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1 of the TA chain to either peptidoglycan or a glycolipid.
2 vivo by incorporating an NKT cell-activating glycolipid.
3 n that is retained within the membrane via a glycolipid.
4 related to the receptor and the role of this glycolipid.
5 ily members that are specific for C1P versus glycolipid.
6 mechanism for recognizing this mycobacterial glycolipid.
7 membrane lipids are replaced with amino- or glycolipids.
8 of total non-starch lipids, or non-polar and glycolipids.
9 of globotrioasylceramide (GL-3) and related glycolipids.
10 throughput annotations of previously unknown glycolipids.
11 ing the superior antitumor potency of phenyl-glycolipids.
12 2-fold higher than those treated with phenyl-glycolipids.
13 ccharides, glycoproteins, glycopeptides, and glycolipids.
14 s had no A antigens but instead expressed Fs glycolipids.
15 hydrate antigen, HNK-1, in glycoproteins and glycolipids.
16 ycerolipids, bacterial lipoglycans and plant glycolipids.
17 ria are known to produce polysaccharides and glycolipids.
18 ide (NO) upon challenge with corynebacterial glycolipids.
19 teraction of the M. leprae-specific phenolic glycolipid 1 (PGL-1) with myelinating glia and their sub
21 T cell function by endogenous brain-derived glycolipids, a family of molecules traditionally deempha
23 iency in which the ganglioside GM2 and other glycolipids accumulate intracellularly within lysosomes.
28 augmented and or prolonged presentation of a glycolipid Ag leads to increased activation of NK cells
29 y, treating DR4tg mice with a TH2-polarizing glycolipid agonist of iNKT cells reduced SEB-inflicted m
32 re a unique subset of T cells that recognize glycolipid Ags presented in the context of CD1d molecule
33 tion of Siglec-7 can be exploited to deliver glycolipid Ags to their target cell and increase the eff
35 ion, including exogenous NKT cell activator, glycolipid alpha-GalCer, and endogenous prostaglandin E2
37 table for studying protein interactions with glycolipids, an important class of cellular receptors.
39 st glycerolphosphate (GroP) subunit onto the glycolipid anchor and the LTA synthase LtaS(Lm) extends
42 ehalose 6,6'-dimycolate (TDM) is a cell wall glycolipid and an important virulence factor of mycobact
43 eered sialic acids were detected in both the glycolipid and glycoprotein fractions of MLV producer ce
44 terial cord factor, is an abundant cell wall glycolipid and major virulence factor of Mycobacterium t
45 tides constitute a major component of myelin glycolipids and are known to be capable of raising an im
49 ides (GlcAGroAc2) are functionally important glycolipids and membrane anchors for cell wall lipoglyca
50 Like proteins, such as CD1D and MR1, present glycolipids and microbial riboflavin precursor derivativ
51 which exploits nanodiscs (NDs) to solubilize glycolipids and mimic their natural cellular environment
53 al lipids, consisting of 72.8% punicic acid, glycolipids and phospholipids rich in essential fatty ac
55 e of several enzymes that controls levels of glycolipids and whose activity is linked to several huma
56 eins involved in the modification of surface glycolipids and, surprisingly, the auxiliary proteins of
57 AP domain are able to bind sterol and acidic glycolipid, and are involved in sterol transport and bet
58 LEC18 modulates host immunity via binding to glycolipids, and are also involved in glycolipid transpo
60 cted examples of novel biobased surfactants, glycolipids, and polymers derived from cardanol, and the
61 rafts are ordered assemblies of cholesterol, glycolipids, and proteins that modulate proinflammatory
64 s might increase antigen capture and enhance glycolipid antigen presentation in addition to the class
65 sed expression of CD1c, which is involved in glycolipid antigen presentation, and of the immune compl
69 ed Streptococcus pneumonia, known to express glycolipid antigens activating NKT cells, increased the
70 cells are innate-like T cells that recognize glycolipid antigens and play critical roles in regulatio
71 et of innate-like lymphocytes that recognize glycolipid antigens bound by the major histocompatibilit
72 tective immune response triggered by foreign glycolipid antigens bound to CD1d on antigen-presenting
74 the sharply reduced levels of CD1d-presented glycolipid antigens in ConA-treated GF mice compared wit
75 ubpopulation of T lymphocytes that recognize glycolipid antigens in the context of CD1d-mediated anti
76 which cells are the principal presenters of glycolipid antigens in vivo remains controversial, and i
78 s express CD1d and are capable of presenting glycolipid antigens to invariant natural killer T cells
80 c enzymes and lipases that process lipid and glycolipid antigens, as well as a set of lipid transfer
