ライフサイエンスコーパス: granule exocytosis

1 is the precise role of Munc18-2 during lytic granule exocytosis.

2 tion of myosin 1e antibody inhibits cortical granule exocytosis.

3 cell-receptor (TCR)-mediated cytotoxicity or granule exocytosis.

4 linking of the T cell receptor that leads to granule exocytosis.

5 imulated SNARE complex formation and insulin granule exocytosis.

6 rbol-12-myristate-13-acetate-evoked cortical granule exocytosis.

7 gher levels of CD107a, a marker of lysosomal granule exocytosis.

8 annot account for the profound inhibition of granule exocytosis.

9 n known for many years to be key signals for granule exocytosis.

10 oes not mediate the role of ERK in CTL lytic granule exocytosis.

11 er jasplakinolide or latrunculin A abolished granule exocytosis.

12 r mitochondrial ATP production and secretory granule exocytosis.

13 ing roles for Munc18c and/or Syn4 in insulin granule exocytosis.

14 ion of Mac-1 (CD11b/CD18) and with azurophil granule exocytosis.

15 s via a high-affinity interaction to promote granule exocytosis.

16 ed to identify genes required for dense core granule exocytosis.

17 granules reorientation but crucial for lytic granule exocytosis.

18 on and has been assumed to involve low level granule exocytosis.

19 ged proteins that secretion does not involve granule exocytosis.

20 ty and gamma-interferon secretion as well as granule exocytosis.

21 s of PC12 cell processes at or near sites of granule exocytosis.

22 extracellular Ca2+, is required for perforin/granule exocytosis.

23 hypothesize that rab3 functions in cortical granule exocytosis.

24 induces FasL/Fas-mediated cytolysis but not granule exocytosis.

25 sec, or roughly at the same time as cortical granule exocytosis.

26 nodeficiency characterized by impaired lytic granule exocytosis.

27 alcium dependence of sea urchin egg cortical granule exocytosis.

28 ge-dependent Ca2+ channels to elicit insulin granule exocytosis.

29 a critical orchestrator of goblet cell mucin granule exocytosis.

30 s virulence factors, such as LLO, facilitate granule exocytosis.

31 ositive for the proteins essential for lytic granule exocytosis.

32 ectly associated with primary (or secondary) granule exocytosis.

33 Munc13-4, syntaxin-11, and Munc18-2 in lytic granule exocytosis.

34 e effect of the LAT deletion on each step of granule exocytosis.

35 2+) sensor at rate-limiting priming steps in granule exocytosis.

36 VAMP8 is an essential SNARE in airway mucin granule exocytosis.

37 VAMP8 as one of the SNAREs regulating mucin granule exocytosis.

38 ition improved ERK phosphorylation and lytic granule exocytosis.

39 cal Ca(2+) nanodomains around TPCs stimulate granule exocytosis.

40 ) mobilization and substantial inhibition of granule exocytosis.

41 ) embryos despite fertilization and cortical granule exocytosis.

42 2+)-sensitive regulatory pathway for zymogen granule exocytosis.

43 bers is required for the regulation of lytic granule exocytosis.

44 y active mutant calcineurin A enhanced lytic granule exocytosis.

45 r a critical step between NKIS formation and granule exocytosis.

46 ing proteins are also essential for cortical granule exocytosis.

47 teps of membrane fusion in calcium-dependent granule exocytosis.

48 an important role for myosin 1e in cortical granule exocytosis.

49 g, independent of fertilization and cortical granule exocytosis.

50 y pathways for resting secretion and reserve granule exocytosis, a high capacity, low sensitivity pat

51 -CSF induced the highest sustained azurophil granule exocytosis, almost exclusively in PMNs with acti

52 F. alocis with Toll-like receptor 2 induced granule exocytosis along with a transient ERK1/2 and sus

53 family GTPase Cdc42 is required for insulin granule exocytosis, although the regulatory proteins inv

54 nding of sperm to the egg initiates cortical granule exocytosis, an event that contributes to a susta

55 ase antibodies were able to trigger cortical granule exocytosis and activation of GalTase-expressing

56 FcgammaRIIIA-induced granule exocytosis and both spontaneous and Ab-dependent

57 Among these, cortical granule exocytosis and compensatory endocytosis provide

58 ease-mediated reactions that follow cortical granule exocytosis and contribute to the block to polysp

59 effector-cell responses, including secretory granule exocytosis and cytokine production.

60 nt egg activation events, including cortical granule exocytosis and cytoplasmic segregation.

61 , representing a critical step in lymphocyte granule exocytosis and cytotoxicity.

