ライフサイエンスコーパス: granule

1 in ptst2 mutants contained zero or one large granule.

2 g dry matter) separated from the HHP-treated granule.

3 role heterotrophic bacteria play in anammox granules.

4 neurons, to the cytoplasm to form TDP-43 RNA granules.

5 asm and Dock7 on the membrane of or in alpha-granules.

6 evels, and reductions in cytoplasmic storage granules.

7 ough directed secretion of specialized lytic granules.

8 P-ribosylated proteins in non-membranous RNA granules.

9 oteins co-localized in catecholamine storage granules.

10 eration and promotes the formation of stress granules.

11 f moderate-density content or intracisternal granules.

12 involved in RNA metabolism, including stress granules.

13 gelatinization enthalpy than did the starch granules.

14 ound granule rather than multiple lenticular granules.

15 pithelia, except for a defect in Paneth cell granules.

16 role in the generation and stability of RNA granules.

17 Ca2+ channels in close proximity to insulin granules.

18 mefaciens also increased the number of round granules.

19 el function for Rbfox2 in cytoplasmic stress granules.

20 elopment of wild-type-like lenticular starch granules.

21 lescence of RNA-binding proteins into stress granules.

22 he plasma membrane but did not accumulate at granules.

23 nules, so-called clusters of free eosinophil granules.

24 granule size) to each of 323 archaeological granules.

25 e than 50% of their mRNA molecules in stress granules.

26 ated with microthrombocytopenia and platelet granule abnormalities.

27 The granular layer, which mainly consists of granule and Golgi cells, is the first stage of the cereb

28 gic component of dendrodendritic synapses of granule and mitral cells in the olfactory bulb.

29 rate that hypomorphic Foxc1 mutant mice have granule and Purkinje cell abnormalities causing subseque

30 The protein profiles of the pre-treated granule and the corresponding plasma fraction were studi

31 n all disrupted L-type channel clustering at granules and ablated fast exocytosis.

32 DNA damage, p53 mRNA is released from stress granules and associates with polyribosomes to increase p

33 Eo-MDSC exhibit eosinophilic cytoplasmic granules and express CD11b, the eosinophil marker Syglec

34 identify a functional continuum between germ granules and P bodies in the C. elegans embryo.

35 der characterized by platelets lacking alpha-granules and progressive marrow fibrosis.

36 tion factor V (FV) from the media into alpha-granules and releases functional FV(+)CD42b(+) human pla

37 ere it accumulated specifically at secretory granules and rendered them more prone to undergo exocyto

38 RNA molecules accumulate in mammalian stress granules and that only 185 genes have more than 50% of t

39 complex promote the biogenesis of secretory granules and thereby regulate hormone sorting and secret

40 ic ribonucleoprotein granules such as stress granules and those seeded by the aggregation of specific

41 eration of exocrine cells, decreased zymogen granules, and alterations in the endoplasmic reticulum (

42 g carbonate rosettes and magnetite-haematite granules, and is associated with carbonate in direct con

43 The granules are Ga(OH)3 precipitation, which indicates immo

44 Stress granules are important in the stress response and may co

45 released into soils from uncoated fertilizer granules are lost continuously due to volatilization, le

46 Intracellular ribonucleoprotein (RNP) granules are membrane-less droplet organelles that are t

47 The starch granules are polyhedral, with a diameter of 2.8 to 5.6mu

48 e embryo from the meiotic spindle while yolk granules are transported throughout the embryo by kinesi

49 hanisms for formation and selectivity of RNA granules are unknown.

50 FXGs (Fragile X granules) are axonal RNPs present in a stereotyped subse

51 Formation and disruption of granules, as well as RNA selectivity in granule composit

52 ich DPRs in cells induced spontaneous stress granule assembly that required both eIF2alpha phosphoryl

53 liquid-liquid phase separation may drive RNP granule assembly, the mechanisms underlying their supram

54 s to polarize with filamentous (F)-actin and granules at one pole and the nucleus in a specialized ur

55 ta-actin hotspots colocalize with docked RNA granules at the bases and tips of new branches.

56 cts as a barrier for secretion of such large granules at the cell-cell contact site.

