ライフサイエンスコーパス: goat

1 e, and camel) and small livestock (sheep and goat).

2 zed by the enzyme ghrelin O-acyltransferase (GOAT).

3 in raw milk samples (cow, buffalo, ewe, and goat).

4 oinformatic tools to predict the topology of GOAT.

5 de-based bisubstrate analog that antagonizes GOAT.

6 lls infected with baculovirus encoding mouse GOAT.

7 te the future design of useful inhibitors of GOAT.

8 al diversity, followed by reindeer, and then goat.

9 species, including cow, buffalo, sheep, and goat.

10 alo and a third type (III) was isolated from goat.

11 rminants for scrapie occurrence in sheep and goats.

12 lly occurring BSE has been identified in two goats.

13 nly two instances has BSE been discovered in goats.

14 ng individual raw milk samples of Girgentana goats.

15 e homogeneously distributed in LT than in ST goats.

16 slower and more anisotropic in LT than in ST goats.

17 ities in the offspring of cattle, sheep, and goats.

18 nomically significant diseases of cattle and goats.

19 tion confirming strong genetic resistance in goats.

20 a burnetii-related abortions in 450 pregnant goats.

21 a causative agent of contagious agalactia in goats.

22 of the genome that influence these traits in goats.

23 on influencing fecundity traits within dairy goats.

24 oups of fats in milk samples from individual goats.

25 was identified in swine, cattle, sheep, and goats.

26 h rate of this goat outperformed the control goats.

27 erent abundance between control and infected goats.

28 layed clinical signs compared with wild-type goats.

29 Subsequently, the technique was applied to goat (69.03+/-6.23mg GAE/L), cow (49.00+/-10.77mg GAE/L)

30 In goats, a reduction in dystrophin and nNOS protein conten

31 ment of a novel fluorescence-based assay for GOAT activity and the use of this assay to investigate G

32 GOAT activity could be inhibited by an octanoylated ghre

33 GOAT activity requires catalytic asparagine and histidin

34 Goat adipose-derived stem cells (gADSCs) were transduced

35 ignificantly increased in the left atrium of goats after 2 weeks of AF and in patients who developed

36 GOAT also transferred [(3)H]octanoyl to a pentapeptide c

37 tibial marrow is dependent upon acylation by GOAT and activation of GHS-R.

38 qually effective MERS virus receptors, while goat and bat receptors were considerably less effective.

39 lls to MERS-CoV infection more robustly than goat and bat receptors.

40 fection and passage of these SAT isolates in goat and buffalo cell lines demonstrated a direct correl

41 from five libraries obtained from two mixed goat and cow milk samples, one buffalo mozzarella cheese

42 The oxidation potential of iron fortified goat and cow milks and casein phosphopeptides obtained f

43 n the Se, and Cr intakes for healthy adults, goat and cow yogurts may be important dietary sources.

44 Transcripts for both GOAT and ghrelin occur predominantly in stomach and panc

45 r a deeper understanding of the mechanism of GOAT and other MBOATs and could ultimately advance the d

46 lipid compositions of the MFGM from bovine, goat and sheep milks.

47 res containing beef, chicken, camel, rabbit, goat and sheep with varying percentage of pork (0%, 1%,

48 e natural target species of the virus-sheep, goats and cattle.

49 800 gastric biopsy specimens of cows, sheep, goats and human beings.

50 dies present in the antisera from vaccinated goats and humans bind epitopes overlapping with those of

51 E1E2 antibodies present within antisera from goats and humans immunized with HCV-1 rE1E2 was conducte

52 ed a genome wide association study in French goats and identified 109 regions associated with dairy t

53 orphisms in sheep, they are more numerous in goats and may be restricted to certain breeds or geograp

54 ing season sexual smells of male crocodiles, goats and other animals, too, could have evolved by sexu

55 Goats and sheep are versatile domesticates that have bee

56 prine and ovine 50K SNP BeadChips from Barki goats and sheep that are indigenous to a hot arid enviro

57 to generate Mstn knock-out (KO) rabbits and goats and then analyzed the changes in their phenotypes

58 introduced into 14 additional genes in pig, goat, and cattle fibroblasts using TALEN mRNA and oligon

59 milk metabolomes of different species (cow, goat, and human) and types.