62 Interestingly, alpha-granule exocytosis and deposition of the alpha-granule c

63 Alterations in insulin granule exocytosis and endocytosis are paramount to panc

64 C indicates that cell-mediated immunity with granule exocytosis and Fas pathways have been conserved

65 pases) has been proposed to mediate both the granule exocytosis and Fas-Fas ligand pathways of rapid

66 ) CTL clone that kills via both the perforin/granule exocytosis and FasL/Fas mechanisms, and a clone

67 elets demonstrated a partial defect in dense granule exocytosis and impaired aggregation.

68 y and characterize a role for syntaxin 11 in granule exocytosis and in the generation of cell-mediate

69 its putative role in facilitating secretory granule exocytosis and its consequent extracellular acti

70 or bacteria, bacterial killing, TNF-induced granule exocytosis and phox assembly, and endothelial tr

71 natural killer (NK) cells use Ca2+-dependent granule exocytosis and release of cytotoxic proteins, Fa

72 Based on primary granule exocytosis and scatter profiles, CF airway neutr

73 luation of patients with defects in platelet granule exocytosis and the generation of mice lacking sp

74 coordinated functions: to regulate cortical granule exocytosis and to mediate chromosome separation.

75 and Rac1 are pivotal regulators of adhesion, granule exocytosis, and cellular cytotoxicity.

76 sphorylation, integrin activation, secondary granule exocytosis, and cytokine secretion.

77 From the calcium dependence of cortical granule exocytosis, and from the exposure time and conce

78 dependent functions, including phagocytosis, granule exocytosis, and migration.

79 IP(4) limits NKR-induced IFNgamma secretion, granule exocytosis, and target-cell killing, in part by

80 as the site at which lipids regulate insulin granule exocytosis; and 3) deletion of the N-terminal mi

81 The substrates of PKCs involved in lytic granule exocytosis are currently unknown, but subcellula

82 cytotoxic granules and comparable levels of granule exocytosis are induced by PMA and calcium ionoph

83 membrane in a manner reminiscent of cortical granule exocytosis as described in other species.

84 HUVEC cytolysis was dependent on granule exocytosis, as demonstrated by the paralyzing ef

85 ivation of calcineurin is required for lytic granule exocytosis but suggest that it is not the sole C

86 of activated human NK cells not only induces granule exocytosis, but also subsequently results in the

87 onstrate that PKCdelta is required for lytic granule exocytosis, but is dispensable for activation, c

88 ressive drugs, JNK is not required for lytic granule exocytosis, but we were not able to exclude a ro

89 osylation diminished the effects of GLP-1 on granule exocytosis by approximately 40% in betaTC3 cells

90 Only granule exocytosis by CTLs was markedly impaired in the

91 Granule exocytosis by cytotoxic lymphocytes is the key m

92 ncerning the regulation of TCR-induced lytic granule exocytosis by revealing novel intracellular loca

93 xpressed at the earliest stage that cortical granule exocytosis can be detected in oocytes.

94 Interestingly, cortical granule exocytosis can be elicited in immature Xenopus o

95 a(2+)-dependent events that include cortical granule exocytosis, cell cycle resumption with concomita

96 owed by insemination does not block cortical granule exocytosis, cell cycle resumption, as assessed b

97 egg activation, including abnormal cortical granule exocytosis (CGE), cytoplasmic segregation, cleav

98 The data demonstrate that neutrophil granule exocytosis contributes to phagocytosis-induced r

99 urmised that the involvement of ERK in lytic granule exocytosis could be mediated through cross-talk

100 of Ca2+ release and also inhibited cortical granule exocytosis, cytoplasmic alkalinization, MAP kina

101 The granule exocytosis cytotoxicity pathway is the major mol

102 resence of cathepsin inhibitors requires the granule exocytosis cytotoxicity pathway, as it is normal

103 in the cytotoxic T lymphocyte (CTL)-mediated granule exocytosis death pathway and of granzyme entry i

104 cesses that are expected to be important for granule exocytosis-dependent killing.

105 Granule exocytosis-dependent target cell killing is a co

106 Granule exocytosis did not appear to play a role in Moon

107 HP2, had no effect on Ca2+ release, cortical granule exocytosis, DNA synthesis, or cleavage.

108 ls by both the Fas ligand (FasL)/Fas and the granule exocytosis effector pathways.

109 ced by CTL via the FasL/Fas, but not via the granule exocytosis, effector pathway was specifically bl

110 xerts dual roles in glucose-mediated insulin granule exocytosis, facilitating refilling of releasable

111 mice with genetic deficiencies affecting the granule exocytosis-, Fas-, or tumor necrosis factor rece

112 rab3 functions in the regulation of cortical granule exocytosis following vesicle docking.