57 gulated release of cytotoxic substances from granules at the immunological synapse.

58 sent a model for assembly of one type of RNA granule based on experimentally measured binding interac

59 n be packaged in reversibly stalled polysome granules before their transport to distant synaptic loca

60 ion or proplatelet formation, it dampened MK granule biogenesis and directional migration toward an S

61 Polyphosphate (polyP) granule biogenesis is an ancient and ubiquitous starvati

62 emporally coupled to a net increase in polyP granule biomass, suggesting that net synthesis, rather t

63 nce of Nbeal2 in mast cells above and beyond granule biosynthesis.

64 PF4 is stored in platelet alpha-granules bound to the glycosaminoglycan (GAG) chains of

65 ophyll cells typically contain five to seven granules, but remarkably, most chloroplasts in ptst2 mut

66 arger but similar in morphology to wild-type granules, but those of the double mutant had an aberrant

67 ere, we shift attention onto the mossy fiber granule cell (GrC) relay.

68 Glutamine had no effect on granule cell activation earlier, during epilepsy develop

69 psy development, and significantly increased granule cell activation in both control and chronically

70 Granule cell activity covaried trial by trial to form a

71 expected rewards elicited markedly different granule cell activity despite identical stimuli and lick

72 ikes to repetitive theta-frequency cycles of granule cell activity.SIGNIFICANCE STATEMENT Long-term s

73 ies reported monosynaptically coupled mitral/granule cell connections and neither attempted to determ

74 ocking NRSF transiently after eFSE prevented granule cell dysmaturation, restored a functional balanc

75 se-patch amplifier, we have recorded unitary granule cell EPSPs evoked in response to mitral cell act

76 g the transverse axis, powerfully regulating granule cell firing by imposing inhibition during a spec

77 recordings to show that selective tuning of granule cell inputs and bidirectional tuning of interneu

78 ds CA1-4, the dentate gyrus (DG) including a granule cell layer (GCL) and a molecular layer (ML) that

79 the deficiency of adult neurogenesis in the granule cell layer of the dentate gyrus and rescues hipp

80 GABAergic interneurons in or adjacent to the granule cell layer, but not with the loss of parvalbumin

81 aGeo) mice modulates H3ac and H3K4me3 in the granule cell layer, with concomitant rescue of both the

82 combinatorial and temporal diversity in the granule cell layer.

83 e cells and the transformed human cerebellar granule cell line DAOY, OGR1 promoted expression of the

84 yrus, seizures drive retrograde sprouting of granule cell mossy fiber axons.

85 nced neurogenesis and neuronal activation of granule cell neurons (GCNs) in the DG and produced compu

86 itic spines in newly generated dentate gyrus granule cell neurons of the hippocampus after a clinical

87 dendrites of hippocampal cornu ammonis 1 and granule cell neurons, effects that were also observed in

88 press high levels of Ptchd1 mRNA: cerebellar granule cell precursors and dentate granule cells in the

89 nstrate that following postnatal ablation of granule cell progenitors, Nestin-expressing progenitors,

90 over, we investigated the dentate gyrus (DG) granule cell reactivity and synaptic plasticity in naive

91 Hz reliably induced STDP at the mossy fiber-granule cell synapse, with potentiation and depression s

92 modeling of synaptic activity at cerebellar granule cell to Purkinje cell synapses of mice, we descr

93 monosynaptic inputs onto adult-born dentate granule cells (DGCs) are altered in experimental mesial

94 New dentate granule cells (DGCs) are continuously generated, and int

95 Dentate granule cells (DGCs) have a single, complex, apical dend

96 he role of upstream inputs to PCs-excitatory granule cells (GCs) and inhibitory molecular layer inter

97 he dentate gyrus receive inputs from dentate granule cells (GCs) and project back to GCs locally, con

98 interactions between mitral cells (MCs) and granule cells (GCs) can generate synchronized oscillatio

99 vel, highly detailed active model of dentate granule cells (GCs) replicating a wide palette of experi

100 s to result from interactions with GABAergic granule cells (GCs), yet the incidence of MC-GC connecti

