ライフサイエンスコーパス: glyoxalase I

1 tivity relevant to Ni(II)-containing E. coli glyoxalase I.

2 planation for the stereochemical behavior of glyoxalase I.

3 ve inhibitor of the anticancer target enzyme glyoxalase I.

4 inhibit the methylglyoxal-detoxifying enzyme glyoxalase I.

5 ate that forms along the reaction pathway of glyoxalase I.

6 C is diminished in the absence of functional glyoxalase I.

7 ay for MG in E. coli and that the product of glyoxalase I activity, S-lactoylglutathione, is the acti

8 Glyoxalase-I activity in these cells was increased 28-fo

9 To evaluate directly the effect of glyoxalase-I activity on intracellular AGE formation, GM

10 Glyoxalase I alone among the core MG protective systems

11 ncient betaalphabetabetabeta fold motif with glyoxalase I and bleomycin resistance protein families,

12 is of published values for the activities of glyoxalase I and glyoxalase II in lysed erythrocytes and

13 Comparison with related enzymes (glyoxalase I and MnSOD) suggests that the change in the

14 or detoxification of reactive electrophiles: glyoxalase I and N-ethylmaleimide reductase.

15 ied proteins, whereas other targets, such as glyoxalase I and ribose 5-phosphate isomerase, detoxify

16 elated to at least two other metalloenzymes, glyoxalase I and the Mn2+- or Fe2+-containing extradiol

17 The structure of the active site of human glyoxalase I and the reaction mechanism of the enzyme-ca

18 Glyoxalase-I and gamma-glutamyl transpeptidase, both inv

19 strains contained the glutathione-dependent glyoxalases I and II, as well as the glutathione-indepen

20 Thus, glyoxalase I appears to be a novel example of a single p

21 ites of human, yeast, and Pseudomonas putida glyoxalase I, as the log K(i) values for these mechanism

22 llographic measurements, indicate that human glyoxalase I binds the syn-conformer of S-(N-aryl-N-hydr

23 For the glyoxalase-I-catalyzed isomerization of glutathione (GSH

24 Glyoxalase I catalyzes still another glutathione-depende

25 Glyoxalase-I catalyzes the conversion of MG to S-D-lacto

26 Overexpression of glyoxalase-I completely prevented both hyperglycemia-ind

27 s that are catalyzed include isomerizations (glyoxalase I), epimerizations (methylmalonyl-CoA epimera

28 Cells overexpressing glyoxalase I exhibit enhanced tolerance of methylglyoxal

29 um-1,2-diolate) , we observed both decreased glyoxalase I expression and activity relative to untreat

30 nct superfamily of metalloenzymes containing glyoxalase I, extradiol dioxygenases, and methylmalonyl-

31 The glyoxalase I gene (gloA) of Escherichia coli has been cl

32 on is performed by a trypanothione-dependent glyoxalase I (GLO1) containing a nickel cofactor; all ot

33 say of MGS by coupling of the MG produced to glyoxalase I (Glx I): MG + glutathione (GSH) --> (S)-lac

34 The BSH-dependent pathway utilizes glyoxalase I (GlxA, formerly YwbC) and glyoxalase II (Gl

35 The metalloenzyme glyoxalase I (GlxI) converts the nonenzymatically produc

36 Escherichia coli glyoxalase I (GlxI) is a metalloisomerase that is maxima

37 ed to study the catalytic mechanism of human glyoxalase I (GlxI).

38 domain-swapped dimer but Pseudomonas putida glyoxalase I has been reported to be monomeric.

39 Human glyoxalase I has the structure of a domain-swapped dimer

40 The structures of human glyoxalase I in complexes with S-(N-hydroxy-N-p-iodophen

41 Overexpression of glyoxalase I in HRP protected against S-p-bromobenzylglu

42 the role of MGO and its metabolizing enzyme, glyoxalase I, in high glucose-induced apoptosis (annexin

43 c complexicity that have plagued the area of glyoxalase I inhibition.

44 se in the intracellular concentration of the glyoxalase I inhibitor (kapp = 1.41 +/- 0.03 min-1 (37 d

45 thylglyoxal metabolism with a cell permeable glyoxalase I inhibitor provoked these responses in normo

46 (N-aryl-N-hydroxycarbamoyl)glutathione-based glyoxalase I inhibitors culminated in the discovery of t

47 We show here that recombinant P. putida glyoxalase I is an active dimer (kcat approximately 500

48 Our findings indicate that glyoxalase I is critical for pericyte survival under hyp

49 data suggest that the glutathione-dependent glyoxalase I is the dominant detoxification pathway for

50 Glyoxalase-I is a glutathione-binding protein involved i

51 or the more active H-2d-linked allele at the Glyoxalase I locus.

52 Knowledge regarding the regulation of glyoxalase-I may provide insights into the importance of

53 hibition is due to competitive inhibition of glyoxalase I, preincubation of L1210 cells with 2(Et)2 i

54 on-dependent kinetic properties of the yeast glyoxalase I reaction have been measured by means of vis

55 e quantum motif for the investigation of the glyoxalase I reaction.

56 of the enzyme and about the mechanism of the glyoxalase I reaction.

57 To gain a better understanding of the glyoxalase-I regulation under normal physiological condi

58 lopentyl diester, a competitive inhibitor of glyoxalase I, resulted in apoptosis along with a dramati

59 In contrast, in glyoxalase-I-transfected cells, 30 mM glucose incubation

60 endothelial cells that stably express human glyoxalase-I were generated.