ライフサイエンスコーパス: glycogenolysis

1 alyses the final step of gluconeogenesis and glycogenolysis.

2 of an elevation of both gluconeogenesis and glycogenolysis.

3 l glucose production and glucagon-stimulated glycogenolysis.

4 edly increasing HGP as a result of increased glycogenolysis.

5 hrough glucose cycling, gluconeogenesis, and glycogenolysis.

6 zes the terminal step in gluconeogenesis and glycogenolysis.

7 on was solely attributable to an increase in glycogenolysis.

8 m to limit lactate accumulation during rapid glycogenolysis.

9 ta-oxidation of fatty acids, glycolysis, and glycogenolysis.

10 c equilibrium between glycogen synthesis and glycogenolysis.

11 accelerated gluconeogenesis, and decelerated glycogenolysis.

12 n from glycogen in the cascade activation of glycogenolysis.

13 flux, and gluconeogenesis without increasing glycogenolysis.

14 equivalent estimates of gluconeogenesis and glycogenolysis.

15 oma cells by suppressing gluconeogenesis and glycogenolysis.

16 (alphabetagammadelta)(4) complex, regulates glycogenolysis.

17 (by approximately 75%), gluconeogenesis, and glycogenolysis.

18 limited oxidative capacity caused by blocked glycogenolysis.

19 ter GP because of a compensatory decrease in glycogenolysis.

20 ate by promoting hepatic gluconeogenesis and glycogenolysis.

21 pendent pathway causing inhibition of GP and glycogenolysis.

22 urce of blood glucose is gluconeogenesis and glycogenolysis.

23 irrhotic patients because of a lower rate of glycogenolysis (0.63 +/- 0.23 vs. 1.22 +/- 0.23 mg.kg-1.

24 p was due to a marked suppression of hepatic glycogenolysis (0.7 +/- 0.1 versus 4.1 +/- 0.6 mg/kg.min

25 36%) was from gluconeogenesis, 1.40 was from glycogenolysis, 0.30 was retained in glycogen via UDP-gl

26 oneogenesis from the TCA cycle (67.3+/-5.6), glycogenolysis (1.0+/-0.8), pyruvate cycling (154.4+/-43

27 lucagon-stimulated cAMP production (55%) and glycogenolysis (27%) in human hepatocytes.

28 We conclude that glycogenolysis accounts for the majority of EGP during t

29 that this M6P originates from glycogen, with glycogenolysis activated by the kinase domain of the str

30 Glycogenolysis and astrocytic lactate transporters are a

31 After a 4-h fast, glucose production from glycogenolysis and conversion of glycerol to glucose rem

32 hanism by which insulin inhibits net hepatic glycogenolysis and endogenous glucose production in huma

33 uccessfully determined that gluconeogenesis, glycogenolysis and fatty acid oxidation were active in b

34 Furthermore, pharmacological attenuation of glycogenolysis and functional depletion of glycogen both

35 Glycogenolysis and gluconeogenesis are sensitive to nutr

36 HNPs inhibited glycogenolysis and gluconeogenesis in isolated hepatocyt

37 genes encoding the rate-limiting enzymes for glycogenolysis and gluconeogenesis, including liver glyc

38 glycogenesis and the release of glucose via glycogenolysis and gluconeogenesis.

39 Glc-6-P to glucose in the terminal stages of glycogenolysis and gluconeogenesis.

40 possible mechanism for the direct linkage of glycogenolysis and glycolysis in skeletal muscle.

41 ; this adaptation results in slower rates of glycogenolysis and lactic acid accumulation in muscle du

42 n ischaemic exercise ATP is supplied only by glycogenolysis and net splitting of phosphocreatine (PCr

43 Glycogenolysis and PEP-gluconeogenesis (2.1 +/- 0.3 mg/k

44 organic phosphate (Pi) levels, which impacts glycogenolysis and proton buffering, and in intracellula

45 e that energy is supplied in milliseconds by glycogenolysis and that between contractions, glycogenes

46 gen metabolizing enzymes, the enhancement of glycogenolysis, and a dramatic decrease in cellular glyc

47 n increase in endogenous glucose production, glycogenolysis, and gluconeogenesis from phosphoenolpyru

48 hepatic glucose production, gluconeogenesis, glycogenolysis, and glucose cycling.

49 of appearance, production, gluconeogenesis, glycogenolysis, and hexoneogenesis were measured by usin

50 nd metabolic (endogenous glucose production, glycogenolysis, and lipolysis) responses were increased

51 ncluding glycolysis, pentose phosphate (PP), glycogenolysis, and polyols to translate the glucose met

52 tractility, platelet aggregation, lipolysis, glycogenolysis, and smooth muscle contraction.