60 55 swine, 50 cattle, 25 horses, 57 sheep, 14 goats, and 1 llama were obtained and plated onto Enteroc

61 Cattle, sheep, goats, and camels are particularly susceptible to RVF an

62 uding domesticated livestock (cattle, sheep, goats, and camels) and wildlife collected from a total o

63 re economically important diseases of sheep, goats, and cattle, respectively.

64 ing swabs and EDTA blood from control sheep, goats, and cattle.

65 tissues from experimentally infected sheep, goats, and cattle.

66 All sheep, goats, and mice challenged with the isogenic etx mutant

67 n an intraduodenal challenge model in sheep, goats, and mice using a virulent C. perfringens type D w

68 All sheep and goats, and most mice, challenged with the WT isolate dev

69 perfringens type D causes disease in sheep, goats, and other ruminants.

70 n toxin causes fatal enterotoxemia in sheep, goats, and possibly humans.

71 spongiform encephalopathy (TSE) of sheep and goats, and scrapie eradication in sheep is based in part

72 and Mn concentrations of different types of goat- and cow-milk fermented products and evaluate the i

73 In early 2009, a dairy-goat annex care farm in South Limburg, the Netherlands,

74 at streptavidin could inhibit the binding of goat anti-biotin antibodies for biotin-cap-1,2-dipalmito

75 the competitive binding of streptavidin and goat anti-biotin for biotin-conjugated lipids was explor

76 Likewise, the binding of goat anti-hamster immunoglobulin G (IgG) antibody was no

77 histamine release in response to polyclonal goat anti-human IgE > or = 10% are classified as CIU res

78 d with anti-biotin antibody and FITC-labeled goat anti-mouse antibody, and examined under a confocal

79 Mouse IgG and goat anti-mouse IgG are selected as a model antigen-anti

80 MAb VC-812 and the goat anti-mouse immunoglobulin G (GAM) antibody were spr

81 L cells stimulated using bivalent F(ab')(2) -goat anti-mu antibody (goat anti-mu) exhibited higher me

82 g bivalent F(ab')(2) -goat anti-mu antibody (goat anti-mu) exhibited higher membrane proximal respons

83 ut more cell proliferation and survival than goat anti-mu.

84 e contributed to similar immune responses to goat anti-rabbit IgA and nonspecific goat IgG.

85 nst one of the same epitopes combined with a goat anti-rabbit secondary antibody produced very strong

86 IgG fraction of goat anti-TG3 or control IgG were administered i.p. to 2

87 All mice that received goat anti-TG3 produced papillary dermal immune deposits,

88 Measurements employed goat antichicken secondary antibodies (Ab(2)) labeled wi

89 ng this technique, we were able to show that goat antimouse IgG antibody labeled with Alexa Fluor 488

90 The immunized-goat antiserum was shown to compete with the binding of

91 This knowledge of GOAT architecture is important for a deeper understandin

92 Dairy goats are one of the most utilized domesticated animals

93 Ghrelin O-acyltransferase (GOAT) attaches octanoate to proghrelin, which is process

94 from groundwater in the vicinity of infected goat barnyards that employed aeration of the water was p

95 when game show host Monty Hall revealed the goat behind one of the remaining doors in "Let's Make A

96 Analysis of the mouse genome revealed that GOAT belongs to a family of 16 hydrophobic membrane-boun

97 n insulin cDNA with expression driven by the goat beta-casein gene promoter were generated.

98 by propagating prions from scrapie-infected goat brain in mice.

99 The data obtained for Girgentana goat breed showed that A, B, F variants were alleles ass

100 milk of homozygous individuals of Girgentana goat breed.

101 p improve the management of the French dairy goat breeding program.