113 ling has been solely attributed to cytotoxic granule exocytosis from activated CD8(+) T cells.

114 nc18c is required for SNARE-mediated insulin granule exocytosis from islet beta cells and GLUT4 vesic

115 alpha Granule exocytosis from VAMP-7(-/-) platelets was dimini

116 ing of which SNARE isoforms mediate platelet granule exocytosis has occurred following evaluation of

117 ome events of egg activation, e.g., cortical granule exocytosis, however, appear more sensitive to in

118 and recruitment of maternal mRNAs; cortical granule exocytosis, however, did not occur normally.

119 Following cortical granule exocytosis, however, rab3 reassociates with a di

120 rylated on the activation loop and regulates granule exocytosis in a kinase-dependent manner.

121 s show the capacity of MARCKS-ED to regulate granule exocytosis in a PKC-dependent manner, consistent

122 s well as by interfering with the process of granule exocytosis in CD8(+) T cells.

123 ignaling pathway(s) that selectively induces granule exocytosis in CTL has not been defined to date.

124 ion in helper T cells, plays a role in lytic granule exocytosis in cytotoxic T lymphocytes (CTLs).

125 ibe characteristics of fusion during zymogen granule exocytosis in exocrine pancreatic acinar cells.

126 evidence of histamine secretion by classical granule exocytosis in human mast cells in vivo.

127 miR-7 genomic circuit that regulates insulin granule exocytosis in pancreatic beta cells and support

128 ed calcium signaling and, therefore, insulin granule exocytosis in pancreatic beta cells.

129 second/granule mobilization phase of insulin granule exocytosis in pancreatic islet beta cells, altho

130 with syntaxin enhanced Ca2+-triggered dense granule exocytosis in permeabilized cells.

131 Premature granule exocytosis in Rho-deficient neutrophils activate

132 at small central synapses, as well as single granule exocytosis in secretory cells, have been detecte

133 contrast, the caspase inhibitors blocked CTL granule exocytosis-induced target apoptotic nuclear dama

134 Control of mast cell granule exocytosis is a major therapeutic goal for aller

135 Hence, cytotoxic granule exocytosis is a sequential, multivesicle fusion

136 s of the rab3 protein, we find that cortical granule exocytosis is inhibited in eggs injected with ef

137 In pancreatic beta cells, insulin granule exocytosis is regulated by SNARE (soluble N-ethy

138 Mucin granule exocytosis is regulated by specific protein comp

139 les are heterogeneous and demonstrating that granule exocytosis is required for platelet spreading.

140 Lytic granule exocytosis is the major effector function used b

141 Lytic granule exocytosis is the major pathway used by CD8+ CTL

142 tients with CHS and how LYST regulates lytic granule exocytosis is very limited.

143 In cells specialized for secretory granule exocytosis, lysosomal hydrolases may enter the r

144 ement for specific PKC localization in lytic granule exocytosis may have important implications for t

145 channels; and (iii) Ca(2+)-dependent insulin granule exocytosis, measured as increases in membrane ca

146 -and-run exocytosis (as determined by single-granule exocytosis measurements) in which the fusion por

147 ve lost the ability to kill via the perforin/granule exocytosis mechanism of killing, although they e

148 se for its inability to trigger the perforin/granule exocytosis mechanism of killing.

149 The perforin/granule exocytosis mechanism uses preformed cytolytic gr

150 h receptor pathways mediated by caspases and granule exocytosis mediated by direct GrB activity or Gr

151 kines and exhibit a potent Ag-specific lytic granule exocytosis-mediated cytolytic effector function

152 Granule exocytosis-mediated cytotoxicity by CD8(+) CTL p

153 l known to be critical for the regulation of granule exocytosis-mediated cytotoxicity in CD8+ T cells

154 tions, we show that PKCdelta is required for granule exocytosis-mediated lytic function in mouse CD8+

155 n interaction with target cells sensitive to granule exocytosis-mediated spontaneous cytotoxicity, an

156 n, showing neither lytic activity, nor lytic granule exocytosis, nor IFN-gamma production.

157 attachment protein receptor (SNARE)-mediated granule exocytosis occur in islet beta cells, adipocytes

158 Cytolytic granule exocytosis occurs at peptide concentrations insu

159 mage, but show that target cell lysis by CTL granule exocytosis occurs by a caspase-independent pathw

160 We find that whereas cortical granule exocytosis occurs over a narrow threshold range

161 Lymphocyte-mediated cytotoxicity via granule exocytosis operates by the perforin-mediated tra

162 PMA together with Ionomycin did not induce granule exocytosis or cytotoxicity by YT cells.

163 which effector mechanisms of CD8(+) T cells, granule exocytosis or Fas ligand expression, play a role

164 lular Ca2+, resume meiosis, undergo cortical granule exocytosis, or ZP2 cleavage to ZP2f.

