ライフサイエンスコーパス: glycoside hydrolase

1 nd the type I dockerin module from the Cel9D glycoside hydrolase.

2 or for the detection and characterization of glycoside hydrolases.

3 gically and industrially important family of glycoside hydrolases.

4 (CE4s) and a domain structurally similar to glycoside hydrolases.

5 de that the GH61 proteins are unlikely to be glycoside hydrolases.

6 uding an unusual repertoire of extracellular glycoside hydrolases.

7 arrel structure, which is common to family 1 glycoside hydrolases.

8 ide hydrolases (GH), including 32 family GH2 glycoside hydrolases.

9 volved in binding and import of glycans, and glycoside hydrolases.

10 like system to control production of several glycoside hydrolases.

11 t indicates that it is a member of family 64 glycoside hydrolases.

12 talytic motif of families 16 and 7 retaining glycoside hydrolases.

13 omologous and functionally diverse family of glycoside hydrolases.

14 was proposed that these enzymes function as glycoside hydrolases.

15 /Trp chains appear almost exclusively in the glycoside hydrolases.

16 ycans, S. pneumoniae deploys a wide array of glycoside hydrolases.

17 Glycoside hydrolase 12 (GH12) proteins act as virulence

18 ve proteomics study in which we identify two glycoside hydrolase 13 family enzymes, and three ABC tra

19 315 is an inactive beta-1,3-glucanase of the glycoside hydrolase 16 (GH16) family.

20 in beta-glucosidase that belongs to the GH3 (glycoside hydrolase 3) family.

21 62 family enzyme was very similar to that of glycoside hydrolase 43 family enzymes, and the catalytic

22 terization of small-molecule activators of a glycoside hydrolase (a bacterial O-GlcNAc hydrolase).

23 activity in vivo, and could also be used for glycoside hydrolase activation in many industrial proces

24 This biosensor allowed detection of glycoside hydrolase activities at the picomolar level us

25 est performance to date for the detection of glycoside hydrolase activities.

26 alyzing an MSI data set of a high-throughput glycoside hydrolase activity screen comprising 384 sampl

27 his array for detecting exo- and endo-acting glycoside hydrolase activity using commercial enzymes, a

28 the GhCTL group are assigned to family GH19 glycoside hydrolases along with numerous authentic chiti

29 These linkages are primarily cleaved by glycoside hydrolases, although recently, a family of gly

30 e (NCOAT) is a bifunctional enzyme with both glycoside hydrolase and alkyltransferase activity.

31 paradigm of protein complex assembly beyond glycoside hydrolase and carbohydrate active enzymes, and

32 A comparison of the glycoside hydrolase and cellulosome functional genes rev

33 12 protein, PF13204 and PF12904, as putative glycoside hydrolase and glycoside hydrolase-associated C

34 s are also present in several other R. albus glycoside hydrolases and are phylogentically distinct fr

35 drate-binding modules (CBMs) are appended to glycoside hydrolases and can contribute to the degradati

36 New secreted glycoside hydrolases and carbohydrate esterases were ide

37 ption, biochemical analysis of all predicted glycoside hydrolases and carbohydrate-binding proteins,

38 ure of GTase closely resembles the family 13 glycoside hydrolases and conservation of key catalytic r

39 ferent types of carbohydrate-active enzymes, glycoside hydrolases and glycosyltransferases, have conv

40 Globally, 9,003 sequences for glycoside hydrolases and lytic polysaccharide mono-oxyge

41 e-degrading and -modifying enzymes including glycoside hydrolases and lytic polysaccharide monooxygen

42 s interaction with cohesin modules, and only glycoside hydrolases and other carbohydrate active enzym

43 nisms have evolved elaborate sets of modular glycoside hydrolases and similar enzymes aimed at the de

44 accharide utilization loci encoding numerous glycoside hydrolases, and by signaling the host to produ

45 n proteins such as polysaccharide synthases, glycoside hydrolases, and carbohydrate-binding modules.

46 c of the B(2) (or theme D) group of family 9 glycoside hydrolases, and Cel48A is structurally similar

47 Glycoside hydrolases are clustered into families based o

48 ces, the biochemical properties of these GH2 glycoside hydrolases are currently unclear.

