor facilitator superfamily, moves external glycerol 3-phosphate (G3P) into the cytoplasm in exchang

203 te transporter (GlpT) mediates the import of glycerol 3-phosphate (G3P) using the gradient of inorgan

204 osephosphate isomerase (TIM) in complex with glycerol 3-phosphate (G3P).

205 Gram-positive bacterial pathogens carry out glycerol-3-phosphate (G3P) acylation, which is the first

206 loss-of-function mutation in the plastidial glycerol-3-phosphate (G3P) acyltransferase (act1) have e

207 pressors demonstrated that a balance between glycerol-3-phosphate (G3P) and 18:1 levels is critical f

208 onical GPD enzymes catalyze the synthesis of glycerol-3-phosphate (G3P) by reduction of dihydroxyacet

209 null mutations in transketolase A (tktA) and glycerol-3-phosphate (G3P) dehydrogenase (glpD) increase

210 glpD encodes the glycerol-3-phosphate (G3P) dehydrogenase, which is invol

211 e (DHAP) and its subsequent conversion to sn-glycerol-3-phosphate (G3P) for synthesis of phospholipid

212 lely by glycerol kinase (encoded by glpK) to glycerol-3-phosphate (G3P) in Haloferax volcanii.

213 Glycerol-3-phosphate (G3P) is an important component of

214 Glycerol-3-phosphate (G3P) is an important metabolite th

215 The metabolism of glycerol-3-phosphate (G3P) is important for environmenta

216 of the major facilitator superfamily is the glycerol-3-phosphate (G3P) transporter (GlpT) from the E

217 The glycerol-3-phosphate (G3P) transporter (GlpT) of the E.

218 secondary active transporter family, the sn-glycerol-3-phosphate (G3P) transporter (GlpT) of the inn

219 The glycerol-3-phosphate (G3P) transporter, GlpT, from Esche

220 GlpQ hydrolyzes deacylated phospholipids to glycerol-3-phosphate (G3P) while GlpT transports G3P int

221 the signaling molecules azelaic acid (AzA), glycerol-3-phosphate (G3P), and salicylic acid (SA).

222 esponse to extracellular phosphates, such as glycerol-3-phosphate (G3P), glucose-6-phosphate (G6P), a

223 ne and storage glycerolipids is acylation of glycerol-3-phosphate (G3P).

224 from cytidine diphosphate-diacylglycerol and glycerol 3-phosphate, generating the precursor phosphati

225 The glpE gene, a member of the sn-glycerol 3-phosphate (glp) regulon of E. coli, encodes t

226 When the alpha-site ligand (ASL) alpha-D,L-glycerol 3-phosphate (GP) binds and closes the alpha-sit

227 y glycerophosphate dehydrogenase (GPD) to sn-glycerol 3-phosphate (GP), which is then converted by gl

228 ipid biosynthesis that controls acylation of glycerol 3-phosphate (GPAT) at the sn-1 position.

229 cally hydrolyze glycerophosphodiesters to sn-glycerol 3-phosphate (Gro3P) and their corresponding alc

230 FA cycle is regulated by the availability of glycerol-3-phosphate (Gro3P) and fatty acyl-CoA.

231 lpha-site, indole is cleaved from 3-indole-D-glycerol 3'-phosphate (IGP) and is channeled to the beta

232 mimic the binding of substrates, 3-indole-d-glycerol 3'-phosphate (IGP) or d-glyceraldehyde 3-phosph

233 ntrations of glucose intermediates including glycerol-3-phosphate increased when simulating IR due to

234 as not inhibited by either orthophosphate or glycerol 3-phosphate, indicating that either a glycerol

235 nthesis of GlpD and subsequent channeling of glycerol-3-phosphate into metabolic pathways.

236 of this superfamily, GlpT, which transports glycerol-3-phosphate into the cytoplasm and inorganic ph

237 e initial step of acylation of the precursor glycerol 3-phosphate is not essential for the synthesis

238 ose phosphate acquisition pathway whereby sn-glycerol-3-phosphate is directly transported and incorpo

239 This depletion of glycerol-3-phosphate is predicted to limit phospholipid

240 Lysophosphatidic acid (LPA, 1- or 2-acyl-sn-glycerol 3-phosphate) is an important phospholipid media

241 , protein synthesis, and ATP levels, whereas glycerol 3-phosphate levels were increased in the mutant

242 ve sufficient acyltransferase activities and glycerol-3-phosphate levels to support rates of TAG synt

243 lacked appreciable acylating activity toward glycerol 3-phosphate, lysophosphatidic acid, lysophospha

244 No differences in glucose, lactate, alanine, glycerol 3-phosphate, malate, myo-inositol, or stearic a

245 mutants affected in pathways involved in sn-glycerol-3-phosphate metabolism have led to the identifi

246 Similarly, glycerol 3-phosphate, necessary for the penultimate step

247 Most interestingly B. mori glycerol-3-phosphate O-acyltransferase (BmGPAT) was foun

248 transferase activities were detected against glycerol 3-phosphate or a variety of lysophospholipids,

249 ombinant ALCAT1 were detected against either glycerol-3-phosphate or a variety of other lysophospholi

250 from oxidation of ATP by glycerol kinase and glycerol 3-phosphate oxidase entrapped in the second lay

251 s able to produce hydrogen peroxide by using glycerol-3-phosphate oxidase, and addition of glycerol t

252 based on the activity of glycerol kinase and glycerol-3-phosphate oxidase.

