ライフサイエンスコーパス: glycolytic

1 ) T cells that invade the EAE CNS are highly glycolytic.

2 n the same depot are more oxidative and less glycolytic.

3 EC haplo-deficiency or blockade of the glycolytic activator PFKFB3 did not affect tumor growth,

4 We recently identified a key role for the glycolytic activator PFKFB3 in vessel sprouting by regul

5 ctose-2,6-bisphosphate, leading to increased glycolytic activity but decreased routing of metabolites

6 eficient neutrophil precursors had increased glycolytic activity but impaired mitochondrial respirati

7 etabolic pathways and gene sets regulated by glycolytic activity in the heart.

8 Finally, we provide evidence that high glycolytic activity of NSCs is required to prevent their

9 Reducing glycolytic activity or glucose availability rendered eff

10 Exercise-induced decreases in glycolytic activity stimulate physiological cardiac remo

11 imulation of human DCs resulted in increased glycolytic activity that was also antagonized by FP7.

12 germinal center B cells, which require high glycolytic activity to support growth and proliferation

13 on, while minimal lymphadenopathy and higher glycolytic activity were observed in moribund NHPs early

14 ly phosphorylation-mediated reprogramming of glycolytic activity, supported additionally by widesprea

15 To assess the relevance of changes in glycolytic activity, we determined how cardiac-specific

16 renewal division but also display diminished glycolytic activity.

17 igomerization and thus an inhibitor of GAPDH glycolytic activity.

18 und that the surface pH is sensitive to cell glycolytic activity: the pH decreases in high glucose an

19 Using the glycolytic ADP-dependent kinases of archaea, including t

20 ake and glucose transporters, alterations in glycolytic and acetate metabolism in neurons and astrocy

21 tion is a hallmark of human cancers, and the glycolytic and glutamine metabolism pathways were shown

22 erapeutic prospects in targeting the dynamic glycolytic and mitochondrial interactions and between me

23 ) that exhibit constitutive reprogramming of glycolytic and mitochondrial metabolism, accompanied by

24 ccurring p53 mutants in cancers, focusing on glycolytic and mitochondrial oxidative phosphorylation p

25 We provide a simple spreadsheet to calculate glycolytic and oxidative ATP production rates from raw e

26 SBMA muscles and induced hypertrophy of both glycolytic and oxidative fibers.

27 o lactate and bicarbonate, indicating active glycolytic and OxPhos metabolism in sperm.

28 st time that a chromatin remodeler regulates glycolytic and respiratory capacity, thereby maintaining

29 measured by using stable isotope tracing of glycolytic and tricyclic acid intermediary metabolites.

30 Consequently, glycolytic- and glutamine-derived intermediates that are

31 approximately 10 mm min(-1) ) and anaerobic glycolytic ( approximately 1 mm min(-1) ) components wer

32 own and muscle acidification, eliminated the glycolytic-associated contribution to ATP synthesis, and

33 hich showed that mitochondrial hydrolysis of glycolytic ATP maintained DeltaPsi in the absence of res

34 ndex quantify the responses of oxidative and glycolytic ATP production to alterations in glycolysis a

35 overall energy utilization, particularly in glycolytic ATP production.

36 further increased by 2DG due to the lack of glycolytic ATP required to maintain mitochondrial health

37 We find that TBSV co-opts the cellular glycolytic ATP-generating pyruvate kinase (PK) directly

38 me responsible for the detoxification of the glycolytic byproduct methylglyoxal (MG).

39 In glycolytic cancer cells cultured in high glucose, we obs

40 Glycolytic cancer cells produce large quantities of lact

41 Thus, supporting the adaptive nature of glycolytic cancer cells to MG dicarbonyl stress when com

42 oxic drugs could overcome drug-resistance in glycolytic cancers.

43 analyses revealed that RNS60 increased spare glycolytic capacity (SGC) under normal culture condition

44 ty in resting CD8(+)CD28(+) T cells enhanced glycolytic capacity and granzyme B production as in CD8(

45 itochondrial respiration and increased their glycolytic capacity.