101 y mitral cells (MCs) and inhibitory internal granule cells (IGCs), but the physiological mechanisms a

102 es posit that a large, diverse population of granule cells allows for highly detailed representations

103 Mature granule cells also contributed to functional mossy fiber

104 By targeting Pten in cerebellar granule cells and activating the AKT1-mTOR pathway, we i

105 Our findings suggest that the granule cells and mossy cells could be modulated separat

106 rophysiology-based classification of dentate granule cells and mossy cells in mice that we validated

107 In both normal granule cells and the transformed human cerebellar granu

108 Our results suggest that individual granule cells are able to influence relatively large gro

109 ent mixing.SIGNIFICANCE STATEMENT Cerebellar granule cells are among the simplest neurons, with tiny

110 ests a role for the cerebellum in cognition, granule cells are known to encode only sensory and motor

111 ce dendritic arborization of differentiating granule cells as a relevant step in eliciting this respo

112 amp recordings from retrovirally labeled new granule cells at 7-8 days post retroviral injection (dpi

113 Granule cells at the input layer of the cerebellum compr

114 optogenetics, we demonstrate that adult-born granule cells born before SE form functional recurrent m

115 rmanently pulse-label age-defined cohorts of granule cells born either before or after pilocarpine-in

116 Interestingly, granule cells born shortly after SE did not form functio

117 l adult neurogenesis, and adult-born dentate granule cells contribute to the pathologic retrograde sp

118 eveal that sprouted synapses from adult-born granule cells have a diminished ability to sustain recur

119 in of mitochondria, from hippocampal dentate granule cells in mice does not affect low-frequency dent

120 Granule cells in the dentate gyrus of the hippocampus ar

121 rebellar granule cell precursors and dentate granule cells in the hippocampus.

122 s are significantly more active than dentate granule cells in vivo, exhibit spatial tuning during hea

123 Aberrant integration of newborn hippocampal granule cells is hypothesized to contribute to the devel

124 ic input, the facilitating cortical input to granule cells is more powerful and less variable.

125 syltransferase encoded by the COX10 gene, in granule cells of the adult dentate gyrus.

126 n, but previous work suggests that GABAergic granule cells plays an important role, especially during

127 Some granule cells responded preferentially to reward or rewa

128 and the specific contribution of adult-born granule cells to functional mossy fiber sprouting is unk

129 s would limit the contribution of adult-born granule cells to hippocampal hyperexcitability in the ep

130 using targeted optogenetic activation of DG granule cells while recording in whole-cell patch-clamp

131 mossy cell, forms an intricate circuit with granule cells, CA3c pyramidal cells, and local interneur

132 modulating tonic inhibition in dentate gyrus granule cells, in a process involving crosstalk between

133 l methods were used to measure hilar ectopic granule cells, mossy cells, mossy fiber sprouting, astro

134 mossy cells, in contrast to sparse firing of granule cells, suggests differential involvement in patt

135 Cerebellar granule cells, which constitute half the brain's neurons

136 l principal cells from strongly depolarizing granule cells, which likely discharge in response to eit

137 nosynaptic excitatory connections with other granule cells.

138 al and tufted projection neurons, and 5T4 in granule cells.

139 ynaptic function in Ptchd1-deficient dentate granule cells.

140 quence, reduces the neuronal activity of the granule cells.

141 young (developing) but not mature adult-born-granule-cells (abGCs) in the olfactory bulb.

142 ducing TIA1 decreased the number and size of granules co-localizing with stress granule markers.

143 n of granules, as well as RNA selectivity in granule composition are regulated by distinct concentrat

144 One class of RNP granules consists of P bodies, which consist of nontrans

145 microgranules throughout the nucleoid, polyP granules consolidate and become transiently spatially or

146 on displayed altered expression of cytotoxic granule constituents and produced interferon-gamma upon

147 At their peak, mature granules constitute approximately 2% of the total cell v

148 Amorphous solid granules containing calcium and phosphorus were pervasiv

149 resent in the venous wall, and the number of granule-containing MCs decreased with thrombosis.

