ライフサイエンスコーパス: glycerophospholipid

1 role for this plasmalogen molecular species glycerophospholipid.

2 small molecules biosynthesized from membrane glycerophospholipid.

3 atalyzes a critical step in the synthesis of glycerophospholipids.

4 these AGPATs in remodeling of several of the glycerophospholipids.

5 increased plasma and BALF glycerolipids and glycerophospholipids.

6 developed for the rapid analyses of cellular glycerophospholipids.

7 lds near-complete structural information for glycerophospholipids.

8 the nonionic detergent NP-40, together with glycerophospholipids.

9 ion of the membrane, examined by doping with glycerophospholipids.

10 d fractional turnover of 16:0 in the choline glycerophospholipids.

11 ducing lysophosphatidic acid (LPA) from lyso-glycerophospholipids.

12 s required for the chlamydial uptake of host glycerophospholipids.

13 e in the biosynthesis of triacylglycerol and glycerophospholipids.

14 s at both the sn-1 and sn-2 positions of the glycerophospholipids.

15 minimal increase in activity with alkylacyl glycerophospholipids.

16 and certain other fatty acids into the major glycerophospholipids.

17 enoic acid and other isomers within platelet glycerophospholipids.

18 mallest and structurally simplest of all the glycerophospholipids.

19 gen atom into the arachidonate esterified to glycerophospholipids.

20 only 10.9 nmol/10(9) platelets from choline glycerophospholipids.

21 rred tool for structural characterization of glycerophospholipids.

22 rs through hydrolysis of membrane-associated glycerophospholipids.

23 ylserine and phosphatidylglycerol were minor glycerophospholipids.

24 between the two halophytes and the different glycerophospholipids.

25 ds from acyl-ACP to the 1-position of 2-acyl-glycerophospholipids.

26 abolite profiles with high levels of various glycerophospholipids.

27 nutrient-sensing pathways and regulation of glycerophospholipids.

28 cum increases mycolate content and decreases glycerophospholipids.

29 lly metabolizes PAF and structurally related glycerophospholipids.

30 Since the oxidized glycerophospholipid 1-hexadecyl-2-azelaoyl glycerophosph

31 The glycerophospholipid 1-stearoyl-2-oleoyl-sn-glycero-3-pho

32 ons of 14 amino acids, 17 acylcarnitines, 81 glycerophospholipids, 14 sphingomyelins, and ferritin we

33 for 3 h, tetra-acylated lipid A species and glycerophospholipids accumulate in the inner membrane.

34 All characterized P4-ATPases flip glycerophospholipids across the bilayer to the cytosolic

35 ensing pathways showed reciprocal changes in glycerophospholipid acyl chain lengths.

36 Compared to their parent glycerophospholipids, all lyso analogs had greater tempe

37 < 0.001) and pathways related to NF-kappaB, glycerophospholipid and ether lipid metabolism, as well

38 ipid A are nearly normal in MKV15, as is the glycerophospholipid and membrane protein composition.

39 ction) were 3- to 29-fold higher for choline glycerophospholipid and phosphatidylinositol than for et

40 d phosphatidylinositol than for ethanolamine glycerophospholipid and phosphatidylserine at each of th

41 f lipids: (i) mono/di/triacylglycerols, (ii) glycerophospholipids and (iii) cardiolipins.

42 In contrast, more than 50% of glycerophospholipids and 30% of cholesterol were found i

43 While the bundle glycerophospholipids and acyl chains resemble those of o

44 n-cell line specific changes in fatty acids, glycerophospholipids and carbohydrates over time, induce

45 es we have spectrally resolved more than 130 glycerophospholipids and determined changes initiated by

46 ell wall, as demonstrated by perturbation of glycerophospholipids and fatty acids.

47 he blockade of the chlamydial uptake of host glycerophospholipids and impairment in chlamydial growth

48 s that is esterified to the sn-2-position of glycerophospholipids and is released from selected lipid

49 s that is esterified to the sn-2 position of glycerophospholipids and is released from selected phosp

50 containing rafts contained more ethanolamine glycerophospholipids and less sphingomyelin than did the

51 s revealed the buildup of several species of glycerophospholipids and other storage lipids in selecti

52 lipids were observed for multiple classes of glycerophospholipids and polyphosphatidylinositides betw

53 lyzed plasmenylcholine > phosphatidylcholine glycerophospholipids and selectively cleaved phospholipi

54 Numerous interactions between glycerophospholipids and sphingolipids are observed in t

55 abundance and determine the turnover rate of glycerophospholipids and sphingolipids by direct analysi

56 nly explained by the lower concentrations of glycerophospholipids and sphingolipids in vegans.