253 ed examination of H(2)O(2) production during glycerol 3-phosphate oxidation by skeletal muscle, brown

254 hosphatidate phosphatase (PAP) enzyme in the glycerol 3-phosphate pathway for triglyceride storage an

255 Therefore, we investigated the role of the glycerol 3-phosphate pathway in dietary lipid absorption

256 which phosphatidic acid synthesized via the glycerol-3-phosphate pathway inhibits mTORC2 activity by

257 data support roles for intermediates in the glycerol-3-phosphate pathway of triacylglycerol synthesi

258 alyze the formation of diacylglycerol in the glycerol-3-phosphate pathway, implicating them in the re

259 zation of a putative organic Pi transporter, Glycerol-3-phosphate permease (G3Pp) family, comprising

260 aracterization indicate that Rv1692 is a D,L-glycerol 3-phosphate phosphatase.

261 f the functional thermodynamic cycle for the glycerol-3-phosphate:phosphate antiporter GlpT by using

262 molecule, may largely determine the rate of glycerol 3-phosphate production.

263 tly increased the dihydroxyacetone phosphate/glycerol 3-phosphate ratio in INS-1(832/13) cells, indic

264 inferred from the dihydroxyacetone phosphate:glycerol-3-phosphate ratio), mitochondrial membrane pote

265 tions in different conserved portions of the glycerol 3-phosphate repressor which are not part of the

266 Aat1 [aspartate amino transferase]) and the glycerol-3-phosphate shuttle (Gut2, glycerol-3-phosphate

267 function: the standing triglyceride pool and glycerol-3-phosphate shuttle-assisted flight.

268 cluding the malate-aspartate shuttle and the glycerol-3-phosphate shuttle.

269 ed in substrate binding and catalysis at the glycerol-3-phosphate site.

270 ubfamilies, LONG-CHAIN ACYL-COA SYNTHETASE2, GLYCEROL-3-PHOSPHATE SN-2-ACYLTRANSFERASE4, and the ATP-

271 Glycerol-3-phosphate (sn-glycerol-3-P, G3P) acyltransfer

272 aturating amounts of a substrate analogue DL-glycerol 3-phosphate so that the populations of the open

273 ty is of parasite origin and is specific for glycerol 3-phosphate substrate.

274 ck III appear to be important in binding the glycerol 3-phosphate substrate.

275 Both the gly1 mutation, which reduces glycerol-3-phosphate supply to the prokaryotic pathway,

276 (3) Glyceroneogenesis contributes more to glycerol-3-phosphate synthesis during epinephrine infusi

277 nvolved in binding of the phosphate group of glycerol 3-phosphate to the enzyme.

278 redox enzyme that catalyzes the oxidation of glycerol-3-phosphate to dihydroxyacetone phosphate.

279 were rapidly esterified with glucose-derived glycerol-3-phosphate to form lysophosphatidic acid, mono

280 Binding of either CTP or glycerol-3-phosphate to GCT was biphasic, with two bindi

281 thesis, it was demonstrated that addition of glycerol-3-phosphate to the growth medium ameliorated th

282 recognition to the crystal structure of the glycerol 3-phosphate transporter (GlpT) from Escherichia

283 Glycerol 3-phosphate transporter (GlpT) mediates the imp

284 Using the x-ray structure of the glycerol 3-phosphate transporter (GlpT), we devised a mo

285 omology model that used the Escherichia coli glycerol 3-phosphate transporter as a template has been

286 ure similar to that of the distantly related glycerol 3-phosphate transporter GlpT.

287 Hence, the data support the glycerol 3-phosphate transporter-based homology model of

288 robic glycerol 3-phosphate dehydrogenase and glycerol 3-phosphate transporter/phosphodiesterase, resp

289 omic structures of the related transporters, glycerol-3-phosphate transporter (GlpT) and lactose perm

290 In the sn-glycerol-3-phosphate transporter (GlpT) from Escherichia

291 ophosphodiester phosphodiesterase (GlpQ) and glycerol-3-phosphate transporter (GlpT), respectively.

292 In addition, the glycerol-3-phosphate transporter is monomeric and stable

293 ry transporter structures (lactose permease, glycerol-3-phosphate transporter) as well as to a low re

294 whose putative product shows homology to the glycerol-3-phosphate transporter.

295 , biophysical, and structural studies of the glycerol-3-phosphate transporter.

296 cotransporter from the unrelated lactose and glycerol 3-phosphate transporters.

297 e second step in triglyceride formation from glycerol-3-phosphate, was studied in 3T3-L1 adipocytes a

298 ymes, D38A, W74A, and D94A, for both CTP and glycerol-3-phosphate were 6-130-fold higher than that of

299 Glycerol 3-phosphate, which is produced in vivo by a gly

300 glycerolipid biosynthesis, the acylation of glycerol 3-phosphate with saturated long-chain acyl-CoAs