49 These producer-derived glycoside hydrolases are public goods transported extrac

50 Processive glycoside hydrolases are the key components of enzymatic

51 nge of carbohydrate-active enzymes, of which glycoside hydrolases are the main components.

52 Glycoside hydrolases are ubiquitous enzymes involved in

53 lex called a cellulosome, which co-ordinates glycoside hydrolase assembly, bacterial adhesion to subs

54 PF12904, as putative glycoside hydrolase and glycoside hydrolase-associated C-terminal domain respect

55 By contrast, glycoside hydrolases attacking celluloses and nitrogen f

56 -binding modules (CBMs) derived from modular glycoside hydrolases belonging to families 2a, 6, and 29

57 Here we study a family 117 glycoside hydrolase (BpGH117) encoded within a recently

58 ereal type family inhibitors (CTIs) bound to glycoside hydrolases but is structurally analogous to bi

59 metagenomics provide access to libraries of glycoside hydrolases but the biochemical characterizatio

60 s to show that among the dozens of different glycoside hydrolases C. phytofermentans secretes on cell

61 These findings suggest that glycoside hydrolases can exhibit activity against divers

62 D is a modular enzyme containing a family 30 glycoside hydrolase catalytic domain and an attached car

63 glucanase comprising an N-terminal family 81 glycoside hydrolase catalytic module, an internal family

64 e-enhancing factors," such as those from the glycoside hydrolase (CAZy) GH61 family.

65 rolase (Cel9B), and the other is a family 48 glycoside hydrolase (Cel48A).

66 One of the polypeptides is a family 9 glycoside hydrolase (Cel9B), and the other is a family 4

67 n, and loop flexibility between the family 7 glycoside hydrolase cellobiohydrolases from H. irregular

68 me, there are fundamental differences in the glycoside hydrolase content that appear to be diet drive

69 We therefore hypothesized that these glycoside hydrolases could exhibit antibiofilm activity

70 Glycoside hydrolases displaying multiple catalytic funct

71 structural data reveal that PlyCA contains a glycoside hydrolase domain in addition to the previously

72 Proteins containing glycoside hydrolase domains have recently been identifie

73 activity, suggesting that T6S peptidoglycan glycoside hydrolase effector families may comprise signi

74 e define novel families of T6S peptidoglycan glycoside hydrolase effectors.

75 propose a scheme of sequential action by the glycoside hydrolases encoded by the beta-mannan PUL and

76 This work shows that Sph3 is a glycoside hydrolase essential for GAG production and def

77 hat they are beta-porphyranases belonging to glycoside hydrolase families 16 and 86, respectively.

78 d a (beta/alpha)8 fold, with similarities to glycoside hydrolase families 18, 27, and 84.

79 of processive and nonprocessive enzymes from glycoside hydrolase families 6 and 7.

80 Cellulases comprise many glycoside hydrolase families and exist as processive or

81 The glycoside hydrolase families GH5 (PaMan5A) and GH26 (PaM

82 ructural features typical of the grouping of glycoside hydrolase families known as clan GH-A, with th

83 homologous sequences are present in various glycoside hydrolase families.

84 cruiting enzymes from two previously unknown glycoside hydrolase families.

85 lases have been classified into 13 of the 62 glycoside hydrolase families.

86 identified beetle myrosinase belongs to the glycoside hydrolase family 1 and has up to 76% sequence

87 % to 92% amino acid identity with members of glycoside hydrolase family 1, including their catalytic

88 ucture of a xylanase not belonging to either glycoside hydrolase family 10 or family 11.

89 ted uronyl hydrolases classified in the CAZy glycoside hydrolase family 105.

90 Although xylanases from glycoside hydrolase family 11 (GH11) have been extensive

91 The catalytic domain of XynCDBFV, a glycoside hydrolase family 11 (GH11) xylanase from rumin

92 The enzyme is a member of glycoside hydrolase family 12, which had previously elud

93 ndo-1,4-beta-glucanase (Cel12A) belonging to glycoside hydrolase family 12.