57 The glycerophospholipids and sphingolipids that appear as in

58 Serum concentrations of most acylcarnitines, glycerophospholipids and sphingolipids were altered in s

59 ibution and localization of major classes of glycerophospholipids and sphingolipids.

60 oups because of lower concentrations of some glycerophospholipids and sphingolipids.

61 generated by enzymatic cleavage of stores of glycerophospholipids and sphingomyelin, respectively, in

62 chromofuscus PLD is known to hydrolyze both glycerophospholipids and sphingomyelin.

63 e tentative identification of markers showed glycerophospholipids and their oxidized lipids were sign

64 tive intensities for at least five different glycerophospholipids and three free fatty acids in the n

65 T2 generates precursors for the synthesis of glycerophospholipids and triacylglycerols.

66 an, serotonin, taurine, 8 acylcarnitines, 13 glycerophospholipids, and 3 sphingolipids) exhibited sig

67 Because ATX hydrolyzes nucleotides, lyso-glycerophospholipids, and phosphosphingolipids into bioa

68 Lipid remodeling of glycerolipids, glycerophospholipids, and prenols also take place, indic

69 Glycerolipids, glycerophospholipids, and sphingolipids exhibited diurna

70 ighest concentrations of the acylcarnitines, glycerophospholipids, and sphingolipids, and fish eaters

71 Networks associated with inositol phosphate, glycerophospholipids, and sterol metabolism are tightly

72 ization of 29 sulfoglycosphingolipids and 45 glycerophospholipids, and we confirmed lipid identities

73 unsaturated fatty acid (VLC-PUFA)-containing glycerophospholipids are highly enriched in the retina;

74 and function of these highly unusual retinal glycerophospholipids are lacking.

75 Ethanolamine glycerophospholipids are ubiquitous cell membrane compon

76 ular lipids, and identified the accumulating glycerophospholipid as acylphosphatidylglycerol (acyl-PG

77 ynthesize the majority of their ethanolamine glycerophospholipids as 1-O-alk-1'-enyl-2-acyl-sn-glycer

78 Glycerophospholipids as well as other family lipids, suc

79 ases A2 (sPLA2's) are enzymes that hydrolyze glycerophospholipids at the sn-2 position, which leads t

80 phospholipase A(2) (iPLA(2)beta) hydrolyzes glycerophospholipids at the sn-2-position to yield a fre

81 proteins, we discovered that E-Syts transfer glycerophospholipids between membrane bilayers in the pr

82 ng, and hydrogen-bonding behaviors of SM and glycerophospholipid bilayers found remarkable difference

83 with tryptophan derivatives interacting with glycerophospholipid bilayers in vesicles, tryptophan par

84 Phosphatidylserine (PS), another anionic glycerophospholipid, binds to mCD14 with lower apparent

85 nvolved in both membrane ornithine lipid and glycerophospholipid biosynthesis.

86 intermediates from sphingolipid pathways to glycerophospholipid biosynthesis.

87 whereas SREBP-1 controls triacylglycerol and glycerophospholipid biosynthesis.

88 Such lipids included glycerophospholipids (both diacyl and aryl-acyl), sphing

89 lung tissue and P. carinii differed from the glycerophospholipids by the presence of high levels of s

90 characterization of complex lipids, such as glycerophospholipids, by tandem mass spectrometry (MS/MS

91 imulated sphingolipid (glucosylceramide) and glycerophospholipid (cardiolipin) synthesis.

92 the level of incorporation into the choline glycerophospholipids (ChoGpl).

93 protein that is homologous to enzymes called glycerophospholipid-cholesterol acyltransferases and, fo

94 enterica serovar typhimurium translocates a glycerophospholipid:cholesterol acyltransferase (SseJ) i

95 mophila, such as phospholipases A (PLAs) and glycerophospholipid:cholesterol acyltransferases (GCATs)

96 ometry was used to separate and quantify the glycerophospholipid classes as well as molecular species

97 ction of molecular species within particular glycerophospholipid classes.

