ライフサイエンスコーパス: gonadotrope

1 ncrease expression of the LHbeta gene in the gonadotrope.

2 in the expression of the LHbeta gene by the gonadotrope.

3 are heterodimeric glycoproteins expressed in gonadotropes.

4 lishes essential role(s) of SF1 in pituitary gonadotropes.

5 channels in alphaT3-1 cells and primary rat gonadotropes.

6 equency of [Ca(2+)](cyt) oscillations in rat gonadotropes.

7 cates a defect of LH regulation in pituitary gonadotropes.

8 f the alpha and LHbeta subunits in pituitary gonadotropes.

9 in clonal (alphaT3-1) and primary pituitary gonadotropes.

10 a signal from the hypothalamus to pituitary gonadotropes.

11 one secretion in isolated male rat pituitary gonadotropes.

12 tenuated activity in trophoblasts but not in gonadotropes.

13 igh in pituitary non-gonadotropes as well as gonadotropes.

14 ntil stimulated by FSH secreted by pituitary gonadotropes.

15 expression of FSHB, the hormone secreted by gonadotropes.

16 mechanism of GnIH action in GnRH neurons and gonadotropes.

17 ed signaling from brain neurons to pituitary gonadotropes.

18 bpopulation of anterior pituitary cells, the gonadotropes.

19 II receptor is expressed in the majority of gonadotropes.

20 coprotein subunit-expressing thyrotropes and gonadotropes.

21 al significance of this factor in developing gonadotropes, a knockdown of p8 in L beta T2 cells was g

22 sic factors critical for embryonic pituitary gonadotrope and thyrotrope cell differentiation have bee

23 ituitary cells and found that it can inhibit gonadotrope and thyrotrope differentiation.

24 ative regulator of reproduction by acting on gonadotropes and gonadotropin-releasing hormone (GnRH) n

25 relatively sustained in alpha T3-1 pituitary gonadotropes and HEK293 cells but is transient in immort

26 e investigated whether FOXO1 is expressed in gonadotropes and if it can modulate LH beta-subunit (Lhb

27 9 induced FSHbeta expression in immortalized gonadotropes and in mouse primary pituitary cells.

28 ssary for specification and expansion of the gonadotropes and Pit1 lineage within the ventral and cau

29 ization is regulated by insulin signaling in gonadotropes and that FOXO1 inhibits Lhb transcription.

30 r regulation of alpha-GSU gene expression in gonadotropes and thyrotropes in the developing human fet

31 s single copy gene is expressed in pituitary gonadotropes and thyrotropes of all mammals and in place

32 le in differentiation of ventral cell types (gonadotropes and thyrotropes) by inducing Bmp2 expressio

33 ponsible for Cga cell-specific expression in gonadotropes and thyrotropes, and we show here that it e

34 matin immunoprecipitation assay with LbetaT2 gonadotropes, and this effect is enhanced by gonadotropi

35 istal sequences using purified primary mouse gonadotropes as an in vitro model system.

36 ctivin) was relatively high in pituitary non-gonadotropes as well as gonadotropes.

37 le for PROP1 in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and c

38 es (alpha T3-1 and L beta T2) that represent gonadotropes at early and late stages of development, re

39 n activate transcription through the CREs in gonadotropes but not in trophoblasts.

40 trope program by inhibiting GATA2 binding to gonadotrope- but not thyrotrope-specific genes, indicati

41 the control of biosynthesis in the pituitary gonadotrope by hypothalamic gonadotropin-releasing hormo

42 n beta subunits in vivo, we deleted Dicer in gonadotropes by a Cre-lox genetic approach.

43 e they were induced only in purified primary gonadotropes by activin A (50 ng/ml) and inhibited by Gn

44 AA is transported back into gonadotropes by the AA transporter and increases intrace

45 ude that adenoviral-based studies in primary gonadotropes can adequately recognize regulatory element

46 uction of a committed but immature pituitary gonadotrope cell line by directing expression of the onc

47 d the activity of the LHbeta promoter in the gonadotrope cell line LbetaT2.

48 layer of human chorionic villus but not in a gonadotrope cell line that also expresses the alpha subu

49 cursor cell line, alphaT1-1, and an immature gonadotrope cell line, alphaT3-1, identified by using cD

50 cancer cells, is present in mouse pituitary gonadotrope cell lines.

