ライフサイエンスコーパス: grand

1 sion or single-subject/session maps from the grand (5-session) maps.

2 a single Cd(II) binding site, GrandL12AL16C [Grand = AcG-(LKALEEK)(5)-GNH(2)], GrandL26AL30C, and Gra

3 ecific populations, the genetic basis of the grand adaptive sweep of selective evolutionary change, m

4 sponsible for Mendelian disorders provides a grand and unprecedented opportunity for geneticists.

5 ion of RTG2 diminishes ERC formation in both grandes and petites.

6 e classified into a Murre virus species; and Grand Arbaud virus, Precarious Point virus, and Manawa v

7 d to cover a wide range of hydrophobicities (grand average hydropathy (GRAVY) scores of -0.6 to 1.9).

8 The grand average of all the significantly correlated subtha

9 s most clearly in the difference between the grand-average ERPs for attending to vs. ignoring the con

10 The grand-averaged difference in root mean squared voltage b

11 , 53 cousin, 7 grandparent-grandchild, and 9 grand-avuncular pairs.

12 ca and the Bahamas (Abaco, Eleuthera, Exuma, Grand Bahama, Long Island and New Providence).

13 anging from 79.1% to 100% in Long Island and Grand Bahama, respectively, illustrating the capacity of

14 ranged from 0.989 in Long Island to 1.000 in Grand Bahama, with limited haplotype sharing observed am

15 A case study was conducted on the Grand Banks of Newfoundland, Canada.

16 oints to a few specific locations around the Grand Banks where LSW is most often injected into the in

17 Equilibrium BD simulations in the grand canonical ensemble indicate that the channel is ve

18 The grand canonical ensemble lies at the core of quantum and

19 We then perform grand canonical ensemble simulations that enable us to s

20 d at an atomistic resolution within the semi-grand canonical ensemble using mutation moves to rapidly

21 iversal features of disordered bosons in the grand canonical ensemble.

22 nt to that of a lattice gas of bosons in the grand canonical ensemble; bromine doping introduces diso

23 A grand canonical formalism is developed to combine discre

24 ed physiological concentration, although the grand canonical free energy profiles are uphill for HTT

25 et was allowed to fluctuate via the use of a Grand Canonical Monte Carlo (GCMC) methodology.

26 Grand canonical Monte Carlo (GCMC) simulation provides m

27 d vapor adsorption experiments together with Grand Canonical Monte Carlo (GCMC) simulations, and coul

28 uantum mechanics (QM)-based force fields and grand canonical Monte Carlo (GCMC) simulations.

29 ntal observations are consistent with ReaxFF grand canonical Monte Carlo (ReaxFF-GCMC) calculations,

30 ns based on molecular dynamics combined with grand canonical Monte Carlo and free energy simulations

31 Grand canonical Monte Carlo Brownian dynamics (GCMC/BD)

32 Enabled by a new grand canonical Monte Carlo method for membrane simulati

33 Grand canonical Monte Carlo simulation reveals that not

34 of 26.7 kJ/mol, which was validated through grand canonical Monte Carlo simulation studies of CH4 ad

35 tical and methodological developments to the grand canonical Monte Carlo simulation technique.

36 Grand canonical Monte Carlo simulations and single compo

37 CO(2)/H(2)O gas mixtures were determined by grand canonical Monte Carlo simulations at temperature/p

38 hotoelectron spectroscopy, and complementary grand canonical Monte Carlo simulations coupled to a tig

39 Extensive grand canonical Monte Carlo simulations in combination w

40 Grand canonical Monte Carlo simulations of defective can

41 The study starts with grand canonical Monte Carlo simulations on a suite of 10

42 e filling of one site compared to the other: grand canonical Monte Carlo simulations support these ex

43 Grand canonical Monte Carlo simulations were also perfor

44 f Cs migration in partially saturated clays, Grand Canonical Monte Carlo simulations were applied to

45 Grand canonical Monte Carlo simulations were carried out

46 In this work, grand canonical Monte Carlo simulations were used to pre

47 n these structures was studied by performing grand canonical Monte Carlo simulations with appropriate

48 diffraction, density functional theory, and grand canonical Monte Carlo simulations, we show that in

49 terpenetrated structure has been modelled by grand canonical Monte Carlo simulations.