46 th and demonstrate that fermentation on many glycolytic carbon sources is not limited by carbon uptak

47 Moreover, upon exogenous MG challenge, glycolytic cells showed elevated amounts of intracellula

48 phenomenon causes partial oxphos dormancy in glycolytic cells via disruption of ATP synthase dimers.

49 ss, suggesting that astrocytes are naturally glycolytic cells.

50 cells, h3T-p53 KO T cells exhibited enhanced glycolytic commitment that correlated with increased pro

51 hosphorylation of a variety of sugars to the glycolytic conversion of phosphoenolpyruvate (PEP) to py

52 in response to stresses requiring increased glycolytic demand, the core autophagy machinery also fac

53 ent with cytochrome oxidase involvement, the glycolytic effect was enhanced at a low oxygen level and

54 aptive advantages, for example, in improving glycolytic efficiency in Thermococcales.

55 notypic peculiarities: (i) CRIS-A: mucinous, glycolytic, enriched for microsatellite instability or K

56 xhibited elevated ROS, NOX4, HIF-1alpha, and glycolytic enzyme and PDK1 expression, suggesting that D

57 properties, including (i) displacement of a glycolytic enzyme complex from the membrane, (ii) inhibi

58 and higher protein carbonyls; in both, lower glycolytic enzyme enolase.

59 bules undergoing atrophy exhibited increased glycolytic enzyme expression and inhibitory phosphorylat

60 ADORA2A knockdown decreases hypoxia-induced glycolytic enzyme expression, glycolytic flux, and endot

61 a indicate that pyruvate kinase M2 (PKM2), a glycolytic enzyme for Warburg effect, is strongly upregu

62 by which this results in acetylation of the glycolytic enzyme GAPDH and improves the recall function

63 We determined that the glycolytic enzyme GAPDH negatively regulates HIF1A expre

64 n that, in turn, regulates expression of the glycolytic enzyme hexokinase 2 (HK2).

65 amine that is detected in the cytosol by the glycolytic enzyme hexokinase.

66 eck (including molecular chaperone Hsp82 and glycolytic enzyme Pgk1).

67 s, which in turn promote dimerization of the glycolytic enzyme pyruvate kinase M2 (PKM2) and enable i

68 Human lactate dehydrogenase (hLDH5), a glycolytic enzyme responsible for the conversion of pyru

69 Pyruvate kinase (PYK) is an essential glycolytic enzyme that controls glycolytic flux and is c

70 -Myc and pyruvate kinase M2 isoform, the key glycolytic enzyme transcriptionally activated by c-Myc.

71 hese findings reveal a new behavior of a key glycolytic enzyme with insights on spatial organization

72 PKM2 is a glycolytic enzyme with nonmetabolic nuclear oncogenic fu

73 Fructose-1,6-bisphosphate (FBP) aldolase, a glycolytic enzyme, catalyzes the reversible and stereosp

74 hosphate dehydrogenase (GAPDH), an important glycolytic enzyme, has a non-catalytic (thus a non-canon

75 establish that aldolase, as well as being a glycolytic enzyme, is a sensor of glucose availability t

76 ycolysis has been attributed to the terminal glycolytic enzyme, lactate dehydrogenase (LDH).

77 he highly transcribed ribosomal protein- and glycolytic enzyme-encoding genes.

78 n leakage, and altered expression of several glycolytic enzymes (hexokinase II, pyruvic dehydrogenase

79 ed mitochondrial mass, reduced expression of glycolytic enzymes and decreased neuronal differentiatio

80 membrane, induces release of membrane-bound glycolytic enzymes and in turn switches glucose flux tow

81 articular environment provides the necessary glycolytic enzymes and lipases that process lipid and gl

82 HIF-1alpha increased glycolytic enzymes and pyruvate dehydrogenase kinase-1 (

83 hage-specific Adora2a deletion decreases key glycolytic enzymes and reduces pathological neovasculari

84 actate production and elevated expression of glycolytic enzymes at the mRNA level.