98 results illustrate that large differences in glycerophospholipid composition may exist, even in close

99 rometry (FTICR-MS) to measure changes in the glycerophospholipid composition of total lipid extracts

100 iator biosynthesis in the context of overall glycerophospholipid composition.

101 al-based mechanism of oxidation of pulmonary glycerophospholipids containing arachidonate.

102 Glycerophospholipids containing arachidonic acid (20:4)

103 ice showed a significant decrease in retinal glycerophospholipids containing VLC-PUFAs, specifically

104 Mass spectrometry of total glycerophospholipids demonstrated a marked difference in

105 olipids, sphingosine 1-phosphate, and diacyl-glycerophospholipids did not activate FUS1::lacZ.

106 LDI-TOF MS approach for analysis of cellular glycerophospholipids directly from extracts of mammalian

107 a compound structurally dissimilar to acidic glycerophospholipids, efficiently releases the nucleotid

108 ial metabolites were closely associated with glycerophospholipid, fatty acid and amino acid metabolis

109 of 219 molecular ions, including CLs, other glycerophospholipids, fatty acids, and metabolites, were

110 tely 5-fold and resolved it from both the ER glycerophospholipid flippase activity and the geneticall

111 ane proteins in the Triton extract; and (iv) glycerophospholipid flippase activity in the ER can be a

112 sing an activity-enriched fraction devoid of glycerophospholipid flippase activity, we now report tha

113 Cardiolipin is a glycerophospholipid found predominantly in the mitochond

114 membrane, but how these enzymes distinguish glycerophospholipids from sphingolipids is not known.

115 l activation of the host cPLA2 and uptake of glycerophospholipids from the host cells.

116 disrupted lipid metabolism in AIS, including glycerophospholipid, glycerolipid and fatty acid metabol

117 es in relative abundances of >600 individual glycerophospholipid, glycerolipid, sphingolipid and ster

118 compositions of a series of fatty acids and glycerophospholipid (GP) species between the normal and

119 ype phospholipases (PLAs) are key players in glycerophospholipid (GPL) homeostasis and in mammalian c

120 complete structural information for a given glycerophospholipid (GPL) species.

121 ide (LPS) and the inner leaflet is formed by glycerophospholipid (GPL).

122 olysaccharide (LPS), and an inner leaflet of glycerophospholipids (GPLs).

123 es of this free fatty acid as well as of the glycerophospholipids harboring it.

124 t the most prominent components of all major glycerophospholipid headgroup classes in islets are arac

125 cylcarnitines, amino acids, biogenic amines, glycerophospholipids, hexose, and sphingolipids related

126 -1 analog that regulates triacylglycerol and glycerophospholipid homeostasis in response to low oxyge

127 scriptional regulator of triacylglycerol and glycerophospholipid homeostasis in S. pombe, analogous t

128 a cells showed disrupted triacylglycerol and glycerophospholipid homeostasis, most notably with an in

129 31.8 nmol/10(9) platelets from ethanolamine glycerophospholipids (hydrolysis of plasmenylethanolamin

130 Among 96 of the unsaturated fatty acids and glycerophospholipids identified from rat brain tissue, 5

131 dylcholine was found to be the most abundant glycerophospholipid in both seed oils whereas phosphatid

132 Phosphatidylcholine (PC) is the major glycerophospholipid in eukaryotic cells and is an essent

133 ass spectrometry (MS/MS), several classes of glycerophospholipids in A. pallida.

134 y expressed and metabolically interconnected glycerophospholipids in eukaryotes and prokaryotes.

135 Roles for glycerophospholipids in exocytosis have been proposed, b

136 We used mass spectrometry to quantify glycerophospholipids in mock-infected and virus-infected

137 tectable changes in specific 20:4-containing glycerophospholipids in peritoneal cells, but not in RAW

138 Transbilayer flipping of glycerophospholipids in the endoplasmic reticulum (ER) i

139 no acids, acylcarnitines, sphingolipids, and glycerophospholipids in the liver and blood.

140 of PLA2 catalyzed hydrolysis of zwitterionic glycerophospholipids in the presence of bile salts.

141 egreesC accumulate hexa-acylated lipid A and glycerophospholipids in their inner membranes.

