ライフサイエンスコーパス: glycosphingolipid

1 of membrane traffic when loaded with excess glycosphingolipid.

2 is the precursor for all of the more complex glycosphingolipids.

3 h results in the progressive accumulation of glycosphingolipids.

4 ese types of strains to a panel of different glycosphingolipids.

5 s partition, are enriched in cholesterol and glycosphingolipids.

6 howed enlarged lysosomes and accumulation of glycosphingolipids.

7 in CDT binding, including glycoproteins, and glycosphingolipids.

8 ized by lysosomal storage of cholesterol and glycosphingolipids.

9 from glycoproteins, and glycan nitriles from glycosphingolipids.

10 cultured with GM2 or GM3 alone or with other glycosphingolipids.

11 icking defect with secondary accumulation of glycosphingolipids.

12 de GM3, but to a much lesser degree by other glycosphingolipids.

13 s supplementation of LacCer but not by other glycosphingolipids.

14 tor is mediated by the availability of other glycosphingolipids.

15 etain the phenotype of elevated globo-series glycosphingolipids.

16 xogenously supplied LacCer, but not by other glycosphingolipids.

17 reduced the accumulation of cholesterol and glycosphingolipids.

18 lipid-binding domains specific for PI4P and glycosphingolipids.

19 ed as novel mimics of glycoglycerolipids and glycosphingolipids.

20 e diseases involves the lysosomal storage of glycosphingolipids.

21 The mechanism through which glycosphingolipid accumulation causes these manifestatio

22 elated to myocardial iron overload states or glycosphingolipid accumulation in Anderson-Fabry disease

23 iency of alpha-galactosidase A, resulting in glycosphingolipid accumulation in organs and tissues, in

24 a-galactosidase A enzyme activity leading to glycosphingolipid accumulation, mainly globotriaosylcera

25 -stimulate interleukin (IL)-13 production by glycosphingolipid-activated NKT cells.

26 migration; however, the mechanisms by which glycosphingolipids affect integrins are unknown.

27 like molecule that presents phospholipid and glycosphingolipid Ags to a subset of CD1d-restricted T c

28 Unexpectedly, the third compound was the glycosphingolipid alpha-galactosylceramide (alpha-GalCer

29 lipid Ags, such as the marine sponge-derived glycosphingolipid alpha-galactosylceramide (alphaGalCer)

30 he synthesis of specific glioma cell-surface glycosphingolipids alters invasivity in a manner that ma

31 We have previously shown that glycosphingolipid analogs are internalized primarily via

32 ypically, 40-60% of the cellular pool of GM1 glycosphingolipid and 10-20% of the total cellular chole

33 ablish an unexpected connection between this glycosphingolipid and the fungal responses to physiologi

34 ude that the predominant lectin ligands are: glycosphingolipids and an O-linked, fucose-containing gl

35 We found that 1) the glycosphingolipids and cholesterol components of lipid r

36 rotein involved in the cellular transport of glycosphingolipids and cholesterol that is mutated in a

37 o characterize the structures of amphiphilic glycosphingolipids and gangliosides in comparison to col

38 to widespread tissue accumulation of neutral glycosphingolipids and is associated with premature vasc

39 cell receptor that has specificity for self glycosphingolipids and microbial cell wall alpha-glycuro

40 s not only corroborate the critical role for glycosphingolipids and programmed cell death in regulati

41 n is a viable option for analysis of neutral glycosphingolipids and that Gb4Cer may play a role in th

42 ceptors: beta1-linked galactosyl residues in glycosphingolipids and the phosphocholine group in phosp

43 Herein, the ability of glycosphingolipids (and their sphingolipid metabolites)

44 urated lipids (the lipid analog diI-C(18) or glycosphingolipids)) and lipid-anchored proteins coredis

45 luding N- and O-glycans, glycosaminoglycans, glycosphingolipids, and glycophosphatidylinositol anchor