51 monstrated that FOXO1 is expressed in murine gonadotrope cells and that insulin signaling increased F

52 ppear to be due to a change in the number of gonadotrope cells in the pituitary gland.

53 regulated by insulin signaling in pituitary gonadotrope cells is the FOXO subfamily of forkhead tran

54 Fshb expression levels obtained in pituitary gonadotrope cells perifused with varying GnRH pulse freq

55 ne biosynthesis and secretion from pituitary gonadotrope cells, and together, inhibin and activin con

56 In LbetaT2 gonadotrope cells, FSHbeta gene induction depended predo

57 ation with its DNA binding cofactor Foxl2 in gonadotrope cells, mice make essentially no FSH and fema

58 g endogenous expression of SET with siRNA in gonadotrope cells.

59 rgy transfer reporters in live mouse LbetaT2 gonadotrope cells.

60 or-mediated signaling in L beta T2 pituitary gonadotrope cells.

61 In alphaT3-1 mouse anterior pituitary gonadotropes, chronic activation of gonadotropin-releasi

62 We incubated AtT-20 cells, pituitary gonadotropes, cultured cerebellar granule cells, and yea

63 Several hypotheses for how the gonadotrope decodes GnRH frequency to regulate gonadotro

64 Analysis of gonadotrope deep-sequencing data identified a global reg

65 cate that GnRH activates MKP-2 expression in gonadotropes, dependent upon activation of multiple MAPK

66 unctional transfection studies in the murine gonadotrope-derived alphaT3-1 cell line, we have localiz

67 , follistatin transcription was evaluated in gonadotrope-derived alphaT3-1 cells.

68 t inhibited activin signaling in a pituitary gonadotrope-derived cell line (LbetaT2) in a dose-depend

69 minimal HSV thymidine kinase promoter in the gonadotrope-derived cell line alphaT3-1.

70 SRII expression in rat pituitary cells and a gonadotrope-derived cell line and MIS-mediated activatio

71 Using LbetaT2 cells, a murine gonadotrope-derived cell line, we have evaluated the eff

72 uitary glands mirrored its expression in the gonadotrope-derived cell lines and coincided with the fi

73 This profile of human fetal gonadotrope development differs from the current mouse m

74 ilure of the entire Pit1 lineage and delayed gonadotrope development.

75 a cell that represents a subsequent stage of gonadotrope differentiation (expression of alpha-subunit

76 , which are necessary for repressing ectopic gonadotrope differentiation.

77 Furthermore, mutants lacking Dicer in gonadotropes displayed severely reduced fertility and we

78 ell responses showed that whereas individual gonadotropes exhibited two response states, inactive and

79 hb We demonstrate that poorly differentiated gonadotropes express a TET1 isoform lacking the N-termin

80 onfocal microscopy, we found that most fetal gonadotropes expressed alpha-GSU, LHbeta, and FSHbeta go

81 Gonadotropes expressing alpha-GSU and FSHbeta only were

82 1 bp of the ovine FSHB gene are required for gonadotrope expression of ovine FSHB.

83 enic factor-1 (SF-1), a protein required for gonadotrope function.

84 gonadotropin-releasing hormone neuronal and gonadotrope function.

85 their signaling, suggests different roles in gonadotrope functioning.

86 and by Galpha(s) and implicate autocrine and gonadotrope-gonadotrope paracrine regulatory loops in th

87 In pituitary gonadotropes, gonadotropin-releasing hormone (GnRH) acti

88 the activation of the G(q/11) protein in the gonadotrope; however, GnRH II is more potent in the stim

89 bunit (FSHbeta) gene expression in pituitary gonadotropes in a frequency-sensitive manner.

90 tuitaries, increasing in proportion to total gonadotropes in both males and females from 14 (approxim

91 y or in pulses, respectively, from pituitary gonadotropes in many vertebrates, and regulate ovarian f

92 d number of corticotropes, melanotropes, and gonadotropes in the pituitary.

