ライフサイエンスコーパス: granule cell

1 rarely "inherited" place fields from single granule cells.

2 changed following COX10 removal from dentate granule cells.

3 tion of excitatory synapses in dentate gyrus granule cells.

4 on-induced activation of hippocampal dentate granule cells.

5 but rather to all synapses formed by dentate granule cells.

6 ease of both glutamate and GABA onto dentate granule cells.

7 es in the activation of deep and superficial granule cells.

8 quence, reduces the neuronal activity of the granule cells.

9 cells are the only interneurons that inhibit granule cells.

10 ostsynaptic ionic mechanisms at the level of granule cells.

11 ium indicators specifically to dentate gyrus granule cells.

12 h of which provide inhibition to hundreds of granule cells.

13 uclear output neurons contact both Golgi and granule cells.

14 e is known about how sensory input activates granule cells.

15 tex by decreasing Golgi cell inhibition onto granule cells.

16 er synaptic input and spike output in single granule cells.

17 le is known about how sensory input recruits granule cells.

18 nosynaptic excitatory connections with other granule cells.

19 al and tufted projection neurons, and 5T4 in granule cells.

20 ynaptic function in Ptchd1-deficient dentate granule cells.

21 te normal dendritic spine density on dentate granule cells.

22 l responses of both maturing and established granule cells.

23 Adult-born granule cells (abGCs) have been implicated in cognition

24 ed the functional life history of adult-born granule cells (abGCs) in the olfactory bulb using multip

25 young (developing) but not mature adult-born-granule-cells (abGCs) in the olfactory bulb.

26 rst proof-of-concept data demonstrating that granule cell ablation therapy applied at a clinically re

27 The present study also demonstrates that granule cell ablation, while reducing seizure frequency,

28 learning progressed, two-thirds of monitored granule cells acquired a conditional response whose timi

29 In epileptic mice, sparse granule cell activation could be restored by glutamine a

30 Glutamine had no effect on granule cell activation earlier, during epilepsy develop

31 psy development, and significantly increased granule cell activation in both control and chronically

32 Calcium imaging of granule cell activity 600-800 mum below the hippocampal

33 seems to promote spatial group selection of granule cell activity as a function of timing of mossy f

34 Granule cell activity covaried trial by trial to form a

35 expected rewards elicited markedly different granule cell activity despite identical stimuli and lick

36 which reduces aggression in mice, reduced DG granule cell activity during resident-intruder interacti

37 approach enables the analyses of individual granule cell activity over time and provides a powerful

38 forward inhibition as critical regulators of granule cell activity.

39 ikes to repetitive theta-frequency cycles of granule cell activity.SIGNIFICANCE STATEMENT Long-term s

40 at exclusive inhibition of JNK in adult-born granule cells alleviates anxiety and reduces depressive-

41 es posit that a large, diverse population of granule cells allows for highly detailed representations

42 In addition to asynchronous excitation, each granule cell also received synchronous feedforward inhib

43 Mature granule cells also contributed to functional mossy fiber

44 However, granule cells also provide excitatory input to Golgi cel

45 By targeting Pten in cerebellar granule cells and activating the AKT1-mTOR pathway, we i

46 between the primary cilia of mature dentate granule cells and behavior will require further investig

47 ore than 40 lipid species from dentate gyrus granule cells and CA1 pyramidal neurons of the hippocamp

48 t computational mechanisms: sparse coding in granule cells and changes in firing field locations in m

49 0 and Kif3A (respectively) in mature dentate granule cells and investigated hippocampus-dependent con

50 Our findings suggest that the granule cells and mossy cells could be modulated separat

51 rophysiology-based classification of dentate granule cells and mossy cells in mice that we validated

52 neuronal classes of the hippocampus; namely, granule cells and mossy cells of the dentate gyrus, and

53 ll-defined characteristics that can identify granule cells and mossy cells.

54 ns from synapsing with proximal dendrites of granule cells and raise questions about the recurrent ex

55 ssed in cortico-bulbar axons that synapse on granule cells and receptor activation reduces the feedfo

56 In both normal granule cells and the transformed human cerebellar granu

57 edicts that the dimensions of the cerebellar granule-cell and Drosophila Kenyon-cell representations

58 recursors, in proliferating and post-mitotic granule cells, and in Purkinje cells.

