ライフサイエンスコーパス: glycine transporter

1 av3 channels; and 4) inhibition of the GLYT2 glycine transporter.

2 uences of deleting the two genes that encode glycine transporters.

3 gy proposed for the closely related GABA and glycine transporters.

4 and examined its activity against the cloned glycine transporters.

5 Here we show that administration of a glycine transporter 1 (GlyT1) inhibitor, or molecular Gl

6 In the present study we tested several glycine transporter 1 (GlyT1) inhibitors including NFPS,

7 synthesized a potent selective inhibitor of glycine transporter 1 (GlyT1), and characterized its act

8 r1 : :GFP(+) amacrine cells colabeled with a glycine transporter 1 antibody.

9 and HMGN3b upregulate the expression of the glycine transporter 1 gene (Glyt1).

10 ine racemase homozygous knockout (SR-/-) and glycine transporter 1 heterozygous mutant (GlyT1-/+).

11 (2) Activation of glycine transporter 1(GlyT1) induced by VEGF led to an i

12 e inner nuclear layer, is immunopositive for glycine transporter 1, and shows the typical morphology

13 The glycine transporter 1, localized to glial cells, regulat

14 ansmission is regulated by the action of the glycine transporters 1 and 2 (GlyT1 and GlyT2)--members

15 d the effects of combining treatments of the glycine transporter-1 (GlyT-1) inhibitor, Org24598, with

16 yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1 (GlyT-1), represented by analogues

17 rminals were loaded with [3H]glycine via the glycine transporter-1 (GlyT-1), which localized to the c

18 ess disabled-1 (Dab1) but lack expression of glycine transporter-1 (GlyT-1).

19 carboxylic acid hydrochloride (Org 25935), a glycine transporter-1 (GlyT1) inhibitor, and placebo pre

20 ion of glycine reuptake from the synapse via glycine transporter-1 (GlyT1).

21 signaling by treatment with an inhibitor of glycine transporter-1 that elevates levels of extracellu

22 appears to be a misplaced AII cell, by being glycine transporter-1-immunoreactive and by resembling t

23 y was strongly enhanced by inhibition of the glycine-transporter-1 (GlyT1).

24 not of SEC24D, reduced surface levels of the glycine transporter-1a, the betaine/GABA transporter and

25 transgenic mice where neurons expressing the glycine transporter 2 (GlyT2) gene coexpress enhanced gr

26 uorescent protein (GFP) under control of the glycine transporter 2 (GLYT2) regulatory sequences to st

27 to the presynaptic terminal by the neuronal glycine transporter 2 (GlyT2) to maintain quantal glycin

28 D67), a marker for GABAergic neurons, or for glycine transporter 2 (GLYT2), a marker for glycinergic

29 utations in SLC6A5, encoding the presynaptic glycine transporter 2 (GlyT2), also cause hyperekplexia.

30 lutamic acid decarboxylase [GAD]67-eGFP, and glycine transporter 2 (GlyT2)-eGFP, respectively).

31 expressed in glycinergic preBotC neurons of glycine transporter 2 (Glyt2, also known as Slc6a5)-Cre

32 These cells express the glycine transporter 2 gene and are the only known ipsila

33 neurons, but no colocalization of sst2a and glycine transporter 2 mRNA in the BotC.

34 ght interneurons were immunoreactive for the glycine transporter 2 or were apposed to gephyrin but di

35 ird, SLC6A5, encodes the cognate presynaptic glycine transporter 2.

36 Glutamic acid decarboxylase, glycine transporter-2, and choline acetyltransferase wer

37 Glycine transporter-2-bouton density on lateral motoneur

38 e Botzinger region of the rVRC, they express glycine-transporter-2, and their axons arborize througho

39 uman SLC6A5 gene encoding the neuronal GlyT2 glycine transporter are responsible for the presynaptic

40 urrents dominate, blocking neuronal or glial glycine transporters enhances tonic glycinergic currents

41 yR), notably the GlyRalpha1 subunit, and the glycine transporter (GlyT) isoforms GlyT1 and GlyT2.

42 of glutamate decarboxylase (GAD)-67 mRNA or glycine transporter (GlyT)-2 mRNA detected with in situ

43 e mutation in the slc6a9 gene that encodes a glycine transporter (GlyT1) was identified as the cause

44 Pharmacological studies suggest that the glycine transporter, GlyT1, maintains subsaturating conc

45 f whether the transcription of two different glycine transporters, Glyt1 and Glyt2, is influenced by

46 ted by the Na+/Cl(-) dependent high-affinity glycine transporters, GlyT1 and GlyT2.

47 The glycine transporters GlyT1A, GlyT1B, GlyT1C, and GlyT2 w

48 B) and the presynaptic Na(+)/Cl(-)-dependent glycine transporter GlyT2 (SLC6A5).

49 tations in the gene encoding the presynaptic glycine transporter GlyT2 are a second major cause of hu

50 ons in the presynaptic Na(+)/Cl(-)-dependent glycine transporter GlyT2 gene (SLC6A5) are rapidly emer

51 The neuronal glycine transporter GlyT2 plays a fundamental role in th

52 sicular glutamate transporter VGluT2 and the glycine transporter GlyT2.

53 sicular glutamate transporter VGluT2 and the glycine transporter GlyT2.

54 enes for glutamatergic neurons, the neuronal glycine transporter (GLYT2) for glycinergic neurons, and

55 enes for glutamatergic neurons, the neuronal glycine transporter (GLYT2) for glycinergic neurons, and

56 which are regulated by Na(+)/Cl(-)-dependent glycine transporters (GlyTs) in neurones and glia.

57 The recent discovery of glycine transporters in both the central nervous system

58 Dab1 co-localizes with the high-affinity glycine transporter, indicating that these amacrine cell

59 s with hypofunctional NMDA receptors such as glycine transporter inhibitors and mGlu5 receptor PAMs.

60 king either, or both, the glial and neuronal glycine transporters markedly decreased PV+ IN excitabil

61 ll lines recapitulate the characteristics of glycine transporters observed in tissue preparations.

62 All four glycine transporters of the "GLYT family" also belong to

63 However, we found that block of the glial glycine transporter prolongs the glycine transient.

64 Interestingly, GlyT1, the glial glycine transporter, regulates the strength of tonic gly

65 thologue SLC25A38 are the main mitochondrial glycine transporters required for heme synthesis, provid

66 receptor (GlyR) and the cognate presynaptic glycine transporter (SLC6A5/GlyT2) are well-established

67 the serine racemase knockout (SR-/-) and the glycine transporter subtype 1 heterozygote mutant (GlyT1

68 tro, demonstrated that exogenous glycine and glycine transporter type 1 (GLYT1) antagonist selectivel

69 e three amino-terminal isoforms of the human glycine transporter type 1 (GlyT1).

70 ficiently regulated in synaptic areas by the glycine transporter type 1 (GlyT1).

71 Estimates of bitopertin binding to glycine transporter type 1 showed that low to medium lev

72 Blockade of the glycine transporter type 1 to inhibit glycine reuptake a

73 arcinoma (JAR) cells endogenously expressing glycine transporter type 1a (GlyT1a) have been cultured

74 The rat GLYT-1 gene encodes two glycine transporter variants, GLYT-1a and GLYT-1b, that

75 ter-1 (GAT-1), GAT-3, and the vesicular GABA/glycine transporter (VGAT) were evaluated in the develop

76 ing transgenic reporter mice [vesicular GABA/glycine transporter (Vgat)-GFP], we then show that >50%

77 GLUT1)] and GABA/glycinergic [vesicular GABA/glycine transporter (VGAT)] vesicular transporters in po