46 ophilic polymorphonuclear leukocytes contain glycosphingolipid- and cholesterol-enriched lipid raft m

47 Glycosphingolipids are a subgroup of glycolipids that co

48 Glycosphingolipids are abundant in the kidney, have role

49 s are strongly associated with emphysema and glycosphingolipids are associated with COPD exacerbation

50 Sphingolipids and glycosphingolipids are emerging as major regulators of t

51 Glycosphingolipids are found on all vertebrate cells and

52 Glycosphingolipids are important structural constituents

53 Glycosphingolipids are known to play roles in integrin-m

54 Our results suggest that glycosphingolipids are likely important participants in

55 Most glycosphingolipids are synthesized by the sequential add

56 Glycosphingolipids are ubiquitous components of mammalia

57 Glycosphingolipids are ubiquitous constituents of eukary

58 rate that sulfatides, highly charged anionic glycosphingolipids, are important for maintaining high p

59 Gangliosides, which are sialylated glycosphingolipids, are the major class of glycoconjugat

60 nize isoglobotrihexosylceramide, a mammalian glycosphingolipid, as well as microbial alpha-glycuronyl

61 phoglycerolipids to alpha- and beta-anomeric glycosphingolipids, as well as microbial alpha-glycosyl

62 ptors, we found that an A. fumigatus-derived glycosphingolipid, asperamide B, directly activates inva

63 ulfated galactosylceramides (sulfatides) are glycosphingolipids associated with cholesterol- and sphi

64 also of endogenous ligands, such as the self-glycosphingolipid beta-glucopyranosylceramide, up-regula

65 HET-C2 is a fungal protein that transfers glycosphingolipids between membranes and has limited seq

66 fficiency was observed unexpectedly with the glycosphingolipid-binding mutant protein.

67 e have shown that FAPP2, a PI4P effector and glycosphingolipid-binding protein, is recruited to the H

68 ose metabolism, prostaglandin synthesis, and glycosphingolipid biology that may either play an adapti

69 activity of several other genes involved in glycosphingolipid biosynthesis also suppresses the effec

70 and translation, octaBDE and BEH-TEBP affect glycosphingolipid biosynthesis and BZ54 affects Wnt and

71 Biochemical profiling of glycosphingolipid biosynthesis confirmed a lack of GM2 i

72 Blocking glycosphingolipid biosynthesis in cultured human neutrop

73 Additionally, when oral glycosphingolipid biosynthesis inhibitors (beta-hexosami

74 The glycosphingolipid biosynthesis is initiated by monoglyco

75 re we show that the egghead gene involved in glycosphingolipid biosynthesis provides an essential com

76 atment of cells with a chemical inhibitor of glycosphingolipid biosynthesis, which suppresses the exp

77 GlcCer is a main precursor for higher order glycosphingolipids but might also serve as intracellular

78 The metabolism of glycosphingolipids by the malaria-causing parasite Plasm

79 Here, we show that addition of the glycosphingolipid, C8-lactosylceramide (C8-LacCer), or f

80 ial cells and support the idea that specific glycosphingolipids can be harnessed as molecular vehicle

81 Previous reports have shown that glycosphingolipids can modulate the activity of the insu

82 Although many glycosphingolipid catabolic defects have been defined, o

83 Gangliosides are a family of glycosphingolipids characterized by mono- or polysialic

84 es results in the repartitioning of MOG into glycosphingolipid-cholesterol membrane microdomains ("li

85 rainiac catalyzes a step in the synthesis of glycosphingolipids, components of lipid rafts that are t

86 Consequently, unique viral glycosphingolipids, composed of unusual hydroxylated C17

87 sted evolutionary adaptation for the simpler glycosphingolipid compositions of filamentous fungi.

