ライフサイエンスコーパス: gonocyte

1 hat enter meiosis synchronously with ovarian gonocytes.

2 on of cells that express markers specific to gonocytes.

3 nd found that Foxo1 specifically marks mouse gonocytes and a subset of spermatogonia with stem cell p

4 ombination are born with significantly fewer gonocytes and exhibit defective spermatogenesis and redu

5 o ablate Sin3a from perinatal quiescent male gonocytes and from postnatal differentiating spermatogon

6 t UTF1 is expressed in embryonic and newborn gonocytes and in a subset of early spermatogonia.

7 s being born with severely reduced number of gonocytes and oocytes.

8 ling the proliferation or differentiation of gonocytes and spermatogonia and possibly the somatic lin

9 Zfp145 expression was restricted to gonocytes and undifferentiated spermatogonia and was abs

10 ized that maintenance and differentiation of gonocytes and/or spermatogonial stem cells would be modu

11 cellular microenvironment, were followed by gonocyte apoptosis and near complete disappearance of th

12 In mice, the SSC pool arises from gonocytes approximately 6 days after birth.

13 Gonocytes are a transient population of male germ-line s

14 beginning at approximately 2 months of age, gonocytes are replaced by adult dark (Ad) and pale (Ap)

15 m neonatal transgenic rats demonstrated that gonocytes are the only cells that express a lacZ reporte

16 e by in situ hybridization in fetal day 15.5 gonocytes but was detectable at a low abundance by RT-PC

17 Sin3a is required for the mitotic reentry of gonocytes, but is dispensable for the maintenance of dif

18 tosis and near complete disappearance of the gonocytes by day 2 after birth.

19 In contrast to spermatogonial stem cells, gonocytes can be identified easily in neonatal rat testi

20 evated in both human spermatogonia and mouse gonocytes compared to somatic cells.

21 In addition, conditional ablation of NRF1 in gonocytes dramatically down-regulated these germline gen

22 provide new information on the regulation of gonocyte fate and exciting new evidence supporting a lin

23 We observed aberrant exit of gonocytes from mitotic arrest, migration toward cord per

24 Since surviving gonocytes give rise to subsequent generations of germ ce

25 of neonatal testes containing Sin3a-deleted gonocytes identified upregulated transcripts highly asso

26 oli cells is required for the maintenance of gonocytes in an undifferentiated state during fetal deve

27 B-cadherin (STPB-C) in promoting survival of gonocytes in neonatal rats and we have linked its expres

28 ber of critical events including re-entry of gonocytes into the cell cycle and eventual loss of many

29 In contrast, perinatal gonocytes lacking Sin3a underwent rapid depletion that c

30 differentiated), induction of multinucleated gonocytes (MNGs), and aggregation of differentiated germ

31 functional changes that drastically affected gonocyte numbers and physiology.

32 The B-myb mRNA is expressed most highly in gonocytes of the fetal testis and in spermatogonia and e

33 Together, the pseudopod and round gonocyte populations will provide powerful tools for the

34 gically normal; however, at post-natal day 3 gonocyte proliferation is impaired and expression of spe

35 genetic ablation of Brg1 in murine embryonic gonocytes results in arrest during prophase of meiosis I

36 ation of germ cell apoptosis and survival in gonocyte-Sertoli cell co-cultures, and direct study of t

37 present almost exclusively in the pseudopod gonocyte subpopulation.

38 Two gonocyte subpopulations, designated pseudopod and round,

39 11.5 dpc, and that FGF9 directly promotes XY gonocyte survival after 11.5 dpc, independently from Ser

40 FGF9 is necessary for 11.5 dpc XY gonocyte survival and is the earliest reported factor wi

41 th prepubertal human spermatogonia and mouse gonocytes than in somatic cells.

42 and adult testes, p53R172H was expressed in gonocytes, type A, Int, B spermatogonia as well as in pr

43 n germ cells with increasing expression from gonocytes/type A spermatogonia to pachytene spermatocyte

44 taining indicated that the majority of round gonocytes undergo apoptosis.

45 of prepubertal human spermatogonia and mouse gonocytes were selected from testis biopsies and validat