50 We performed grand canonical Monte Carlo/Brownian dynamics (GCMC/BD)

51 rameworks (COFs) from first-principles-based grand canonical Monte-Carlo simulations.

52 In this article we make use of a grand canonical screening approach recently proposed to

53 The grand canonical simulation method accounts for the acid/

54 osition pathways of LiBH4 nanoclusters using grand-canonical free-energy minimization based on total

55 nic structure methods and characterized with Grand-canonical Monte Carlo simulations for methane upta

56 By calculating the grand-canonical partition function term by term, we show

57 w paleocanyon that was carved in the eastern Grand Canyon 25 to 15 million years ago (Ma), negating t

58 poch lava flowed into the inner gorge of the Grand Canyon and formed lava dams, as high as 600 m, tha

59 consistent with a 5 to 6 Ma age for western Grand Canyon and Marble Canyon.

60 (4)He/(3)He spectra for eastern Grand Canyon apatites of differing He date, radiation da

61 (4)He/(3)He thermochronometry data from the Grand Canyon basement that tightly constrain the near-su

62 al. reported that development of the western Grand Canyon began about 17 million years ago.

63 that geological observations do not require Grand Canyon carving coeval with Colorado River integrat

64 and inferred incision data indicate that the Grand Canyon evolved via headward erosion from west to e

65 The age and evolution of the Grand Canyon have been subjects of great interest and de

66 leading to their inference that the western Grand Canyon incised much earlier than previously though

67 Using Grand Canyon incision rates and Pliocene basaltic volcan

68 Flowers and Farley propose that the Grand Canyon is 70 million years old.

69 The Grand Canyon is one of the most dramatic features on Ear

70 nium-lead dating evidence for an old western Grand Canyon on the assumption that groundwater table de

71 Similar data for the western Grand Canyon provide evidence that it was excavated to w

72 ast 17 million years, in contrast to eastern Grand Canyon samples that yielded much faster rates (166

73 nterior-basin deposits near the mouth of the Grand Canyon show that no paleocanyon existed in that ar

74 ndicator speleothems) from nine sites in the Grand Canyon showed uranium-lead dating evidence for an

75 hronometry to propose that the western paleo-Grand Canyon was nearly as deep 70 million years ago (Ma

76 Samples in the western Grand Canyon yielded apparent water table decline rates

77 tarkly contrasting models for the age of the Grand Canyon-70 versus 6 million years-can be reconciled

78 er-term rates derived from sites outside the Grand Canyon.

79 congenital ataxia restricted to one area of Grand Cayman Island.

80 at affect this process identified two genes, GRAND CENTRAL (GCT)and CENTER CITY (CCT).

81 by CENTER CITY (CCT; Arabidopsis MED12) and GRAND CENTRAL (GCT; Arabidopsis MED13) are required for

82 single- or few-layered nanosheets remains a grand challenge and becomes the bottleneck to essential

83 The grand challenge before us is to sustainably meet humanit

84 eously produce viable tools for a biological grand challenge domain with no extant solutions.

85 tanding of human intelligence is perhaps the grand challenge for 21st-century science, with broad imp

86 atalyzing any desired chemical reaction is a grand challenge for computational protein design.

87 neered and industrial environments remains a grand challenge for geomicrobiology.

88 cules that target allosteric sites remains a grand challenge for ligand discovery.

89 the neural correlates of consciousness is a grand challenge for neuroscience.

90 emical and thermal properties is viewed as a grand challenge for scientists and engineers.

91 There is a grand challenge for the detection of target molecules at

92 rochemical window in solid electrolytes is a grand challenge for the synthesis of battery materials.

93 ing the combination of these properties is a grand challenge for the synthesis of sulfide-based solid

94 This grand challenge has mostly proved ineffective because of

95 er in response to environmental stimuli is a grand challenge in active materials, structures, and rob

96 reserving 3D context, represents an enduring grand challenge in biology.

97 enome of an organism into its phenotype is a grand challenge in biology.

98 characterization of supported catalysts is a grand challenge in catalytic science.

