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1 ers containing peptides such as pardaxin and gramicidin.
2 those pertaining before the insertion of the gramicidin.
3 nopore through the support, as recently with gramicidin.
4 study the folding of the antibiotic peptide gramicidin.
5 of the peptide to the double-helical form of gramicidin.
6 orded with the Cl(-)-impermeable pore former gramicidin (25--75 microg ml(-1)) in HCO(3)(-)-free bath
7 e-iodine and 7 days for neomycin-polymyxin B-gramicidin (95% confidence interval [CI] for difference
10 ts on the transfer of protons in both native gramicidin A (gA) and in covalently linked SS- and RR-di
11 ces to protons (g(H)) were studied in native gramicidin A (gA) and in the SS and RR diastereoisomers
12 channel proton conductances (g(H)) in native gramicidin A (gA) and in two diastereoisomers (SS and RR
14 lar dynamics simulations were performed on a gramicidin A (gA) channel in a fully hydrated dimyristoy
15 ts of halothane, a clinical anesthetic, on a gramicidin A (gA) channel in a fully hydrated dimyristoy
18 mechanism and examined genistein's effect on gramicidin A (gA) channels in planar phospholipid bilaye
20 dipole moment of the four Trp side chains in gramicidin A (gA) channels modify channel conductance th
21 ferent stereoisomers of the dioxolane-linked gramicidin A (gA) channels reconstituted in planar lipid
22 ferent stereoisomers of the dioxolane-linked gramicidin A (gA) channels were individually synthesized
23 single SS stereoisomers of dioxolane-linked gramicidin A (gA) channels were measured in different ph
24 of the four tryptophans of membrane-spanning gramicidin A (gA) channels, the inclusion of the perpend
26 rried out coarse-grained (CG) simulations of gramicidin A (gA) dimer association and analyzed the res
27 the three-dimensional stress field around a gramicidin A (gA) dimer in lipid bilayers that feature d
28 ly kinetics and conformer preferences of the gramicidin A (GA) dimer is investigated using a combinat
29 The conformational preferences adopted by gramicidin A (GA) dimers inserted into phospholipid bila
30 ize the volatile anesthetic binding sites in gramicidin A (gA) incorporated into sodium dodecyl sulfa
31 be the solution phase structure of dimerized Gramicidin A (GA) inserted into lipid vesicle bilayers i
34 ata set for homodimeric channels formed from gramicidin A (gA) or any of eight fluorinated Trp analog
35 as replaced by Ser at position 3 or 5 in the gramicidin A (gA) sequence: formyl-VG(2)A(3)LA(5)VVVWLWL
36 le ion channel conductance of derivatives of gramicidin A (gA) upon reaction with analytes in solutio
37 rom labeled tryptophans in membrane-spanning gramicidin A (gA)(1) channels to refine the geometry of
38 protons in water wires was studied in native gramicidin A (gA), and in the SS- and RR-diastereoisomer
39 of measurements of proton conduction through gramicidin A (gA), B (gB), and M (gM) homodimer channels
40 gallate (nPG)--on bilayer properties using a gramicidin A (gA)-based fluorescence quench assay to pro
43 tors incorporate transmembrane peptide pores gramicidin A and alamethicin in the lipid bilayer they c
44 mer or doubly charged monomer of the peptide gramicidin A and conformers of the [M + 5H](5+) form of
45 rent-voltage relations of (5F-Indole)Trp(13) gramicidin A and gramicidin A channels (, 75:2830-2844).
46 ublished homodimer conductance data for both gramicidin A and gramicidin M channels confirms this con
47 shable populations about halfway between the gramicidin A and gramicidin M homodimer conductances.