59 provide fast, slow, and tonic inhibition to granule cells, and thus allow Purkinje cells to regulate

60 ic neurons [cerebellar nuclear (CN) neurons, granule cells, and unipolar brush cells (UBCs)].

61 Mitral and granule cell Arc ensembles in OB showed enhanced stabili

62 Our results suggest that individual granule cells are able to influence relatively large gro

63 ent mixing.SIGNIFICANCE STATEMENT Cerebellar granule cells are among the simplest neurons, with tiny

64 rocal connections, little is known about how granule cells are excited.

65 Inhibitory granule cells are involved critically in shaping odor-ev

66 ests a role for the cerebellum in cognition, granule cells are known to encode only sensory and motor

67 ding hypothesis that newly generated dentate granule cells are pro-epileptogenic and contribute to th

68 of its principal neurons, the dentate gyrus granule cells, are missing.

69 atergic cell types, including mature dentate granule cells, area CA1-3 pyramidal cells and mossy cell

70 ts thus identify feedforward inhibition onto granule cells as a core feature of olfactory bulb circui

71 ce dendritic arborization of differentiating granule cells as a relevant step in eliciting this respo

72 amp recordings from retrovirally labeled new granule cells at 7-8 days post retroviral injection (dpi

73 Granule cells at the input layer of the cerebellum compr

74 TOR) signaling pathway with rapamycin blocks granule cell axon (mossy fiber) sprouting after epilepto

75 aV3.2, and KV7.2/7.3 subunit localization in granule cell axons.

76 ition in epileptic animals at basket cell-to-granule cell (BC-->GC) synapses, which normally are reli

77 el of temporal lobe epilepsy, basket cell-to-granule cell (BC-->GC) synaptic transmission is more lik

78 e were no changes in Bdnf mRNA in the parent granule cell bodies.

79 optogenetics, we demonstrate that adult-born granule cells born before SE form functional recurrent m

80 rmanently pulse-label age-defined cohorts of granule cells born either before or after pilocarpine-in

81 Interestingly, granule cells born shortly after SE did not form functio

82 -toxin receptor expression was induced among granule cells born up to 5 weeks before pilocarpine-indu

83 g, storage, and recall of information in the granule cell-CA3 cell network.

84 mossy cell, forms an intricate circuit with granule cells, CA3c pyramidal cells, and local interneur

85 patial scale over which interneurons such as granule cells can affect principal cells is a critical s

86 st evidence that ablation of newly generated granule cells can be an effective therapy when begun at

87 emonstrate that targeted ablation of newborn granule cells can produce a striking improvement in dise

88 indicating that bursts of activity in single granule cells can recruit feedback inhibition from Golgi

89 simple and compact morphology of cerebellar granule cells (CGCs) has led to the view that heterogene

90 ies reported monosynaptically coupled mitral/granule cell connections and neither attempted to determ

91 l adult neurogenesis, and adult-born dentate granule cells contribute to the pathologic retrograde sp

92 lcium imaging in behaving mice, we show that granule cells convey information about the expectation o

93 The mossy fiber (MF) axons of the dentate granule cells convey strong excitatory drive to CA3 pyra

94 o the inner molecular layer and synapse with granule cell dendrites despite rapamycin treatment.

95 ergic synapses formed by Golgi cell axons on granule cell dendrites within the IGL.

96 Stress also significantly affected granule cell dendrites.

97 lar hemispheres with stunted folia, profound granule cell depletion, Bergmann gliosis, and signs of P

98 y distributions and significantly attenuates granule cell depolarization within local subcellular com

99 cerebellum only has minor defects involving granule cells despite Pax6 being expressed throughout ce

100 Silenced dentate granule cells develop with input-specific decreases in s

101 it is not known whether mature dentate gyrus granule cells (DG GCs) also contribute.

102 egration and functions of adult-born dentate granule cell (DGCs) are poorly understood.

