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1 tides with glycans attached to each specific glycosylation site.
2 he N38S amino acid change and a loss of an N-glycosylation site.
3 main, was not affected by mutation of this N-glycosylation site.
4 envelope proteins or introduction of a novel glycosylation site.
5 extensive heterogeneity associated with each glycosylation site.
6 in the V3 region rather than losing the N332 glycosylation site.
7 g specificity and remove a critical N-linked glycosylation site.
8 s associated with the presence of a specific glycosylation site.
9 on sequence motif will lead to the loss of a glycosylation site.
10 structural determination of the alpha7 nAChR glycosylation site.
11 of this viral strain lacks the new putative glycosylation site.
12 en to modify the mouse genome to remove this glycosylation site.
13 rands, with the former burying one prominent glycosylation site.
14 roxylases (P4Hs), defines their subsequent O-glycosylation sites.
15 sion protein that contains multiple N- and O-glycosylation sites.
16 beta-hCG bearing model glycans at all native glycosylation sites.
17 g glycan structures with their corresponding glycosylation sites.
18 was then used to pinpoint the 12 occupied O-glycosylation sites.
19 O-linked glycans and located the occupied O-glycosylation sites.
20 a reesei Family 7 cellobiohydrolase at three glycosylation sites.
21 hat of JR-FL or with mutations in putative N-glycosylation sites.
22 enaviruses is glycosylated at 11 conserved N-glycosylation sites.
23 te domains incorporated at all of the native glycosylation sites.
24 of HIV diversity by tracking gp120 N-linked glycosylation sites.
25 IL-15Ralpha and characterization of multiple glycosylation sites.
26 labelling to be the hexose at several of the glycosylation sites.
27 id of glycans at the first, second or both N-glycosylation sites.
28 inatorial mutagenesis of all six potential N-glycosylation sites.
29 involved modifications of potential N-linked glycosylation sites.
30 -fold depletion in substitutions at O-linked glycosylation sites.
31 , FM/47, and FW/50 differ in the presence of glycosylation sites.
32 the disaccharide chitobiose at the natural N-glycosylation sites.
33 ndered nonfunctional by disruption of single glycosylation sites.
34 rved N-glycan or the deletion of predicted O-glycosylation sites.
35 nto glycosylation, resulting in unoccupied N-glycosylation sites.
36 It bears 11 glycosylation sites.
37 e high evolutionary conservation of all four glycosylation sites.
38 acid substitutions and continual addition of glycosylation sites.
39 but failed to detect those further from the glycosylation sites.
40 98 degrees C), and absence of cysteines and glycosylation sites.
41 se is glycosylated at all twelve potential N-glycosylation sites.
42 Exon 16 also includes two O-glycosylation sites.
43 h of gp120 at the Asn332, Asn392, and Asn386 glycosylation sites.
44 hages transfected with FcgammaRIa in which N-glycosylation sites 1, 4, and 5 are mutated to alanines
48 mapping and comparing variable loop N-linked glycosylation sites across populations of HIV-1 sequence
49 Moreover, classical cadherins have multiple glycosylation sites along their extracellular regions.
50 antibody sensitivity, and putative N-linked glycosylation sites along with a comprehensive sequence
51 f gp120, here we report the first systematic glycosylation site analysis of gp120 derived from virion
53 web server described here, the HIV N-linked Glycosylation Site Analyzer, was developed to facilitate
54 tionic 6-deoxymannose sugar at the canonical glycosylation site and a second sugar, an unusual 4-O-me
55 ot ROM1, is glycosylated and we examined the glycosylation site and glycan composition of ROM1 by liq
56 ed for extracting DIA data is common to that glycosylation site and not dictated by a specific MS1 va
57 able the identification of peptide sequence, glycosylation site and the structure of intact glycopept
58 esults demonstrate a critical role for the N glycosylation sites and cysteines for the structure and
59 -III, di-sialylated glycans at multiple A1AT glycosylation sites and desialylated A2HSG, and depleted
60 have enabled the identification of specific glycosylation sites and glycan structures that modulate
61 correlates inversely with putative N-linked glycosylation sites and positively with virion infectivi
63 shown to be heavily N-glycosylated, but the glycosylation sites and the biological role of N-linked
64 lating H3N2 viral strain (that possesses the glycosylation site) and humans vaccinated with baculovir
65 eneity (different glycoforms attached to one glycosylation site) and macroheterogeneity (site occupan
66 fied as a 73 amino acid protein having one N-glycosylation site, and a variant 74 residue non-glycosy
68 edicted secretion leader sequences, N-linked glycosylation sites, and a putative site of tyrosine sul
69 he K(2P) channels possess consensus N-linked glycosylation sites, and here we demonstrate that the co