81 turing and presenting a variety of different glycolipid antigens, including multiple forms of alpha-g
83 alciparum apicoplasts, suggesting that these glycolipids are a hallmark of photosynthetic plastids an
86 suggest that these microbial alpha-mannosyl glycolipids are capable of being recognized by both the
91 cerol and glucuronosyl diacylglycerol or all glycolipids are not impaired in growth or virulence duri
93 Due to their charge and ability to coalesce, glycolipids are therefore the likely primary EF sensor d
95 -to-analyze structures (e.g., proteoglycans, glycolipids), are functionally important in a biological
97 y approach that utilizes essential microbial glycolipids as chemical fingerprints for identification
98 tions for the development of NKT-stimulatory glycolipids as vaccine adjuvants and anticancer therapeu
99 aride molecules represent a unique family of glycolipids based on a highly conserved lipid moiety kno
100 n the synthesis and biological properties of glycolipids based on glucose and trehalose scaffolds whi
104 probes, we studied the mobilities of labeled glycolipids by time-lapse microscopy and fluorescence re
105 n the thymus, precursor cells recognize self-glycolipids by virtue of their semi-invariant TCR, which
106 material (CRM) 197 (DT), and combined with a glycolipid C34 as an adjuvant designed to induce a class
107 n average (DT-RM4.7) and adjuvanted with the glycolipid C34, the combination exhibited the strongest
108 us homologous series of l-ascarylose-derived glycolipids called ascarosides, which include several hi
111 osaccharides (LOSs) are cell surface-exposed glycolipids capable of modulating the host immune system
112 typal CDC requires interaction with the sLeX glycolipid cellular receptor as an essential step before
113 he enzymes that build the conserved terminal glycolipid characterizing other capsules using this meth
114 ycolipid antibodies that bind to heteromeric glycolipid complexes has generated new insights in this
115 to which the relative abundances of protein-glycolipid complexes observed by ESI-MS reflect the rela
117 for iNKT cells has led to the development of glycolipid containing nanoparticles which efficiently ac
118 The potentially antigenic alpha-mannosyl glycolipids contributed to the protection of mice agains
119 raits of Pi starvation, such as phospholipid/glycolipid conversion, and the accumulation of starch an
121 nd O-glycans from pig lung glycoproteins and glycolipid-derived glycans were fluorescently tagged and
122 re sialylated N-glycans but not O-glycans or glycolipid-derived glycans, and each virus demonstrated
123 antigen, including binding analyses with the glycolipid extract of the prostate cancer cell line PC3,
124 ract of infants, and studies have shown that glycolipids extracted from the cell surface of these bac
126 e bartolosides, unprecedented cyanobacterial glycolipids featuring aliphatic chains with chlorine sub
129 represent an attractive method to solubilize glycolipids for protein interaction studies in aqueous s
130 omycoketide (C32-MPM), a naturally occurring glycolipid found in the cell walls of Mycobacterium tube
132 f sufficient quantities of carbohydrates and glycolipids from biological samples remains a significan
133 ification and structural characterization of glycolipids from the cell wall of bifidobacteria is the
134 forms of Shiga toxin, Stx1 and Stx2, use the glycolipid globotriaosylceramide (Gb3) as their cellular
135 in A and lipids, PDs), to screen mixtures of glycolipids (GLs) against water-soluble proteins to dete
136 ith the use of nanodiscs (NDs) to solubilize glycolipids (GLs) has recently emerged as a promising an
138 njugates (glycosaminoglycans, glycoproteins, glycolipids, glycosylphosphatidylinositol-anchored prote
141 seven different lipids species including the glycolipid GM3 in the outer leaflet and the anionic lipi
142 ed form of GIFT4 was constructed by fusing a glycolipid (GPI)-anchoring sequence and incorporated int
143 trafficking of individual glycoproteins and glycolipids has been noted in NPC cells and other storag
147 een developed in order to obtain constituent glycolipids, having multivalent sugar moieties and their
149 eral blood samples, along with anti-phenolic glycolipid I serology and skin tests from the same indiv
152 T cell activation across diverse settings of glycolipid immunization and systemic infection with Stre
153 Globo-H ceramide (GHCer), the most prevalent glycolipid in a majority of epithelial cancers and one t
154 a small number of phospholipids, to display glycolipids in a lipid environment for protein-glycolipi
155 resent evidence that hopanoids interact with glycolipids in bacterial outer membranes to form a highl
160 induce antibodies that cross-react with self-glycolipids in peripheral nerves, causing neuropathy.