88 a fluidizing effect is seen that varies with glycosphingolipid concentration, but results do not dire

89 Biochemical analysis of plasma glycosphingolipids confirmed that affected individuals l

90 Recently, GM3, a glycosphingolipid containing monosaialic acids, is thoug

91 Binding to artificial glycosphingolipid-containing vesicles, human saliva, and

92 f NaPi activity is mediated by the increased glycosphingolipid content of the potassium-deficient api

93 glucosylceramide, and possibly higher-order glycosphingolipids, could contribute to the pathogenesis

94 This glycosphingolipid, DB06-1, is similar in chemical struct

95 in peptides that are essential for lysosomal glycosphingolipid degradation.

96 was resistant to neuraminidase treatment and glycosphingolipid depletion.

97 However, it is unknown whether glycosphingolipids directly take part in the membrane in

98 been attributed to this family of sialylated glycosphingolipids, e.g. in modulation of ion channels a

99 e clustering of beta1-integrins within these glycosphingolipid-enriched domains and the activation of

100 lls induced the formation of cholesterol and glycosphingolipid-enriched Golgi domains that contained

101 Lipid rafts are small cholesterol- and glycosphingolipid-enriched membrane subdomains.

102 osidosis, GM1-ganglioside accumulates in the glycosphingolipid-enriched microdomain (GEM) fractions o

103 udied based on organization of components in glycosphingolipid-enriched microdomain (GEM) in WI38 cel

104 ptor known as phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG).

105 ese proteins, phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1) was ide

106 itioned in cholesterol-, sphingomyelin-, and glycosphingolipid-enriched microdomains of the apical me

107 regulation of phosphoprotein associated with glycosphingolipid-enriched microdomains/Csk binding prot

108 asts at 10 degrees C causes the formation of glycosphingolipid-enriched plasma membrane domains as sh

109 ds, we found that treatment with B. fragilis glycosphingolipids-exemplified by an isolated peak (MW =

110 Globotriaosylceramide (Gb3), a glycosphingolipid found in the plasma membrane of animal

111 gest the possibility that aberrant levels of glycosphingolipids found in cancer cells may influence c

112 Gangliosides, sialylated glycosphingolipids, found on all vertebrate cells and ti

113 The total non-acid glycosphingolipid fractions were characterized by antibo

114 In the present study, total non-acid glycosphingolipid fractions were isolated from two human

115 , which is a major sphingoid base in complex glycosphingolipids from Arabidopsis leaves, was a relati

116 hat most mouse and human NKT cells recognize glycosphingolipids from Sphingomonas, Gram-negative bact

117 Glcbeta1Cer), and a mixture of three complex glycosphingolipids (Fucalpha2Galbeta4GlcNAcbeta6(Fucalph

118 s; little is known, however, about how these glycosphingolipids function in neural stem cell (NSC) fa

119 The preparation of the glycosphingolipid galactosyl ceramide from an orthogonal

120 tures each containing a long-chain saturated glycosphingolipid, galactosylceramide (GalCer), and chol

121 imental evidence that sialic acid-containing glycosphingolipids (gangliosides) are also ligands for h

122 Platelets were engaged by the sialated glycosphingolipids (gangliosides) integrated in the rigi

123 e lectin LecA and its cellular receptor, the glycosphingolipid Gb3, triggers plasma membrane bending

124 x binding with the more abundantly expressed glycosphingolipid Gb4.

125 colleagues demonstrate that the cell surface glycosphingolipid GlcCer is essential for the fungus to

126 ive to Stx2 because they lacked the receptor glycosphingolipid globotriaosylceramide (Gb(3)) in vitro

127 rmal human colonic epithelial cells lack the glycosphingolipid globotriaosylceramide (Gb(3)), this mo

128 ce expressed high levels of the globo-series glycosphingolipid globotriaosylceramide (Gb3).