70 in the stalk region abolishing the N-linked glycosylation site; and 2 variants represented the head
71 elucidation of the glycan structure and the glycosylation site are needed to reveal the biological f
72 ons in both the number and distribution of N-glycosylation sites are found in the 18 alpha and 8 beta
73 lastidal reporter proteins with artificial N-glycosylation sites are indeed glycosylated during trans
74 or wild type KCNE1, the overlapping N- and O-glycosylation sites are innocuous for subunit biogenesis
75 t form, three of the four potential N-linked glycosylation sites are modified by carbohydrate attachm
76 of FlgA1 confirm that its three predicted N-glycosylation sites are modified with covalently linked
77 ere linkers connect to structured domains, O-glycosylation sites are observed less frequently, wherea
81 lidated the congruence of the potential HA N-glycosylation sites as well as the presence of the HA pe
85 procal experimental approach, deletion of HA glycosylation sites (Asn 142 and Asn 177, but not Asn 71
86 1)NDS N-glycosylation motif, but not other N-glycosylation sites (Asn(260), Asn(371), and Asn(394)),
90 pies Cys200/Cys209 residues, one of the SERT glycosylation sites, Asp208 located between the two Cys
91 attenuated in mice by adding two additional glycosylation sites (asparagine [Asn] 71 and Asn 286) on
96 nsitive to the presence of a single N-linked glycosylation site at asparagine 297 of the Fc, with deg
97 epeats contain an evolutionarily conserved O-glycosylation site at position -1 of the first cysteine
98 ion of an additional fully occupied N-linked glycosylation site at the N terminus at position 1 (equi
99 milarity with beta-hLH, including a common N-glycosylation site at the N-terminus but differs mainly
100 tudy, we have introduced individual N-linked glycosylation sites at several positions spaced at inter
101 ssociated with changes in potential N-linked glycosylation sites but not CD4 independence or CXCR4 us
102 quantification of glycosylated peptides and glycosylation sites but not glycosylation occupancy or g
103 eted protein was due not to the loss of an N-glycosylation site, but rather an SNP-specific targeting
104 red for histamine catabolism, has multiple N-glycosylation sites, but their roles, for example in DAO
105 ein abundance but also the occupancy of each glycosylation site by different glycoforms during biolog
106 ssess the relative occupancies of numerous N-glycosylation sites by endoglycosidase H-resistant N-gly
107 es have been identified for the selection of glycosylation sites by GalNAc-Ts: confined sequence reco
108 an side chain remains intact in ETD, and the glycosylation site can be localized on the basis of the
110 re conditions, or introduction of artificial glycosylation sites, can alter CBM binding affinity to c
111 in PNS myelin and mutations in which at the glycosylation site cause Charcot-Marie-Tooth neuropathy,
114 oplasmic reticulum or mutation of the Asn-24 glycosylation site decreased GC activity, but neither in
115 uences into NCAM Ig5, including an "extra" N-glycosylation site, decreases or completely blocks NCAM
116 al elimination of evolutionarily conserved N-glycosylation sites did not abolish proper KOR1 folding,
118 We suggest that the occasional absence of glycosylation sites encoded in the conserved regions of
119 IgM exhibits different accessibility of the glycosylation sites, explaining site-specific glycosylat
122 lycosylation sites to 1918 HA and removal of glycosylation sites from SI/06 HA imposed constraints on
123 s focus mainly on either the de-glycosylated glycosylation site (glycosite)-containing peptides or th
125 we confirmed that such mutations at multiple glycosylation sites greatly diminish viral infectivity a
131 C.2a H3N2 viruses possessing a new predicted glycosylation site in antigenic site B of HA emerged, an
132 e ~10 amino acids that surround the Asn(154) glycosylation site in each of the 180 envelope glycoprot
134 ession and that a mutation that eliminates a glycosylation site in HA(1) allows the Israel810 HA to g
135 ion CLRN1(N48K), which affects a conserved N-glycosylation site in hCLRN1, is a common causative USH3
136 we demonstrate that the conserved putative N-glycosylation site in K(2P)3.1 and K(2P)9.1 is a glycan
137 sequence motif, VNDT, containing an N-linked glycosylation site in the envelope (E) protein, is polym
138 um channels have a highly conserved N-linked glycosylation site in the first extracellular loop, with
139 of glycosylation at both or the first PrP(C) glycosylation site in the host results in almost complet
142 t and N-glycosylation analysis identified 73 glycosylation sites in 65 aleurone layer proteins, with
143 l-amino acid cassettes into closely spaced O-glycosylation sites in a single, high-yielding solid-sup
144 in the greatest number of glycoproteins and glycosylation sites in biological duplicate experiments.