94 The enzyme has been classified into glycoside hydrolase family 12; this is the first structu

95 In particular, transglycosylases from glycoside hydrolase family 13 (GH13) and GH77 play well

96 logy to members of the alpha-amylase family (glycoside hydrolase family 13), which all have a (beta/a

97 The XTH gene products compose a subfamily of glycoside hydrolase family 16 (GH16), which also compris

98 two distant bacterial phyla, which belong to glycoside hydrolase family 16 and cleave the beta-1,4 li

99 ive beta-porphyranases, all belonging to the glycoside hydrolase family 16.

100 3-1,4-beta-glucan 4-glucanohydrolases of the glycoside hydrolase family 16.

101 lar protein that is predicted to contain two glycoside hydrolase family 18 (GH18) catalytic domains,

102 oh_4555 (ChiA), a 168.9-kDa protein with two glycoside hydrolase family 18 (GH18) domains, was target

103 gnificant similarity to other members of the glycoside hydrolase family 23 (GH23), such as the g-type

104 It encodes two glycoside hydrolase family 26 (GH26) beta-mannanases, Bo

105 d drug design efforts on alpha-GAL and other glycoside hydrolase family 27 enzymes by developing liga

106 The secreted glycoside hydrolase family 29 (GH29) alpha-L-fucosidase

107 physiological roles of the four C. japonicus glycoside hydrolase family 3 (GH3) members on diverse be

108 rchitecture as observed previously for other glycoside hydrolase family 3 beta-glucosidases.

109 Arabidopsis thaliana) beta-glucosidases from glycoside hydrolase family 3.

110 rase and isomaltase) that both belong to the glycoside hydrolase family 31 (GH31) and differ in subst

111 The enzyme belongs to glycoside hydrolase family 31 (GH31) but degrades starch

112 lgi alpha-mannosidase II (GMII), a member of glycoside hydrolase family 38, cleaves two mannosyl resi

113 Here we test the hypothesis that glycoside hydrolase family 43 (GH43) provides a suitable

114 n be differentially modulated in vitro using glycoside hydrolase family 43 and family 51 arabinofuran

115 characterization, and kinetic analysis of a glycoside hydrolase family 43 beta-xylosidase (Xyl43A) f

116 Multiple glycoside hydrolase family 47 (GH47) alpha-mannosidases,

117 Enzymes from glycoside hydrolase family 48 (GH48) are a critical comp

118 To gain insights into how the two glycoside hydrolase family 5 (GH5) enzymes may aid the b

119 Carbohydrate-Active Enzyme (CAZy) database, glycoside hydrolase family 5 (GH5) is a large family wit

120 The recent classification of glycoside hydrolase family 5 (GH5) members into subfamil

121 The diversity of activities across glycoside hydrolase family 5 (GH5) suggests that this fa

122 An arabinose specific xylanase from glycoside hydrolase family 5 (GH5) was used to hydrolyse

123 nases revealed three distinct subfamilies of glycoside hydrolase family 5 (GH5).

124 45 kDa, 413-amino acid protein belonging to glycoside hydrolase family 5, has been determined by mul

125 from Bacillus agaradhaerens, classified into glycoside hydrolase family 5, has been studied in a cata

126 lanase activity and subsequently assigned to glycoside hydrolase family 5.

127 Here we present the crystal structure of a glycoside hydrolase family 50 exo-beta-agarase, Aga50D,

128 Glycoside hydrolase Family 6 (GH6) CBHs act from nonredu

129 hydrate binding module family 33 (CBM33) and glycoside hydrolase family 61 (GH61) are likely to play

130 Glycoside hydrolase family 62 (GH62) is currently a smal

131 -L-arabinofuranosidase, which belongs to the glycoside hydrolase family 62 (GH62), hydrolyzes arabino

132 saccharide glucanotransferase belongs to the glycoside hydrolase family 66 and catalyzes an intramole

133 and O-glycosylation on a model, multimodular glycoside hydrolase family 7 cellobiohydrolase (Cel7A),

134 haride unit during the processive cycle of a glycoside hydrolase family 7 cellobiohydrolase.