93 FSHB) is expressed specifically in pituitary gonadotropes in vertebrates.

94 alpha-GSU appears to be the lead protein in gonadotropes, in thyrotropes which ultimately express al

95 The terminal differentiation of pituitary gonadotropes is delayed, resulting in transient hypogona

96 e with defective Lhx3 genes are deficient in gonadotrope, lactotrope, somatotrope, and thyrotrope pit

97 hyrotrope cells and SF-1-expressing cells of gonadotrope lineage.

98 some cell types, such as pituitary cells of gonadotrope lineage.

99 Using cAMP and calcium biosensors in gonadotrope living cells, we showed that SET knockdown s

100 a subunit mRNAs, were suppressed in purified gonadotropes of mutant mice.

101 The target cells of GnRH include the gonadotropes of the anterior pituitary gland and the cel

102 ceptor (GnRHR) is expressed primarily in the gonadotropes of the anterior pituitary.

103 t IGSF1 is expressed both in thyrotropes and gonadotropes of the pituitary and in Leydig and germ cel

104 heptapeptide enters the regulated pathway in gonadotropes of transgenic mice, and is released in resp

105 cts high level expression to thyrotropes and gonadotropes of transgenic mice.

106 1), is expressed in the pituitary and in the gonadotrope precursor cell line, alphaT3-1, where it is

107 n of an endogenous gene in LbetaT2 pituitary gonadotrope precursor cells.

108 that all three TET enzymes are expressed in gonadotrope-precursor cells, but Tet1 mRNA levels decrea

109 it1, suppressing the ventral GATA2-dependent gonadotrope program by inhibiting GATA2 binding to gonad

110 ferent tissues, such that its direct role in gonadotropes remains uncertain.

111 various patterns of pulsatile GnRH regulate gonadotrope responsiveness remain poorly understood.

112 Loss of DICER-dependent microRNAs in gonadotropes resulted in profound suppression of gonadot

113 n of transcription factors characteristic of gonadotropes, SF1 and ISL1, but no gonadotropin expressi

114 t LHbeta gene promoter acting at a consensus gonadotrope-specific element (GSE) located at position -

115 -subunit gene through transactivation of the gonadotrope-specific element (GSE).

116 er elements between -2871/-750 necessary for gonadotrope-specific expression of ovine FSHB in vivo.

117 ssion of the oncogene SV40 T antigen using a gonadotrope-specific region of the human glycoprotein ho

118 Thus, gonadotrope-specific regulation associated with the prox

119 They all showed gonadotrope-specific regulation since they were induced

120 s on the ovine FSHB promoter associated with gonadotrope-specific regulation/expression, but that mor

121 lucidate the genomic repertoire required for gonadotrope specification and luteinizing hormone beta (

122 secretion from dopamine- or serotonin-loaded gonadotropes, the secretagogue action of PMA develops mo

123 Although synthesized in the same pituitary gonadotropes, the secretion profiles of lutropin (LH) an

124 ariant CREs have similar overall activity in gonadotropes, the variant CREs make a much smaller contr

125 It gives rise to gonadotrope, thyrotrope, somatotrope, corticotrope and l

126 f the hormone-producing pituitary cell types-gonadotropes, thyrotropes, somatotropes, lactotropes, co

127 The response of the pituitary gonadotrope to gonadotropin-releasing hormone (GnRH) cor

128 we studied the biosynthetic response of the gonadotrope to varying GnRH concentrations, focusing on

129 onadotropin-releasing hormone (GnRH) acts at gonadotropes to direct the synthesis of the gonadotropin

130 The response of pituitary gonadotropes to gonadotropin-releasing hormone (GnRH) co

131 ional and post-transcriptional regulation in gonadotropes to orchestrate the hypothalamus-pituitary-g

132 yristate-13-acetate (PMA) stimulates as many gonadotropes to secrete as does gonadotropin-releasing h

133 The presence of two GnRH receptors in gonadotropes, together with the differences in their sig

134 that p8 is a stage-specific component of the gonadotrope transcriptome that may play a functional rol

135 Pituitary gonadotropes transduce hormonal input into cytoplasmic c

136 genes that are regulated by GnRH in a murine gonadotrope tumor cell line (LbetaT2).

137 expand our previous study on GnIH actions in gonadotropes, we investigated the potential signal trans

138 When FSHbeta or LHbeta genes were expressed, gonadotropes were non-dividing.