85 Glycolytic enzymes colocalize, suggesting the ad hoc for

86 ished in response to graded transcription of glycolytic enzymes downstream of fibroblast growth facto

87 asing aerobic glycolysis by upregulating the glycolytic enzymes hexokinase 2 and phosphofrucokinase,

88 tion, and overexpression of several critical glycolytic enzymes in MPhiM-CSF compared with MPhiGM-CSF

89 eostasis and increased hepatic expression of glycolytic enzymes in Ppp1r3b(Delta)(hep) mice relative

90 caudiverbera) OSN cilia, SC microvilli, and glycolytic enzymes in rat cilia.

91 onditions that explore the in silico role of glycolytic enzymes in the mitochondrion.

92 Inspired by the oriented immobilization of glycolytic enzymes on the fibrous sheath of mammalian sp

93 Under conditions of energy stress, glycolytic enzymes redistribute from a diffuse localizat

94 rane, enhances the release of membrane-bound glycolytic enzymes to the cytosol, induces glycolysis an

95 on promotes the transcriptional induction of glycolytic enzymes via ERK- and Akt-dependent translatio

96 Simultaneously, expression of multiple glycolytic enzymes was decreased, while lactate producti

97 ting the expression of glucose transporters, glycolytic enzymes, and metabolic regulators through the

98 s the expression of glucose transporters and glycolytic enzymes, inhibiting SIRT6 has been proposed a

99 wledge of the regulation and biochemistry of glycolytic enzymes, we have limited understanding on how

100 In total, 20 proteins, including 12 glycolytic enzymes, were identified and quantified.

101 mulated lactate production and expression of glycolytic enzymes, with notable expression of lactate d

102 rectly binding and activating genes encoding glycolytic enzymes.

103 riptionally up-regulates many genes encoding glycolytic enzymes.

104 e of altered expression of gluconeogenic and glycolytic enzymes.

105 n factor HIF1alpha drives expression of many glycolytic enzymes.

106 ively easy synthesis and their resistance to glycolytic enzymes.

107 lated skeletal muscle fiber-type switch from glycolytic fast-twitch (type IIb) to oxidative slow-twit

108 ction of uncoupled respiration whereas their glycolytic flux and 2-deoxy-(3)H-glucose uptake rates we

109 Such glycolytic flux and elevated reactive oxygen species is

110 l responses were dependent upon increases in glycolytic flux and glycogen stores.

111 an essential glycolytic enzyme that controls glycolytic flux and is critical for ATP production in al

112 ondrial dysfunction, partially by increasing glycolytic flux and PGC-1alpha mRNA in cultured podocyte

113 achinery also facilitates glucose uptake and glycolytic flux by promoting cell surface expression of

114 nd macrophages, increased glucose uptake and glycolytic flux fuel the generation of mitochondrial rea

115 tate, consumed more glucose, and had greater glycolytic flux in a bioenergetics stress test.

116 We first showed that the enhanced glycolytic flux in atheromatous plaques of ApoE(-/-) mic

117 a increased the glucose uptake and activated glycolytic flux in neutrophils, resulting in a significa

118 le to identify the optimal point to redirect glycolytic flux into heterologous engineered pathways in

119 We find that this enhanced glycolytic flux is crucial for IFN-gamma-dependent contr

120 mesoderm and endoderm differentiation, high glycolytic flux is maintained and, in fact, essential du

121 gether, our simulations suggest that reduced glycolytic flux is the greatest contributor to the pheno

122 bine in pancreatic cancer, whereby increased glycolytic flux leads to glucose addiction in cancer cel

123 DCs to lymph nodes associated with increased glycolytic flux may contribute to their reduced ability

124 mmune cells ((111)In-WBC SPECT), or enhanced glycolytic flux seen in inflammatory cells ((18)F-FDG PE

125 trinsic determinant of NPC fate, with a high glycolytic flux supporting self-renewal and inhibition o

126 nment of RA T cells-specifically, by reduced glycolytic flux that led to deficiencies in ATP and pyru

127 not, however, observe important increases in glycolytic flux through hypoxia and priming alone.