99 proteins from first principles represents a grand challenge in chemistry and structural biology.

100 pologies at the molecular level represents a grand challenge in chemistry.

101 dioxide to multicarbon products remains as a grand challenge in electrochemical CO2 reduction.

102 A grand challenge in material science is to understand the

103 anostructures and identical composition is a grand challenge in materials chemistry.

104 A grand challenge in materials research is to understand c

105 has been developed to address the number one grand challenge in metabolomics, which is the large-scal

106 d particularly protein folding, is a classic grand challenge in molecular biophysics.

107 and materials at the level of electrons is a grand challenge in science, relevant to our understandin

108 tionship to solid-state phase formation is a grand challenge in synthesis science.

109 A grand challenge in synthetic biology is to use our curre

110 n from large-scale functional data sets is a grand challenge in systems biology.

111 A grand challenge is assembling and positioning the nanopa

112 A grand challenge is to develop a general cancer screening

113 ction and provision of human sustenance, the grand challenge is to intervene before more tipping poin

114 Modern chemistry's grand challenge is to significantly improve catalysts fo

115 It is currently a grand challenge of chemistry, materials science, and eng

116 starting purely from a protein sequence is a grand challenge of computational biology.

117 tein structure from amino acid sequence is a grand challenge of computational molecular biology.

118 ell as climate atmosphere ocean science is a grand challenge of contemporary science with important s

119 us providing instrumental technology for the grand challenge of engineering N2-fixing cereals.

120 n as a complementary solution to address the Grand Challenge of global food security and environmenta

121 ution in deep tissue is often considered the grand challenge of optical imaging.

122 stly arising from feed production, is thus a grand challenge of sustainability science.

123 A grand challenge of systems biology is to predict the kin

124 ow-entropy states is an essential step and a grand challenge of the whole emulation enterprise.

125 liquids, and offering the potential to solve grand challenge problems.

126 A grand challenge that crosses synthetic chemistry and bio

127 veloped a new microgel array to address this grand challenge through robotic printing of complex stem

128 It is a grand challenge to develop a truly effective medication

129 However, it has been a grand challenge to maintain the viability, functionality

130 It remains a grand challenge to replace platinum group metal (PGM) ca

131 Control of these complex systems is a grand challenge, for example, in mitigating the effects

132 Once regarded as a grand challenge, protein folding has seen great progress

133 Princeton University Health Grand Challenge, US National Institutes of Health (NIH),

134 choose, an aspiration of the Dial-a-Molecule Grand Challenge.

135 and fabricate biological machines remains a grand challenge.

136 films at submicrometer resolution presents a grand challenge.

137 t unite all lineages (the tree of life) is a grand challenge.

138 and their ecological determinants remains a grand challenge.

139 ever, in silico vaccine prediction remains a grand challenge.

140 uld accelerate progress toward meeting this "grand challenge."

141 Special attention will be paid to the grand-challenge related to detection, quantification and

142 Grand Challenges Canada (Government of Canada), Saving B

143 Bill & Melinda Gates Foundation, Grand Challenges Canada, and the UK Medical Research Cou

144 Grand Challenges Canada, Bill & Melinda Gates Foundation

145 Grand Challenges Canada, the Bill & Melinda Gates Founda

146 Bill & Melinda Gates Foundation, Grand Challenges Canada, UK Medical Research Council.

147 Bill & Melinda Gates Foundation, Grand Challenges Canada, UK Medical Research Council.

148 National Institutes of Health, Grand Challenges Canada.

149 ment to define this conversion as one of the Grand Challenges for Biology in the 21st Century.

150 One of the grand challenges in chemistry has been to directly obser

151 Grand challenges in global change research and environme

152 Health (as part of the Bill & Melinda Gates Grand Challenges in Global Health Initiative).

153 n international panel announces a list of 14 Grand Challenges in Global Health, and scientists throug

154 reservoir of enzymes that could help address grand challenges in human health, energy, and sustainabi

155 tocatalyts for water splitting is one of the grand challenges in solar energy conversion.

156 and Nervous System Disorders established a "Grand Challenges Initiative." The goal is to help frame

157 One of the grand challenges of human genetics to systematically map

158 cular profile datasets represents one of the grand challenges of Systems Biology.