165 These CD4+ T-cell lines lysed targets by the granule exocytosis pathway and reduced the viability of

166 Biochemical inhibition of the granule exocytosis pathway in CD4(+) and CD8(+) T cells

167 suggest involvement of the perforin/granzyme granule exocytosis pathway in immune regulation of gamma

168 Our data implicate the granule exocytosis pathway in TB-IRIS pathophysiology.

169 me C can support CTL-mediated killing by the granule exocytosis pathway in the absence of functional

170 However, target lysis via the granule exocytosis pathway is completely resistant to ca

171 d natural killer cells comes from either the granule exocytosis pathway or the Fas pathway.

172 Although the granule exocytosis pathway plays a major role in NK cell

173 TL activity was blocked by inhibitors of the granule exocytosis pathway such as ethylene-glyco-tetra-

174 Cytotoxic lymphocytes use the granule exocytosis pathway to kill pathogen-infected cel

175 though activated murine NK cells can use the granule exocytosis pathway to kill target cells immediat

176 hus, when caspase activation is blocked, the granule exocytosis pathway triggers several parameters o

177 The granule exocytosis pathway utilizes perforin to traffic

178 as ligand interaction and CD8(+) CTL via the granule exocytosis pathway.

179 cells exhibited notable abnormalities in the granule exocytosis pathway.

180 ng of target cells by the perforin-dependent granule exocytosis pathway.

181 phocytes (CTLs) can kill target cells by the granule/exocytosis pathway or the Fas-mediated apoptosis

182 when induced by the FasL/Fas, but not by the granule exocytosis, pathway.

183 Our findings imply that secretory granule exocytosis pathways in other cell types may also

184 he native J-domain of csp inhibited cortical granule exocytosis, point mutations that interfere with

185 it ligand/stem cell factor-induced secretory granule exocytosis, proliferation, and phosphorylation o

186 ocrine cells, that upon stimulated secretory granule exocytosis, raft-associated Tac-CPE25 was rapidl

187 ion," resulting in calcium release, cortical granule exocytosis, recruitment of maternal mRNAs, and c

188 and then examined the effect on the cortical granule exocytosis, recruitment of maternal mRNAs, and c

189 Whereas granule exocytosis targets any antigen-bearing cell, fas

190 lar phase of synthesis, packaging and apical granule exocytosis that is followed by an extracellular

191 ificantly inhibited cytotoxicity-mediated by granule exocytosis, that is, cytotoxicity of alloantigen

192 raacetic acid, which inhibit cytotoxicity by granule exocytosis, the CD4(+) cytotoxic T lymphocytes (

193 on events such as sperm-egg fusion, cortical granule exocytosis, the elevation of phosphatidylinosito

194 E proteins have been implicated in cytotoxic granule exocytosis, the role of vesicular SNARE proteins

195 lso appears to have an essential function in granule exocytosis through actions mediated by its E pep

196 racellular granzyme (Gr) B content and lytic granule exocytosis through surface CD107a expression.

197 y, use distinct members of the TNF family or granule exocytosis to mediate target cell death.

198 4 bound Ca(2+) and restored Ca(2+)-dependent granule exocytosis to permeable cells (platelets, mast,

199 ng the transcriptional profile while leaving granule exocytosis unabated.

200 We investigated the role of Ca(2+) influx in granule exocytosis using TALL-104 human leukemic cytotox

201 internalized TrkA receptors promote insulin granule exocytosis via F-actin reorganization.

202 ted in the trans-Golgi network and secretory granule exocytosis was more responsive to secretagogue.

203 that bypasses TCR/CD3-dependent signalling, granule exocytosis was not significantly altered, sugges

204 ression of full-length Xenopus csp, cortical granule exocytosis was reduced by approximately 80%.

205 IP(3)-induced cortical granule exocytosis was significantly decreased in these

206 locis-induced secretory vesicle and specific granule exocytosis were p38 MAPK dependent.

207 I and cortical actin filaments in chromaffin granule exocytosis were studied by confocal fluorescence

208 tural killer cells, that are released during granule exocytosis when a specific virus-infected or tra

209 myosin 1e augments the kinetics of cortical granule exocytosis, whereas tail-derived fragments of my

210 quent egg activation steps, such as cortical granule exocytosis, which modifies the vitelline membran

211 e fact that Arg1 activation requires primary granule exocytosis, which occurs in CF, but not HC, airw

212 and suggest a mechanism whereby VAMP-7 links granule exocytosis with actin reorganization.

213 r involving, at least in part, inhibition of granule exocytosis without affecting effector/target cel