102 hich in turn can be used in the selection of goat breeds for environmental adaptation and domesticati

103 ge (9-13x) sequences from eight domesticated goat breeds, representing morphologically or geographica

104 ese results demonstrate that transmission of goat BSE is genotype dependent, and they highlight the p

105 PRNP genotypes were orally inoculated with a goat-BSE isolate to assess their relative susceptibility

106 Of note, enJSRVs are present in sheep and goats but not cattle.

107 While higher doses of organism in goats can produce acute fatal disease, the dose investig

108 est semi-domesticated cervid), and the dairy goat (Capra aegagrus, member of the family Bovidae), to

109 art for de novo assembly using the domestic goat (Capra hircus) based on long reads for contig forma

110 The goat (Capra hircus) is one of the first farm animals tha

111 te and highly suitable for quantification of goat casein genetic variants of homozygous individuals.

112 g isolated and combined probiotic strains to goat "coalho" cheese.

113 These data suggest that goat colostrum and ewe milk (15th day) could be consider

114 Twenty samples of ewe and 20 samples of goat colostrum and milk were collected at the 1st, 2nd,

115 in the abosamal pH was observed in infected goats compared to uninfected controls.

116 nstrates binding to the C-terminal region of GOAT, consistent with a role of His-338 in the active si

117 It is assumed that sheep and goats consumed the same bovine spongiform encephalopathy

118 on shift immunoblotting, we demonstrate that GOAT contains 11 transmembrane helices and one reentrant

119 lity of MERS-CoV to bind the DPP4s of camel, goat, cow, and sheep.

120 In total, 137 goat, cow, sheep, and buffalo milk samples were collecte

121 samples, one buffalo mozzarella cheese, one goat crescenza cheese and one artisanal cured ricotta ch

122 y acid (FA) composition is important for the goat dairy industry because of its influence on cheese p

123 Goats developed various effects, including necrotizing c

124 R/Q211 goats displayed delayed clinical signs compared with wil

125 and Eurasia-a reliance on cattle, sheep and goats emerged as a stable and widespread way of life, lo

126 Together with data from previous studies of goats exposed to infection in the field, these data supp

127 Goats expressing HLZ in their milk were generated and ex

128 with pasteurized milk from either transgenic goats expressing HLZ or non-transgenic control goats in

129 ile of Goat-null mice, as well as determined Goat expression in different tissues using the lacZ repo

130 Linking a single dairy-goat farm to a human Q-fever cluster, we show widespread

131 osure of persons in the vicinity of infected goat farms; the relative risk of exposure through inhala

132 Since RPV vaccine protects sheep and goats from PPRV, it is important to determine if the rev

133 , and recent genetic deletion studies of the Goat gene (Goat(-/-)) uncovered the role of ghrelin in t

134 s vertebrates, and genetic disruption of the GOAT gene in mice leads to complete absence of acylated

135 Here, we eliminate the Goat gene in mice, thereby eliminating all octanoylated

136 n picture naming, semantic errors (horse for goat) generally result from something having gone awry i

137 s, considering that commercial standards for goat genetic variants were not available.

138 The newly described de novo goat genome sequence is the most contiguous diploid vert

139 Here, we identify GOAT (Ghrelin O-Acyltransferase), a polytopic membrane-b

140 This is the first report that the GOAT/ghrelin system regulates bile acid metabolism, and

141 nderstand the physiological functions of the GOAT/ghrelin system, we have conducted a metabolomic and

142 Topical application of 0.02% MMC to intact goat globes resulted in MMC in the CE at 0.37 microg/mL

143 agenomic library from Capra hircus (domestic goat) gut.

144 The domestication of cattle, sheep and goats had already taken place in the Near East by the ei

145 Milk from HLZ transgenic goats had significantly more migration compared to contr

146 Goats harboring wild-type, R/Q211 or Q/K222 PRNP genotyp

147 small numbers of S146 and K222 heterozygous goats have become naturally infected with scrapie, sugge

148 (amino acid substitutions S146 and K222) in goats have been significantly underrepresented in scrapi

149 with early evidence for an economy based on goat herding, ca. 10,000 BP.

150 olds to increase consumption, increase their goat herds (which bodes poorly for the argan forest), an

151 inhibition and interactions underlying human GOAT (hGOAT) substrate selectivity.

152 opical and systemic immunization with either goat IgG anti-rabbit IgA or nonspecific goat IgG.