53 ects of leptin on GP, on gluconeogenesis, on glycogenolysis, and/or on the hepatic expression of the

54 hydrogen at carbon 2 of glucose produced via glycogenolysis are estimated from the enrichments to be

55 15 mm glucose, AdCMV-P46 treatment activated glycogenolysis, as indicated by a 50% reduction in glyco

56 ay also have an important role in inhibiting glycogenolysis at rest as well as improving the efficien

57 portant regulatory role in the inhibition of glycogenolysis at rest.

58 arlier exhaustion of glycogen stores, slowed glycogenolysis before complete glycogen depletion, and/o

59 aining induces adaptations that downregulate glycogenolysis before there is an increase in functional

60 Therefore, glycolysis and glycogenolysis behave independently in vascular smooth m

61 ates of total glucose production and hepatic glycogenolysis but similar rates of gluconeogenesis comp

62 r by the decreased inhibition of hepatic net glycogenolysis by hyperglycemia (3.3 +/- 0.8 and 1.1 +/-

63 vels within the liver secondary to increased glycogenolysis caused by systemic hypoglycemia.

64 nzyme activity and that this interferes with glycogenolysis causing increased levels of glycogen in h

65 bit glycogen phosphorylase, in turn blocking glycogenolysis causing the massive liver in Mauriac dise

66 d reduced glycogen accumulation and enhanced glycogenolysis compared with their respective controls,

67 creased rates of gluconeogenesis and perhaps glycogenolysis contribute to hepatic insulin resistance.

68 +/- 9% of total hepatic glucose output with glycogenolysis contributing the remainder.

69 metabolic (glucose kinetics, lipolysis, and glycogenolysis) counterregulatory responses.

70 This kinetic model of glycogenolysis, coupled to creatine kinase and adenylate

71 ic gluconeogenesis increased by 70%, and net glycogenolysis declined by 20%.

72 This may occur via increased glycogenolysis during beta1-AR stimulation, facilitating

73 has been used to measure gluconeogenesis and glycogenolysis during hyperinsulinemic-euglycemic clamps

74 e quantified the contribution of net hepatic glycogenolysis during insulin-induced hypoglycemia in 10

75 Glycogenolysis, essentially 0 in +/+ rats after a 24-h f

76 Rates of net hepatic glycogenolysis, estimated by 13C nuclear magnetic resona

77 phofructokinase together with ATP demand and glycogenolysis exert the highest control on the glycolyt

78 The data do not support the hypothesis that glycogenolysis follows Michealis-Menten kinetics with an

79 haustion of glycogen stores but by depressed glycogenolysis from the onset of ischemia.

80 Conversely, glycogenolysis (GL) increased from 41.9% at 16 hours to

81 luconeogenesis (GNG) (determined with 2H2O), glycogenolysis (GL), and endogenous glucose production (

82 (EGP) via changes in gluconeogenesis (GNG), glycogenolysis (GL), or both, we measured GNG (with (2)H

83 ose production secondary to an inhibition of glycogenolysis, gluconeogenesis, and glucose-6-phosphata

84 ardial glycogen and the rates of glycolysis, glycogenolysis, glucose utilization, and glycolytic ATP

85 glucose production (EGP) occurs via hepatic glycogenolysis (GLY) and gluconeogenesis (GNG) and plays

86 creased while both GP and calculated hepatic glycogenolysis (GLY) decreased.

87 age diseases resulting from known defects in glycogenolysis, glycolysis, and glycogen synthesis that

88 pd 1 is capable of blocking glucagon-induced glycogenolysis in a dosage-dependent manner.

89 ed hepatic lipogenesis, gluconeogenesis, and glycogenolysis in an AHR-dependent manner.

90 otal endogenous glucose production) rates of glycogenolysis in both the nondiabetic and diabetic subj

91 ally, CP-91149 inhibited glucagon-stimulated glycogenolysis in isolated rat hepatocytes (P < 0.05 at

92 PST also triggers glycogenolysis in liver and reduces glucose uptake in ad

93 In addition, Cpd 1 blocked glucagon-mediated glycogenolysis in primary human hepatocytes.

94 Phosphorylase kinase, a regulatory enzyme of glycogenolysis in skeletal muscle, is a hexadecameric ol

95 phabetagammadelta)(4) complex that regulates glycogenolysis in skeletal muscle.

96 reas glucagon stimulates gluconeogenesis and glycogenolysis in the liver.

