ライフサイエンスコーパス: gradual

1 st that pancreatic cancer progression is not gradual.

2 seed coats, and that the rate of change was gradual.

3 Loss of FGF signaling results in a gradual accumulation of atrial cells, a corresponding lo

4 acterial killing (~5 log10CFU/mL), while the gradual accumulation of colistin resulted in no bacteria

5 ese data are unlikely to be explained by the gradual accumulation of copy number events over time.

6 relapsing-remitting multiple sclerosis, the gradual accumulation of disability that characterises pr

7 The gradual accumulation of genetic mutations in human adult

8 In conclusion, we propose that the gradual accumulation of long-lived active receptor compl

9 The gradual accumulation of mutations by any of a number of

10 Gradual accumulation of nucleotide and amino acid substi

11 deterministic and stochastic factors, as the gradual accumulation of sensory evidence (deterministic)

12 structural examinations of such DNs revealed gradual accumulation of tubular ER in axonal termini, an

13 rvasive remodeling process that promotes the gradual acquisition of distinct molecular signatures, of

14 to the casein-iron precipitates resulted in gradual adsorption of the orthophosphate, causing re-dis

15 resistance and skin) arteries demonstrate a gradual, age-related impairment in vascular function tha

16 Despite the gradual aging of the mother cell, all daughters are born

17 a minimum in the early Holocene, followed by gradual and continuous increase towards the mid-to-late-

18 Moreover, we found that gradual and county closures may be slightly more easily

19 By contrast, gradual and delayed transitions accompanied shifts towar

20 evolution during domestication may have been gradual and encourage further paleogenomic research to a

21 leaf demonstrated stable performance despite gradual and eventually severe accumulation of salt cryst

22 ally accepted paradigm is that such aging is gradual and its origin is in slower than exponential mic

23 In addition, both gradual and rapid deglacial radiocarbon changes in these

24 his compositional shift were the result of a gradual and reversible evolutionary trajectory.

25 lly weakens hydrophobic interactions, causes gradual and reversible exposure of the coreceptor-bindin

26 criptome analysis revealed that M9 induces a gradual and specific conversion of fibroblasts toward a

27 lost per student, reactive school-by-school, gradual, and county-wide closure give comparable outcome

28 clearly evident and quantified based on the gradual appearance of new crystalline domains in TEM ima

29 nd during exposure to hypobaric hypoxia on a gradual ascent to Mount Everest Base Camp (5,300 m).

30 th survival, and there was a significant and gradual association between survival and categories of t

31 CKD is the gradual, asymptomatic loss of kidney function, but curre

32 The planar-globular transition is gradual at room temperature rather than a sharp transiti

33 ajectory of pancreatic cancer progression is gradual because each alteration is acquired independentl

34 ntal ventral premotor (PMv) network during a gradual behavioral transition from full alertness to los

35 y recent radiation of cottoid fishes shows a gradual blue-shift in the wavelength of the absorption m

36 Gradual bone uptake was, however, also observed.

37 th increasing temperature, demonstrating the gradual breakdown of the hydrogen-bond network.

38 PP and beta-band signals exhibited a similar gradual build-up following evidence onset, but whereas c

39 sophila locomotor behavior, bringing about a gradual buildup of kinematic degrees of freedom during t

40 with prescribed distributions, ranging from gradual buildup to sudden delivery, based only on the ch

41 n contrast, inhalation of C110 resulted in a gradual but progressive transport of Ag to and retention

42 r eight years experiment, we have obtained a gradual but stable increase in crop yields with a 9.6-fo

43 Progressive remodelling appears to be gradual, but not universal, and the duration of untreate

44 al reactions between solid phases are either gradual (by deformation-induced mixing), or self-propaga

45 The gradual caspase-dependent loss of the shelterin complex

46 If gradual cessation is as successful, smokers can be advis

47 Participants who preferred gradual cessation were significantly less likely to be a

48 However, many quit attempts involve gradual cessation.

49 , 12.0% to 19.7%) of the participants in the gradual-cessation group were abstinent compared with 22.

50 , 34.0% to 44.4%) of the participants in the gradual-cessation group were abstinent compared with 49.