103 monosynaptic inputs onto adult-born dentate granule cells (DGCs) are altered in experimental mesial

104 terneurons peak when adult-generated dentate granule cells (DGCs) are approximately 4 weeks of age, a

105 New dentate granule cells (DGCs) are continuously generated, and int

106 Dentate granule cells (DGCs) have a single, complex, apical dend

107 loping dendrites of adult-born mouse dentate granule cells (DGCs) in vivo and found that they underwe

108 based mechanisms by which adult-born dentate granule cells (DGCs) modulate pattern separation to infl

109 application of FGF22 on the axons of dentate granule cells (DGCs), which are presynaptic to CA3 pyram

110 The continuous addition of new dentate granule cells (DGCs), which is regulated exquisitely by

111 r-mediated tonic inhibition in dentate gyrus granule cells (DGGCs), thereby contributing to the regul

112 iring properties of dentate mossy cells from granule cells during behavior.

113 ocking NRSF transiently after eFSE prevented granule cell dysmaturation, restored a functional balanc

114 se-patch amplifier, we have recorded unitary granule cell EPSPs evoked in response to mitral cell act

115 High-frequency spiking in single granule cells evoked IPSCs in approximately 5% of neighb

116 ossy fiber input invoked a large increase in granule cell excitability by modifying the biophysical p

117 s, and thus allow Purkinje cells to regulate granule cell excitability on multiple timescales.

118 Granule cells exhibited sparse firing, had a single plac

119 revealed that its dual role is critical for granule cell fate and morphogenesis.

120 Cerebellar granule cells fire in bursts, and their parallel fibre a

121 tacellular recording techniques, showed that granule cells fired very sparsely, whereas mossy cells i

122 ly bound output, (2) a wide dynamic range of granule cell firing and (3) transient and coherent gatin

123 g the transverse axis, powerfully regulating granule cell firing by imposing inhibition during a spec

124 mined the properties of the primary input to granule cells for the first time and show that these con

125 Mossy fiber afferents to cerebellar granule cells form the primary synaptic relay into cereb

126 Our approach opens new avenues to elucidate granule cell function, plasticity mechanisms, and networ

127 annels, suggesting that action potentials in granule cells function to coordinate GABA release at rel

128 cal circuit interneurons, including axonless granule cells, function to facilitate fine odor discrimi

129 on is mediated exclusively by enhancement of granule cell GABAA receptor currents, which only occurs

130 Cerebellar granule cell GABAA receptor responses to alcohol vary as

131 trate that genetic differences in cerebellar granule cell GABAA receptor responses to recreational co

132 the dentate gyrus (DG) control formation of granule cell (GC) assemblies during memory acquisition.

133 These adult-born granule cell (GC) interneurons form new GABAergic synaps

134 ith local inhibitory interneurons, including granule cells (GCs) and external plexiform layer (EPL) i

135 he role of upstream inputs to PCs-excitatory granule cells (GCs) and inhibitory molecular layer inter

136 he dentate gyrus receive inputs from dentate granule cells (GCs) and project back to GCs locally, con

137 a key component of spatial memory circuits - granule cells (GCs) are known to be morphologically dive

138 Newly generated dentate granule cells (GCs) are relevant for input discriminatio

139 interactions between mitral cells (MCs) and granule cells (GCs) can generate synchronized oscillatio

140 es of epigenetic pathway genes in cerebellar granule cells (GCs) during circuit formation.

141 e role of olfactory bulb interneurons called granule cells (GCs) in odor processing by imaging the ac

142 n the OB and olfactory cortex that innervate granule cells (GCs) may interfere and prevent robust res

143 vel, highly detailed active model of dentate granule cells (GCs) replicating a wide palette of experi

144 tively target and control the activity of DG granule cells (GCs) while performing whole-cell and juxt

145 tiation, and synaptic integration of newborn granule cells (GCs), migrating from the subventricular z

146 or underlying foliation is the generation of granule cells (gcs), the most numerous neuron type in th

147 s to result from interactions with GABAergic granule cells (GCs), yet the incidence of MC-GC connecti

148 We find that granule cells generate a sustained depolarization of Pur

149 Hippocampal granule cells generated in the weeks before and after an

150 c neuronal progenitors as well as cerebellar granule cells give rise to MBG3 with their distinct grow

151 ere, we shift attention onto the mossy fiber granule cell (GrC) relay.

152 Granule cells (GrCs) sample approximately four mossy fib

153 rebellar cortex by releasing GABA to inhibit granule cells (grcs).