97 ree-enzyme complex, a novel net reaction for glycogenolysis in the vicinity of the sarcoplasmic retic

98 glucose lowering resulted from inhibition of glycogenolysis in vivo.

99 for the final stages of gluconeogenesis and glycogenolysis, in which glucose-6-phosphate (G6P) is hy

100 hepatic glucose production due to increased glycogenolysis, indicating hepatic insulin resistance; t

101 lucose production, and they demonstrate that glycogenolysis inhibitors may be useful in the treatment

102 In the final steps of glycogenolysis, intracellular glucose 6-phosphate (Glc-6

103 During the early stages of fasting, hepatic glycogenolysis is a primary energy source.

104 These results indicate that liver glycogenolysis is acutely sensitive to small changes in

105 The ability to fuel neurons via glycogenolysis is believed to be an important function o

106 The final step of gluconeogenesis and glycogenolysis is catalyzed by the glucose-6-phosphatase

107 It is concluded that the rate of glycogenolysis is determined by the content of glycogen

108 diminish glucose release from the liver when glycogenolysis is not needed.

109 o blood glucose, and the duration of reduced glycogenolysis is short-lived after relaxation of energy

110 ate that after an overnight fast, basal HGP (glycogenolysis) is highly sensitive to the hepatic sinus

111 is (glycerol, nonesterified fatty acid), and glycogenolysis (lactate) were also reduced during day 2

112 to glucose production of gluconeogenesis and glycogenolysis, measured by labeling of blood glucose by

113 eas in protocol II inhibition of net hepatic glycogenolysis occurred exclusively through the activati

114 Inhibition of net hepatic glycogenolysis occurred in both protocols I and II compa

115 Inhibition of net hepatic glycogenolysis occurred in protocol I mostly due to decr

116 Since suppression of glycogenolysis occurred without a decrease in UDP-glucos

117 ed with its inhibitory effect on net hepatic glycogenolysis, occurred within 30 min, and was associat

118 nphosphorylated form, "GPb," which catalyzes glycogenolysis only in the presence of appropriate allos

119 hyperglycemia, per se, inhibits net hepatic glycogenolysis primarily through inhibition of glycogen

120 perinsulinemia, per se, inhibits net hepatic glycogenolysis primarily through stimulation of glycogen

121 In contrast, glycogenolysis rates were markedly increased, suggesting

122 umol/ min per gram wet weight [P < .001] for glycogenolysis, respectively, at 2.5 minutes of ischemia

123 were abolished, and a marked suppression of glycogenolysis resulted in decreased GP.

124 whereas it decreased fluxes associated with glycogenolysis, TCA cycle, fatty acid oxidation and elec

125 with reduced proglucagon gene expression and glycogenolysis that result from pancreatic islet cell de

126 ase (ANOVA; P < 0.05) in the contribution of glycogenolysis to EGP (4.7 +/- 1.7 vs. 3.4 +/- 1.2 vs. -

127 are required to suppress the contribution of glycogenolysis to EGP in healthy nondiabetic humans.

128 with the contribution of gluconeogenesis and glycogenolysis to EGP.

129 n response to hormonal signaling, fine-tunes glycogenolysis to fulfill energetic and metabolic requir

130 As a result, PTG-G(L) expression permitted glycogenolysis under 5 mm glucose conditions that was pr

131 sess rates of hepatic glycogen synthesis and glycogenolysis under euglycemic (approximately 5 mmol/l)

132 The estimated initial increase in glycogenolysis was approximately 1.7 and 2.3 mg/kg x min

133 This lower rate of glycogenolysis was associated with lower hepatic glycoge

134 On the other hand, glycogenolysis was equally suppressed in both groups.

135 (G6Pase) gene expression, however net liver glycogenolysis was impaired in C/EBPbeta-/- mice.

136 periments were designed to determine whether glycogenolysis was influenced by the glycogen concentrat

137 Importantly, the reduction in the rate of glycogenolysis was larger and out of proportion to the r

138 h groups receiving ICV leptin, while hepatic glycogenolysis was markedly suppressed (0.7 +/- 0.3 and

139 se and urea production, gluconeogenesis, and glycogenolysis were calculated using stable isotope meth

140 0.01); however, rates of glucose uptake and glycogenolysis were similar between the two groups.

141 analysis indicated both gluconeogenesis and glycogenolysis were suppressed in Snell dwarfs.

142 ree methods of measuring gluconeogenesis and glycogenolysis were used: 1) the hepatic arteriovenous d

143 effect on NHGO, caused by the suppression of glycogenolysis, while an equal increment in arterial ins

144 arlier mathematical model of skeletal muscle glycogenolysis with pH-dependent enzyme kinetics and rea