135 H. jecorina Cel7A, cellobiohydrolase I, from glycoside hydrolase family 7, is the workhorse enzyme of

136 3-GBD-CD2 is a transglucosylase belonging to glycoside hydrolase family 70 (GH70) that catalyzes the

137 Highly conserved glycoside hydrolase family 70 glucansucrases are able to

138 n GTF180-DeltaN and GTF-SI glucansucrases of glycoside hydrolase family 70.

139 32 carbohydrate binding module (CBM32) of a glycoside hydrolase family 8 chitosanase from Paenibacil

140 fringens unsaturated glucuronyl hydrolase of glycoside hydrolase family 88 in the CAZy classification

141 One of these, CelA, comprises a glycoside hydrolase family 9 and a family 48 catalytic d

142 es and endo-alpha-1,2-mannanases, members of glycoside hydrolase family 99 (GH99), are interesting ta

143 s highest overall structural similarity to a glycoside hydrolase family associated with peptidoglycan

144 Rice (Oryza sativa) Os9BGlu31 is a glycoside hydrolase family GH1 transglycosidase that act

145 snapshots along the reaction coordinate of a glycoside hydrolase family GH29 alpha-L-fucosidase unvei

146 CAZy glycoside hydrolase family GH3 consists primarily of ste

147 quently hydrolyzed by members of the unusual glycoside hydrolase family GH4.

148 Glycoside hydrolase family GH85 is a family of endo-beta

149 GYxYP-containing proteins constitute a novel glycoside hydrolase family of as yet unknown specificity

150 g the structural feature of this family as a glycoside hydrolase family of enzymes.

151 Recently three members of a glycoside hydrolase family, GH115, were shown to hydroly

152 sential for GAG production and defines a new glycoside hydrolase family, GH135.

153 cation is still needed, as is exemplified by glycoside hydrolase family-3 (GH3) proteins.

154 We propose that the increased affinity of glycoside hydrolases for polysaccharides, through the sy

155 ence-quenched substrates for other mammalian glycoside hydrolases for use in live cell imaging.

156 Starting with the family 98 glycoside hydrolase from Streptococcus pneumoniae SP3-BS

157 A fungal endoxylanase belonging to the glycoside hydrolase gene family 11 (GH11) was obtained f

158 Expression profiles of most endo-acting glycoside hydrolase genes correlated well with their rep

159 biochemical properties, although exo-acting glycoside hydrolase genes displayed less specific expres

160 lucose generally repressed expression of all glycoside hydrolase genes, other sugars induced or repre

161 Remarkably, some beta-glucosidases of the glycoside hydrolase (GH) 1 family are tolerant to or eve

162 Many glycoside hydrolase (GH) enzymes act via a processive me

163 Nature uses a diversity of glycoside hydrolase (GH) enzymes to convert polysacchari

164 lobal MS data, revealing ABP selectivity for glycoside hydrolase (GH) enzymes, in addition to a large

165 beta-Mannanases, located in glycoside hydrolase (GH) families 5 and 26, hydrolyze gl

166 Organization of glycoside hydrolase (GH) families into clans expands the

167 In plants, Glycoside Hydrolase (GH) Family 1 beta -glycosidases are

168 ed carbohydrate active genes encode a unique glycoside hydrolase (GH) family 10 endoxylanase (BiXyn10

169 antii harbors four genes predicted to encode glycoside hydrolase (GH) family 3 (GH3) enzymes.

170 A putative glycoside hydrolase (GH) family 3 beta-D-glucosidase gen

171 the pK(a) values of titratable residues of a glycoside hydrolase (GH) family 6 cellobiohydrolase (Cel

172 enzymes have 97% identity and belong to the glycoside hydrolase (GH) family GH36 for which few struc

173 e, BT3686, which is the founding member of a glycoside hydrolase (GH) family, GH145.

174 ermite hindgut was observed when we compared glycoside hydrolase (GH) profile of buffalo rumen metage

175 Glycoside hydrolases (GH) are enzymes that mainly hydrol

176 h, produces an extensive array of exo-acting glycoside hydrolases (GH), including 32 family GH2 glyco

177 we identify and characterize a new family 20 glycoside hydrolase, GH20C, from S. pneumoniae.