165 nd chemical modifications (including various glycolipids) in the PDB, and both PDB and PDBx/mmCIF for
172 ycolipids in a lipid environment for protein-glycolipid interaction studies in aqueous solution.
173 f the assay for identifying specific protein-glycolipid interactions from biologically relevant mixtu
174 of low, moderate, and high affinity protein-glycolipid interactions serve to demonstrate the reliabi
175 micelles include: (i) insertion of synthetic glycolipids into matrix lipids; (ii) preparation of glyc
176 our results suggest that R-LPS or a similar glycolipid is a physiological substrate of MacAB-TolC.
177 ral killer T (NKT) -cells activated with the glycolipid ligand alpha-galactosylceramide (alpha-GalCer
178 dated, but the basis for enhanced binding to glycolipid ligands, in which hydrophobic substituents ar
179 he cerebellum, and secondary accumulation of glycolipids like GM2 and GM3 gangliosides and unesterifi
180 vaccine incorporating an NKT cell-activating glycolipid linked to an MHC class I-restricted peptide f
181 glycerides affected transfer action by human glycolipid lipid transfer protein (GLTP), which is glyco
183 d by concentrating the tuberculosis-specific glycolipid, lipoarabinomannan (LAM), a promising urinary
185 mannan, and lipoarabinomannan, which are key glycolipids/lipoglycans of the mycobacterial cell envelo
186 mannan, and lipoarabinomannan, which are key glycolipids/lipoglycans of the mycobacterial cell envelo
188 1 was originally proposed to translocate the glycolipid Man5GlcNAc2-PP-dolichol (needed to synthesize
190 These results demonstrate that bacterial glycolipid mass spectra represent chemical barcodes that
195 rected mutagenesis, and binding studies with glycolipid mimics have been used to define an extended b
200 wed that blocking binding of Ply to the sLeX glycolipid on RBCs prevents deposition of the toxin in t
201 can induce aggregation with glycoproteins or glycolipids on the cell surface and thereby regulate cel
202 lycans that are carried as glycoproteins and glycolipids on the outer leaflets of their plasma membra
208 veal in vivo functions for specific phenolic glycolipids (PGLs) in the mycobacteria that cause tuberc
212 2 and interferon-beta in the context of both glycolipid presentation and Toll-like receptor-mediated
215 e and innate lymphocytes, and they recognize glycolipids presented by an MHC class I-like CD1d molecu
216 live pathogens, they do respond to bacterial glycolipids presented by CD1d on liver macrophage that h
219 cells are innate lymphocytes that respond to glycolipids presented by the MHC class Ib molecule CD1d
220 e thymus and periphery due to defective self glycolipid processing and presentation by DP thymocytes
221 nthesis proteins, YpfP and LtaA, involved in glycolipid production, and LtaS, required for LTA backbo
222 n glycans (sugars) existing predominantly as glycolipids, proteoglycans, or glycoproteins formed by t
225 HIV infection, and tracked the mycobacterial glycolipid-reactive T-cell repertoire by using CD1b tetr
226 It has been shown that CD1d expression and glycolipid-reactive, CD1d-restricted NKT cells exacerbat
228 orientation and directly competing with the glycolipid receptor binding site on the surface of the B
232 n human iNKT and Tregs upon pathogen-derived glycolipid recognition that has a significant impact on
236 link clinical and mechanistic evidence that glycolipid-responsive, polycytotoxic T cells contribute
237 obacteria, nocardia, and rhodococci) share a glycolipid-rich cell wall dominated by mycolic acids (te
238 sistant membranes, which contain cholesterol-glycolipid-rich membrane regions known as lipid rafts, s
239 hese data indicate that, in addition to self-glycolipids, self-lysophospholipids are also recognized
240 ipid lipid transfer protein (GLTP), which is glycolipid-specific and has few cationic residues near i
242 Invariant natural killer T (iNKT) cells (glycolipid-specific, CD1d-restricted innate lymphocytes)
244 ase activity and protein levels, and reduced glycolipid storage in both iPSC-derived macrophages and
247 asurements of enzyme catalyzed hydrolysis of glycolipid substrates and the detection of low, moderate
248 d glucocerebrosidase activity and stored the glycolipid substrates glucosylceramide and glucosylsphin
249 t was previously thought that recognition of glycolipids such as alpha-galactosylceramide (alpha-GalC
250 own a distinct mode of recognition of a self-glycolipid sulfatide bound to CD1d by a type II NKT TCR.