153 t IgG specific for rabbit IgA or nonspecific goat IgG led to similar increases in antigen-specific Ig

154 Topical application of either goat IgG specific for rabbit IgA or nonspecific goat IgG

155 Significant levels of sIgA against goat IgG were present in tears of pre-immune animals.

156 n antibody/antigen pair (rabbit antigoat IgG/goat IgG) at increasing antigen concentrations.

157 ther goat IgG anti-rabbit IgA or nonspecific goat IgG.

158 nses to goat anti-rabbit IgA and nonspecific goat IgG.

159 vivo and validated neuronal uptake using Cy5-goat IgPxcIgY ex vivo.

160 help pave the way for clinical targeting of GOAT in metabolic diseases.

161 The occurrence of ghrelin and GOAT in stomach and pancreas tissues demonstrates the re

162 ncreas tissues demonstrates the relevance of GOAT in the acylation of ghrelin and further implicates

163 d these findings suggest a novel function of GOAT in the regulation of intestinal bile acid reabsorpt

164 GO-CoA-Tat potently inhibits GOAT in vitro, in cultured cells, and in mice.

165 Demographic data collected from 447 mountain goats in 10 coastal Alaska, USA, populations over a 37-y

166 pricolum subsp. capripneumoniae that affects goats in Africa and Asia.

167 newly discovered Anaplasma species infecting goats in China.

168 ats expressing HLZ or non-transgenic control goats in the presence and absence of EAEC strain 042 (O4

169 m water buffalo in Vietnam and Thailand, and goats in Zambia.

170 domestication history of cattle, sheep, and goats, indicated that C. parvum IId subtypes were probab

171 lthy sheep, and abortion cases of cattle and goats, indicating the broad distribution of this pathoge

172 ity and the use of this assay to investigate GOAT inhibition and interactions underlying human GOAT (

173 al metabolic effects are due specifically to GOAT inhibition.

174 luc) reporter genes and injected in isolated goat intervertebral discs (IVD).

175 GOAT is a conserved orphan membrane-bound O-acyl transfe

176 GOAT is a member of the membrane-bound O-acyltransferase

177 Although GOAT is a potential therapeutic target for the treatment

178 GOAT is conserved across vertebrates, and genetic disrup

179 The data suggest that GOAT is subjected to end-product inhibition and this inh

180 GOAT is the only member of this family that octanoylates

181 ngiform encephalopathy (BSE) transmission to goats is not clear.

182 Ghrelin O-acyltransferase (GOAT) is a polytopic integral membrane protein required

183 his modification, ghrelin O-acyltransferase (GOAT), is receiving increased interest as a potential dr

184 ble compared to Fluc in monitoring gADSCs in goat IVDs.

185 ibm-infused UAG was completely abolished in GOAT-KO mice.

186 In goat left atrial free walls, most of the breakthroughs c

187 rapie under natural conditions.IMPORTANCE In goats, like in sheep, there are PRNP polymorphisms that

188 e fat content of yogurts was in the order of goat<cow<sheep.

189 uggested that such a polymorphism in Cypriot goats may lie in codon 146.

190 Goats may serve as a scrapie reservoir, and to date ther

191 er ghrelin or GH normalized blood glucose in Goat(-/-) mice and prevented death.

192 orie restriction maintained autophagy in the Goat(-/-) mice and prevented lethal hypoglycemia.

193 subjected to 60% calorie restriction, WT and Goat(-/-) mice both lost 30% of body weight and 75% of b

194 um metabolite profile analysis revealed that Goat(-/-) mice exhibited increased secondary bile acids

195 On normal or high fat diets, Goat(-/-) mice grew and maintained the same weights as w

196 Fasting fat-depleted Goat(-/-) mice showed a blunted increase in GH and a mar

197 Glucose production in Goat(-/-) mice was reduced by 60% when compared with sim

198 ice showed normal physical activity, whereas Goat(-/-) mice were moribund.

199 In Goat(-/-) mice, glucose continued to decline, reaching 1

200 e, or a fatty acid restored blood glucose in Goat(-/-) mice.

201 ly in calorie-restricted WT mice and less in Goat(-/-) mice.