51 g and sharply delineated state, but rather a gradual change in crucial cellular pathways, that transf

52 A gradual change in methylation status at the boundaries o

53 due to modified local ionic screening and a gradual change in polymer brightness, reflecting release

54 Quantitative real-time imaging revealed a gradual change in the oxidation state of cytosolic gluta

55 We infer that the experimentally observed gradual change of the wetting angle with increase of the

56 g in the embryo and larva, and following the gradual changes by which these landmarks become integrat

57 stands in apparent contradiction to the more gradual changes in cell division potential and different

58 ate to gradients in protein accumulation and gradual changes in cellular properties.

59 oned abruptly from grassland to woodlands as gradual changes in CO2 and fire shifted the balance in f

60 in shaping biodiversity patterns rather than gradual changes in long-term climatic means.

61 In response to gradual changes in oxygen influx, this model abruptly tr

62 Gradual changes in response to drought stress were monit

63 rementally by selection when, as a result of gradual changes in their biotic partners and enemies, th

64 me, discrete steps in firing rate instead of gradual changes that represent the accumulation of evide

65 To screen gradual changes upon drought, Brachypodium leaves subjec

66 nopsin (and/or rods) contributing under more gradual changes.

67 l role for oligomerized condensin in driving gradual chromatin compaction by step-like and slow "cree

68 y, whereas prolonged activation prevents the gradual chromatin compaction that occurs naturally in de

69 each climate, as well as 100-y scenarios of gradual climate change following adaptation to a referen

70 latively continuous external forcing such as gradual climate warming or sea-level rise.

71 ARCH is defined as the gradual, clonal expansion of HSPCs carrying specific, di

72 of all schools at the same time to reactive gradual closure, starting from class-by-class, then grad

73 ory of global cognition was characterized by gradual cognitive decline beginning approximately 15 yea

74 n on muskeg, a mix of partial excavation and gradual compaction with the strategic placement of filli

75 at ontogenetic tooth loss in Limusaurus is a gradual, complex process.

76 but not all behavior seems to conform to the gradual convergence that is a central feature of RL.

77 nland exhibited a clear diurnal signal and a gradual decline at the commencement of the melt season,

78 Among absorptive roots, we observed a gradual decline in chemical defenses (phenolic compounds

79 imals known as generalization gradients: the gradual decline in conditioned responding as the present

80 decrease in growth may be associated with a gradual decline in hydraulic performance coupled with de

81 There has been a gradual decline in the prevalence of abnormal stress sin

82 of IL-18, IL-1beta, and TGF-beta, despite a gradual decline in TNF-alpha expression and macrophage i

83 esulted in a 2.5-fold increase followed by a gradual decline.

84 The unique synthesis benefits from the gradual decomposition of the preformed metal-boron (M-B,

85 interface front result, respectively, in the gradual decrease and increase of interfacial stability w

86 ridus) exhibit diurnal volume changes with a gradual decrease during daytime and a total recovery dur

87 two-step response to the applied pressure; a gradual decrease followed by an increase at around 15-20

88 between 7.5 and 9.0, which was caused by a gradual decrease in atmospheric pCO2 in response to sola

89 ulin from swellable MN patches, leading to a gradual decrease in blood glucose levels.

90 2 +/- 5 muM above S. gordonii, followed by a gradual decrease in H2O2 concentration (>30 min) to almo

91 We found that daptomycin causes a gradual decrease in membrane potential but does not form

92 more natural chair rotations), including the gradual decrease in nystagmus as the set point changes o

93 te-derived macrophages, however, encounter a gradual decrease in oxygen availability during its migra

94 Spectromicroscopic measurements showed a gradual decrease in reduced carbon forms (aromatic/alken

95 n the skin of those patients followed by the gradual decrease in sensitization over 50 days was also

96 A gradual decrease in the length of chains was observed as

97 eraction may be a factor responsible for the gradual decrease of growth rates in batch cultures durin

98 asing severity scores were associated with a gradual decrease of LTB4 and PGE2, and a gradual increas

99 tching, except for caudal brainstem, where a gradual decrease was observed during the last week of em

100 he prevalence of asymptomatic ICAS showed no gradual decrease with the increase of HDL-C levels.