48 implies that the principle difference in the gramicidin A and gramicidin M transport free-energy prof
49 elated to the free-energy difference between gramicidin A and gramicidin M, we construct an effective
50 (1)H spin diffusion experiments on unlabeled gramicidin A are sufficient to discriminate between the
53 ferent stereoisomers of the dioxolane-linked gramicidin A channel (the SS and RR dimers) were measure
55 rifluorocyclobutane (F3), was found to alter gramicidin A channel function by enhancing Na(+) transpo
57 ifluorocyclobutane causes minimal changes in gramicidin A channel structure in sodium dodecyl sulfate
58 d closing of the monovalent cation selective gramicidin A channel through single channel conductance,
59 we consider ion permeation energetics in the gramicidin A channel using a novel polarizable force fie
61 have been proposed for the membrane-spanning gramicidin A channel: one based on solid-state NMR exper
65 re the consequences of lipid diversity using gramicidin A channels embedded in phosphatidylcholine (P
67 ree energy governing K(+) conduction through gramicidin A channels is characterized by using over 0.1
74 lular membrane with the liposomes containing gramicidin A forming cation-conductive beta-helix in the
75 channel formed by a dimer of the polypeptide gramicidin A has a single-stranded, right-handed helical
76 n of the gramicidin channel, four analogs of gramicidin A have been synthesized in which the tryptoph
77 ld slower in gramicidin M homodimers than in gramicidin A homodimers and that first- and second-ion e
78 t claim, the solid-state NMR constraints for gramicidin A in a lipid bilayer are not consistent with
79 hree-dimensional continuum elastic model for gramicidin A in a lipid bilayer is shown to describe the
81 m transport study showed that with 75 microM gramicidin A in a vesicle suspension of 66 mM PC/PG, F3
83 age relations for ion permeation through the gramicidin A ion channel embedded in membranes character
84 h is utilized to predict current through the Gramicidin A ion channel, a narrow pore in which the app
88 the conductance of the pore-forming peptide gramicidin A to monitor PLD activity, the work presented
90 k lipid membranes (BLMs) functionalized with gramicidin A were conducted using a fast perfusion syste
93 of depths in membrane systems is applied to gramicidin A, a membrane-bound peptide of known structur
94 using experimental solid-state NMR data from gramicidin A, a monovalent cation channel in lipid bilay
95 ture of the channels when compared to native gramicidin A, and only small effects are seen on side-ch
97 l as hydrophilic defects and the ion channel gramicidin A, to provide parallels to membranes deformed
98 a backbone fold identical to that of native gramicidin A, with only small changes in the side chain
99 utions were introduced into the enantiomeric gramicidin A-, gA-.) Circular dichroism spectra of [D-Al
100 Unlike dioleoyl phosphatidylethanolamine and gramicidin A-DOPC, small-angle x-ray scattering and (31)
101 tions, dioleoyl phosphatidylethanolamine and gramicidin A-DOPC, which form the negatively curved hexa
114 ced cytotoxicity and direct Na(+) loading by gramicidin-A caused Pico145-resistant cytotoxicity in th
116 ramework model for proton conduction through gramicidin; a model designed to incorporate information
118 that include formation of a water-insoluble gramicidin aggregate, dissociation from the aggregate, p
120 gAB transcription was shown to be induced by gramicidin and CCCP, agents known to dissipate the proto
123 than the known membrane targeting antibiotic gramicidin and the known antifungal agent amphotericin B
124 e experimental values of bilayer thinning by gramicidin and the shift in the peak position of the in-
125 icked by treatment with the sodium ionophore gramicidin and were correlated with the increased intrac
126 agent (sodium arsenite), K-releasing agent (Gramicidin) and a metal ionophore (dithiocarbamate).