178 d comprises a cohesin module and a family 25 glycoside hydrolase (GH25).

179 r2455) were identified that encode family 39 glycoside hydrolases (GH39s), and have conserved structu

180 Family 43 glycoside hydrolases (GH43s) are known to exhibit variou

181 f EXPB1 domain 1 resembles that of family-45 glycoside hydrolase (GH45), with conservation of most of

182 PMOs were incorrectly annotated as family 61 glycoside hydrolases (GH61s) or family 33 carbohydrate-b

183 Family 72 glycoside hydrolases (GH72) are ubiquitous in fungal org

184 hy3367 gene, which encodes the sole family 9 glycoside hydrolase (GH9) in the C. phytofermentans geno

185 Carbohydrate-active enzymes such as glycoside hydrolases (GHs) and glycosyltransferases (GTs

186 These SLH proteins include five glycoside hydrolases (GHs) and one polysaccharide lyase,

187 Glycoside hydrolases (GHs) cleave glycosidic linkages in

188 Glycoside hydrolases (GHs) distort carbohydrate ring geo

189 Glycoside hydrolases (GHs) have attracted considerable a

190 The conversion of glycoside hydrolases (GHs) into transglycosylases (TGs),

191 comprised of glycosylated linkers connecting glycoside hydrolases (GHs) to carbohydrate-binding modul

192 Processive glycoside hydrolases (GHs), like cellobiohydrolase Cel7A

193 by mixtures of processive and nonprocessive glycoside hydrolases (GHs), which exhibit synergistic ac

194 micellulose, facilitated by a diverse set of glycoside hydrolases (GHs).

195 sessed a gene cluster containing multidomain glycoside hydrolases (GHs).

196 uster of eight genes (nixE to nixL) encoding glycoside hydrolases (GHs).

197 Deficiency of the lysosomal glycoside hydrolase glucocerebrosidase (GCase) leads to

198 ed action of a variety of enzymes, including glycoside hydrolases, glycoside phosphorylases, and tran

199 ing is controlled by the equilibrium between glycoside hydrolases, glycosyltransferases, and transgly

200 filtrate was identified as the only family 7 glycoside hydrolase in the genome, which consists of a s

201 alysis revealed the existence of 29 putative glycoside hydrolases in addition to the previously ident

202 Glycoside hydrolases in family 101 are presently the onl

203 ite more efficiently than mannan-hydrolyzing glycoside hydrolases in related enzyme families.

204 ule to potentiate the activity of a range of glycoside hydrolases including cellulases.

205 ing the activity of endogenous levels of any glycoside hydrolases, including GCase, has proven proble

206 ean, MGIIa_P contained higher proportions of glycoside hydrolases, indicating the ability of MGIIa_P

207 Evaluated as glycoside hydrolase inhibitors, these quinolizidines rev

208 highly conserved, significant differences in glycoside hydrolase inventories and numbers of carbohydr

209 The degradation of the plant cell wall by glycoside hydrolases is central to environmentally susta

210 bohydrate-binding modules (CBM) of microbial glycoside hydrolases is central to natural and efficient

211 The function of CBMs appended to exo-acting glycoside hydrolases is unclear because their typical en

212 rrespondence to other family 5 and family 10 glycoside hydrolases, lie inside this cleft on the C-ter

213 urated uronic acid, is removed from AGP by a glycoside hydrolase located in family GH105, producing t

214 C. japonicus possesses an extensive range of glycoside hydrolases, lyases, and esterases.

215 ultifunctional enzyme mixtures consisting of glycoside hydrolases, lytic polysaccharide mono-oxygenas

216 we propose a new variation of the retaining glycoside hydrolase mechanism wherein the intervening wa

217 t A.actinomycetemcomitans produces a soluble glycoside hydrolase named dispersin B, which degrades PG

218 thetaiotaomicron contains a large number of glycoside hydrolases not represented in our own proteome