101 end strongly on moisture changes, and that a gradual deepening of the active layer will create a stro

102 response of the protein under conditions of gradual dehydration had not been investigated.

103 The results showed gradual deliquescence of these aerosol particles charact

104 tronic states localized on the acenes due to gradual departure from a perfect circular symmetry.

105 oS2 both symmetric and asymmetric GBs show a gradual dependence on mismatch angles.

106 gic) neurons in the substantia nigra and the gradual depletion of dopamine (DA).

107 There was gradual depletion of dopaminergic projections in the str

108 B) and Nitrosopumilus maritimus (AOA) during gradual depletion of TAN (NH3 + NH4+) and O2 .

109 ments increased rapidly and stimulated their gradual depolymerization (unlike their rapid degradation

110 Ripening events are accompanied by gradual depolymerization of pectic polysaccharides, incl

111 esponse to the periodic drive, and observe a gradual development of a cascade characterized by an iso

112 ascent release sites, which contrasts to the gradual development of cytoplasmic vesicle pools in conv

113 Gross pathologic analysis showed gradual device resorption until 32 weeks after deploymen

114 levels of RE, most likely as the result of a gradual disappearance of HSCs in livers of Lipa(-/-) mic

115 e with AnkG are much more stable and undergo gradual disintegration with sequential loss of nodal com

116 of PKG-triggered initiation of egress and a gradual dismantling of the host erythrocyte cytoskeleton

117 nent analysis of (18)F-FDG PET data showed a gradual disruption of functional brain connectivity with

118 results confirm that sand patties undergo a gradual dissolution of DOM in both the dark and in the l

119 ribution in calcium signals is governed by a gradual, distance-dependent decline in spine size, which

120 mitochondrial apoptosis is accompanied by a gradual drop in extra-mitochondrial pH and a decline in

121 When analyzing the gradual dynamics in the transcriptomic profile, we could

122 Nevertheless, gradual dysfunction and failure of the right ventricle (

123 d between 13 and 8 kyr ago and was initially gradual eastward into the Atlantic, then subsequently re

124 st after 8 wk, in contrast to more acute and gradual effects in the LFHC group.

125 c' alterations while others display a clear 'gradual', either progressive increase or decrease in exp

126 hysiological cations was examined and showed gradual emission enhancement which makes R an ideal cand

127 reased following GR activation, facilitating gradual enhancer maturation next to PPARA target genes a

128 We detected gradual enrichment of neutrophil transcripts during prog

129 om a seasonally stratified lake to show that gradual environmental changes can induce oxic-anoxic reg

130 Here we show that gradual environmental changes induced by, for example, e

131 of the DNA-binding specificity of PRDM9 and gradual erosion of PRDM9-binding sites by gene conversio

132 Here we provide empirical evidence for a gradual escalation of self-serving dishonesty and reveal

133 contrast, our data challenge the paradigm of gradual evolution, showing that the majority of copy num

134 y thus represent an intermediate link in the gradual evolutionary transition from the intron-specific

135 A gradual expansion of population and benefits coverage ha

136 etimes involved in sex chromosome evolution, gradual expansion of the non-recombining region could po

137 Here we report that, in mice, gradual exposure to severe systemic hypoxaemia, in which

138 (SRF) were evident on SD-OCT, followed by a gradual extension of the treatment interval by 2 weeks u

139 bolide impact contrasts with ideas of a more gradual extinction involving flood volcanism or climatic

140 mmediate for the implant group as opposed to gradual for the systemic group.

141 slides anti-parallel microtubules apart with gradual force buildup while parallel microtubule bundles

142 how that self-driven jamming arises from the gradual formation and sudden collapse of force chains dr

143 This gradual frequency change is due to ion energy loss from

144 t selection, rather than drift, explains the gradual frequency changes observed in the highland popul

145 The rate of the gradual frequency shift increases with protein mass and

146 Our results reveal a key role for the gradual generation of ssDNA in modulating the binding mo

147 More gradual glucose starvation, amino acid deprivation or ra

148 ergo first-order transition with hysteresis, gradual, hysteretic two-step or multistep transitions, a

149 Skeletal muscle insulin sensitivity showed a gradual impairment at low degrees of IHTG accumulation,

150 s to propose a consensus on the position and gradual implementation of the principles of PM within ex

151 gically relevant hemodynamic stress requires gradual imposition of mechanical loads in a nutrient-ric

152 r high-serum conditions, iPSC-CMs subject to gradual imposition of stress were comparable to iPSC-CMs

153 concussion generally follows a trajectory of gradual improvement, but symptoms can abruptly worsen wi

154 ely; all P < .001), followed by a continuous gradual improvement.