202 The extraction technique was applied to goat milk and involved the addition of methanol, acetoni

203 presence of both HLZ transgenic and control goat milk compared to cells with no milk.

204 These data demonstrated that goat milk is able to repair intestinal barrier function

205 these results suggest that GABA in camel and goat milk may participate in GABA-modulated functions of

206 nd also of quantifying the ratio of sheep to goat milk mixture in different Feta cheese commercial pr

207 However, goat milk produced significantly lower amounts of malond

208 ify individuals consuming cattle, sheep, and goat milk products in the archaeological record.

209 levels were significantly lower in fermented goat milk products than in fermented cow milk products (

210 We directly compared digestion of cow and goat milk proteins, varying pH, enzyme concentrations an

211 ugh products are commonly based on cow milk, goat milk provides an alternative.

212 Caseins from goat milk tended to be more efficiently digested compare

213 were fed hLZ-milk or non-transgenic control goat milk three times a day for two days.

214 antification of camel milk adulteration with goat milk was investigated.

215 eins from cow milk and peptide profiles from goat milk were distinct from cow milk.

216 ier function damage induced by EAEC and that goat milk with a higher concentration of lysozyme offers

217 Goat milk with and without human lysozyme (HLZ) may impr

218 Cow, sheep and goat milk yogurts contain respectively 0.128-1.501, 0.40

219 (whole and skimmed cow milk and semi-skimmed goat milk) and yogurt (an unsweetened natural yogurt) pr

220 milk and, 2.25 and 7.5mg/ml respectively for goat milk.

221 fficient to activate GABArho1 receptors than goat milk.

222 who contracted infection from unpasteurized goat milk.

223 e interpretation of the nutritional value of goat milk.

224 m and another one without it), and fermented goats' milk samples available in the market were evaluat

225 estigate the prevalence of mislabeling among goat-milk products and, consequently, how far the ingred

226 We found that camel and goat milks have significantly more bioavailable GABA tha

227 rom two experimental ultrafiltered fermented goats' milks (one of them with the probiotic Lactobacill

228 of the Sal-Ag vaccine against challenge in a goat model as compared to the live attenuated vaccine MA

229 al alterations in the atrial free walls in a goat model of AF.

230 We also used a goat model of pacing-induced atrial fibrillation (24 wit

231 By using goat models of pacing-induced AF or of atrial structural

232 Consistent with its function, GOAT mRNA is largely restricted to stomach and intestine

233 obtained from cattle (n = 5), birds (n = 4), goats (n = 3), bison (n = 3), and humans (n = 9) were in

234 cted a metabolomic and microarray profile of Goat-null mice, as well as determined Goat expression in

235 sults of these studies illustrate that while goats of all genotypes can be infected by i.c. challenge

236 The discovery of ghrelin O-acyltransferase (GOAT) opens the way to the design of drugs that block th

237 enting bacteria used in commercial fermented goat or cow milks or in the lab-produced goat yoghurt.

238 is often acquired by ingesting contaminated goat or sheep milk and cheese.

239 The early stage growth rate of this goat outperformed the control goats.

240 thin bundles) was significantly larger in LT goats, particularly in the outer millimeter of the atria

241 The goat peptides produced non-significantly different level

242 human TMJ disc, and also discs from the cow, goat, pig, and rabbit.

243 est Asia in the eighth millennium BC, sheep, goats, pigs and cattle have been remarkably successful i

244 uctured population model to project mountain goat population trajectories for 10 different GCM/emissi

245 Projected declines of mountain goat populations are driven by climate-linked bottom-up

246 ng climate-driven effects influence mountain goat populations, we developed an age-structured populat

247 aits, as well as high altitude adaptation in goat populations.

248 differential fecundity in two Laoshan dairy goat populations.

249 Sheep pox (SP), goat pox (GP), and lumpy skin disease (LSD), caused by c

250 Ruminants, such as cows, sheep, and goats, predominantly ferment in their rumen plant materi

251 effects of polymorphisms at codon 146 of the goat PRNP gene on resistance to disease.

252 aneous catheter-based RDN was performed in 8 goats (RDN-AF).