150 ed respiratory burst together with promoting granule content release could contribute to the chronic

151 s morphologic findings induced by neutrophil granule contents.

152 encing (RNA-seq) analysis of purified stress granule cores and single-molecule fluorescence in situ h

153 mRNA accumulation in stress granules correlates with longer coding and UTR regions a

154 oisture content decreased as the size of the granules decreased.

155 grees characterized by neutropenia, specific granule deficiency, myelodysplasia with excess of blast

156 n, DeltaPsi and ROS increased, and secretory granules disappeared.

157 w that casein kinase 2 (CK2) promotes stress granule dynamics.

158 oteins of the endocytic machinery to mediate granule endocytosis.

159 a identify Flower as a key protein mediating granule endocytosis.

160 e-enclosed compartments, including secretory granules, endosomes, and lysosomes.

161 cted enzymatically active neutrophil primary granule enzymes, myeloperoxidase, and human neutrophil e

162 dependent functions, including phagocytosis, granule exocytosis, and migration.

163 nodeficiency characterized by impaired lytic granule exocytosis.

164 is the precise role of Munc18-2 during lytic granule exocytosis.

165 antigen to TH1 cells, co-opting MC secretory granules for antigen processing and presentation and cre

166 MCs co-opt their secretory granules for antigen processing and presentation.

167 1 and SS4 are differently involved in starch granule formation and do not act in series.

168 f protein synthesis by downregulating stress granule formation through G3BP1.

169 lipid production leads to upregulated stress granule formation.

170 RNP granules formed by ALS-linked mutant TDP-43 are more vis

171 elium, and they were not colocalized with Zn granules found in the lysosome-containing vesicles or Fe

172 on the protein profile and microstructure of granule fractions from egg yolk.

173 t factor limiting the release of large lytic granules from NK cells from patients with CHS and could

174 chemically isolated reporter-tagged Mbp mRNA granules from primary cultured mammalian oligodendrocyte

175 r results show that liposomes and chromaffin granules fuse with GUVs containing activated SNAREs with

176 solution microscopy, we now show that, after granule fusion, actin recovers at the synapse and no fur

177 ocytotic events were represented by compound granule fusion, and the remainder were accounted for by

178 ional machinery is associated with Fragile X granules (FXGs), which are restricted to axons in a ster

179 esistance to diverse environmental stresses, granule genesis is poorly understood.

180 cell dramatically increases, and individual granules grow to occupy diameters as large as approximat

181 These granules have been identified as those of Solanum jamesi

182 Defects in stress granule homeostasis constitute a cornerstone of ALS/FTLD

183 ltigranular compound events (i.e. granule-to-granule homotypic fusion) was severely reduced in the ab

184 The formation of normal starch granules in Arabidopsis (Arabidopsis thaliana) leaf chlo

185 Here, we show that TDP-43 RNP granules in axons of rodent primary cortical neurons dis

186 matrices in a large population of individual granules in differentiated primary bronchial epithelial

187 e have identified a subset of docked insulin granules in human beta cells and rat-derived clonal insu

188 ls triggers exocytosis of insulin-containing granules in pancreatic beta cells and is required for th

189 g diathesis characterized by a lack of alpha granules in platelets.

190 agile X mental retardation protein on stress granules in response to arsenic treatment.

191 e and conformation of insulin in its storage granules in the pancreas are not known.

192 s ability to trigger the formation of Stress Granules in vivo.

193 , localizes to lysosome-like organelles (gut granules) in the intestine under copper overload conditi

194 of bioactive compounds from their secretory granules, including mast cell-restricted proteases such

195 l B.P., also contained tools with S. jamesii granules, indicating at least 4,000 y of intermittent us

196 Following cell cycle exit, granules initially retain a tight spatial organization,

197 ith STARCH SYNTHASE4 (SS4), which influences granule initiation and morphology.

198 scovered two plastidial proteins involved in granule initiation in Arabidopsis thaliana leaves.

199 ose that PTST2 and PTST3 are critical during granule initiation, as they bind and deliver suitable ma

200 the anterior ventral V-SVZ and regulate deep granule interneuron production depending on feeding beha

201 onse.Sequestering mRNA in cytoplasmic stress granules is a mechanism for translational repression.