219 subfamily would rather work in synergy with glycoside hydrolases of the GH92 and GH18 families in th

220 Glycoside hydrolases often contain multiple copies of no

221 drate binding modules (CBMs) of cell surface glycoside hydrolases often drive binding to the target s

222 nt processes, such as bioprospecting for new glycoside hydrolases or identifying novel energy sources

223 In nature, many microbes secrete mixtures of glycoside hydrolases, oxidoreductases, and accessory enz

224 endent enzymes (EC 1.14.99.53-56) that, with glycoside hydrolases, participate in the degradation of

225 Microbial glycoside hydrolases play a dominant role in the biochem

226 d to analyze both endo-acting and exo-acting glycoside hydrolases, polysaccharide lyases, carbohydrat

227 Many glycoside hydrolases possess carbohydrate-binding module

228 membrane polysaccharide-binding proteins and glycoside hydrolases, prioritized the consumption of lib

229 genetic studies have shown that the putative glycoside hydrolase PslG is essential for Psl biosynthes

230 residues similar to those of other family 39 glycoside hydrolases, PslG(31-442) exhibits a unique 32-

231 Cellulases are the glycoside hydrolases responsible for the enzymatic break

232 on a polysaccharide if the producer-derived glycoside hydrolase, responsible for PBP generation, is

233 Endoglycosidase S (EndoS) is a glycoside-hydrolase secreted by the bacterium Streptococ

234 at from MvX56, a module found in a family 33 glycoside hydrolase sialidase from Micromonospora viridi

235 It encodes three glycoside-hydrolases specific for xylo-oligosaccharides,

236 case (OGA), representing the first family 84 glycoside hydrolase structure.

237 Across many environments microbial glycoside hydrolases support the enzymatic processing of

238 c onto proteins and O-GlcNAcase (OGA) is the glycoside hydrolase that acts to remove O-GlcNAc from pr

239 ate binding modules (CBMs) are components of glycoside hydrolases that attack generally inaccessible

240 in the identification of several families of glycoside hydrolases that can degrade mannan.

241 Among the many families of glycoside hydrolases that catalyze cellulose and hemicel

242 the relatively high cost of enzymes such as glycoside hydrolases that catalyze cellulose hydrolysis

243 Hyaluronidases are a family of endolytic glycoside hydrolases that cleave the beta1-4 linkage bet

244 oned, expressed and characterized all of the glycoside hydrolases that contain a dockerin module.

245 indicates that they are members of family 16 glycoside hydrolases that have significant sequence iden

246 alpha-L-arabinofuranosidases are glycoside hydrolases that specifically hydrolyze non-red

247 analysis reveals approximately 130 predicted glycoside hydrolases that target the major structural an

248 This system contains several glycoside hydrolases that trim the remnants of other pec

249 A multidisciplinary analysis of a beta-glycoside hydrolase, the Cel5A from Bacillus agaradhaere

250 d in this enzyme and those of other family 9 glycoside hydrolases, the active site of GH9_CbhA is blo

251 domain with significant similarity to known glycoside hydrolases, the C-terminal domain has a beta-s

252 ative protein-coding genes, of which 103 are glycoside hydrolases, the highest detected number in clu

253 The inhibition of glycoside hydrolases, through transition-state mimicry,

254 ofermentans has a repertoire of 108 putative glycoside hydrolases to break down cellulose and hemicel

255 ulases, hemicellulases, xylanases, and other glycoside hydrolases to facilitate the degradation of hi

256 idomain extracellular and S-layer-associated glycoside hydrolases to process the carbohydrate content

257 functional transpeptidases and glycosidases (glycoside hydrolases), trimeric peptide crosslinks, cell

258 hypothetical protein with low similarity to glycoside hydrolases was shown to possess endoxylanase a

259 larity to any of the 97 existing families of glycoside hydrolases, we have proposed to assign this un

260 Glycoside hydrolases, which are ubiquitous in nature, ty

261 modules (CBMs) are ubiquitous components of glycoside hydrolases, which degrade polysaccharides in n

262 er feature differs from the vast majority of glycoside hydrolases, which use a carboxylic acid, highl