129 Stx2 binds to the glycosphingolipid globotriaosylceramide receptor, expres

130 tant strain lacking the cell wall-associated glycosphingolipid glucosylceramide (Delta gcs1), previou

131 Here we show that the glycosphingolipid glucosylceramide (GlcCer), which is pr

132 The glycosphingolipid GM1 binds cholera toxin (CT) on host c

133 A tetramethylrhodamine-labeled glycosphingolipid (GM1-TMR) was used as a substrate.

134 unt of intracellular CMP-Neu5Ac consumed for glycosphingolipid (GSL) biosynthesis, we can increase th

135 he view that saposin C has multiple roles in glycosphingolipid (GSL) catabolism as well as a prominen

136 Unlike disorders of glycosphingolipid (GSL) degradation, very little is know

137 Interest in cellular glycosphingolipid (GSL) function has necessitated the de

138 s) is mediated by an interaction between the glycosphingolipid (GSL) GM3 on virus particles and CD169

139 e approximately 80 amino acid stimulators of glycosphingolipid (GSL) hydrolases that derive from a si

140 unctions as an activity enhancer for several glycosphingolipid (GSL) hydrolases.

141 -mediated recognition of GM3, a host-derived glycosphingolipid (GSL) incorporated into the virus part

142 e outer membrane of S. paucimobilis contains glycosphingolipid (GSL) instead of lipopolysaccharide (L

143 It has been shown previously that inhibiting glycosphingolipid (GSL) synthesis increases insulin sens

144 Mutations in glycosphingolipid (GSL)-degrading glucocerebrosidase are

145 ronment, suitable for screening libraries of glycosphingolipids (GSL) against proteins to identify sp

146 e possible contribution of Sphingomonas spp. glycosphingolipids (GSL) and its extracellular polymeric

147 Glycosphingolipids (GSL) have been associated with a var

148 Glycosphingolipids (GSL) on the surface of cells are imp

149 most potent NKT cell antigens identified are glycosphingolipids (GSL).

150 erol or ceramide backbones, including simple glycosphingolipids (GSLs) and gangliosides.

151 The Sphingomonas glycosphingolipids (GSLs) and sulfatide variants were sh

152 Glycosphingolipids (GSLs) are essential constituents of

153 Glycosphingolipids (GSLs) are important constituents of

154 Previous studies demonstrated that certain glycosphingolipids (GSLs) are involved in various cell f

155 Glycosphingolipids (GSLs) are of fundamental importance

156 Glycosphingolipids (GSLs) at the cell surface membrane a

157 an altered profile of lipid raft-associated glycosphingolipids (GSLs) compared with that of healthy

158 Glycosphingolipids (GSLs) constitute major components of

159 nstrate a crucial role for host cell-derived glycosphingolipids (GSLs) for the initial interactions o

160 Glycosphingolipids (GSLs) have been shown to undergo str

161 ellular ceramide levels and the synthesis of glycosphingolipids (GSLs) in cellular membranes.

162 ceed in detection and structural analysis of glycosphingolipids (GSLs) in crude lipid extracts, which

163 Accumulation of glycosphingolipids (GSLs) in lysosomal storage diseases

164 ontributions of the N-glycans, O-glycans and glycosphingolipids (GSLs) in regulating complex biologic

165 d increased amounts of GlcCer and downstream glycosphingolipids (GSLs) in SOD1(G86R) muscle compared

166 he present study demonstrates involvement of glycosphingolipids (GSLs) in the EMT process by using no

167 lation may exist between increased levels of glycosphingolipids (GSLs) in the lipid rafts of T cells

168 ently, we showed that the expression of some glycosphingolipids (GSLs) is down-regulated during EMT i

169 The biological function of glycosphingolipids (GSLs) is largely determined by their

170 not known, however, whether other structural glycosphingolipids (GSLs) or bioactive signaling sphingo

171 The ability of different glycosphingolipids (GSLs) to activate type I natural kil

172 Coccolithoviruses employ a suite of glycosphingolipids (GSLs) to successfully infect the glo

173 oside GM2, suggesting a close association of glycosphingolipids (GSLs) with EMT.