155 effects contrast with the longer-term, more gradual improvements that are characteristic of perceptu

156 ibed by a curvilinear relationship, was more gradual in patients than in controls (13.4; 95% confiden

157 at the increase with depth of tau cr is very gradual in the uppermost several metres of the depositio

158 n the mid-1970s, having followed 60 years of gradual increase as the US population aged.

159 We found a gradual increase in call frequency and amplitude towards

160 h a gradual decrease of LTB4 and PGE2, and a gradual increase in CXCL1 and CCL2.

161 The decline in LEF is paralleled by a gradual increase in cyclic electron transport to maintai

162 eoplastic transformation is accompanied by a gradual increase in FGF13 expression and increased depen

163 change over time in ECs, suggesting that the gradual increase in integrated HIV DNA observed in ECs w

164 L929 cells with fluorescein PMs, there was a gradual increase in intracellular fluorescence, indicati

165 Furthermore, this gradual increase in neural differences between the stori

166 J dynamics in an epithelium that undergoes a gradual increase in packing order, without concomitant l

167 Phosphate starvation led to gradual increase in Pro content in wild-type Arabidopsis

168 This gradual increase in receptor activity following desensit

169 rmeabilized RV cardiomyocytes demonstrated a gradual increase in RV myofibril stiffness, which was pa

170 Strikingly, we observed a gradual increase in SAC strength after each round of div

171 The gradual increase in sea-surface temperature, a consequen

172 ion of surface proteins in contributing to a gradual increase in Signal 1 and Signal 2.

173 Upon proteolysis, a gradual increase in the golden color of the sensor surfa

174 trial of the ramp phase of adaptation when a gradual increase in the visuomotor rotation caused movem

175 This is associated with a gradual increase in whole-cell membrane capacitance.

176 e first year posttransplantation, there is a gradual increase of all immunoglobulins and IgG subclass

177 th of soil overlay decreases, resulting in a gradual increase of light fluences.

178 ing elongated growth showed either a delayed gradual increase or pulsatile dynamics of Fus3 activity.

179 All of the six classes showed a gradual increase over the milking season with the highes

180 h a rapid and profound decrease, followed by gradual increase towards levels observed in CKD counterp

181 munization, SAM Ag expression has an initial gradual increase.

182 ge, ancient populations subjected to coupled gradual increases in [CO2(aq)] and temperature over a fe

183 Cryo-scanning electron microscopy revealed gradual increases in collapse from approximately -2 MPa

184 by mild electric footshocks for 10 days with gradual increases in shock intensity.

185 of oceanographic measurements has evidenced gradual increases in temperature and salinity of western

186 w that this decision is not made through the gradual increasing of stimulus-related firing, but rathe

187 drainage and ice flow to show that limited, gradual leakage of water and lowering of water pressure

188 gradual transfer of the drugs across FLM and gradual liberation into acceptor solution (30-240 s).

189 Rather than a gradual linear decline in productivity, there is some li

190 a much thicker root (>250 kilometers) and a gradual lithosphere-asthenosphere transition, consistent

191 f a solid electrolyte interphase followed by gradual loss in subsequent cycles.

192 on of PRC1 in male germ cells results in the gradual loss of a stem cell population and severe differ

193 nd levels during osteoarthritis (OA) promote gradual loss of cartilage.

194 bably reflects channel rundown, which is the gradual loss of channel activity that follows prolonged

195 However, some ES cell lines demonstrated gradual loss of donor mtDNA and reversal to the maternal

196 Although a gradual loss of muscle mass normally occurs with advanci

197 Aging is associated with a gradual loss of naive T cells and a reciprocal increase

198 Thereafter, there was a gradual loss of the 160S virion peak in sucrose gradient

199 rain is the arbiter of a death preceded by a gradual loss of the essence of being.