253 ain and stirred fruit yogurts were made from goat's milk using bacterial cultures comprising, Lactoba

254 common genetic variants of alphas1-casein in goat's milk, to evaluate the effect of alphas1-casein po

255 not able to detect this bacterium in all 200 goat samples.

256 via these methods is shown in pig blood and goat serum as examples of complex biological fluids.

257 Six age-matched naive goats served as uninfected controls.

258 try, for rapid identification of DNA of cow, goat, sheep and buffalo in dairy products, and for quant

259 iruses in human stool samples and local cow, goat, sheep, camel, and chicken meat samples indicated t

260 ddle East livestock species, such as camels, goats, sheep, and cows, these form a potential MERS-CoV

261 ion of etx knockout restored virulence; most goats, sheep, and mice receiving this complemented mutan

262 In contrast, none of the Q/K222 goats showed any evidence of clinical prion disease.

263 erformed the first oral scrapie challenge of goats singly heterozygous for either PRNP S146 or K222.

264 Goat staining was consistently observed in the pituitary

265 the presence of H. pylori in cow, sheep and goat stomach, determine the bacterium virulence factors

266 These data implicate the ghrelin-GOAT system as a signaling pathway that alerts the centr

267 orf virus (ORFV) is a pathogen of sheep and goats that has been used as a preventive and therapeutic

268 is a highly infectious disease of sheep and goats that is caused by PPR virus, a member of the genus

269 identification and characterization of human GOAT, the ghrelin O-acyl transferase.

270 ontrast, myocyte diameters were larger in LT goats throughout the atrial walls.

271 2 PRNP variant in the oral susceptibility of goats to BSE.

272 Antibodies raised in goats to LDC-rich extracts from E. corrodens cell surfac

273 for assessing the genetic susceptibility of goats to scrapie.

274 t genetic deletion studies of the Goat gene (Goat(-/-)) uncovered the role of ghrelin in the regulati

275 Ten goats undergoing a sham procedure served as control (SHA

276 we efficiently generated Mstn KO rabbits and goats using CRISPR/Cas9 technology.

277 PBMCs from goats vaccinated with Sal-Ag and challenged with MAP gen

278 etobacter spp., while milk from reindeer and goat was dominated by unclassified bacteria from the fam

279 Using the same method, one out of four goats was generated with edition at Mstn locus.

280 Ghrelin O-acyltransferase (GOAT) was identified as a specific acyl-transferase for

281 Fourteen parasite naive goats were inoculated with 5,000 H. contortus infective

282 Eighteen goats were instrumented with an atrial endocardial pacem

283 Goats were killed at different time points during the in

284 e compared to other regions, where sheep and goats were relatively common and milk use less important

285 Polyclonal antibodies generated in goats were superior reagents for capture and detection o

286 zed that consumption of milk from transgenic goats which produce human lysozyme (hLZ-milk) in their m

287 the gene encoding ghrelin O-acyltransferase (GOAT), which catalyzes a required acylation of the pepti

288 We find that the ghrelin O-acyl transferase (GOAT), which is essential for ghrelin acylation, is regu

289 ctivating enzyme ghrelin O-acyl transferase (GOAT), which is located in the membranes of lipid traffi

290 ique bacterial communities compared with the goat, which might reflect host microbial adaptation caus

291 for agriculturally significant phenotypes in goats, which in turn can be used in the selection of goa

292 Identification of GOAT will facilitate the search for inhibitors that redu

293 ntact mapping was performed in left atria of goats with acute AF (n=6) or persistent AF (n=5).

294 g data recorded in left atrial free walls of goats with acute AF, 3 weeks and 6 months of AF (all n=7

295 n was upregulated in atria from AF patients, goats with electrically maintained AF, and dogs with tac

296 with atrial enlargement and spontaneous AF, goats with lone AF, and patients with chronic AF.

297 mposed of SAA3 expanding the uterine wall of goats with near-term fetuses.

298 structural alterations, and AF complexity in goats with persistent AF, independent of changes in bloo

299 ts the results of experimental challenges of goats with scrapie by both the intracerebral (i.c.) and

300 ted goat or cow milks or in the lab-produced goat yoghurt.