174 e, which we found to be comprised largely of glycosphingolipids (GSLs) with lesser amounts of polar g

175 We focus on glycosphingolipids (GSLs), a class of glycoconjugates th

176 that homeostasis of a subset of lipids, the glycosphingolipids (GSLs), is severely perturbed in the

177 t is widely believed that these self-Ags are glycosphingolipids (GSLs), molecules that contain cerami

178 An accompanying storage of glycosphingolipids (GSLs), most notably GM2 and GM3 gang

179 However, glycosphingolipids (GSLs), not cell surface proteins, we

180 Glycosphingolipids (GSLs), particularly globo-series GSL

181 tegrin signaling are stimulated by exogenous glycosphingolipids (GSLs).

182 y insufficient degradation of myelin-related glycosphingolipids (GSLs): galactosylceramide and galact

183 Depletion of glycosphingolipids (GSLs; a subgroup of SLs) selectively

184 Galactosyl ceramide, a glycosphingolipid, has been postulated to be a receptor

185 Glycosphingolipids have been shown to accumulate in huma

186 ngliosides, which are sialic acid-containing glycosphingolipids highly enriched in the mammalian nerv

187 ctosidase, and beta-galactosidase) mediating glycosphingolipid hydrolysis were also elevated up to th

188 Here, we report that ganglioside GD2 (a glycosphingolipid) identifies a small fraction of cells

189 h the recognition of an endogenous lysosomal glycosphingolipid, iGb3, presented by LPS-activated dend

190 lts demonstrate the caveolar accumulation of glycosphingolipids in an in vitro model of a lysosomal s

191 e cycle and suggests a link between PI4P and glycosphingolipids in HCV genome replication.

192 ation, further arguing for the importance of glycosphingolipids in HCV RNA synthesis.

193 ly sensitive method to monitor the uptake of glycosphingolipids in infected red blood cells (iRBCs).

194 leads to the accumulation of cholesterol and glycosphingolipids in late endosomes and early lysosomes

195 s to massive accumulation of cholesterol and glycosphingolipids in late endosomes and lysosomes.

196 ntracellular accumulation of cholesterol and glycosphingolipids in many tissues, including the brain.

197 The present study describes the role of glycosphingolipids in neuroinflammatory disease and inve

198 Our study sheds new light on the impact of glycosphingolipids in the cellular invasion of bacterial

199 tes, for the first time, the crucial role of glycosphingolipids in the HCV life cycle and suggests a

200 idase A (alpha -GalA), which leads to excess glycosphingolipids in tissues, mainly globotriaosylceram

201 tructural characterization of membrane-bound glycosphingolipids include their high internal dynamic m

202 contain large quantities of cholesterol and glycosphingolipids, including glucosylceramide synthase

203 Ganglioside GM3, a host-derived glycosphingolipid incorporated in the membrane of human

204 tor studies, pharmacological accumulation of glycosphingolipids increased activation of the endoplasm

205 Purified glycosphingolipids induced biochemical hallmarks of prog

206 Glycosphingolipid inhibitors augmented insulin-stimulate

207 Glycosphingolipids, integral components of the cell memb

208 he recruitment of PI(4,5)P2, cholesterol and glycosphingolipids into larger clusters.

209 The x2 glycosphingolipid is expressed on erythrocytes from indi

210 sting that fine specificity for alpha-linked glycosphingolipids is influenced by Valpha-encoded TCR r

211 Lysosomal degradation of glycosphingolipids is mediated by the consecutive action

212 While the accumulation of cholesterol and glycosphingolipids is seen as a primary hallmark of NPC1

213 Galactosylceramide (GalCer), a glycosphingolipid, is believed to exist in the extracell

214 d mass spectrometry characterization of acid glycosphingolipids isolated from a large number (1 x 10(

215 urther work we found that application of the glycosphingolipid lactosylceramide to CLN3-deficient cel

216 minidase 1 expression, and the levels of the glycosphingolipid lactosylceramide.