200 Decreased activity and/or gradual loss of the identified neuronal cell group provi

201 to 74-year old subgroup; however there was a gradual loss of these advantages with increasing age.

202 maging (BLI) of transplanted ASCs revealed a gradual loss of transplanted cells, with a similar rate

203 erapy initiation are fully in line with this gradual loss of X4 tropism during therapy.

204 phase of strongly interacting micelles in a gradual manner with increasing concentration, the format

205 new perspective as compared to conventional, gradual mechanochemical synthesis, where thermal effects

206 acilitate proton leakage and may explain the gradual membrane depolarization observed with daptomycin

207 In this gradual move toward more effective and personalized medi

208 uent serial gonioscopy every 3 months showed gradual narrowing of the right eye angle and finally thr

209 ties of the subsurface flow path explain the gradual, near-exponential decline of both collapse rate

210 rol synthesis and accretion, which may cause gradual neurodegeneration, and we reveal how beta-cyclod

211 If the error persists gradual neuronal adjustments cause the eye movement agai

212 t pancreatic cancer tumorigenesis is neither gradual nor follows the accepted mutation order.

213 For example, with gradual occlusion development over a year, the method fo

214 me countries already have some experience of gradual or regional closures for seasonal influenza outb

215 ng the nature of past sea-level rises (i.e., gradual or stepwise) during deglaciation is critical for

216 hanges in neural representations support the gradual organization of discrete episodes into structure

217 This gradual pattern is inconsistent with the hybrid-sterilit

218 The gradual phenomenon of calcein release would be due to a

219 elin and cholesterol, we observed an overall gradual phenomenon of contents release, together with so

220 Our results are consistent with a gradual population expansion from a limited number of in

221 This unusual poise enables gradual post-translational regulation of the BiP chapero

222 nd on regulatory T cells (Tregs) followed by gradual, presumably peripheral, clonal deletion of donor

223 owever, this approach risks undervaluing the gradual progression from nonlanguage to language over ho

224 with a 4-year history of insidious onset and gradual progression of visual symptoms including right h

225 reater risk stratification and a steady, but gradual progression toward precision medicine.

226 he APs without EADs (no-EAD response) showed gradual prolongation of AP duration (APD), and were anni

227 n maize and its wild relatives, suggesting a gradual, protracted domestication process.

228 ing dynamics of system change (eg, abrupt vs gradual psychosis onset), and determining the factors to

229 rimental and numerical results indicate that gradual pumping of the network combined with multiple sp

230 Ecological niche modeling suggested that a gradual range expansion of P. hwangshanensis during the

231 ion in actinopterygians is compatible with a gradual, rather than a drastic saltation event.

232 ons, and occur much faster than conventional gradual reactions.

233 In this review, we address the gradual recognition that a growing number of polycistron

234 of tryptophan residues leads initially to a gradual reduction in activity before a precipitous reduc

235 This gradual reduction in delta(18)O and delta(2)H values une

236 e phase boundary near the substrate drives a gradual reduction in droplet-substrate contact.

237 us methylation, reduced cmyb expression, and gradual reduction in HSPCs.

238 sustained M-current depression resulted in a gradual reduction in intrinsic excitability.

239 All three groups showed gradual reduction in PI, GI, and OHI-S levels from basel

240 While gradual reduction of risk behaviors along with syphilis

241 for smokers who initially prefer to quit by gradual reduction.

242 hysiologically relevant workloads and during gradual reductions in myocardial oxygenation.

243 In addition, DCN neurons exhibit gradual reductions in their responses to acoustic stimul

244 A gradual regression of liver fibrosis was reported (Metav

245 Gradual regulation of behaviors via this system is requi

246 extremely long half-lives, accumulation and gradual release from subcellular depots.

247 progression of chromosome synapsis, and the gradual release of the individual centromeres from the c

248 t pattern formed during learning, as well as gradual reorganization of this representation toward a s

249 Results suggest that gradual replacement of shortening with oleogels may be a

250 The gradual reprogramming of haematopoietic precursors into

251 ached during first 4 weeks of follow-up with gradual resolution of intraretinal- and subretinal fluid

252 ic atrophy; fluorescein angiography revealed gradual restoration of the choroidal blood flow and unma

253 Upon a gradual retrieval of connectivity, the synchrony evolves

254 (n = 176) or 24 hours (n = 179), followed by gradual rewarming of 0.5 degrees C per hour until reachi

255 llowed by further linear growth and eventual gradual saturation.

