ライフサイエンスコーパス: glycopyrrolate

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1 following cardiac parasympathetic blockade (glycopyrrolate).

2 in salivary response to an anti-sialogogue (glycopyrrolate).

3 ts with and without cholinergic blockade via glycopyrrolate.

4 lder--60-77 yrs) received 4.0 microg/kg i.v. glycopyrrolate.

5 g min-1) were assessed after vagal blockade (glycopyrrolate, 1.2 mg).

6 0.16 +/- 0.01 mg kg(-1); mean +/- S.E.M.) or glycopyrrolate (12.6 +/- 1.6 microg kg-1).

7 .003 mg kg(-1)) or parasympathetic blockade (glycopyrrolate, 13.6 +/- 1.5 microg kg(-1)).

8 daily), indacaterol (27.5 mug twice daily), glycopyrrolate (15.6 mug twice daily), or placebo, all d

9 nts were randomized (1:1:1:1) to indacaterol/glycopyrrolate (27.5/15.6 mug twice daily), indacaterol

10 ith subjects who received the active placebo glycopyrrolate (4 microg/kg) and subjects who were not i

11 P < 0.05, n = 3) following administration of glycopyrrolate (-8.1 +/- 4.5 ms) compared to PS alone (-

12 e efficacy and safety of QVA149 (indacaterol/glycopyrrolate), a fixed-dose combination of a long-acti

13 ses in isolated guinea pig vagal tissue, but glycopyrrolate and atropine did not.

14 control (no drug), parasympathetic blockade (glycopyrrolate) and beta-adrenergic blockade (metoprolol

15 edication use were observed with indacaterol/glycopyrrolate compared with placebo (P < 0.001).

16 ol) and a long-acting muscarinic antagonist (glycopyrrolate), compared with its monocomponents and pl

17 e (metoprolol) and parasympathetic blockade (glycopyrrolate) conditions.

18 s during which they received neostigmine and glycopyrrolate for NMB reversal.

19 inistration of either propranolol (PROP), or glycopyrrolate (GLYC), or PROP and GLYC in combination (

20 blockade (NMB) reversal with neostigmine and glycopyrrolate has been reported to cause cardiac arrest

21 8.0 mg propranolol i.v. and (3) after 0.8 mg glycopyrrolate i.v.

22 would support the safety of neostigmine and glycopyrrolate in cardiac transplantation patients.

23 Whereas pilocarpine and glycopyrrolate increased and decreased sweating, respect

24 Metoprolol decreased and glycopyrrolate increased HR and cardiac output both at r

25 bacine) and slowly dissociating (tiotropium, glycopyrrolate) ligands.

26 ases in vagal tone were induced using either glycopyrrolate or mild rhythmic exercise.

27 trol of HR was significantly attenuated with glycopyrrolate (P < 0.05).

28 Glycopyrrolate reduced the maximal gain (G(max)) ofthe C

29 Indacaterol/glycopyrrolate twice daily can be an alternative treatme

30 o demonstrate the superiority of indacaterol/glycopyrrolate versus its monocomponents for standardize

31 daily rescue medication use with indacaterol/glycopyrrolate versus placebo.

32 Indacaterol/glycopyrrolate was statistically superior in terms of FE

33 Focusing on one of these hits, glycopyrrolate, we confirm the role for muscarinic choli

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