128 paired PDH activity and a redirection of the glycolytic flux toward lactate production.

129 In mouse retinae lacking Sirt6, effectors of glycolytic flux were dramatically increased, leading to

130 ting that this compound serves to coordinate glycolytic flux with epigenetic modifications.

131 ypoxia-induced glycolytic enzyme expression, glycolytic flux, and endothelial cell proliferation, spr

132 IL-1beta or IL-1alpha resulted in increased glycolytic flux, glucose use, expression of glycolysis g

133 ls resulted in altered ATP levels, decreased glycolytic flux, Nrf-2 and glutathione levels, ultimatel

134 ifferentiation pathways in the NPC decreased glycolytic flux.

135 ltered in cancer cells, along with increased glycolytic flux.

136 expression of glycolytic genes and increases glycolytic flux.

137 phages that is mediated by the disruption of glycolytic flux.

138 lung SqCC, which augments glucose uptake and glycolytic flux.

139 46 and shikonin were used to manipulate PKM2 glycolytic function.

140 suggest that posttranscriptional control of glycolytic gene expression may be an important response

141 nt downregulation of glucose transporter and glycolytic gene expression pointing to metabolic alterat

142 racting with NK cell priming at the level of glycolytic gene transcription.

143 synaptic activity caused an up-regulation of glycolytic genes and a concomitant down-regulation of ge

144 sn2 and Msn4 exhibit prevalent repression of glycolytic genes and a significant delay of acetyl-CoA a

145 e report that TGF-beta induces expression of glycolytic genes and increases glycolytic flux.

146 le PAH BOECs, corrected the dysregulation of glycolytic genes and lactate production, and partially r

147 expression, and significant dysregulation of glycolytic genes in the rat SUGEN-hypoxia model of sever

148 stigating the expression of PGK1, one of the glycolytic genes most affected after nitrogen replenishm

149 xplained rapid, transient down-regulation of glycolytic genes.

150 glycolysis and identifies cells as primarily glycolytic (glycolytic index > 50%) or primarily oxidati

151 We show that a posterior glycolytic gradient is established in response to graded

152 ruvate to PEP) during both gluconeogenic and glycolytic growth.

153 doperoxide classes targeting proteins in the glycolytic, hemoglobin degradation, antioxidant defence,

154 proteome that shows alkylated targets in the glycolytic, hemoglobin degradation, antioxidant defense,

155 nd identifies cells as primarily glycolytic (glycolytic index > 50%) or primarily oxidative.

156 The glycolytic index reports the proportion of ATP productio

157 The Warburg effect is a chronic increase in glycolytic index, quantified by the Warburg index.

158 thod was further used for naked-eye tracking glycolytic inhibition in living cells.

159 n glycolysis renders lung SqCC vulnerable to glycolytic inhibition, while lung ADC exhibits significa

160 Cells were exposed to the glycolytic inhibitor, 2-deoxyglucose, or fatty acid synt

161 , in cancer cells OLIG and 2-deoxyglucose, a glycolytic inhibitor, depolarized mitochondria after res

162 sensors and thus identify MG as a potential glycolytic inhibitor.

163 In addition, we observed that glycolytic inhibitors and metabolic conditions affecting

164 ect with 2DG, whereas glucose deprivation or glycolytic inhibitors iodoacetate and sodium fluoride sy

165 as a stress protectant but also serves as a glycolytic input.

166 Glycolytic interconversion of phosphoglycerate isomers i

167 by induction of p53 and accumulation of the glycolytic intermediate fructose 6-phosphate, leading to

168 glycerate (2,3-BPG), an erythrocyte-specific glycolytic intermediate, which facilitates O2 release.

