ライフサイエンスコーパス: glycerol kinase

1 that of actin, heat shock protein hsc70, and glycerol kinase.

2 increase in the activity of the enterococcal glycerol kinase.

3 ed domain closure that has been proposed for glycerol kinase.

4 membrane channel protein GlpF and the enzyme glycerol kinase.

5 fected by the loss of IIA(Glc) inhibition of glycerol kinase.

6 levant regulatory interaction of IIAGlc with glycerol kinase.

7 t with X-ray studies on the Escherichia coli glycerol kinase.

8 ricolum EIIA has no effect on the homologous glycerol kinase.

9 es, including the isoforms of hexokinase and glycerol kinase.

10 mino acid change Gly-304 to Ser (G-304-S) in glycerol kinase.

11 es, including the isoforms of hexokinase and glycerol kinase.

12 hich could explain its inability to regulate glycerol kinase.

13 attributed to a null allele of Gk5, encoding glycerol kinase 5 (GK5), a skin-specific kinase expresse

14 s been reported that islets contain abundant glycerol kinase activity and oxidize glycerol efficientl

15 We also showed that zonation of glycerol kinase activity is minor in rat liver.

16 Glycerol kinase activity was dependent on the glpK gene

17 Escherichia coli EIIA inhibits Gram-negative glycerol kinase activity, the M. capricolum EIIA has no

18 lls was shown to cause a marked elevation in glycerol kinase activity.

19 Enzyme assays revealed that gli1 lacks glycerol kinase activity.

20 nsulinoma cell line INS-1 contain negligible glycerol kinase activity.

21 udy, we examined whether adenoviral-mediated glycerol kinase (AdV-CMV-GlyK) expression in isolated ra

22 Three E. coli glycerol kinase amino acids that are located at least 15

23 tion which resulted from oxidation of ATP by glycerol kinase and glycerol 3-phosphate oxidase entrapp

24 eloped biosensor is based on the activity of glycerol kinase and glycerol-3-phosphate oxidase.

25 lationships between allosteric regulation of glycerol kinase and specific repression in glucose contr

26 The longer form of miR-307a represses glycerol kinase and taranis mRNA expression.

27 aluate this possibility, variants of E. coli glycerol kinase and the chimeric, allosteric H. influenz

28 and better the physiological significance of glycerol kinase and the pathophysiology of its deficienc

29 eron encodes glycerol diffusion facilitator, glycerol kinase, and as shown here, a fructose 1,6-bisph

30 sterol regulatory element-binding protein 1, glycerol kinase, and beta3-adrenergic receptor.

31 glpA, which encode the glycerol facilitator, glycerol kinase, and glycerol-3-phosphate dehydrogenase,

32 ng SCD1, FAS, ACC1, ACC2, ATP-citrate lyase, glycerol kinase, and HMG-CoA reductase.

33 FBP binds to both the dimer and tetramer of glycerol kinase, and the FBP concentration dependence of

34 g result that however closely hexokinase and glycerol kinase are related structurally the site around

35 hate dehydrogenase (mGPD, cGPD) plus that of glycerol kinase are required for the use of glycerol in

36 e sugar kinase/hsp70/actin superfamily, with glycerol kinase as its closest relative.

37 an allosteric inhibitor of Escherichia coli glycerol kinase, binding more than 25 A from the kinase

38 m E. coli glycerol kinase into H. influenzae glycerol kinase by interconverting only 11 of the differ

39 of allosteric regulation of Escherichia coli glycerol kinase by the glucose-specific phosphocarrier o

40 Glycerol kinase catalyzes the metabolism of endogenously

41 structures of the enzyme I-HPr and IIA(Glc)-glycerol kinase complexes reveal how similar binding sur

42 Glycerol kinase deficiency (GKD) is an X-linked inborn e

43 These mice share some features of both glycerol kinase deficiency and hereditary fructose intol

44 Isolated glycerol kinase deficiency has an inconstant phenotype,

45 Glycerol kinase deficiency in humans occurs as an isolat

46 hophysiology of its deficiency, we generated glycerol kinase-deficient mice by gene targeting.

47 The biochemical features observed in glycerol kinase-deficient mice provide the basis for fur

48 Earlier work indicates that glycerol kinase displays a dimer-tetramer equilibrium in

49 One of these target proteins is glycerol kinase (EC 2.1.7.30, ATP:glycerol 3-phosphotran

50 The catalytic activity of glycerol kinase (EC 2.7.1.30, ATP:glycerol 3-phosphotran

51 Escherichia coli glycerol kinase (EC 2.7.1.30; ATP-glycerol 3-phosphotran

52 Escherichia coli glycerol kinase (EC 2.7.1.30; ATP:glycerol 3-phosphotran

53 that glycerol metabolism proceeds through a glycerol kinase encoded by glpK and suggest that a glyce

54 Glycerol is catabolized solely by glycerol kinase (encoded by glpK) to glycerol-3-phosphat

55 glucose control of glycerol utilization and glycerol kinase expression is not affected by the loss o

56 We conclude from these studies that glycerol kinase expression is sufficient to activate gly

57 The first structure of a glycerol kinase from a Gram-positive organism, Enterococ

58 sites of yeast 3-phosphoglycerate kinase and glycerol kinase from Candida mycoderma.