145 ring MCTC, with viruses of shorter and fewer glycosylation sites in env present in IP transmission, o
147 The determination of N- and O-glycans and O-glycosylation sites in etanercept provides a basis for f
150 ortance of the conserved cysteines and the N-glycosylation sites in NBCe1-A EL-3, we analyzed the pot
152 y machinery, including the identification of glycosylation sites in secreted proteins, an important g
153 upon complex oligosaccharide processing of N-glycosylation sites in the amino-terminal domain and dow
154 e investigate the contribution of individual glycosylation sites in the formation of this so-called i
156 homa (FL), but not normal B cells, acquire N-glycosylation sites in the immunoglobulin variable regio
158 ations (Asn to Gln) at the seven potential N-glycosylation sites in the NiV G ectodomain (G1 to G7) i
160 were shorter and had fewer putative N-linked glycosylation sites in the V1-V5 region than matched mat
161 ly shown that ablation of the three N-linked glycosylation sites in the West Nile virus NS1 protein c
162 Mass spectrometric analysis identified five glycosylation sites in type I collagen (i.e. alpha1,2-87
163 f HIV-1 sequence alignment by using N-linked glycosylation sites in variable loops as alignment ancho
165 2 is insensitive to disruption of multiple N-glycosylation sites, in contrast with the related recept
166 haracterize C. jejuni JHH1 and identified 93 glycosylation sites, including 34 not previously reporte
168 s suggest that the loss of the N173 N-linked glycosylation site increases SIVmac239 replication in ma
172 merization could be abolished by engineering glycosylation sites into the dimer interface; other inte
173 DT motif is deleted or in which the N-linked glycosylation site is mutated by single-amino-acid subst
175 an species from both the Fab and Fc N-Linked glycosylation sites is consistent with quantification us
176 data indicate that utilization of several N-glycosylation sites is important for KOR1 activity, wher
178 the IgG sequence, in addition to unambiguous glycosylation site localization and extensive coverage o
180 we found that the elimination of a conserved glycosylation site located in Loop D and two glycosylati
181 glycosylation site located in Loop D and two glycosylation sites located in variable region 5 of Env
182 to routinely assess the glycan type at each glycosylation site may facilitate design of improved vac
183 the most N-terminal of three beta3 subunit N-glycosylation sites, might reduce GABAergic inhibition b
186 irus-expressed H3 antigens (that possess the glycosylation site motif) were able to efficiently recog
187 he cellular and supernatant fractions, while glycosylation site mutants did not adversely affect viri
189 atory sequences established that all eight N-glycosylation sites (N1 to N8) are used in the wild type
190 xtracellular domain of KOR1 contains eight N-glycosylation sites, N1 to N8, of which only N3 to N7 ar
192 229) is needed for TC-Cbl binding, but the N-glycosylation sites (N126, N195, and N213) are of no imp
193 A2m(1), the engineered molecule lacked two N-glycosylation sites (N166 and N337), two free cysteines
194 ere, we identify a highly conserved N-linked glycosylation site (N173 in SIV, corresponding to N160 i
197 ses contains 2 completely conserved N-linked glycosylation sites (NGSs) at N563 and N618, suggesting
198 nce analysis shows that PRRSV-01 lacks two N-glycosylation sites, normally present in wild-type (wt)
199 r Envs displayed marked differences in their glycosylation site occupancies and in their amounts of c
203 nsmitted/founder Envs had similar degrees of glycosylation site occupancy as well as similar glycan p
209 8% of the variations that lead to changes in glycosylation sites occur at the loop and bend regions o
210 of-function mutation (S562L) in a putative S-glycosylation site of GmCLV1A causes stem nodal identity
211 e how hemophilia mutations near the unused N-glycosylation site of the A2 domain (N582) of FVIII affe
214 r indicated that, among the four potential N-glycosylation sites of E-cadherin, Asn-554 is the key si
215 vation of any of the four predicted N-linked glycosylation sites of Ly49B, nor was it affected by rem
216 o elucidate the functional significance of N-glycosylation sites of STIM1, we created different mutat
219 is heavily glycosylated at approximately 25 glycosylation sites, of which approximately 7-8 are loca
220 sites, a third novel, albeit low abundant, N-glycosylation site on C9 is identified, which surprising
225 ered A(H1N1)pdm IAV with differing potential glycosylation sites on HA for sensitivity to collectins
226 s spectrometry-based technique for mapping O-glycosylation sites on herpes simplex virus type 1.