169 n shunt functions to maintain homeostasis of glycolytic intermediates and ATP during large shifts in

170 lytic phenotype (decreased the production of glycolytic intermediates and byproducts, ie, lactate), r

171 metabolism, accounting for the depletion of glycolytic intermediates during each oscillatory burst.

172 mediated metabolic reprogramming to generate glycolytic intermediates essential for rapid biomass gen

173 on (oxphos) to generate sufficient levels of glycolytic intermediates for use as anabolic substrates.

174 t upregulation in pentose phosphate flux and glycolytic intermediates in HCFs.

175 merase, which inhibits GAPDH, shunting early glycolytic intermediates into pathogenic signaling pathw

176 This re-directs the glycolytic intermediates into the pentose phosphate (PPP

177 Concentrations of multiple glycolytic intermediates were elevated in transgenic end

178 During exercise, glycolytic intermediates, TCA cycle intermediates, and p

179 nse that occurs upon accumulation of certain glycolytic intermediates.

180 2 and PGK3 were the plastidial and cytosolic glycolytic isoforms, respectively.

181 ux, buffer capacity and the contributions of glycolytic (L) and oxidative (Q) rates to ATP synthesis

182 ization towards the proinflammatory and more glycolytic M1 phenotype, but not to M2 macrophage differ

183 CNS correlate with upregulated expression of glycolytic machinery and is essential for inflammatory r

184 whether and how primary cancer alters T cell glycolytic metabolism and affects tumor immunity in canc

185 WAT is positively correlated with markers of glycolytic metabolism and inversely correlated with obes

186 ta2, and HK2 are an important determinant of glycolytic metabolism and metastasis in HCC cells and su

187 l function suppressed the shift to primarily glycolytic metabolism and reduced mitochondrial length c

188 In contrast, we found that constitutive glycolytic metabolism and suppression of oxidative phosp

189 hydrolysis / synthesis, oxygen consumption, glycolytic metabolism and viability all indicate a signi

190 sufficient to reduce oxidative and increase glycolytic metabolism in cultured adipocytes.

191 We found that p63 promotes glycolytic metabolism in epidermal keratinocytes.

192 ver, FXR activation has little effect on the glycolytic metabolism in healthy primary hepatocytes in

193 de the required transition from oxidative to glycolytic metabolism in nuclear reprogramming.

194 nd fraction, possibly due to a shift towards glycolytic metabolism in response to impaired respiratio

195 f ALDH1A3 expression and maintenance of high glycolytic metabolism in the developing cortex.

196 However, the issue of whether glycolytic metabolism influences metastasis in HCC remai

197 This work demonstrates that glycolytic metabolism regulates the translation of HIF1A

198 However, the functional contribution of glycolytic metabolism to the pluripotent state is unclea

199 -mediated upregulation of HIF1alpha, HK2 and glycolytic metabolism was also highly active in vivo as

200 glucose and various indexes of oxidative and glycolytic metabolism were evaluated in nonactivated mur

201 We modeled glycolytic metabolism with a system of coupled ordinary

202 Tbx15 differentially regulates oxidative and glycolytic metabolism within subpopulations of white adi

203 tisol concentrations regulate uteroplacental glycolytic metabolism, producing lactate for use in uter

204 t tumor endothelial cells (ECs) have a hyper-glycolytic metabolism, shunting intermediates to nucleot

205 onal mitochondrial respiration and increased glycolytic metabolism.

206 increased levels of lactate, a by-product of glycolytic metabolism.

207 the photosynthetic apparatus under low-light glycolytic metabolism.

208 The primary glycolytic metabolite 1,3-bisphosphoglyceric acid (1,3-B

209 scaffolding proteins, and disruption of the glycolytic metabolon blocks the synaptic vesicle cycle,

210 Local formation of the glycolytic metabolon is dependent on presynaptic scaffol

211 formation of a glycolysis compartment, or a "glycolytic metabolon," that can maintain local levels of

212 ripotency, they are thought to switch from a glycolytic mode of energy generation to one more depende

213 We report here that several factors affected glycolytic mRNA stability, among which were glucose sens

214 ction, whereas in resistance arterioles from glycolytic muscle, alterations in both nitric oxide and

215 In both oxidative and glycolytic muscle, late-life exercise training reverses

216 d muscle and restored insulin sensitivity in glycolytic muscles from LCR rats.