159 US National Institutes of Health, Princeton Grand Challenges Program.

160 Future directions and grand challenges to realize these goals are highlighted

161 We then examine several environmental "grand challenges" and discuss how urban land teleconnect

162 r conclusions, we present our choice of the "grand challenges" for the preservation and sharing of ch

163 One of the remaining "grand challenges" in chemistry is the development of a n

164 e social dynamics prevent the formation of a grand coalition and therefore full cooperation.

165 As part of the "Grand Convergence: Aligning Technologies and Realities i

166 These grand cycle variations are probed by alpha - Omega dynam

167 leads to beating effects responsible for the grand cycles (350-400 years) superimposed on a standard

168 kward for 800 years reveals the two 350-year grand cycles superimposed on 22 year-cycles with the fea

169 r the next millennium predicts further three grand cycles with the closest grand minimum occurring in

170 asymmetric cell divisions, only one in four 'grand-daughter' cells undergoes a 'mating-type switch',

171 aternal grandmother smoking in pregnancy and grand daughters having adverse scores in Social Communic

172 affect fertility of resulting daughters and grand-daughters.

173 o now subsume all of the other shuttles as a grand description of the role(s) of lactate in numerous

174 up in longevity gains, and avoid a so-called grand divergence in health and longevity.

175 e but refute the anthropocentric view that a grand enhancement in Darwinian selection underlies human

176 experiment, the first multi-thousand-member grand ensemble of simulations using a general circulatio

177 hed that uses the many ongoing projects as a grand experiment.

178 Islands provide the venue of one of nature's grand experiments in evolution.

179 trolled by nuclear control factors, and in a grand feedback the cell adhesion and signaling systems d

180 Grand fir (Abies grandis Lindl.) has been developed as a

181 Grand fir (Abies grandis) has been developed as a model

182 The oleoresin secreted by grand fir (Abies grandis) is composed of resin acids der

183 o wound-inducible sesquiterpene synthases of grand fir (Abies grandis), and the olefin product of thi

184 e initial step of resin acid biosynthesis in grand fir (Abies grandis).

185 abietadiene synthase has been isolated from grand fir and the heterologously expressed bifunctional

186 atalyzed by the sesquiterpene synthases from grand fir are among the most complex of any terpenoid cy

187 Abietadiene synthase from grand fir catalyzes two sequential, mechanistically dist

188 was converted to todomatuic acid in induced grand fir cells, and the time course of appearance of bi

189 e synthase was isolated from a wound-induced grand fir stem library by a PCR-based strategy and was f

190 Assays of cell-free extracts from grand fir stem with farnesyl diphosphate as substrate in

191 es and/or inhibitors for recombinant AS from grand fir.

192 ction of all of the resin acid precursors of grand fir.

193 of monoterpene and diterpene synthases from grand fir.

194 tric cardiology site), and the Altru Clinic, Grand Forks, North Dakota (primary care site), which is

195 a childhood in Germany and being a youth in Grand Forks, North Dakota, I went to Harvard University,

196 dering at the mesoscopic scale are among the grand fundamental science challenges.

197 oil washing ashore in Plaquemines Parish and Grand Isle, Louisiana, and Pensacola, Florida, in May 20

198 across HRRs from 0.58 chronic conditions in Grand Junction, Colorado, to 1.23 in Miami, Florida (mea

199 he dissolved phases, were collected from the Grand, Kalamazoo, Saint Joseph, and Lower Fox rivers and

200 les from five Lake Michigan tributaries [the Grand, Kalamazoo, St. Joseph, and Lower Fox Rivers, and

201 )(5) M for Baby L12C to 2.5 x 10(-)(9) M for Grand L9C for binding of the third thiolate to a linear

202 The binding of Hg(II) to the peptide Grand L9C is similar in energetics for metal binding in

203 Approximately, 11 kcal/mol of the Hg(II)(Grand L9C)(3)(-) stability is due to peptide interaction

204 ilies, JME was most common (40%) followed by grand mal (GM) only (35%).