217 ncy results in intracellular accumulation of glycosphingolipids, leading to a variety of clinical man

218 XCR3, reducing renal T cell infiltration and glycosphingolipid levels.

219 allowed identification of several novel acid glycosphingolipids, like the gangliosides sialyl-lactote

220 rate conformation has broad implications for glycosphingolipid macromolecule recognition and ligand b

221 lactosidase A and subsequent accumulation of glycosphingolipids (mainly globotriaosylceramide, Gb3),

222 how early and significant dysfunction of the glycosphingolipid metabolic pathway in the kidneys of lu

223 d vestibular neurons suggests that alternate glycosphingolipid metabolic pathways predominate in thes

224 ylceramide (LacCer) is a key intermediate in glycosphingolipid metabolism and is highly enriched in d

225 used to quantify cell-to-cell variability in glycosphingolipid metabolism as a function of cellular l

226 Here, we show dysfunctional glycosphingolipid metabolism in patients with lupus neph

227 We report a method for the analysis of glycosphingolipid metabolism in single cells.

228 Inhibiting glycosphingolipid metabolism increased insulin sensitivi

229 Here, we investigated whether altered glycosphingolipid metabolism is a modulator of disease c

230 Thus, dysfunctional glycosphingolipid metabolism may contribute to metabolic

231 cent genetic evidence suggests that aberrant glycosphingolipid metabolism plays an important role in

232 Glycosphingolipid metabolism relies on selective recruit

233 of cell-to-cell diversity and regulation of glycosphingolipid metabolism.

234 5) and neuraminidase 1, enzymes that mediate glycosphingolipid metabolism.

235 The endogenous glycosphingolipid metabolite, isoglobotrihexosylceramide

236 also known as phosphoprotein associated with glycosphingolipid microdomains (PAG), is the membrane ad

237 ht to evaluate the therapeutic potential for glycosphingolipid modulation as a new approach to treat

238 ic stem cells, a number of type 2 core chain glycosphingolipids (neo-lactotetraosylceramide, the H ty

239 the conclusion that on human neutrophils the glycosphingolipid NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-3[G

240 ailable crystal structures of alpha-anomeric glycosphingolipids now sheds light on the structural bas

241 ons in association with lysosomal storage of glycosphingolipids occurs in patients with this disease,

242 It is the most abundant non-acid glycosphingolipid on erythrocytes and displays the same

243 d weak agonist, galacturonic acid-containing glycosphingolipid, or a synthetic agonist, alpha-galacto

244 metabolomic reports connect dysregulation of glycosphingolipids, particularly ceramide and glucosylce

245 Here, we provide evidence that glycosphingolipids play an important role in muscle inne

246 ucosylceramide (GlcCer), one of the simplest glycosphingolipids, plays key roles in physiology and pa

247 ed sugar, mammalian self Ags are beta-linked glycosphingolipids, posing the interesting question of h

248 Gangliosides, sialic acid-containing glycosphingolipids present in the outer leaflet of plasm

249 Natural killer T (NKT) cells recognize glycosphingolipids presented by CD1d molecules and have

250 T (NKT) cells recognize a restricted set of glycosphingolipids presented by CD1d molecules, includin

251 on to the globo-series and type 1 core chain glycosphingolipids previously described in human embryon

252 omains as shown by visualizing a fluorescent glycosphingolipid probe, BODIPY-LacCer, incorporated int

253 phingomonas spp.) known to express antigenic glycosphingolipid products.

254 toxin, gains entry into human cells via the glycosphingolipid receptor Gb3.