252 e in co-ordination with cell division, while glycolipid synthesis takes place throughout the membrane
253 Another iminosugar activity, inhibition of glycolipid synthesis, resulted in a drug for Gaucher dis
256 Glycosylphosphatidylinositol (GPI) is a glycolipid that anchors >150 various proteins to the cel
257 en length in the lipopolysaccharide (LPS), a glycolipid that forms most of the outer leaflet of the o
259 pids into matrix lipids; (ii) preparation of glycolipids that aggregate to liposomes and micelles and
260 vironment and process it to form cholesterol glycolipids that are incorporated onto their membranes.
261 alactan layer or incorporated into trehalose glycolipids that associate with the MM non-covalently.
264 drate antigens (TACAs) and immunostimulatory glycolipids that hold promise as immunotherapeutics.
265 eromeric complexes are structurally distinct glycolipids that interact to form new molecular shapes c
266 arides, glycoproteins, and proteoglycans, to glycolipids that make up a complex glycan code that impa
267 acid terminates glycans of glycoproteins and glycolipids that play numerous biological roles in healt
268 re we show that ascaroside pheromones, small glycolipids that signal population density, suppress exp
269 n done to identify the structures of natural glycolipids that stimulate NKT cells and to determine ho
270 e C-type lectin Mincle as receptor for these glycolipids that triggers the FcRgamma-Syk-Card9 pathway
271 en implicated in producing complex cell wall glycolipids, the biological function of PKS11 is unknown
272 g strategy to generate strong Th1-polarizing glycolipids through increased binding either to CD1d or
273 found to play a key role in the binding of a glycolipid to the carbohydrate recognition domain of the
274 traction of the lipid-microdomain preferring glycolipid to the lo phase, while the phospholipid remai
275 ical MHC molecule able to present lipids and glycolipids to a specialized subset of T cells known as
276 ydrophilic lipooligosaccharides and phenolic glycolipids to hydrophobic phthiocerol dimycocerosates,
277 use the coordinated action of two cell wall glycolipids to regulate macrophage recruitment to initia
278 hesis, assembly, and export of these complex glycolipids to the cell surface are the object of the pr
279 d nearly ubiquitous two-layer, alpha-helical glycolipid transfer protein (GLTP)-fold now further adva
282 ing to glycolipids, and are also involved in glycolipid transportation and protein aggregation in the
285 trated that recognition of the mycobacterial glycolipid trehalose dimycolate (cord factor) by the C-t
286 (TdmhMtb) that hydrolyzes the mycobacterial glycolipid trehalose dimycolate and plays a critical rol
287 w route to access original glycopeptide- and glycolipid-type analogues possessing a C-C bond at the C
288 erium tumefaciens accumulates four different glycolipids under phosphate deficiency, including digala
289 Phosphatidyl-inositol mannosides (PIM) are glycolipids unique to mycobacteria and other related bac
290 so review studies designed to understand how glycolipid variants, both natural and synthetic, can alt
291 lectin mincle to trehalose dimycolate, a key glycolipid virulence factor on the surface of Mycobacter
292 amers to isolate clones recognizing the same glycolipid, we identified a previously unknown pattern o
295 nd can recognize both alpha- and beta-linked glycolipids, whereas type II NKT cells are less well stu
296 ly, we found the intestinal bacteria contain glycolipids which can be presented by CD1d and recognize
297 large family of glycans of glycoproteins and glycolipids whose branching and peripheral substitutions
299 yl cyclophosphatidic acid and a mixed acetal glycolipid, with the latter subsequently being isolated
300 the underlying organization and dynamics of glycolipids within the cell envelope remain poorly under
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