142 he rapid loss of phosphocholine from choline glycerophospholipids, in conjunction with neutral-loss s

143 alterations in both choline and ethanolamine glycerophospholipids, including a decreased plasmenyleth

144 he side chains of biological lipids, such as glycerophospholipids, is also essential.

145 : (i) fatty acyls, (ii) glycerolipids, (iii) glycerophospholipids, (iv) cardiolipins, (v) sphingolipi

146 ) catalyzes release of arachidonic acid from glycerophospholipids, leading to thromboxane A(2) (TxA(2

147 Glycerophospholipid levels inCerS5-deficient mice were n

148 ted at similar rates to lipid IV(A), whereas glycerophospholipids like phosphatidic acid or phosphati

149 confirm that selected TCL1 clones react with glycerophospholipid, lipoprotein, and polysaccharides th

150 combining the sphingolipid SM C22:3 and the glycerophospholipid lysoPCaC24:0 was discovered for seps

151 The glycerophospholipid lysoPCaC26:1 identified patients wit

152 We discover three additional pathways viz., Glycerophospholipid metablism, h-Efp pathway and CARM1 a

153 ine and proline metabolism (P=1.12x10(-7) ), glycerophospholipid metabolism (P=1.3x10(-10) ), and the

154 osphatidic acid (LPA) is a common product of glycerophospholipid metabolism and an important mediator

155 etween renal tubulointerstitial fibrosis and glycerophospholipid metabolism and L-carnitine metabolis

156 etabolites related to amino acid metabolism, glycerophospholipid metabolism and mitochondrial beta-ox

157 nique defects in nucleotide, one-carbon, and glycerophospholipid metabolism at the transcript and pro

158 riptome suggests the possible involvement of glycerophospholipid metabolism in the development of res

159 Via TEAK we identified a nonlinear glycerophospholipid metabolism subpathway involving the

160 linked to lipid metabolism, inflammation and glycerophospholipid metabolism that were associated with

161 Twenty three metabolites related to glycerophospholipid metabolism, oxidation and antioxidat

162 tty acid, eicosanoid, and fatty acid-derived glycerophospholipid metabolism, resulting in an overall

163 votal role in regulation of triglyceride and glycerophospholipid metabolism.

164 easily integrated into the lipid bilayer of glycerophospholipid model membranes.

165 mice exhibited normal hemodynamic function, glycerophospholipid molecular species composition, and n

166 he quantity of other classes of lipid (e.g., glycerophospholipid) molecular species present, thereby

167 s in clinical cohort studies demand detailed glycerophospholipid molecule information and the applica

168 ansmembrane protein, which binds cardiolipin glycerophospholipids near the inner membrane and promote

169 bacterial cells by integrating extraction of glycerophospholipids on a microchip with a nanoelectrosp

170 n the acyl chain composition of any class of glycerophospholipid or diacylglycerol between lipid extr

171 dentified a novel family of oxidized choline glycerophospholipid (oxPC) molecular species enriched in

172 turally conserved family of oxidized choline glycerophospholipids (oxPC(CD36)) that serve as novel hi

173 the most significant metabolites map to the glycerophospholipid pathway.

174 A significant enrichment of the glycerophospholipids pathway was identified (P = 4.7 x 1

175 s fatty acyl information, in the case of the glycerophospholipids (PE, PS, and PC), via ester bond cl

176 ivity of PAF-AH in bile toward byproducts of glycerophospholipid peroxidation.

177 s formed upon electrospray ionization of the glycerophospholipids phosphatidylcholine (PC) and phosph

178 lace Cer-1-P in a class more akin to certain glycerophospholipids (phosphatidylethanolamine, phosphat

179 idic acid (PAs), phosphatidylglycerol (PGs), glycerophospholipids (PI), phosphatidylcholines (PCs) an

180 phosphatidylcholine, and the proinflammatory glycerophospholipid platelet-activating factor (PAF) wer

181 (DGKalpha) knockout mice were determined for glycerophospholipids, polyphosphatidylinositides (GPInsP

182 d 63% of the mass lost from the ethanolamine glycerophospholipid pool) but only 10.9 nmol/10(9) plate

183 ses occurred in the choline and ethanolamine glycerophospholipid pools in murine myocardium (collecti

184 Furthermore, 19606R exhibited a shift in its glycerophospholipid profile towards increased abundance

185 1 deficiency significantly modulates hepatic glycerophospholipid profile.