154 eveal that sprouted synapses from adult-born granule cells have a diminished ability to sustain recur

155 ls, and native GABAA receptors of cerebellar granule cells, hippocampal neurons, and thalamic relay n

156 ide extrusion as a mechanism contributing to granule cell hyperactivation specifically during early e

157 theory, optogenetic gate restoration through granule cell hyperpolarization efficiently stopped spont

158 y mitral cells (MCs) and inhibitory internal granule cells (IGCs), but the physiological mechanisms a

159 iological studies of AOB inhibitory internal granule cells (IGCs), many of which upregulate the immed

160 eptors causing first winner keeps winning of granule cells, illustrate how fundamental properties of

161 chronic, functional imaging of dentate gyrus granule cells in awake, behaving mice in an intact hippo

162 We show that the majority of granule cells in Crus II of the cerebrocerebellum receiv

163 revealed that very young, one-week-old, new granule cells in male C57Bl/6 mice receive input not onl

164 in of mitochondria, from hippocampal dentate granule cells in mice does not affect low-frequency dent

165 cultures of rat hippocampal neurons, dentate granule cells in mouse organotypic slices, and layer 2/3

166 at hippocampal and cortical neurons, dentate granule cells in mouse organotypic slices, and layer 2/3

167 Furthermore, activating granule cells in non-epileptic animals evoked acute seiz

168 Despite the critical role of granule cells in olfaction, little is known about how se

169 ABAergic connections between Golgi cells and granule cells in the cerebellum is persistently altered

170 ent-intruder interactions strongly activated granule cells in the dentate gyrus (DG).

171 Granule cells in the dentate gyrus of the hippocampus ar

172 feration and neuronal development of dentate granule cells in the hippocampus.

173 rebellar granule cell precursors and dentate granule cells in the hippocampus.

174 GABAergic inhibition of hippocampal dentate granule cells in vivo and in vitro.

175 fibre synapses might be silent, however, and granule cells in vivo fire in bursts.

176 in the ER, is upregulated in Clcc1-deficient granule cells in vivo, and ubiquitinated proteins accumu

177 s are significantly more active than dentate granule cells in vivo, exhibit spatial tuning during hea

178 modulating tonic inhibition in dentate gyrus granule cells, in a process involving crosstalk between

179 ked IPSCs in approximately 5% of neighboring granule cells, indicating that bursts of activity in sin

180 markers and electron microscopic profiles of granule cells, indicating that the collaterals of nuclea

181 While previous work has shown that recurrent granule cell inhibition could in principle generate a wi

182 recordings to show that selective tuning of granule cell inputs and bidirectional tuning of interneu

183 Using a 3D model of mitral and granule cell interactions supported by experimental find

184 requirement likely enables the sparse mitral/granule cell interconnections to develop highly odor-spe

185 ogenesis continually supplies new inhibitory granule cells into existing circuitry, we isolated the d

186 of predictive, non-sensorimotor encoding in granule cells is a major departure from the current unde

187 Aberrant integration of newborn hippocampal granule cells is hypothesized to contribute to the devel

188 ic input, the facilitating cortical input to granule cells is more powerful and less variable.

189 implies that burst activity in dentate gyrus granule cells is required for detonation.

190 e most common local interneuron subtype, the granule cell, is excited during odor processing beyond t

191 rons in vitro and in vivo Adult-born dentate granule cells lacking Trim9 similarly exhibited excessiv

192 ning at E16.5, which prevented generation of granule cells later in development.

193 ds CA1-4, the dentate gyrus (DG) including a granule cell layer (GCL) and a molecular layer (ML) that

194 erformed on laser-microdissected hippocampal granule cell layer (GCL) and on plasma, at different tim

195 Combinatorial expansion by the cerebellar granule cell layer (GCL) is fundamental to theories of c

196 ons, labeled fibers were found mostly in the granule cell layer (GCL), not the GL.

197 s path from the subgranular zone through the granule cell layer and ensheathe local synapses and vasc

198 functional synaptic organization between the granule cell layer and its main targets, the Purkinje ce

199 ted fatty acid analysis of the dentate gyrus granule cell layer and the CA1 pyramidal layer with a 20

200 inje cell layer, but only postnatally in the granule cell layer and the dentate nucleus.

