ライフサイエンスコーパス: granulin

1 ulin is cleaved into smaller peptides called granulins.

2 carriers whereby more GRN is processed into granulins.

3 The granulin A repeat unit of GEP is required and sufficient

4 Interestingly, expression of individual granulins alone had little effect on behavior.

5 n old mice expressed low levels of CSF1R and granulin and failed to promote tumor outgrowth, suggesti

6 Despite the unusual structure of the granulin and granulin-polyhedrin inclusions, they intera

7 receptors and the intracellular functions of granulins and progranulin is crucial for understanding t

8 radigm approach in 13 presymptomatic (n = 13 Granulin) and 14 symptomatic (n = 11 Granulin, n = 3 C9o

9 vitro, whereas increasing concentrations of granulin antibody inhibited cell growth in a dose-depend

10 Granulins are a family of protein growth factors that ar

11 Progranulin and granulins are attributed with roles in cancer, inflammat

12 or the human blood fluke Schistosoma mansoni Granulins are growth factors that drive proliferation of

13 These granulins are present in complexes with Tat and P-TEFb i

14 We identified granulin as a cyclin T1-interacting protein that repress

15 enome, raising the possibility of developing granulin-based inhibitors of viral infection.

16 tive disulfide bonds lack the characteristic granulin beta-hairpin structure.

17 cterize a progranulin [Biomphalaria glabrata granulin (BgGRN)] from the snail B. glabrata, a natural

18 Granulin bound to the histidine-rich domain of cyclin T1

19 rogranulin is proteolytically processed into granulins, but the role of granulins in the pathogenesis

20 Granulins DE and E bind Tat but do not interact directly

21 Granulins DE and E repress transcription from the HIV-1

22 cing a nuclear localization signal (KRKK) in granulin directed more granulin to the nucleus and resul

23 e for subfamilies, and the carboxyl-terminal granulin domain occurs in two PLCP subfamilies, in which

24 with RD21 (responsive to desiccation 21), a granulin domain-containing cysteine protease implicated

25 members probably evolved by deletion of the granulin domains.

26 Finally, we show that granulin E, a cleavage product of PGRN, is sufficient to

27 Granulin epithelin precursor (GEP) has been implicated i

28 teine-rich polypeptides called epithelins or granulins (epithelin/granulin precursor).

29 ADAMTS-7 associates with granulin-epithelin precursor (GEP), an autocrine growth

30 This led to the identification of granulin-epithelin precursor (GEP), an autocrine growth

31 Granulin-epithelin precursor (GEP/progranulin) is an aut

32 in, acrogranin, PC-derived growth factor, or granulin-epithelin precursor) is a secreted glycoprotein

33 Previous studies showed that the granulin/epithelin precursor (GEP) binds the histidine-r

34 The granulin/epithelin precursor (GEP) has been identified a

35 e gel electrophoresis, was identified as the granulin/epithelin precursor by an accurate determinatio

36 The granulin/epithelin precursor is a little known growth fa

37 Granulin expression inhibited Tat transactivation, and t

38 ains interacting most with perlecan harbored granulins F and B.

39 We show that granulin formed stable complexes in vivo and in vitro wi

40 in human neurodegenerative disease subjects, granulin fragments accumulated specifically in diseased

41 the first demonstration of a toxic role for granulin fragments in a neurodegenerative disease model.

42 nly detects full-length GRN, no intermediate granulin fragments.

43 An orthologue of granulin from the human parasitic liver fluke Opisthorch

44 Substitution of granulin from the Trichoplusia ni granulosis virus (TnGV

45 rounding the human alphaIIb locus showed the Granulin gene approximately 18 kb downstream to alphaIIb

46 In 2006, mutations in the granulin gene were identified in patients with familial

47 We then identified granulin (GRN) as the most upregulated gene in instigati

48 f progranulin (PGRN) due to mutations in the granulin (GRN) gene causes frontotemporal lobar degenera

49 Mutations within the granulin (GRN) gene that encodes progranulin (PGRN) caus

50 Granulin (GRN) is a potent mitogen and growth factor imp

51 ntotemporal lobar degeneration (FTLD) due to Granulin (GRN) mutations might present a specific patter

52 Granulin (GRN) mutations represent one of the most frequ

53 Granulin (GRN, or progranulin) is a protein involved in

54 ion suggest a potentially important role for granulin in the pathogenesis and/or malignant progressio

55 ly processed into granulins, but the role of granulins in the pathogenesis of neurodegenerative disea

56 etrahedral occlusions with more virions than granulin inclusions but many fewer than wild-type polyhe

57 These same granulins increased TDP-43 levels via a post-translation

58 but the large cuboidal inclusions formed by granulin indicate that the amino acid sequence is not th

59 Thus, granulin is a cellular protein that interacts with cycli

60 Immunity, Park et al. present evidence that granulin is a cofactor for TLR9 activation, delivering C

61 ins in granuloviruses are located within the granulin matrix.

62 g [3H]thymidine incorporation indicated that granulin may be a glial mitogen, as addition of syntheti

63 oduced, much larger, cryocooled granulovirus granulin microcrystals.

64 The granulins, mitogenic growth factors containing repeats o

65 The 2.1-kb granulin mRNA was expressed predominantly in glial tumor

66 nerative-related protein accumulation, human granulin mutation cases were investigated by histochemic

67 wed a neuronal and glial tau accumulation in granulin mutation cases.

68 Granulin mutations were initially found in tau-negative

69 (n = 13 Granulin) and 14 symptomatic (n = 11 Granulin, n = 3 C9orf72) subjects with a pathogenic muta

70 The failure of granulin or the granulin-polyhedrin chimera to properly

71 odv-e66, odv-e18), and polyhedra (polyhedrin/granulin, p10, pp34, and fp25k).

72 be a glial mitogen, as addition of synthetic granulin peptide to primary rat astrocytes and three dif

73 l surface receptors for progranulin, but not granulin peptides, have been reported.

74 change in inclusion shape obtained with the granulin-polyhedrin chimera demonstrates that the primar

75 A granulin-polyhedrin chimera produced tetrahedral occlusi

76 The failure of granulin or the granulin-polyhedrin chimera to properly occlude AcMNPV v

77 te the unusual structure of the granulin and granulin-polyhedrin inclusions, they interacted with AcM

78 rived growth factor is acrogranin (epithelin/granulin precursor), a factor that possesses growth-regu

79 es called epithelins or granulins (epithelin/granulin precursor).

80 an 88-kDa glycoprotein corresponding to the granulin precursor.

81 C cell line and corresponds to the epithelin/granulin precursor.

82 ese studies suggest that presence of cleaved granulins, rather than or in addition to loss of full-le

83 we show that GEP and some of its constituent granulin repeats can inhibit HIV-1 transcription via Tat

84 alent cation requirements, and we identified granulin repeats that bind differentially to Tat and cyc

85 Binding of granulin to P-TEFb inhibited the phosphorylation of a CT

86 ulated CSF-1R and secreted the growth factor granulin to support stromal activation and robust tumor

87 tion signal (KRKK) in granulin directed more granulin to the nucleus and resulted in more structurall

88 specifically interrogate the contribution of granulins to the neurodegenerative process.

89 Granulin transcript haploinsufficiency has been proposed

90 pondin motifs of ADAMTS-7/ADAMTS-12 and each granulin unit of GEP mediated their interactions.

91 In addition, granulin was a substrate for CDK9 but not for the other

92 In contrast, when granulins were coexpressed with TDP-43, they exacerbated

93 vely new class of growth regulators known as granulins, which have tertiary structures resembling the

94 The interactions of granulins with Tat and cyclin T1 differ with respect to