202 anism that initiates the synthesis of starch granules is poorly understood.

203 l through which the entire contents of their granules is released.

204 nd provide insight into the contributions of granule layer anatomical features to afferent mixing.SIG

205 gged with EGFP (EB3-GFP) in primary external granule layer cells showed that netrin-1 differentially

206 primary neurons from the cerebellar external granule layer of P2 mouse pups of both sexes.

207 complement information theoretic studies of granule layer structure and provide insight into the con

208 and controls translational silencing and RNA granule localization.

209 ortion of human TFH cells contain dense-core granules marked by chromogranin B, which are normally fo

210 arker lactoferrin and 82% with the azurophil granule marker elastase.

211 ng phagosomes were enriched for the specific granule marker lactoferrin and 82% with the azurophil gr

212 d size of granules co-localizing with stress granule markers.

213 o assess the rheological properties of mucin granule matrices in live cells.

214 These results suggest that stress granules may not represent a specific biological program

215 rified whole secretory granules or secretory granule membranes uncovered their association with the a

216 ulated that mediators released from platelet granules might be involved.

217 ve inhibition in neutrophils does not affect granule morphology or degranulation, but it causes LAMP1

218 we have previously termed mitochondrial RNA granules (MRGs).

219 n and thus activation of genes essential for granule neuron differentiation.

220 treme cerebellar atrophy due to almost total granule neuron loss.

221 or the regulated proliferation of cerebellar granule neuron progenitors (CGNP) and for the growth of

222 Nestin but not Math1, a marker of committed granule neuron progenitors.

223 interneurons, switch their fate and generate granule neurons in mice.

224 Reduced excitability of dentate granule neurons in response to strong depolarizing stimu

225 xperience increased firing of active dentate granule neurons rapidly and robustly.

226 onjugating enzyme UBC13 in rodent cerebellar granule neurons robustly increases the number of paralle

227 y coupling in vivo Ca(2+) imaging of dentate granule neurons with a novel, unrestrained virtual reali

228 M-dependent neurite elongation in cerebellar granule neurons, a pathway previously shown to be disrup

229 f a set of long neuronal genes in cerebellar granule neurons.

230 compared to quiescent stem cells and mature granule neurons.

231 The mechanisms by which SS4 determines granule number and morphology are not understood.

232 oroplasts in ptst3 had a slight reduction in granule number compared with the wild type, while those

233 inority of cells have divided, yet the total granule number per cell decreases, total granule volume

234 rther, CD25, an IL-2R alpha chain, and lytic granules of NK cells in social microwells were polarized

235 tes zinc enrichment in the insulin secretory granules of the pancreatic beta cell.

236 Pharmacological depletion of MCs granules or prevention of MC degranulation also reduced

237 oteomic analysis of purified whole secretory granules or secretory granule membranes uncovered their

238 ING ENZYME2 (DPE2) displayed only one starch granule per chloroplast under normal growth conditions.

239 harbored a single large and spherical starch granule per plastid.

240 Medulloblastoma cells not arising from granule precursor cells show neither prominent rises in

241 nnels in DAOY cells, but not non-transformed granule precursor cells, results in prominent increases

242 hanced migration, while in normal cerebellar granule (precursor) cells and MB cells not derived from

243 ecursor) cells and MB cells not derived from granule precursors, only small levels of Ca(2+) influx a

244 also regulates insulin synthesis and insulin granule priming and contributes to beta-cell electrical

245 sms by which these sequences could alter RNA granule properties on evolutionary and cellular timescal

246 ed on fusions of an IDR derived from the RNA granule protein FUS (fused in sarcoma) to a multivalent

247 Many RNA granule proteins are composed of both modular domains an

248 hat m(6)A disrupts RNA binding by the stress granule proteins G3BP1/2, USP10, CAPRIN1, and RBM42.

249 Additionally, the eosinophil granule proteins major basic protein and eosinophil pero

250 ssion of CD69 and serum levels of eosinophil granule proteins, were increased posttreatment in both g

251 ctions are closely linked to their cytotoxic granule proteins.