186 that Rv1692 is the final enzyme involved in glycerophospholipid recycling/catabolism, a pathway not

187 pplication of this method to the analysis of glycerophospholipid remodeling in murine primary residen

188 ct on the overall pattern of zymosan-induced glycerophospholipid remodeling.

189 By number and measured intensity, glycerophospholipids represent the largest lipid class,

190 e presence of overlapping peaks from choline glycerophospholipids requiring chromatographic separatio

191 rsity, complex lipids such as glycerolipids, glycerophospholipids, saccharolipids, etc. are construct

192 t transmembrane segment is a key enforcer of glycerophospholipid selection, and specific substitution

193 In more complex bilayers composed of a fluid glycerophospholipid, SM analog, and PCer, the thermal st

194 We synthesized a family of sterol-modified glycerophospholipids (SML) in which the sn-1 or sn-2 pos

195 ion patterns for four subclasses of modified glycerophospholipid species.

196 f the two fractions contained various diacyl-glycerophospholipids species, where the majority of them

197 ized by a distinctive enrichment in hexoses, glycerophospholipids, sphingolipids, and acylcarnitines,

198 ntified hundreds of lipid species, including glycerophospholipids, sphingolipids, and sterols, from a

199 dentification of fatty acids, glycerolipids, glycerophospholipids, sphingolipids, and sterols.

200 gories including fatty acyls, glycerolipids, glycerophospholipids, sphingolipids, sterols, and prenol

201 tion and the positions of chain-branching in glycerophospholipids, sphingomyelins and triacylglycerol

202 gh degree of specificity for LPA; other lyso-glycerophospholipids, sphingosine 1-phosphate, and diacy

203 wing the spatial distributions of particular glycerophospholipids, sphinoglipids, and free fatty acid

204 ommon in all 4 sample types; fatty acyls and glycerophospholipids strongly overlapped between groups.

205 d lipid profiling technology to evaluate the glycerophospholipid structure and composition of two mac

206 plsC316 encodes the main AGPAT required for glycerophospholipid synthesis in R. capsulatus, while ol

207 ga2 and SREBP-1 regulate triacylglycerol and glycerophospholipid synthesis, whereas Sre1 and SREBP-2

208 s required for ether bond formation in ether glycerophospholipid synthesis.

209 mal zymosan-dependent PG synthesis, the only glycerophospholipid that exhibited a significant change

210 Phosphatidylethanolamine is a glycerophospholipid that, together with phosphatidylchol

211 Plasmalogens are a subclass of glycerophospholipids that are enriched in the plasma mem

212 mines) are a biologically important class of glycerophospholipids that have been difficult to synthes

213 r segments with structurally defined choline glycerophospholipids that may serve as a physiological s

214 Structurally defined oxidized choline glycerophospholipids that serve as high-affinity ligands

215 to form EET-CoAs that are incorporated into glycerophospholipids, thereby sequestering EETs.

216 (MS)-based lipidomics strategy that exposes glycerophospholipids to an ethereal solution of diazomet

217 Phospholipase A(2) (PLA(2)) hydrolyzes glycerophospholipids to free fatty acid and lyso-phospho

218 GDPD) catalyzes the hydrolysis of deacylated glycerophospholipids to glycerol phosphate and alcohol.

219 tory phospholipase A(2)s (sPLA(2)) hydrolyze glycerophospholipids to liberate lysophospholipids and f

220 D inhibitors (which block the conversion of glycerophospholipids to phosphatidic acid) to deplete ce

221 e A2 beta enzyme that selectively hydrolyses glycerophospholipids to release free fatty acids.

222 at MsbA plays a role in lipid A and possibly glycerophospholipid transport.

223 The best on-chip extraction efficiency for glycerophospholipids was as high as 83.3% by integrating

224 on flux across membranes composed of choline glycerophospholipids was primarily due to entropic effec

225 sphingolipids (SPs) and cholesterol, whereas glycerophospholipids were reduced, and storage lipids we

226 6:0 was targeted to choline and ethanolamine glycerophospholipids, whereas more [1-(14)C]20:4n-6 was

227 bstantially enriched in sphingomyelin and in glycerophospholipids with a higher degree of saturation

228 a on the relative distribution of individual glycerophospholipids within each of the major classes.

229 of this conformational motif for peroxidized glycerophospholipids within membranes.