205 Families with either pure grand mal epilepsy or absence epilepsy contributed equal

206 Epilepsy with grand mal on awakening (EGMA) is a well-defined subtype

207 Transgenic mice also had a grand mal seizure disorder accompanied by a correspondin

208 rring either randomly during the day (random grand mal) or on awakening (awakening grand mal), and ju

209 random grand mal) or on awakening (awakening grand mal), and juvenile absence epilepsy (JAE).

210 N2O, and NH3 from a 2006 model year Mercury Grand Marquis flexible fuel vehicle (FFV) operating on E

211 Exposure to low-protein grand-maternal diet leads to decreased ovarian reserve a

212 CP without protein or leucine ingestion, the grand mean +/- SEM plasma 3-HIB concentration decreased

213 This effect compared with a grand mean effect of g = -0.98 and was significantly lar

214 Nevertheless, the grand mean firing rate of the whole pyramidal cell popul

215 We calculated a grand mean for individual seafood items, based on report

216 Farmed fish generally had lower grand mean Hg concentrations than their wild counterpart

217 rom 35 +/- 2 to 14 +/- 1 micromol/L) and the grand median [quartiles] FGF21 concentration increased (

218 ting total solar irradiance estimates during grand minima.

219 further three grand cycles with the closest grand minimum occurring in the forthcoming cycles 26-27

220 The most recent "grand minimum" of solar activity, the Maunder minimum (M

221 in the cerebral cortex, cerebellum, parotid grand, myocardium, and bowel mostly reflected the (18)F-

222 two dessert bananas of commercial interest (Grand Nain and Gros Michel), alongside a newly created h

223 Cavendish', 'Giant Cavendish', 'Dwarf Red', 'Grand Nain', 'Eilon', 'Gruesa', 'Silver', 'Ricasa', 'Wil

224 Our findings indicate ways in which the Grand National could be made safer for horses and illust

225 By analysing data from the past 15 Grand National races (consisting of 560 starts by horses

226 As in other competitive sports, the famous Grand National steeplechase, which is held at Aintree in

227 "This grand natural scene was a physical correlate of Francis'

228 witchable fluorescent proteins (PS-FPs) open grand new opportunities in biological imaging.

229 males switching to invest in their existing (grand)offspring, thereby increasing their inclusive fitn

230 cts from the National Heart, Lung, and Blood Grand Opportunity Exome Sequencing Project.

231 ed by the 1000 Genomes Project and the NHLBI Grand Opportunity Exome Sequencing Project.

232 affect silencing of ribosomal DNA in either grandes or petites, which were similar to each other in

233 rameters on million-year time scales induce "grand orbital cycles," but the behavior and the paleoenv

234 Immunomedics, Amgen, Canceropole Grand Ouest, the GOELAMS/LYSA group and the French Natio

235 ," was held on November 10-12, 2009 at Hotel Grand Palace, Tokyo, Japan.

236 and transsexuals by way of retention of the grand parental epigenotype on the X chromosome.

237 ansfer of information, such as the effect of grand parental smoking or exposure to other toxic compou

238 to convey a sense that one need not have a "grand plan" to have a successful life in science.

239 f tissue engineering has not full-filled its grand potential of engineering such combinatorial scaffo

240 The $10 million grand prize will be awarded to the first team to meet al

241 If there is no grand prize winner, lesser awards will be made for singl

242 Cultivars Iceberg and Grand Rapids that were released in the 18th and 19th cen

243 the Michigan Thumper (Michigan Instruments, Grand Rapids, MI), as an industrial standard, and the mi

244 stance at this locus originate from cultivar Grand Rapids.

245 nd cultures such as Greater Nicoya and Casas Grandes represent Mesoamerican outposts in the Isthmo-Co

246 loyed in wastewater-dominated reaches of the Grand River (Kitchener, ON) to verify their feasibility

247 h across an urban environment in the central Grand River watershed (Ontario, Canada).

248 ature, land use and surficial geology in the Grand River, Canada, a seventh-order river in an agricul

249 have been reported for several years in the Grand River, in southern Ontario, Canada, in close proxi

250 uscaloosa, Weyburn-Midale, Bass Islands, and Grand Ronde carbon sequestration geologic formations.