127 rin, mycosubtilin, nikkomycin, enterobactin, gramicidin, and several proteins from the orphan pksX ge
128 dies was tested using the model ion channel, gramicidin, and voltage-clamp fluorometry measurements w
131 e results indicate that two or more forms of gramicidin are in equilibrium with each other in the lay
132 enes for the synthesis of antibiotics of the gramicidin/bacitracin family; however, no bacteriophage
133 evelop a model for proton conduction through gramicidin based on the molecular dynamics simulations o
135 the integration of GABAergic inputs, we used gramicidin-based patch-clamp recording of STN neurons in
138 tion current is consistent with the model of gramicidin being speciated in the monolayer in more than
140 on of the Na(+),K(+)-ATPase or the ionophore gramicidin), cells expressing the D447V mutant rapidly a
141 en the multiple conformational states of the gramicidin channel and its closed and open states in a l
142 eptide side chains has been shown to perturb gramicidin channel conductance without significantly cha
144 nt direct measurements of the orientation of gramicidin channel F-Trp positions for use in analysis o
146 This paper reports on a simulation of a gramicidin channel inserted into a fluid phase DMPC bila
148 o individually access each half of a dimeric gramicidin channel makes it possible to generate asymmet
149 itution on the structure and function of the gramicidin channel, four analogs of gramicidin A have be
152 profile in the presence of a high density of gramicidin channels and ran computer simulations of 81 g
155 solvation effects of side chain residues of gramicidin channels by double acyl chains and by the pre
157 ollection modes to study K+ transfer through gramicidin channels in a horizontal bilayer lipid membra
161 channels and ran computer simulations of 81 gramicidin channels to find the equilibrium distribution
162 probable nearest-neighbor separation between gramicidin channels was 26.8 A in DLPC, but reduced to 2
163 annels are structurally equivalent to native gramicidin channels, as demonstrated by the formation of
164 fluorescence self-quenching from dye-labeled gramicidin channels, we observed that the efficiency of
173 The effects of the channel-forming peptide gramicidin D (gD) on the conductance and electroporation
177 Liquid sample DESI of hydrophobic peptide gramicidin D suggests that the ionization mechanism invo
179 les containing the peptides gramicidin S and gramicidin D were analyzed both with and without the mat
180 ducer of heat shock and oxidative stress, or gramicidin D, a toxin that selectively permeabilizes cel
182 ed by cell sensitization to Vinca alkaloids, gramicidin D, and Taxol with no effect on cell sensitivi
183 ble to the polypeptide pore-forming molecule gramicidin D, independent of the Vsa type and length.
184 cle fusion to a planar bilayer) to show that gramicidin dimer channels do not normally dissociate whe
185 agents: sodium arsenite, an oxidative agent; Gramicidin, eliciting K(+) efflux and calcium influx; di
187 ed protein-protein interactions exhibited by gramicidin embedded in dimyristoylphosphatidylcholine (D
188 In planar bilayers, the Ser-substituted gramicidins form well-defined channels, with cation cond
189 the feasibility of such a mechanism, we used gramicidin (gA) analogues of different lengths together
194 with an x-ray crystallographic structure for gramicidin having a double-stranded, right-handed helix
196 iac glycosides or directly after exposure to gramicidin in low sodium media-is sufficient to disrupt
197 -iodine or antibiotics (neomycin-polymyxin B-gramicidin in the Philippines; ciprofloxacin 0.3% in Ind
198 MR spectroscopy of single-site (15)N-labeled gramicidin in uniformly aligned bilayers in the L(alpha)
199 pectrometry to study the self-association of gramicidin in various organic and mixed solvents that ar
200 estigated by synthesizing and characterizing gramicidins in which Trp(9) was ring-labeled and D-Leu(1
201 annels (e.g., alpha-hemolysin (alpha-HL) and gramicidin) in the bilayer is observed; conversely, reve
202 nide m-chorophenylhydrazone or the ionophore gramicidin, indicating that the synaptic vesicle proton
204 h-clamp fluorescence microscopy by measuring gramicidin ion channel conformational changes in a lipid