217 eneous between arterioles from oxidative and glycolytic muscles.

218 n the formation and metabolic programming of glycolytic myofibers in skeletal muscle.

219 ipolytica with synthetic pathways converting glycolytic NADH into the lipid biosynthetic precursors N

220 to MG dicarbonyl stress when compared to non-glycolytic ones.

221 Across various conditions, including glycolytic or mitochondrial inhibition or cell prolifera

222 P use revealed no significant preference for glycolytic or oxidative ATP by specific ATP consumers.

223 Evidence of chronotaxicity was found in glycolytic oscillations in real yeast cells, verifying t

224 In this paper, we report sustained glycolytic oscillations in single cells without the need

225 that imaging pH offers a new way to measure glycolytic oscillations on individual cells.

226 ae initiates collective NADH dynamics termed glycolytic oscillations.

227 othesis of the Dual Oscillator Model, that a glycolytic oscillator endogenous to islet beta-cells dri

228 ate, which accumulated and thereby curtailed glycolytic outflow in nitrogen-limited yeast.

229 ypoxia, including increased flux through the glycolytic pathway and decreased flux through the tricar

230 However,Mtbalso maintains a functional glycolytic pathway and its role in the cellular metaboli

231 inhibited HIF-1alpha, showed upregulation of glycolytic pathway genes, glucose transporter 1-4 (Glut1

232 ing allostery or key regulatory nodes in the glycolytic pathway impacted the size of the outer segmen

233 on and functional levels and a switch to the glycolytic pathway in mphis, while IL-4-treated mphis ut

234 demonstrate the cell autonomous role of the glycolytic pathway in outer segment maintenance and prov

235 Up-regulation of the anaerobic glycolytic pathway in the muscle of fast-growing fish wa

236 The glycolytic pathway is a potential therapeutic target to

237 e expression of hexokinase-ll (HK-II) in the glycolytic pathway through elevated c-MYC.

238 catalytic activity of two key enzymes in the glycolytic pathway, 6-phosphofructokinase and pyruvate k

239 creased and 20 decreased) clustered into the glycolytic pathway, nucleotide sugars, intermediates of

240 th associated increased glucose flux through glycolytic pathway.

241 the muscle and enhanced the activity of the glycolytic pathway.

242 crease the levels of enzymes involved in the glycolytic pathway.

243 sphofructokinase, an important enzyme in the glycolytic pathway.

244 We introduce modifications in glycolytic pathways and the Calvin Benson cycle to incre

245 rains whose growth depended on two nonnative glycolytic pathways: a complete glycolysis from the rela

246 conduits for dissipating lactate anions from glycolytic PDAC cells.

247 uncontrolled growth of tumors, particularly glycolytic PDAC.

248 erexpression or PTBP1 knockdown reversed the glycolytic phenotype (decreased the production of glycol

249 oma cancer cell lines in relation with their glycolytic phenotype and MG detoxifying capacity.

250 xpression on breast carcinoma and fibroblast glycolytic phenotype and tumor growth.

251 The aerobic glycolytic phenotype of hepatocellular carcinoma (HCC) i

252 ncer cell lines (A2780 and PEO1) displayed a glycolytic phenotype while their chemoresistant counterp

253 The aerobic glycolytic preference in NLRX1(-/-) effector T cells is

254 , validated by experimentation, predict that glycolytic production of ATP drives EC rearrangement by

255 Depletion or knockout of CHIP increased the glycolytic products in both tumor and mouse embryonic fi

256 We identified an increase in a number of glycolytic proteins and lactate production, suggesting a

257 ectivity when compared to other non-specific glycolytic proteins such as d-glucose-6-phosphate dehydr

258 FAK increases key glycolytic proteins, including enolase, pyruvate kinase

259 arily stimulated synthesis of structural and glycolytic proteins.