227 O cells, the number of N-linked and O-GalNAc glycosylation sites on individual host cell proteins (HC
228 rein, we have systematically characterized O-glycosylation sites on recombinant LDLR shed from HEK293
230 uantification results demonstrated that many glycosylation sites on surface proteins were down-regula
232 o determine the influence of these missing N-glycosylation sites on the distinct neutralization pheno
234 d of heavily glycosylated polymers with five glycosylation sites on the mu (heavy) chain and one glyc
235 her attenuated by introducing two additional glycosylation sites on the top of the HA head at Asn 142
237 Ab molecule containing two distinct N-linked glycosylation sites: one present on the heavy chain (HC)
238 creases directly with the number of N-linked glycosylation sites, our results indicate that additiona
239 are distinguished by compact Envs with fewer glycosylation sites, our study points to fusion and poss
240 VWF variant that predicts disruption of an O-glycosylation site (p.Ser1486Leu) and a rare variant enc
244 contained fewer potential asparagine-linked glycosylation sites (PNGSs) in variable region 5 (V5) th
246 sylation, and particularly the enrichment in glycosylation sites proximal to the disulfide linkages a
248 by generating an additional (third) N-linked glycosylation site, resulting in protein misfolding and
250 re were no differences in protease cleavage, glycosylation sites, signal peptides or trans-membrane d
251 ce of protease cleavage sites, Pfam domains, glycosylation sites, signal peptides, trans-membrane pro
252 intact glycopeptides corresponding to eight glycosylation sites (six N-linked and two O-linked sites
253 on or by mutation of all of the 10 predicted glycosylation sites, ST binding and surface localization
254 han nonsynonymous mutations, and conserved N-glycosylation sites, suggesting that some of the HERV-K
256 ionally, we report a newly observed O-linked glycosylation site, T606, and we show that the full O-li
258 ence of multiple phosphorylation sites and a glycosylation site that we find to be occupied by at lea
259 riable regions (V1-V5), and also at N-linked glycosylation sites that contribute roughly half the mas
261 mplex-type biantennary N-glycans linked to N-glycosylation sites that emerge during somatic hypermuta
262 of FI carrying additional surface-exposed N-glycosylation sites that were expected to sterically hin
263 Therefore, for proteins containing multiple glycosylation sites, the individual glycan species prese
264 tures), PRRSV-01 virus quickly regains these glycosylation sites through replication in vivo, suggest
266 this study, we tried to identify atypical N-glycosylation sites using our recently developed solid-p
269 harides and the type of substitution at each glycosylation site was determined by chemical, spectrosc
272 terization of complex proteins with multiple glycosylation sites we utilized 2D LC, where RP separati
273 to decipher the function of its potential N-glycosylation site, we produced pro-KLK2 in Leishmania t
274 on and sequential mutagenesis of potential N-glycosylation sites, we identified TMEM106B as a type 2
276 Vpp and HCVcc that contained this new HVR495 glycosylation site were less sensitive to antibody neutr
280 del for this antibody indicated that several glycosylation sites were critical for neutralization.
283 glycoproteins showed that extreme C-terminal glycosylation sites were modified by an STT3B-dependent
285 dic N-linked oligosaccharides, the six other glycosylation sites were modified with complex N-glycans
288 Glycopeptides from two different N-linked glycosylation sites were separated from all other trypti
289 tries in mouse Notch1 and identified a novel glycosylation site with alanine in place of proline, sug
292 re was considerable variation in potential N-glycosylation sites, with GA2 and ON1 viruses showing up
293 the latter introducing a potential N-linked glycosylation site within a predicted CD4-binding pocket
295 1Delta phenotype, while mutation of a single glycosylation site within Msb2 was sufficient to confer
298 ty assays on CDKAL1 constructs carrying an N-glycosylation site within the luminal domain, we further
299 bution, and mutation of a predicted N-linked glycosylation site within the N-terminus disrupts GAR-3-
300 rom the recent outbreaks contain an N-linked glycosylation site within the viral envelope (E) protein
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