201 rs in the dentate gyrus corresponding to the granule cell layer and the subgranular zone and, contrar

202 inspired influential theoretical work on the granule cell layer as a combinatorial expander, where ea

203 These findings prioritize the loss of granule cell layer interneurons for further testing as a

204 n on sensory information transmission in the granule cell layer of the cerebellum.

205 the deficiency of adult neurogenesis in the granule cell layer of the dentate gyrus and rescues hipp

206 ts substantially enrich our understanding of granule cell layer processing, which seems to promote sp

207 ting enables random neuronal networks in the granule cell layer to provide the necessary signal separ

208 making axosomatic symmetric synapses in the granule cell layer were reconstructed from serial electr

209 Recombined cells in the hippocampal granule cell layer were visualized and quantified by yel

210 rtex (layers III, IV, and V) and cerebellum (granule cell layer), as well as the caudate nucleus in h

211 GABAergic interneurons in or adjacent to the granule cell layer, but not with the loss of parvalbumin

212 aGeo) mice modulates H3ac and H3K4me3 in the granule cell layer, with concomitant rescue of both the

213 combinatorial and temporal diversity in the granule cell layer.

214 signal was in the hippocampal pyramidal and granule cell layers.

215 e cells and the transformed human cerebellar granule cell line DAOY, OGR1 promoted expression of the

216 stimulation of mossy fiber input in lobule 9 granule cells lowered the current threshold to spike and

217 cing of sub-pools in the RRP in terminals of granule cells may play a role in the filtering of sensor

218 originating in the glomerular layer, but not granule-cell-mediated inhibition, reduces MC spike laten

219 containing channels that promote transformed granule cell migration.

220 control distinctive aspects of PCP-mediated granule cell morphogenesis with CELSR1 regulating the di

221 yrus, seizures drive retrograde sprouting of granule cell mossy fiber axons.

222 l methods were used to measure hilar ectopic granule cells, mossy cells, mossy fiber sprouting, astro

223 Although the granule cell-mossy cell synapse was strong and facilitat

224 sive multifocal leukoencephalopathy (PML) or granule cell neuronopathy (GCN).

225 nced neurogenesis and neuronal activation of granule cell neurons (GCNs) in the DG and produced compu

226 This antiviral activity was validated in granule cell neurons derived from the cerebellum and in

227 s, it blocks dendritic outgrowth of immature granule cell neurons in the dentate molecular layer indu

228 itic spines in newly generated dentate gyrus granule cell neurons of the hippocampus after a clinical

229 dendrites of hippocampal cornu ammonis 1 and granule cell neurons, effects that were also observed in

230 Furthermore, new dentate granule cell number, morphology and excitatory synaptic

231 nd decreased inhibitory synaptic inputs onto granule cells of Pafah1b1(+/-) mice.

232 syltransferase encoded by the COX10 gene, in granule cells of the adult dentate gyrus.

233 for structural synapse formation in dentate granule cells or for Shh-dependent neuronal precursor pr

234 Feedforward inhibition onto granule cells originated from deep short-axon cells, whi

235 LTP of granule cell output became evident in response to bursts

236 Tracking the same granule cells over several days of learning revealed tha

237 n is conveyed to Purkinje cells (PC) via the granule cell/parallel fibre (PF) pathway.

238 Inhibition of granule cells plays a key role in gating the flow of sig

239 n, but previous work suggests that GABAergic granule cells plays an important role, especially during

240 we demonstrate chronic two-photon imaging of granule cell population activity in awake mice using a c

241 ponses generates diverse phase coding in the granule cell population, allowing climbing-fiber-driven

242 ed state-dependent differences in the active granule cell population, with some cells displaying high

243 ly one event per 2-5 min per cell across the granule cell population.

244 ependent eyeblink conditioning in mice, that granule cell populations acquire a dense representation

245 We replicated the granule cell precursor proliferation defect in vitro and

246 gnaling controls proliferation of cerebellar granule cell precursors (GCPs), and its aberrant activat

247 press high levels of Ptchd1 mRNA: cerebellar granule cell precursors and dentate granule cells in the

248 ated ZNHIT3 to be expressed in proliferating granule cell precursors, in proliferating and post-mitot

249 us studies have demonstrated that inhibiting granule cell production before an epileptogenic brain in

250 n poorly formed folia and strikingly reduced granule cell production.