252 R4-NOT complex, decapping and decay, or germ granule proteins.

253 hloroplasts typically produce only one round granule rather than multiple lenticular granules.

254 ction in translational repression and stress granule regulation.

255 We conclude that Epac2A controls secretory granule release by binding to the exocytosis machinery,

256 al propagation, more efficient initial lytic granule release, and more sustained cytokine and chemoki

257 al structures of starch, and the presence of granule remnants.

258 hile preserving the effect of nsP3 on stress granule responses and co-localisation with GTPase Activa

259 les were transported as a unit with the yolk granules, resulting in sperm DNA within 2 microm of the

260 Live cell imaging of lytic granules revealed their dynamic and prolonged polarizati

261 ation-dependent increases of alpha and dense-granule secretion and integrin alphaIIbbeta3 activation,

262 owever, how CTLs regulate the termination of granule secretion remains unclear.

263 d that platelet DREAM is important for alpha-granule secretion, Ca(2+) mobilization, and aggregation

264 ) mice, which lack platelet alpha- and dense-granule secretion, show no signs of hemorrhage in models

265 it an increased propensity to trigger stress granule (SG) formation resulting in global translation i

266 Stress granules (SG) are membrane-less organelles that are cond

267 otein that localizes to and primes secretory granules (SGs) for Ca(2+)-evoked secretion in various se

268 sis, during which the membranes of secretory granules (SGs) fuse with each other to form a channel th

269 acteristic properties of convection (such as granule size and contrast) for the most evolved giant an

270 ere higher, and the degree of crystallinity, granule size and gelatinization parameters of core starc

271 We derive a characteristic horizontal granule size of about 1.2 x 10(11) metres, which corresp

272 issure branching, fissure ratio, and maximum granule size) to each of 323 archaeological granules.

273 nts fall along the scaling relations between granule size, effective temperature and surface gravity

274 , which is associated with release of intact granules, so-called clusters of free eosinophil granules

275 stimulated exocytosis of the four neutrophil granule subtypes.

276 e localized to cytoplasmic ribonucleoprotein granules such as stress granules and those seeded by the

277 es that can create an influx of RNA into RNP granules, such as transcription, can spatiotemporally co

278 ckdown of Kv2.1 expression reduces secretory granule targeting to the plasma membrane.

279 st2 ptst3 double mutant contained even fewer granules than ptst2 The ptst2 granules were larger but s

280 contributed to significant changes in starch granules that were determined not only by the amylose co

281 e proteins involved in the formation of germ granules to coalesce into liquid droplets.

282 the yeast AMP kinase Snf1, condensates into granules to tune Snf1 activity.

283 umber of multigranular compound events (i.e. granule-to-granule homotypic fusion) was severely reduce

284 Here, we describe the stress granule transcriptome of yeast and mammalian cells throu

285 were accounted for by full fusion of single granules under basal and stimulated conditions.

286 d arginine, which may be abundant in insulin granules upon processing of pro-insulin, and stable T3R3

287 tal granule number per cell decreases, total granule volume per cell dramatically increases, and indi

288 rect processing of human renin in dense core granules was confirmed by immunogold labeling.

289 The number of starch granules was constant when the light/dark regime was alt

290 reactive oxygen species (ROS), and secretory granules were assessed with parameter-indicating fluorop

291 The distinctive Ga granules were deposited within the intercellular space i

292 ned even fewer granules than ptst2 The ptst2 granules were larger but similar in morphology to wild-t

293 sperm, energy charge was altered, and starch granules were more numerous but smaller on average than

294 ent and is localized in distinct cytoplasmic granules where its target mRNA can be detected.

295 n increased number of perinuclear nuage-like granules where Piwi proteins localize.

296 e remodeling of membranes of large secretory granules, which are integrated into the plasma membrane

297 le RNA-protein assemblies referred to as RNP granules, which are thought to form through multiple pro

298 the presence of significantly enlarged lytic granules with defective exocytosis and impaired integrit

299 and smaller liposomes or purified secretory granules with high temporal and spatial resolution.

300 Quinoa starch has small granules with relatively low gelatinization temperatures