251 In this Grand Round we describe a 2-year-old child from the USA

252 In this Grand Round, we present the case of an otherwise healthy

253 In this Grand Round, we review the clinical features of hypervir

254 In this Grand Round, we review the clinical features, epidemiolo

255 In this Grand Round, we review the clinical features, epidemiolo

256 the man in his world." We hope this unusual Grand Rounds case intrigues you as it reminds you of Cus

257 In celebration of this milestone, a unique Grand Rounds case is presented.

258 linical practice guidelines was ensured by a grand rounds lecture and by posting guideline reminders

259 This Grand Rounds review describes the evaluation and evidenc

260 The Oncology Grand Rounds series is designed to place original report

261 The Oncology Grand Rounds series is designed to place original report

262 The Oncology Grand Rounds series is designed to place original report

263 The Oncology Grand Rounds series is designed to place original report

264 f local physician and nurse opinion leaders; grand rounds site visits; and premeasurement and postmea

265 This Grand Rounds summarizes the factors to consider when cou

266 In this Grand Rounds, 2 prominent clinicians debate whether to i

267 In this Grand Rounds, 2 prominent endocrinologists debate the is

268 coordinator at each facility, consisting of grand rounds, a chart reminder system, group discussion

269 studies, included a presentation at medical grand rounds, a publication in the staff newsletter, mee

270 t physicians and nurses include use of joint grand rounds, patient care seminars, and interprofession

271 In this Grand Rounds, the case of a 30-year-old man with a 12-ye

272 In this Grand Rounds, the guideline is reviewed and an expert di

273 In this grand rounds, we focus on development, validation, and a

274 In this Grand Rounds, we summarize the results of the clinical t

275 Residents of Bocozel or Grand Saline who were eligible for the vaccination campa

276 ation and subsequent protein sequencing on a grand scale to identify individual components.

277 humans have ever created, presents a unique grand-scale natural experiment that allows ecologists to

278 +/- 0.51 D vs 2.03 +/- 1.03 D, P < .001) and Grand Seiko (0.46 +/- 0.45 D vs 0.99 +/- 1.0 D, P < .001

279 Measurements were taken with the Grand Seiko autorefractor (RyuSyo Industrial Co., Ltd.,

280 er manufactured) or a Grand Seiko WR 5100-K (Grand Seiko Co., Hiroshima, Japan) autorefractor.

281 ke Success, NY; no longer manufactured) or a Grand Seiko WR 5100-K (Grand Seiko Co., Hiroshima, Japan

282 s, NY [no longer manufactured] or WR 5100-K; Grand Seiko, Hiroshima, Japan).

283 ta Rica (n = 9; A.D. 800-1250) and the Casas Grandes sites of Paquime and Convento in northwest Mexic

284 ations in the hypothalamus-pituitary-adrenal grand stress.

285 ortality displacement, which is the ratio of grand sum deficit to grand sum excess mortality, decreas

286 , which is the ratio of grand sum deficit to grand sum excess mortality, decreased as a function of e

287 nanotechnology and nanosciences) to the very grand (sustainable development, global change and ecosys

288 Ultimately, this grand synthesis should improve predictive capability of

289 s within both the classical scenario and the Grand Tack scenario of terrestrial planet formation, and

290 ermine how cognitive systems change over the grand time scale of an entire life, as few cognitive sys

291 tive method, the best estimate of the global grand total is roughly 200 extinctions.

292 ome at physiological pH, this resulting in a grand total of 1151 gene products identified after the c

293 ll plates analyzed in 1 day is considered a "grand tray", and the method is cross-validated with stan

294 rse and would constrain new physics from the grand unification scale to the Planck scale.

295 A grand unified model (GUM) is developed to achieve fundam

296 onopoles resulting from symmetry breaking in grand unified theories.

297 Clark argues that predictive coding offers a Grand Unified Theory (GUT) of brain function.

298 oach to evolutionary biology, in lieu of any grand unified theory updated to include microbial genomi

299 cal control agents, these results expand the grand view of the diversity of mycoviruses and provide p

300 ient inhabitants of Greater Nicoya and Casas Grandes with contemporary Isthmo-Columbian and Greater S