205 elastic response provides an explanation for gramicidin ion channel lifetime versus membrane thicknes
206 nt, the mycoplasmas were highly sensitive to gramicidin irrespective of the length of the Vsa protein
210 rsion of a complex porin-like channel into a gramicidin-like channel provides a link between two diff
212 A method is demonstrated to extract the gramicidin-lipid boundary condition from all-atom simula
213 r conductance data for both gramicidin A and gramicidin M channels confirms this conclusion, indicati
216 ion step is approximately 100-fold slower in gramicidin M homodimers than in gramicidin A homodimers
217 id-state NMR to investigate the structure of gramicidin M in a lipid bilayer and to investigate the m
218 principle difference in the gramicidin A and gramicidin M transport free-energy profiles occurs at th
219 e-energy difference between gramicidin A and gramicidin M, we construct an effective ion-Trp free-ene
222 he IPSC reversal potential was determined by gramicidin perforated patch recordings to be -65.3 +/- 5
223 al dentate granule cells were recorded using gramicidin perforated patch techniques at varying times
225 , we performed cell-attached, whole-cell and gramicidin perforated patch-clamp recordings of progenit
239 m the AOB, and used the whole-cell patch and gramicidin-perforated patch clamp techniques to measure
246 both early postnatal and adult periods, and gramicidin-perforated patch-clamp recordings revealed th
248 in embryonic NM neurons using whole-cell and gramicidin-perforated patch-clamp techniques to measure
250 rded from current-clamped neurones using the gramicidin-perforated technique, the application of taur
252 o inhibited the BK-induced inward current in gramicidin-perforated whole-cell patch-clamp recordings
253 corded GABAergic synaptic currents using the gramicidin-perforated-patch method and found their rever
254 functional group attached to one side of the gramicidin pore induces diodelike conductance behavior i
255 The transport of a single proton through the gramicidin pore is described by a potential of mean forc
256 tage of the amplification characteristics of gramicidin pores to sense the activity of picomolar to n
257 Like previous simulations with a lower lipid/gramicidin ratio, it is found that tryptophan-water hydr
258 l and beta-helix formation, as in porins and gramicidin, respectively, represent two distinct mechani
259 previously, dications of the cyclic peptide Gramicidin S (GS) and the photoactive organonometallic c
261 mounts of model peptides HLGLAR (m/z 666.8), gramicidin S (m/z 1142.5), and bovine insulin b chain (m
264 osynthesize the symmetric cyclic decapeptide gramicidin S and the cyclic lipoheptapeptide surfactin A
270 cyclization activity: the TE domain from the gramicidin S NRPS catalyzes head-to-tail cyclization of
271 tion of DPD with viral DNA or the antibiotic gramicidin S resulted in significant biochemical alterat
272 f the nonribosomal peptide synthetase enzyme gramicidin S synthetase A (GrsA-PheA) for a set of nonco
273 tion module PheATE (GrsA) of Bacillus brevis gramicidin S synthetase catalyzes the activation, thiola
274 n (ATE) initiation module of Bacillus brevis gramicidin S synthetase equilibrates the Calpha configur
277 clization of a decapeptide thioester to form gramicidin S, and the TE domain from the surfactin NRPS
279 ly protonated substance P, doubly protonated gramicidin S, doubly protonated neurotensin, and triply
280 on also was observed with the cyclic peptide gramicidin S, indicating the generality of the mechanism
281 n, cephalosporins, streptomycin, fosfomycin, gramicidin S, rapamycin, indolmycin, microcin B17, fumag
289 cules per leaflet were removed to insert the gramicidin, so the resulting preparation had 96 lipid mo
291 ed in redesign for three different proteins: Gramicidin Synthetase A, plastocyanin, and protein G.
293 ated to the maximum signal after addition of gramicidin, the maximal percent increases in fluorescenc
295 2+) influx or stimulation of Na(+) influx by gramicidin was accompanied by a facilitation of cyclic n
301 published data concerning the interaction of gramicidin with bilayers and the hydrophobic mismatch ef
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