256 n is instead better viewed as opposites on a gradual scale, which has more explanatory power and fits

257 ons in all layer 2/3 pathways, we observed a gradual scaling down of the inhibition/excitation ratio

258 However, even gradual sea-level rise can rapidly increase the frequenc

259 itself simultaneously with freezing, driving gradual self-dislodging of droplets cooled via evaporati

260 of correct responses, possibly reflecting a gradual shift from goal-directed execution to automatici

261 We observed a gradual shift in other-regarding preferences from simple

262 H 4.5) after mitophagy, mt-Keima undergoes a gradual shift to longer-wavelength excitation.

263 The lack of C-strand maintenance leads to gradual shortening of the telomeric dsDNA, similar to th

264 the middle face patch was characterized by a gradual spatial enrichment.

265 an brain for years prior to the onset of AD, gradual spontaneous changes to the polypeptides within i

266 ts and report that it is associated with the gradual spread of object-based attention.

267 illing of the 6psigma orbital accompanied by gradual strengthening of Pt-Pt bonding interactions and,

268 ormation of the pseudogap is revealed by the gradual suppression of the featureless conductivity belo

269 In contrast, the gradual sustained Ca(2+) increase occurred independent o

270 single chloroplasts, we confirm findings of gradual, sustained stromal Ca(2+) increases at the tissu

271 lian heart can be reactivated by exposure to gradual systemic hypoxaemia, and highlight the potential

272 n precipitation, o(LA)n-PTX release was more gradual: t1/2 = 14 and 26 h for o(LA)8-PTX and o(LA)16-P

273 g 450 mg/kg of TCC maintained function under gradual TCC addition, but volatile fatty acid concentrat

274 solution of the latest generation (VM3) and gradual temperature lowering to minimize toxicity.

275 Gradual thickening of the arterial wall, changes in wall

276 ing of magnetic domains reveals an unusually gradual thickness-dependent spin reorientation transitio

277 boron-doped diamond (BDD) anode ensured the gradual TOC removal under the action of (*)OH and BDD((*

278 ietveld analysis shows that this is due to a gradual topochemical replacement of coordinated solvent

279 critical role in directing the discrete and gradual transcriptional changes that define T cell devel

280 LM with the drugs (15-60 s) were followed by gradual transfer of the drugs across FLM and gradual lib

281 We predict a gradual transformation from the current epidemic of drug

282 INTERPRETATION: We predict a gradual transformation from the current epidemic of drug

283 trength of the contractile forces regulate a gradual transition between stringlike patterns and vascu

284 Gradual transition from a Siglec-F(med) CD11c(-) to a Si

285 For both proteins, a broad, gradual transition from the native, folded state to the

286 In captivity this is observed as a gradual transition of daytime activity developing into n

287 do-temporal path to order cells based on the gradual transition of their transcriptomes is a useful w

288 differentially expressed genes also showed a gradual trend towards differences between control and PT

289 d by conformational broadening and primarily gradual unfolding, as opposed to the distinct transition

290 ction of cold tolerance was reflected by the gradual up-regulation of abscisic acid-dependent and C-R

291 Immortalization by TPMs requires a gradual up-regulation of telomerase, coinciding with tel

292 We identified a gradual upregulation of four miRNAs: miR-455-3p, miR-466

293 B solutions was evaluated over time, and the gradual uptake of lithium metal was observed.

294 A two-step growth approach along with a gradual variation in Ga-BEP for offsetting the consumpti

295 Stream ecosystems show gradual variation of various selection factors, which ca

296 The effect of gradual warming on decomposition was more pronounced in

297 are strongest next to cryptic exons and that gradual weakening of these motifs contributes to the evo

298 serial episodic disturbances but instead the gradual weathering of soils and soil Ca availability.

299 Gradual weight regain is common after lifestyle interven

300 st, in the Baltic region, the transition was gradual, with little or no genetic input from incoming f