ライフサイエンスコーパス: glycogenin

1 d it extends preexisting chains initiated by glycogenin.

2 ff but this was eliminated by overexpressing glycogenin.

3 roblasts stably overexpressing rabbit muscle glycogenin.

4 chromosomal location of the gene coding for glycogenin.

5 Glycogenin-1 and glycogenin-2 interact with one another,

6 und heterozygous deleterious variants in the glycogenin-1 gene (GYG1).

7 Most patients showed depletion of glycogenin-1 in skeletal muscle, whereas 1 showed presen

8 keletal muscle, whereas 1 showed presence of glycogenin-1 lacking the C-terminal that normally binds

9 ur results indicate that either depletion of glycogenin-1 or impaired interaction with glycogen synth

10 lso expressed the muscle form of glycogenin (glycogenin-1), which was attached to a chromatographical

11 etion in skeletal muscle and accumulation of glycogenin-1.

12 and human RD-ES cell extracts also contained glycogenin-1.

13 to self-glucosylate but not to interact with glycogenin-1.

14 ion of novel forms of glycogenin, designated glycogenin-2 (GN-2), encoded by a second gene that is ex

15 portant since it indicates that the level of glycogenin-2 can determine glycogen accumulation and hen

16 e explains much of the observed diversity in glycogenin-2 cDNA sequences as being due to alternate ex

17 Cloning of the human glycogenin-2 gene, GYG2, has revealed the presence of 11

18 Cloning of cDNAs encoding glycogenin-2 indicated the existence of multiple species

19 Glycogenin-1 and glycogenin-2 interact with one another, based on in vitr

20 Glycogenin-2 is a recently described self-glucosylating

21 Glycogenin-2 is one of two self-glucosylating proteins i

22 Glycogenin-2 maps between the microsatellite anchor mark

23 stent with mapping information obtained from glycogenin-2 STS sequences.

24 Mutation of Tyr-196 in glycogenin-2 to a Phe residue abolished the ability of g

25 -2 to a Phe residue abolished the ability of glycogenin-2 to self-glucosylate but not to interact wit

26 Glycogenin-2 was found in Ewing's sarcoma RD-ES cells wh

27 In human liver extracts, most of the glycogenin-2 was only detectable after treatment with al

28 Stable overexpression of glycogenin-2alpha in Rat-1 fibroblast cells resulted in

29 action, the predominant isoform in liver was glycogenin-2beta.

30 Glycogenin, a self-glucosylating protein involved in the

31 nge in their intracellular localization; (b) glycogenin and elevated glucose have opposing effects on

32 have opposing effects on the distribution of glycogenin and glycogen synthase in rat 1 cells; and (c)

33 Two of the cDNAs encoded glycogenin and glycogen synthase, respectively, proteins

34 e sequenced the cDNA coding for human muscle glycogenin and have deduced the corresponding amino acid

35 n apo-enzyme structure and a complex between glycogenin and UDP-glucose/Mn2+ were solved by molecular

36 By using rabbit skeletal muscle glycogenin as a bait, cDNAs encoding three different pro

37 Initiation of glucose polymerization by glycogenin autoglucosylation at Tyr-194 is required to p

38 Overall, GN-2 has 40-45% identity to muscle glycogenin but is 72% identical over a 200-residue segme

39 gel electrophoresis revealed a continuum of glycogenin-containing species from low molecular mass to

40 Glycogenin contains a conserved DxD motif and an N-termi

41 and could support glycogen accumulation in a glycogenin-deficient yeast strain.

42 cribe the characterization of novel forms of glycogenin, designated glycogenin-2 (GN-2), encoded by a

43 Overexpression of glycogenin did not affect total intracellular glycogen a

44 We conclude that (a) overexpression of glycogenin does not enhance glycogen synthesis but cause

45 eds by intersubunit glucosylation of dimeric glycogenin, even though it has not been demonstrated tha

46 vealed a diffuse cytoplasmic distribution of glycogenin expressed in rat 1 cells.

47 se- or [35S]methionine-labeled extracts from glycogenin-expressing cells by continuous polyacrylamide

48 ne structure is similar to that of the other glycogenin gene, GYG.

49 e forms complexes in solution with the yeast glycogenin Glg2p, but this interaction appears not to af

50 IEC3 cells also expressed the muscle form of glycogenin (glycogenin-1), which was attached to a chrom

51 ooperative action of glycogen synthase (GS), glycogenin (GN), and glycogen branching enzyme and forms

52 ll glucopolymerization capacity of monomeric glycogenin indicates that the enzyme is able to synthesi

53 of unknown function and was designated GNIP (glycogenin interacting protein).

54 Glycogenin is a glycosyltransferase that functions as th

55 Glycogenin is a self-glucosylating protein involved in t

56 Glycogenin is a self-glucosylating protein involved in t

57 Glycogenin is the autocatalytic, self-glucosylating prim

58 The effect of increasing the glycogenin level on glycogen synthesis was studied in ra

59 ral related proteins, GUX2 to GUX5 and Plant Glycogenin-like Starch Initiation Protein6, are Golgi lo

60 s II includes galactinol synthases and plant glycogenin-like starch initiation proteins that are not

61 tent (MSAE) produced by the non-glucosylated glycogenin monomer is 13.3 +/- 1.9 glucose units, simila

62 The MSAE of non-glucosylated glycogenin produced by dimer intrasubunit glucosylation

63 and in addition GNIP2 was shown to stimulate glycogenin self-glucosylation 3-4-fold.

64 the bound UDP-glucose far from Tyr194 in the glycogenin structure raises questions as to the mechanis

65 Unlike the mammalian counterpart, glycogenin, the yeast Glg proteins appear to require mul

66 To identify possible regulators of glycogenin, the yeast two-hybrid strategy was employed.

67 However, partially glucosylated glycogenin was able to almost complete its autoglucosyla

68 he presence of glucose, all of the expressed glycogenin was attached to polysaccharide and the free p

69 Physical interaction between GNIP2 and glycogenin was confirmed by co-immunoprecipitation, and

70 The structure of glycogenin was solved in two different crystal forms.

71 hesis is initiated by a specialized protein, glycogenin, which has the unusual property of transferri

72 the intramonomer glucosylation capability of glycogenin without determining the extent of autoglucopo