59 Glycerol kinase from Escherichia coli, but not Haemophil

60 ing IIAGlc inhibition into the nonallosteric glycerol kinase from Haemophilus influenzae.

61 ombinant adenovirus containing the bacterial glycerol kinase gene (AdCMV-GlpK) was constructed and us

62 LI1 mapped to chromosome 1 near the putative glycerol kinase gene NHO1.

63 utations were predominantly found within the glycerol kinase gene.

64 Liver shows the highest level of glycerol kinase (GK) activity in humans and mice.

65 Microarray analysis identified glycerol kinase (GK) as the second most highly upregulat

66 We demonstrate that isolated glycerol kinase (GK) deficiency in three families result

67 Escherichia coli glycerol kinase (GK) displays "half-of-the-sites" reacti

68 e-dimensional structures of Escherichia coli glycerol kinase (GK) with bound glycerol in the presence

69 We investigated the role of glycerol kinase (GK), phosphoenolpyruvate carboxykinase

70 en by complementation of an Escherichia coli glycerol kinase (glpK) deletion strain.

71 our adaptive non-synonymous mutations to the glycerol kinase (glpK) gene on catalytic function and re

72 The Zn(II)-liganding residue contributed by glycerol kinase (Glu478) is substituted by using site-di

73 ptor (PPAR)-gamma, markedly induce adipocyte glycerol kinase (GyK) gene expression.

74 roarray analysis on liver mRNA from neonatal glycerol kinase (Gyk) knockout (KO) and wild-type (WT) m

75 Glycerol kinase (Gyk) participates in the metabolism of

76 ced during adipogenesis, but others, such as glycerol kinase (GyK), are expressed at low levels in ad

77 ntical to that of the ADP-binding domains of glycerol kinase, hexokinase, the 70-kDa heat shock cogna

78 In this study, a gene encoding a glycerol kinase homolog (glpK; HVO_1541) was deleted fro

79 resence of functionally important amounts of glycerol kinase in skeletal muscle.

80 Glc) inhibition is transplanted from E. coli glycerol kinase into H. influenzae glycerol kinase by in

81 Glycerol kinase is an X chromosome-encoded enzyme involv

82 n and catalytic and regulatory properties of glycerol kinase is consistent with a role for the domain

83 Glycerol kinase is labeled with extrinsic fluorophores c

84 These data show that glycerol kinase is required for glycerol catabolism in A

85 ast, fructose 1,6-bisphosphate inhibition of glycerol kinase is the dominant allosteric control mecha

86 Glycerol kinase is the only IIAGlc target protein for wh

87 e, we show that Arabidopsis NHO1, encoding a glycerol kinase, is required for resistance to and induc

88 In glycerol kinase, it is shown that the proposed domain mo

89 that the Ahch gene is closely linked to the glycerol kinase locus, GyK, on the mouse X chromosome, i

90 is produced in vivo by a glycosome-resident glycerol kinase, mitigated acid inactivation of lysate-d

91 The crystal structure of an Escherichia coli glycerol kinase mutant Gly230 --> Asp (GKG230D) was dete

92 catabolite repression more pronounced in the glycerol kinase mutant.

93 In most bacteria, glycerol kinase plays a crucial role in regulating chann

94 coli strains with these alleles display the glycerol kinase regulatory phenotypes that are expected

95 f the En. casseliflavus and Escherichia coli glycerol kinases, remarkable structural differences have

96 to G3P due to a mutation in the nho1-encoded glycerol kinase renders plants tolerant to glycerol and

97 Inhibition studies of glycerol kinase show significant decreases in binding fo

98 ctors for the IIAGlc-binding site on E. coli glycerol kinase suggest that motions of the allosteric s

99 opriate alignment of the second substrate of glycerol kinase, the ATP molecule, may largely determine

100 entration with a concomitant increase of the glycerol kinase transcript level and enzyme activity.

101 A sequentially contiguous portion of glycerol kinase undergoes an induced fit conformational

102 e and the chimeric, allosteric H. influenzae glycerol kinase were constructed with a non-native cyste

103 In addition, GPD2 and a gene encoding glycerol kinase were up-regulated in Chlamydomonas cells

104 enes involved in glycolysis (glucokinase and glycerol kinase) were decreased in L-Fabp(-/-) mice.

105 eased expression of genes in adipose such as glycerol kinase, which are induced by high affinity PPAR

106 The alleles encode glycerol kinases with normal catalytic properties and sp