251 Cerebellar granule cell progenitors (GCP) proliferate extensively i

252 shown that deletion of Chd7 from cerebellar granule cell progenitors (GCps) results in reduced GCp p

253 erebella indicate that aberrant migration of granule cell progenitors destined to form the posterior-

254 nstrate that following postnatal ablation of granule cell progenitors, Nestin-expressing progenitors,

255 over, we investigated the dentate gyrus (DG) granule cell reactivity and synaptic plasticity in naive

256 Cerebellar granule cells receive five orders of magnitude fewer inp

257 Cerebellar granule cells receive mossy fiber inputs that convey inf

258 o shape signal processing at the mossy fiber-granule cell relay.

259 , its role in the function of mature dentate granule cells remains unknown.

260 ayer as a combinatorial expander, where each granule cell represents a unique combination of inputs.

261 Some granule cells responded preferentially to reward or rewa

262 Initially, granule cells responded to neutral visual and somatosens

263 ablation of AKAP7 specifically from dentate granule cells results in disruption of MF-CA3 LTP direct

264 SnRNA-seq of mouse dentate granule cells reveals large-scale changes in the activat

265 sive and active properties of the cerebellar granule cell's unmyelinated axon.

266 asic inhibition in the dentate gyrus through granule cell-selective knock-out of alpha2-GABAARs or th

267 tly, during differentiation of adult-born DG granule cells, Sema7A promotes dendrite growth, complexi

268 vitro, the extent to which inhibition shapes granule cell sensory responses in vivo remains unresolve

269 of stable connectivity with MCs, adult-born granule cells show dynamic and plastic patterns of synap

270 acts with asynchronous excitation to broaden granule cell spike latency distributions and significant

271 thought to preserve the temporal fidelity of granule cell spikes during mossy fiber stimulation.

272 The increase in granule cell spiking during locomotion is enhanced by gl

273 However, the dendrodendritic synapses from granule cell spines onto M/T dendrites were more prevale

274 mossy cells, in contrast to sparse firing of granule cells, suggests differential involvement in patt

275 can optimally induce STDP at the mossy fiber-granule cell synapse in rats.

276 Hz reliably induced STDP at the mossy fiber-granule cell synapse, with potentiation and depression s

277 tion displayed position-specific patterns of granule cell synaptic inputs that do not strictly match

278 and tau-positive grain-like inclusions into granule cells that extended in the hippocampal hilus and

279 tional recovery following acute depletion of granule cells, the most plentiful neuron population in t

280 related with the generation of hilar ectopic granule cells, the number of mossy cells, the extent of

281 controlling the timing of spikes emitted by granule cells, this form of bidirectional plasticity pro

282 nsic membrane excitability of rat cerebellar granule cells through modification of Kv4 A-type potassi

283 Principal cells interact with granule cells through reciprocal dendrodendritic connect

284 modeling of synaptic activity at cerebellar granule cell to Purkinje cell synapses of mice, we descr

285 and the specific contribution of adult-born granule cells to functional mossy fiber sprouting is unk

286 s would limit the contribution of adult-born granule cells to hippocampal hyperexcitability in the ep

287 prouted mossy fiber synapses from adult-born granule cells to study their synaptic properties.

288 en presented with different contexts, mature granule cells underwent robust remapping of their spatia

289 the cerebellar cortex, also directly inhibit granule cells via their axon collaterals.

290 ins of action potentials at 100 Hz in single granule cells was sufficient to evoke spikes in Golgi ce

291 ritic and distal apical dendritic domains of granule cells, was reliably recruited across sniff rhyth

292 ansgenic approaches to label adult-generated granule cells, we first asked whether a comparable proce

293 Many granule cells were also active during movements of nearb

294 ic synapses in the inner molecular layer per granule cell, which was reduced to 63% of controls 5 day

295 Cerebellar granule cells, which constitute half the brain's neurons

296 l principal cells from strongly depolarizing granule cells, which likely discharge in response to eit

297 lia in the memory function of mature dentate granule cells, which may result from abnormal mossy fibe

298 contains approximately 60 billion cerebellar granule cells, which outnumber all other brain neurons c

299 oxin to ablate peri-insult generated newborn granule cells, which were born in the weeks just before

300 using targeted optogenetic activation of DG granule cells while recording in whole-cell patch-clamp