260 Measurements of both glycolytic rate and mitochondrial pyruvate consumption r

261 osphatase transgene (Glyco(Lo) mice) lowered glycolytic rate and regulated the expression of genes kn

262 Differences in glycolytic rate and VB between SCC and AC are relevant f

263 s enforced the Warburg effect, with a higher glycolytic rate at the expense of mitochondrial respirat

264 reprogramming in cancer drives an increased glycolytic rate that supports maximal production of thes

265 Glucose consumption and glycolytic rate were augmented by a fall in intracellula

266 neration must exist to support the increased glycolytic rate while allowing for the diversion of gluc

267 ase in the activity of hexokinase and in the glycolytic rate, and both processes were dependent on ac

268 , which mimics PFKFB3 activity and increases glycolytic rate, was sufficient to phenocopy the mitocho

269 Elevated glycolytic rates in T cells isolated from the EAE CNS co

270 ating NAD(+), a substrate for GAPDH-mediated glycolytic reaction, promoting PDAC cell growth.

271 letely understood, and it is unknown whether glycolytic regulation is essential to maintain the balan

272 s rely on the glucose transporter GLUT4 as a glycolytic regulatory system to meet the activity-driven

273 ied a critical role of PHD2 for a reversible glycolytic reprogramming in macrophages with a direct im

274 lation with mtDNA and determined whether the glycolytic reprogramming that occurs in response to TGF-

275 activity is unimpaired, suggesting a mode of glycolytic reprogramming.

276 iratory capacity, and greater glycolysis and glycolytic reserve.

277 more abundant cytosolic GAPDH and increased glycolytic reserve.

278 Fructose-driven glycolytic respiration in naked mole-rat tissues avoids

279 cess retraction, which was linked to reduced glycolytic respiratory activity, is reversible until a c

280 enes in metabolic pathways and more dramatic glycolytic responses to hormonal stimulation.

281 Indolepyruvate prevents the LPS-induced glycolytic shift in macrophages.

282 Enzymes in the glycolytic, sorbitol, methylglyoxal and mitochondrial pa

283 es were directly correlated with the induced glycolytic state (fasted versus fed groups).

284 e normal cells have an oxidative state and a glycolytic state, cancer cells can access a hybrid state

285 PKM2 inhibition reversed the glycolytic status of PH-Fibs, decreased their cell proli

286 lating factor/interleukin-3 receptor driving glycolytic substrate utilization by mitochondria.

287 ratory pathways and enhanced growth rates on glycolytic substrates of E. coli, coinciding with acetat

288 enhances oligodendroglial glucose uptake and glycolytic support of fast spiking axons.

289 particular, Kras(G12D/G12D) cells exhibit a glycolytic switch coupled to increased channelling of gl

290 h Ag-specific cytokine production requires a glycolytic switch for optimal cytokine release, glucose

291 n Hilpda cKO macrophages, independent of the glycolytic switch, fatty acid or lipoprotein uptake.

292 hich were recently demonstrated to depend on glycolytic switching.

293 ting for enhanced RICD sensitivity in highly glycolytic T cells.

294 CcO promotes the switch from glycolytic to oxidative phosphorylation (OXPHOS) metabol

295 ol improved muscle pathology, attenuated the glycolytic-to-oxidative metabolic alterations occurring

296 ways can be readily elucidated, we induced a glycolytic tumor in the Drosophila wing imaginal disc by

297 nd ectopic Hsp90 expression to be highest in glycolytic tumors reinforcing its role as an indicator o

298 to Hsp90 inhibition being most effective in glycolytic tumors, we found ectopic Hsp90 expression to

299 adipocyte subpopulations of cells are highly glycolytic, whereas Tbx15(Low) preadipocytes and adipocy

300 Ex vivo Treg cells were highly glycolytic while Tconv cells used predominantly fatty-ac