255 Three glycosphingolipids recognized by both specialist and gen

256 Previously defined foreign glycosphingolipids recognized by NKT cells are uniquely

257 We show that viral glycosphingolipids regulate infection of Emiliania huxle

258 l activation of Valpha14i NKT cells by these glycosphingolipids requires a relatively high-affinity T

259 The consequent abnormal accumulation of glycosphingolipids results in several clinical signs and

260 The addition of cholesterol disrupts the glycosphingolipid selectively but perturbs the di-satura

261 These glycosphingolipid species have been shown to play variou

262 Multiple glycosphingolipid species were also detected.

263 ha-chain elements contribute to alpha-linked glycosphingolipid specificity, whereas TCR beta-chains c

264 , but when it is dysfunctional, sphingosine, glycosphingolipids, sphingomyelin and cholesterol accumu

265 may be important for understanding lysosomal glycosphingolipid storage disorders.

266 n resulted in cholesterol, sphingomyelin and glycosphingolipid storage in these compartments.

267 h the importance of both glycoprotein(s) and glycosphingolipid structures displaying sialyl Lewis X e

268 pha-galactosidase A (alpha-GalA) activities, glycosphingolipid substrate levels, and in vitro mutatio

269 y incubated with three fluorescently labeled glycosphingolipid substrates, GM3-BODIPY-FL, GM1-BODIPY-

270 yme contributes to the cellular recycling of glycosphingolipids such as galabiosylceramide (Ga2), glo

271 lyl-globotetraosylceramide, and the sulfated glycosphingolipids sulfatide, sulf-lactosylceramide, and

272 Inhibition of glycosphingolipid synthesis also suppressed glucosamine-

273 Inhibition of glycosphingolipid synthesis ameliorates atherosclerosis

274 Thus inhibiting glycosphingolipid synthesis can be a bonafide target to

275 Here, we show that an inhibitor of glycosphingolipid synthesis can improve glucose control

276 These results suggest that inhibiting glycosphingolipid synthesis can significantly improve in

277 Here, we have examined whether inhibition of glycosphingolipid synthesis could ameliorate atheroscler

278 Targeting glycosphingolipid synthesis has emerged as a novel appro

279 treatments with methyl-beta-cyclodextrin and glycosphingolipid synthesis inhibitors did not abolish c

280 Thus, inhibition of glycosphingolipid synthesis may be a novel approach to a

281 By linking glycosphingolipid synthesis with tumor growth, renal can

282 ce were fed 5 or 10 mg/kg of an inhibitor of glycosphingolipid synthesis, D-threo-1-phenyl-2-decanoyl

283 r not ceramide glycosylation, which controls glycosphingolipid synthesis, plays a role in modulating

284 ace by a lipid flippase in order to nucleate glycosphingolipid synthesis.

285 which catalyses the first committed step of glycosphingolipid synthesis.

286 abolic products of the fluorescently labeled glycosphingolipid tetramethylrhodamine labeled GM1 (GM1-

287 GM1 ganglioside is a glycosphingolipid that has been reported to be beneficia

288 B pentamer (CTxB) that binds up to five GM1 glycosphingolipids to enter host cells.

289 (HCPs), and the carbohydrate content of CHO glycosphingolipids to estimate the demand of NSs towards

290 of mCD1d and reduced its ability to present glycosphingolipids to NKT cells.

291 Here, we test if the properties of glycosphingolipid trafficking in epithelial cells can be

292 rm of NPC2, suggesting a unique mechanism of glycosphingolipid transfer by NPC2.

293 irus genome replication via PI4P binding and glycosphingolipid transport to the HCV RC.

294 esponse to the accumulation of virus-derived glycosphingolipids upon infection of natural E. huxleyi

295 y, and electron microscopy, whereas sulfated glycosphingolipids were only found in intracellular comp

296 CV significantly increases the level of some glycosphingolipids, whereas adding these lipids to FAPP2

297 hesize gangliosides of the ganglio-series of glycosphingolipids, which are the major ganglioside clas

298 We report here that sialylated glycosphingolipids with 5 N-acetyllactosamine (LacNAc, G

299 Quantitatively minor terminally sialylated glycosphingolipids with 5 to 6 LacNAc repeats and 2 to 3

300 a class of biologically active cell surface glycosphingolipids with known immunosuppressive properti